IS7890A - C-6 breytt indazólýlpýrrólótríazín - Google Patents

C-6 breytt indazólýlpýrrólótríazín

Info

Publication number
IS7890A
IS7890A IS7890A IS7890A IS7890A IS 7890 A IS7890 A IS 7890A IS 7890 A IS7890 A IS 7890A IS 7890 A IS7890 A IS 7890A IS 7890 A IS7890 A IS 7890A
Authority
IS
Iceland
Prior art keywords
indazolylpyrrolotriazine
altered
altered indazolylpyrrolotriazine
Prior art date
Application number
IS7890A
Other languages
English (en)
Inventor
D. Vite Gregory
V. Gavai Ashvinikumar
E. Fink Brian
Mastalerz Harold
F. Kadow John
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of IS7890A publication Critical patent/IS7890A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
IS7890A 2002-12-13 2005-06-10 C-6 breytt indazólýlpýrrólótríazín IS7890A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43319002P 2002-12-13 2002-12-13
PCT/US2003/039542 WO2004054514A2 (en) 2002-12-13 2003-12-12 C-6 modified indazolylpyrrolotriazines

Publications (1)

Publication Number Publication Date
IS7890A true IS7890A (is) 2005-06-10

Family

ID=32595133

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7890A IS7890A (is) 2002-12-13 2005-06-10 C-6 breytt indazólýlpýrrólótríazín

Country Status (27)

Country Link
US (2) US6916815B2 (is)
EP (1) EP1569937B1 (is)
JP (1) JP4511367B2 (is)
KR (1) KR101073801B1 (is)
CN (2) CN1726216A (is)
AR (1) AR042450A1 (is)
AT (1) ATE534648T1 (is)
AU (1) AU2003300877B2 (is)
BR (1) BR0316755A (is)
CA (1) CA2509650C (is)
CO (1) CO5570660A2 (is)
DK (1) DK1569937T3 (is)
ES (1) ES2374393T3 (is)
HR (1) HRP20050535A2 (is)
IS (1) IS7890A (is)
MX (1) MXPA05006164A (is)
NO (1) NO20052733L (is)
NZ (1) NZ540338A (is)
PE (1) PE20040805A1 (is)
PL (1) PL377517A1 (is)
PT (1) PT1569937E (is)
RS (1) RS20050441A (is)
RU (1) RU2356903C2 (is)
TW (1) TW200420565A (is)
UA (1) UA80591C2 (is)
WO (1) WO2004054514A2 (is)
ZA (1) ZA200504507B (is)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US20090197852A9 (en) * 2001-08-06 2009-08-06 Johnson Robert G Jr Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor
WO2003091229A1 (en) 2002-04-23 2003-11-06 Bristol-Myers Squibb Company Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
BR0309669A (pt) 2002-04-23 2005-03-01 Bristol Myers Squibb Co Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
PT1506203E (pt) 2002-08-23 2007-04-30 Sloan Kettering Inst Cancer Síntese de epotilonas, seus intermediários, seus análogos e suas utilizações
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
BRPI0407282A (pt) 2003-02-05 2006-01-31 Bristol Myers Squibb Co Processo para preparação de inibidores de pirrolotriazina cinase
ES2428358T3 (es) * 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
US7064203B2 (en) * 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7102002B2 (en) * 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
TW200600513A (en) * 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US7253167B2 (en) * 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
US7102003B2 (en) * 2004-07-01 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine compounds
US7504521B2 (en) 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
US7148348B2 (en) 2004-08-12 2006-12-12 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
EP1807106A2 (en) * 2004-10-05 2007-07-18 Oregon Health and Science University Compositions and methods for treating disease
US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
BRPI0609079A2 (pt) 2005-04-18 2010-11-16 Novo Nordisk As peptìdeo, composição farmacêutica, método para o tratamento de cáncer, uso de um peptìdeo construto de ácido nucleico, vetor, hospedeiro, e, anticorpo
US7405213B2 (en) * 2005-07-01 2008-07-29 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7402582B2 (en) * 2005-07-01 2008-07-22 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7880004B2 (en) 2005-09-15 2011-02-01 Bristol-Myers Squibb Company Met kinase inhibitors
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
AU2007223342A1 (en) 2006-03-07 2007-09-13 Bristol-Myers Squibb Company Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
CN101553501A (zh) 2006-10-26 2009-10-07 诺沃-诺迪斯克有限公司 Il-21变种
WO2008074863A1 (en) * 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the il-21 receptor
US20090083483A1 (en) * 2007-09-24 2009-03-26 International Business Machines Corporation Power Conservation In A RAID Array
US8166326B2 (en) * 2007-11-08 2012-04-24 International Business Machines Corporation Managing power consumption in a computer
US20090132842A1 (en) * 2007-11-15 2009-05-21 International Business Machines Corporation Managing Computer Power Consumption In A Computer Equipment Rack
US8041521B2 (en) * 2007-11-28 2011-10-18 International Business Machines Corporation Estimating power consumption of computing components configured in a computing system
WO2009124259A1 (en) * 2008-04-04 2009-10-08 Cv Therapeutics, Inc. Pyrrolotriazinone derivatives for use as stearoyl coa desaturase inhibitors
WO2009137201A1 (en) 2008-04-04 2009-11-12 Cv Therapeutics, Inc. Triazolopyridinone derivatives for use as stearoyl coa desaturase inhibitors
WO2009126311A1 (en) * 2008-04-11 2009-10-15 The University Of Texas, M.D. Anderson Cancer Center Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
US8103884B2 (en) 2008-06-25 2012-01-24 International Business Machines Corporation Managing power consumption of a computer
US8041976B2 (en) * 2008-10-01 2011-10-18 International Business Machines Corporation Power management for clusters of computers
US8514215B2 (en) * 2008-11-12 2013-08-20 International Business Machines Corporation Dynamically managing power consumption of a computer with graphics adapter configurations
WO2010071885A1 (en) 2008-12-19 2010-06-24 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
MX2011009413A (es) * 2009-03-11 2011-10-21 Ambit Biosciences Corp Combinacion de una indazolilaminopirrolotriazina y taxano para tratamiento contra cancer.
WO2011112689A2 (en) 2010-03-11 2011-09-15 Ambit Biosciences Corp. Saltz of an indazolylpyrrolotriazine
CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
JP6395798B2 (ja) * 2013-03-11 2018-09-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ カリウムイオンチャネル阻害剤としてのピロロトリアジン
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
ES2616026T3 (es) * 2013-03-11 2017-06-09 Bristol-Myers Squibb Company Pirrolopiridazinas como inhibidores de canales de iones potasio
WO2015081783A1 (zh) * 2013-12-06 2015-06-11 江苏奥赛康药业股份有限公司 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途
CN111533708B (zh) * 2020-06-12 2021-03-16 上海馨远医药科技有限公司 一种手性n-叔丁氧羰基吗啉-3-羧酸的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908056A (en) * 1986-04-25 1990-03-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
ES2200039T3 (es) 1995-12-08 2004-03-01 Pfizer Inc. Derivados heterociclicos sustituidos como antagonistas de crf.
ES2273369T3 (es) 1996-08-28 2007-05-01 Pfizer Inc. Derivados 6,5 heterobiciclicos sustituidos.
ES2258459T3 (es) * 1999-05-21 2006-09-01 Bristol-Myers Squibb Company Pirrolotriazinas inhibidoras de quinasas.
WO2001014378A1 (en) 1999-08-23 2001-03-01 Shionogi & Co., Ltd. PYRROLOTRIAZINE DERIVATIVES HAVING sPLA2-INHIBITORY ACTIVITIES
DK1363910T3 (da) * 2000-11-17 2006-06-26 Bristol Myers Squibb Co Fremgangsmåder til behandling af P39-kinase-associerede tilstande og pyrrolotriazinforbindelser, der er anvendelige som kinase-inhibitorer
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
BR0309669A (pt) * 2002-04-23 2005-03-01 Bristol Myers Squibb Co Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase
WO2003091229A1 (en) * 2002-04-23 2003-11-06 Bristol-Myers Squibb Company Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
TW200400034A (en) * 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine

