IS7857A - Setnar pýrróló-pýrasól afleiður sem kínasa hindrar - Google Patents

Setnar pýrróló-pýrasól afleiður sem kínasa hindrar

Info

Publication number: IS7857A
Authority: IS; Iceland
Prior art keywords: pyrrolo; installs; pyrazole derivatives; inhibit kinase; cell cycle
Prior art date: 2002-12-19

Application number

IS7857A

Other languages

English (en)

Inventor

Gabriella Brasca Maria

Amici Raffaella

Fancelli Daniele

Nesi Marcella

Orsini Paolo

Orzi Fabrizio

Roussel Patrick

Vulpetti Anna

Pevarello Paolo

Original Assignee

Pharmacia Italia S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-19

Filing date

2005-05-23

Publication date

2005-08-18

2005-05-23 Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.

2005-08-18 Publication of IS7857A publication Critical patent/IS7857A/is

Links

108091000080 Phosphotransferase Proteins 0.000 title abstract 2
102000020233 phosphotransferase Human genes 0.000 title abstract 2
GZTPJDLYPMPRDF-UHFFFAOYSA-N pyrrolo[3,2-c]pyrazole Chemical class N1=NC2=CC=NC2=C1 GZTPJDLYPMPRDF-UHFFFAOYSA-N 0.000 title 1
230000022131 cell cycle Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Neurology (AREA)
Dermatology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pathology (AREA)
Radiology & Medical Imaging (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IS7857A 2002-12-19 2005-05-23 Setnar pýrróló-pýrasól afleiður sem kínasa hindrar IS7857A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43495202P	2002-12-19	2002-12-19
PCT/EP2003/050942 WO2004056827A2 (en)	2002-12-19	2003-12-04	Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Publications (1)

Publication Number	Publication Date
IS7857A true IS7857A (is)	2005-08-18

Family

ID=32682128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7857A IS7857A (is)	2002-12-19	2005-05-23	Setnar pýrróló-pýrasól afleiður sem kínasa hindrar

Country Status (33)

Country	Link
US (5)	US7407971B2 (is)
EP (2)	EP2266987B1 (is)
JP (2)	JP4739761B2 (is)
KR (2)	KR20120038465A (is)
CN (1)	CN1726217B (is)
AP (1)	AP2005003343A0 (is)
AR (1)	AR042525A1 (is)
AU (1)	AU2003300255B9 (is)
BR (1)	BR0317455A (is)
CA (1)	CA2508069C (is)
CR (2)	CR7880A (is)
CU (1)	CU23550B7 (is)
EA (1)	EA010596B1 (is)
EC (1)	ECSP055864A (is)
ES (2)	ES2605848T3 (is)
GE (1)	GEP20084435B (is)
HR (1)	HRP20050562A2 (is)
IL (2)	IL169019A (is)
IS (1)	IS7857A (is)
MA (1)	MA27569A1 (is)
ME (1)	MEP52408A (is)
MX (1)	MXPA05006791A (is)
MY (1)	MY141196A (is)
NO (1)	NO333178B1 (is)
NZ (1)	NZ540644A (is)
OA (1)	OA13015A (is)
PL (1)	PL377285A1 (is)
RS (1)	RS20050462A (is)
TN (1)	TNSN05163A1 (is)
TW (1)	TWI327470B (is)
UA (1)	UA81790C2 (is)
WO (1)	WO2004056827A2 (is)
ZA (1)	ZA200504298B (is)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100904157B1 (ko) *	2000-08-10	2009-06-23	파마시아 이탈리아 에스.피.에이.	키나제 억제제로서 활성인 비사이클로-피라졸, 이의제조방법 및 이를 포함하는 약제학적 조성물
UA81790C2 (uk)	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
KR101312736B1 (ko)	2003-02-27	2013-09-27	팔라우 파르마 에스에이	피라졸로피리딘 유도체
CA2518395A1 (en) *	2003-03-11	2004-09-23	Pharmacia Italia S.P.A.	Bicyclo-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2005030776A1 (en)	2003-09-23	2005-04-07	Vertex Pharmaceuticals Incorporated	Pyrazolopyrrole derivatives as protein kinase inhibitors
US7572914B2 (en)	2003-12-19	2009-08-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
WO2005089496A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20050277629A1 (en) *	2004-03-18	2005-12-15	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies (Lansbury)
WO2005089515A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
WO2005089504A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
WO2006023931A2 (en)	2004-08-18	2006-03-02	Takeda San Diego, Inc.	Kinase inhibitors
US7713973B2 (en)	2004-10-15	2010-05-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
EP1824843A2 (en)	2004-12-07	2007-08-29	Locus Pharmaceuticals, Inc.	Inhibitors of protein kinases
CA2589271A1 (en)	2004-12-07	2006-06-15	Locus Pharmaceuticals, Inc.	Urea inhibitors of map kinases
SI1838718T1 (sl)	2005-01-10	2011-08-31	Pfizer	Pirolopirazoli, zmogljivi inhibitorji kinaze
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
MEP0808A (xx) *	2005-12-21	2010-02-10	Pfizer Prod Inc	Karbonilamino pirolopirayoli, snažni inhibitori kinaza
SI1979356T1 (sl) *	2005-12-21	2013-11-29	Pfizer Products Inc.	Karbonilamino pirolopirazoli, močni inhibitorji kinaze
ES2442491T3 (es)	2006-03-03	2014-02-11	Nerviano Medical Sciences S.R.L.	Biciclopirazoles activos como inhibidores de cinasa
GEP20135728B (en)	2006-10-09	2013-01-25	Takeda Pharmaceuticals Co	Kinase inhibitors
EP2089394B1 (en)	2006-10-11	2011-06-29	Nerviano Medical Sciences S.r.l.	Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
JP5161245B2 (ja)	2007-02-07	2013-03-13	ファイザー・インク	ＰＫＣ阻害剤としての３−アミノ−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルボアルデヒド誘導体
UA96618C2 (en) *	2007-02-07	2011-11-25	Пфайзер Инк.	3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors
CA2683695C (en) *	2007-04-12	2013-06-18	Pfizer Inc.	3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldehyde derivatives
US8232402B2 (en) *	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
CA2743717A1 (en) *	2008-11-13	2010-05-20	Link Medicine Corporation	Azaquinolinone derivatives and uses thereof
US9180127B2 (en)	2009-12-29	2015-11-10	Dana-Farber Cancer Institute, Inc.	Type II Raf kinase inhibitors
CA2856291C (en)	2011-11-17	2020-08-11	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-jun-n-terminal kinase (jnk)