Also Published As

Publication number Publication date
CN101723948A (zh) 2010-06-09
DK1569937T3 (da) 2012-01-02
HRP20050535A2 (en) 2005-12-31
US20050222153A1 (en) 2005-10-06
WO2004054514A3 (en) 2004-10-07
CN1726216A (zh) 2006-01-25
EP1569937A4 (en) 2007-08-08
ES2374393T3 (es) 2012-02-16
US7148220B2 (en) 2006-12-12
PE20040805A1 (es) 2004-11-20
AU2003300877B2 (en) 2010-02-18
NO20052733L (no) 2005-07-07
RU2356903C2 (ru) 2009-05-27
KR20050084242A (ko) 2005-08-26
MXPA05006164A (es) 2005-08-26
CA2509650C (en) 2007-10-30
CO5570660A2 (es) 2005-10-31
CA2509650A1 (en) 2004-07-01
EP1569937A2 (en) 2005-09-07
UA80591C2 (en) 2007-10-10
JP2006509826A (ja) 2006-03-23
PT1569937E (pt) 2012-01-04
AR042450A1 (es) 2005-06-22
NO20052733D0 (no) 2005-06-07
WO2004054514A2 (en) 2004-07-01
BR0316755A (pt) 2005-10-25
ATE534648T1 (de) 2011-12-15
JP4511367B2 (ja) 2010-07-28
AU2003300877A1 (en) 2004-07-09
RU2005120650A (ru) 2006-01-20
NZ540338A (en) 2008-05-30
RS20050441A (sr) 2007-04-10
ZA200504507B (en) 2006-08-30
EP1569937B1 (en) 2011-11-23
US20040142931A1 (en) 2004-07-22
PL377517A1 (pl) 2006-02-06
KR101073801B1 (ko) 2011-10-13
TW200420565A (en) 2004-10-16
US6916815B2 (en) 2005-07-12

Similar Documents

Publication Publication Date Title
IS7890A (is) C-6 breytt indazólýlpýrrólótríazín
ATE457980T1 (de) Aryloxime
DE50305852D1 (de) Einspritzventil
ATE427876T1 (de) Luftkissenboot
ATE318817T1 (de) Aza-arylpiperazine
DE50212349D1 (de) Hirurgie
DE50212360D1 (de) Anfahrhilfesteuerungsvorrichtung
DE50301200D1 (de) Wischblatt
ATE349458T1 (de) Etonogestrelester
DE50305301D1 (de) Einspritzventil
ATA1572002A (de) Managementspleisskassette
DE50302660D1 (de) Stopfmachine
DE50301960D1 (de) Hydrolager
BR0311793B1 (pt) Projétil de neblina
DE50301464D1 (de) Schraubensicherung
ATA4142004A (de) Trägerverbau
ATE469773T1 (de) Zugöse
DE50305973D1 (de) Auffangwanne
DE50303317D1 (de) Einschub-leistungsschalter
ATA19152002A (de) Hubkupplung
DE50209283D1 (de) Tropfbewässerungsrohr
ATE396192T1 (de) N-sulfonylaminothiazole
DE50303658D1 (de) Postgutmessvorrichtung
DE50300322D1 (de) Zylinderkopfdichtung
DE10244834B8 (de) Suszeptometer