EP2909194A1 (en)	2012-10-18	2015-08-26	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (cdk7)
US9758522B2 (en)	2012-10-19	2017-09-12	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en)	2012-10-19	2014-04-24	Dana-Farber Cancer Institute, Inc.	Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
AU2014337122B2 (en)	2013-10-18	2019-01-03	Dana-Farber Cancer Institute, Inc.	Heteroaromatic compounds useful for the treatment of proliferative diseases
US10047070B2 (en)	2013-10-18	2018-08-14	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
US9862688B2 (en)	2014-04-23	2018-01-09	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (en)	2014-04-23	2015-10-29	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
EP3145931B1 (en)	2014-05-23	2021-03-31	Mingsight Pharmaceuticals, Inc.	Treatment of autoimmune disease
CA2966164C (en)	2014-10-31	2023-10-17	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole compound
EP3236959B1 (en)	2014-12-23	2025-09-24	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (cdk7)
AU2016243529B2 (en)	2015-03-27	2021-03-25	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
US10702527B2 (en)	2015-06-12	2020-07-07	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
EP3309163A4 (en)	2015-06-15	2019-01-09	UBE Industries, Ltd.	SUBSTITUTED DIHYDROPYRROLO PYRAZOL DERIVATIVE
KR101845931B1 (ko) *	2015-06-18	2018-04-05	한국화학연구원	헤테로아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
EP4019515A1 (en)	2015-09-09	2022-06-29	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
WO2017087318A1 (en) *	2015-11-20	2017-05-26	Mingsight Pharmaceuticals, Inc.	Treatment of autoimmune disease
JP2019112305A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	アトピー性皮膚炎の治療または予防のための医薬組成物
JP2019112307A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
JP2019112306A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	慢性閉塞性肺疾患の治療または予防のための医薬組成物
CN107337674B (zh) *	2016-04-29	2019-09-20	江苏吉贝尔药业股份有限公司	用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途
JP7590185B2 (ja)	2018-06-25	2024-11-26	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用
EP3885347B1 (en)	2018-11-14	2023-11-22	UBE Corporation	Dihydropyrrolopyrazole derivative
AU2019413694B2 (en)	2018-12-28	2025-03-20	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
AU2020319005B2 (en) *	2019-07-23	2026-01-08	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
CN115073471B (zh) *	2021-03-11	2023-03-21	沈阳药科大学	吡唑并四氢吡咯类衍生物、其制备方法和在医药上的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3526633A (en) *	1968-03-06	1970-09-01	American Cyanamid Co	Substituted 2,4,5,6-tetrahydropyrrolo(3,4-c)pyrazoles
GB9911053D0 (en)	1999-05-12	1999-07-14	Pharmacia & Upjohn Spa	4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
GEP20053476B (en)	1999-08-12	2005-03-25	Upjohn Co	3(5)-Amino-Pyrazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents
US6387900B1 (en)	1999-08-12	2002-05-14	Pharmacia & Upjohn S.P.A.	3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
KR100904157B1 (ko) *	2000-08-10	2009-06-23	파마시아 이탈리아 에스.피.에이.	키나제 억제제로서 활성인 비사이클로-피라졸, 이의제조방법 및 이를 포함하는 약제학적 조성물
US20040019046A1 (en) *	2000-11-27	2004-01-29	Paolo Pevarello	Phenylacetamido-pyrazole derivatives and their use as antitumor agents
EP1379524A2 (en) *	2001-01-26	2004-01-14	Pharmacia Italia S.p.A.	Chromane derivatives, process for their preparation and their use as antitumor agents
ES2357502T3 (es)	2001-09-26	2011-04-27	Pfizer Italia S.R.L.	Derivados de aminoindazol activos como inhibidores de quinasa, procedimiento para su preparación y composiciones farmaceuticas que los contienen.
UA81790C2 (uk) *	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази

2003
- 2003-04-12 UA UAA200507098A patent/UA81790C2/uk unknown
- 2003-12-04 ES ES03799536.2T patent/ES2605848T3/es not_active Expired - Lifetime
- 2003-12-04 EP EP10179134.1A patent/EP2266987B1/en not_active Expired - Lifetime
- 2003-12-04 MX MXPA05006791A patent/MXPA05006791A/es active IP Right Grant
- 2003-12-04 GE GEAP20038905A patent/GEP20084435B/en unknown
- 2003-12-04 CA CA2508069A patent/CA2508069C/en not_active Expired - Fee Related
- 2003-12-04 OA OA1200500186A patent/OA13015A/fr unknown
- 2003-12-04 EA EA200501009A patent/EA010596B1/ru not_active IP Right Cessation
- 2003-12-04 AU AU2003300255A patent/AU2003300255B9/en not_active Ceased
- 2003-12-04 KR KR1020127002938A patent/KR20120038465A/ko not_active Ceased
- 2003-12-04 US US10/539,145 patent/US7407971B2/en not_active Expired - Lifetime
- 2003-12-04 AP AP2005003343A patent/AP2005003343A0/xx unknown
- 2003-12-04 NZ NZ540644A patent/NZ540644A/en not_active IP Right Cessation
- 2003-12-04 PL PL377285A patent/PL377285A1/pl unknown
- 2003-12-04 WO PCT/EP2003/050942 patent/WO2004056827A2/en not_active Ceased
- 2003-12-04 JP JP2004561484A patent/JP4739761B2/ja not_active Expired - Fee Related
- 2003-12-04 KR KR1020057011433A patent/KR101223826B1/ko not_active Expired - Fee Related
- 2003-12-04 ES ES10179134.1T patent/ES2635191T3/es not_active Expired - Lifetime
- 2003-12-04 HR HR20050562A patent/HRP20050562A2/hr not_active Application Discontinuation
- 2003-12-04 RS YUP-2005/0462A patent/RS20050462A/sr unknown
- 2003-12-04 BR BR0317455-7A patent/BR0317455A/pt not_active IP Right Cessation
- 2003-12-04 EP EP03799536.2A patent/EP1575954B1/en not_active Expired - Lifetime
- 2003-12-04 ME MEP-524/08A patent/MEP52408A/xx unknown
- 2003-12-04 CN CN2003801064477A patent/CN1726217B/zh not_active Expired - Lifetime
- 2003-12-05 MY MYPI20034670A patent/MY141196A/en unknown
- 2003-12-16 TW TW092135527A patent/TWI327470B/zh not_active IP Right Cessation
- 2003-12-18 AR ARP030104702A patent/AR042525A1/es unknown
2005
- 2005-05-23 IS IS7857A patent/IS7857A/is unknown
- 2005-05-26 ZA ZA200504298A patent/ZA200504298B/en unknown
- 2005-06-06 IL IL169019A patent/IL169019A/en not_active IP Right Cessation
- 2005-06-09 NO NO20052805A patent/NO333178B1/no not_active IP Right Cessation
- 2005-06-14 CU CU20050117A patent/CU23550B7/es not_active IP Right Cessation
- 2005-06-17 TN TNP2005000163A patent/TNSN05163A1/fr unknown
- 2005-06-17 CR CR7880A patent/CR7880A/es unknown
- 2005-06-17 MA MA28347A patent/MA27569A1/fr unknown
- 2005-06-17 EC EC2005005864A patent/ECSP055864A/es unknown
2008
- 2008-07-29 US US12/181,772 patent/US8557857B2/en not_active Expired - Fee Related
- 2008-10-16 CR CR10370A patent/CR10370A/es not_active Application Discontinuation
2011
- 2011-02-14 JP JP2011028813A patent/JP2011144180A/ja not_active Withdrawn
- 2011-10-06 IL IL215617A patent/IL215617A0/en unknown
2012
- 2012-09-13 US US13/614,499 patent/US8481585B2/en not_active Expired - Fee Related
- 2012-09-13 US US13/614,545 patent/US8557845B2/en not_active Expired - Fee Related
2013
- 2013-08-27 US US14/010,819 patent/US8785448B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HRP20050562A2 (en)	2005-12-31
AR042525A1 (es)	2005-06-22
GEP20084435B (en)	2008-07-25
EP1575954B1 (en)	2016-08-03
NO20052805L (no)	2005-07-14
US20130012507A1 (en)	2013-01-10
MXPA05006791A (es)	2005-09-08
RS20050462A (sr)	2007-08-03
EA010596B1 (ru)	2008-10-30
IL215617A0 (en)	2011-11-30
CA2508069A1 (en)	2004-07-08
CA2508069C (en)	2012-05-22
KR20050085796A (ko)	2005-08-29
KR20120038465A (ko)	2012-04-23
CN1726217A (zh)	2006-01-25
AP2005003343A0 (en)	2005-06-30
US7407971B2 (en)	2008-08-05
TNSN05163A1 (fr)	2007-05-14
CU23550B7 (es)	2010-07-20
HK1086256A1 (en)	2006-09-15
EP2266987B1 (en)	2017-05-17
US20090082346A1 (en)	2009-03-26
JP4739761B2 (ja)	2011-08-03
US20070004705A1 (en)	2007-01-04
OA13015A (en)	2006-11-10
US20130344031A1 (en)	2013-12-26
EP1575954A2 (en)	2005-09-21
BR0317455A (pt)	2005-11-16
NZ540644A (en)	2008-09-26
AU2003300255B9 (en)	2010-03-04
US20130017170A1 (en)	2013-01-17
ECSP055864A (es)	2005-09-20
ES2635191T3 (es)	2017-10-02
NO333178B1 (no)	2013-03-25
AU2003300255A1 (en)	2004-07-14
TW200418461A (en)	2004-10-01
MA27569A1 (fr)	2005-10-03
JP2006514026A (ja)	2006-04-27
ZA200504298B (en)	2006-02-22
JP2011144180A (ja)	2011-07-28
WO2004056827A3 (en)	2004-10-28
CN1726217B (zh)	2010-05-26
ES2605848T3 (es)	2017-03-16
TWI327470B (en)	2010-07-21
MY141196A (en)	2010-03-31
US8481585B2 (en)	2013-07-09
EA200501009A1 (ru)	2005-12-29
CR7880A (es)	2005-07-08
US8557857B2 (en)	2013-10-15
MEP52408A (en)	2011-02-10
AU2003300255B2 (en)	2009-10-29
US8557845B2 (en)	2013-10-15
PL377285A1 (pl)	2006-01-23
KR101223826B1 (ko)	2013-01-17
US8785448B2 (en)	2014-07-22
WO2004056827A2 (en)	2004-07-08
EP2266987A1 (en)	2010-12-29
UA81790C2 (uk)	2008-02-11
IL169019A (en)	2011-11-30
CR10370A (es)	2008-10-31

Publication	Publication Date	Title
IS7857A (is)	2005-08-18	Setnar pýrróló-pýrasól afleiður sem kínasa hindrar
SE9900100D0 (sv)	1999-01-15	New compounds
BG108268A (en)	2005-04-30	Pyrazolopyrimidines as therapeutic agents
BG108269A (en)	2004-12-30	Pyrazolopyrimidines as therapeutic agents
CY1112478T1 (el)	2015-12-09	Ενωσεις κιναζολινονης ως αντικαρκινικοι παραγοντες
ATE302775T1 (de)	2005-09-15	Carbolinderivate
ATE495155T1 (de)	2011-01-15	Heterocyclische inhibitoren von mek
PT2420234E (pt)	2013-10-08	1h-benzimidazole-4-carboxamidas substituídas com um carbono quaternário na posição 2 como inibidores de parp para uso no tratamento do cancro
SE0401971D0 (sv)	2004-08-02	Piperidne derivatives
MXPA06009475A (es)	2007-05-15	Derivados de quinazolina y usos terapeuticos de los mismos.
ATE346067T1 (de)	2006-12-15	Carbolinderivate
WO2003063787A3 (en)	2004-01-22	Non-steroidal analogs of 2-methoxyestradiol
GEP20105095B (en)	2010-10-25	Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
NO20054787D0 (no)	2005-10-18	Indenderivater som farmasotiske midler
WO2002070515A3 (en)	2002-12-19	Chromane derivatives, process for their preparation and their use as antitumor agents
NZ547795A (en)	2009-07-31	3-Cyano-quinoline derivatives with antiproliferative activity
ATE368649T1 (de)	2007-08-15	Cyanoguanidin prodrugs
NO20065873L (no)	2007-02-20	3-(4-(2-dihydroisoksazol-3-ylpyridin-5-yl)fenyl)-5-triazol-1-ylmetyloksoazolidin-2-on derivater som MAO inhibitorer i behandlingen av bakterielle infeksjoner
NO20063619L (no)	2006-10-09	Diarylmetylpiperazinderivater, fremstilling og anvendelse derav
EE200200605A (et)	2004-04-15	Asendatud akrüloüüldistamütsiini derivaadi kasutamine ravimi valmistamiseks, mis on ette nähtud glutatiooni kõrge tasemega seotud kasvajate raviks
NO20053805L (no)	2005-10-17	Diarylmetylindenpiperidinderivater, framgangsmate for fremstilling derav, og anvendelse derav
NO20042729L (no)	2004-08-27	Heksasykliske forbindelser
ATE479695T1 (de)	2010-09-15	Sulfopyranosylacylglycerol-derivate zur anwendung in kombination mit bestrahlung in einer tumor- radiotherapie
NO20055142L (no)	2006-01-03	Diarylmetylidenpiperidinderivater, fremstillinger og anvendelser derav
ATE338046T1 (de)	2006-09-15	2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza- cyclopenta(a)naphthalenyl derivate mit antipsychotischer aktivität