NO20052733L - C-6 modifiserte indazolylpyrrolotriaziner - Google Patents

C-6 modifiserte indazolylpyrrolotriaziner

Info

Publication number
NO20052733L
NO20052733L NO20052733A NO20052733A NO20052733L NO 20052733 L NO20052733 L NO 20052733L NO 20052733 A NO20052733 A NO 20052733A NO 20052733 A NO20052733 A NO 20052733A NO 20052733 L NO20052733 L NO 20052733L
Authority
NO
Norway
Prior art keywords
formula
compounds
useful
growth factor
factor receptors
Prior art date
Application number
NO20052733A
Other languages
English (en)
Other versions
NO20052733D0 (no
Inventor
Gregory D Vite
John F Kadow
Ashvinikumar Gavai
Harold Mastalerz
Brian E Fink
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20052733D0 publication Critical patent/NO20052733D0/no
Publication of NO20052733L publication Critical patent/NO20052733L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel I og farmasøytisk akseptable salter derav. Forbindelsene ifølge formel 1 hemmer tyrosinkinase-aktivitet av vekstftdctorreseptorer slik som HERI, HER2 og HER4 og gjør dem derved anvendelige som antiproliferative midler. Forbindelsene ifølge formel 1 er også anvendelige for behandling av andre sykdommer forbundet med signaltransduksjons-overføringsbaner som fungerer gjennom vekstfakiorreseptorer.
NO20052733A 2002-12-13 2005-06-07 C-6 modifiserte indazolylpyrrolotriaziner NO20052733L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43319002P 2002-12-13 2002-12-13
PCT/US2003/039542 WO2004054514A2 (en) 2002-12-13 2003-12-12 C-6 modified indazolylpyrrolotriazines

Publications (2)

Publication Number Publication Date
NO20052733D0 NO20052733D0 (no) 2005-06-07
NO20052733L true NO20052733L (no) 2005-07-07

Family

ID=32595133

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052733A NO20052733L (no) 2002-12-13 2005-06-07 C-6 modifiserte indazolylpyrrolotriaziner

Country Status (27)

Country Link
US (2) US6916815B2 (no)
EP (1) EP1569937B1 (no)
JP (1) JP4511367B2 (no)
KR (1) KR101073801B1 (no)
CN (2) CN101723948A (no)
AR (1) AR042450A1 (no)
AT (1) ATE534648T1 (no)
AU (1) AU2003300877B2 (no)
BR (1) BR0316755A (no)
CA (1) CA2509650C (no)
CO (1) CO5570660A2 (no)
DK (1) DK1569937T3 (no)
ES (1) ES2374393T3 (no)
HR (1) HRP20050535A2 (no)
IS (1) IS7890A (no)
MX (1) MXPA05006164A (no)
NO (1) NO20052733L (no)
NZ (1) NZ540338A (no)
PE (1) PE20040805A1 (no)
PL (1) PL377517A1 (no)
PT (1) PT1569937E (no)
RS (1) RS20050441A (no)
RU (1) RU2356903C2 (no)
TW (1) TW200420565A (no)
UA (1) UA80591C2 (no)
WO (1) WO2004054514A2 (no)
ZA (1) ZA200504507B (no)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO2004018478A2 (en) 2002-08-23 2004-03-04 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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TW200618803A (en) 2004-08-12 2006-06-16 Bristol Myers Squibb Co Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
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US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
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US7402582B2 (en) * 2005-07-01 2008-07-22 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7405213B2 (en) * 2005-07-01 2008-07-29 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
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US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
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WO2008049920A2 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S Il-21 variants
WO2008074863A1 (en) * 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the il-21 receptor
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US20090132842A1 (en) * 2007-11-15 2009-05-21 International Business Machines Corporation Managing Computer Power Consumption In A Computer Equipment Rack
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Also Published As

Publication number Publication date
IS7890A (is) 2005-06-10
CA2509650A1 (en) 2004-07-01
ATE534648T1 (de) 2011-12-15
WO2004054514A2 (en) 2004-07-01
US20040142931A1 (en) 2004-07-22
US20050222153A1 (en) 2005-10-06
PE20040805A1 (es) 2004-11-20
ES2374393T3 (es) 2012-02-16
EP1569937B1 (en) 2011-11-23
US7148220B2 (en) 2006-12-12
US6916815B2 (en) 2005-07-12
DK1569937T3 (da) 2012-01-02
AR042450A1 (es) 2005-06-22
CN101723948A (zh) 2010-06-09
TW200420565A (en) 2004-10-16
PT1569937E (pt) 2012-01-04
BR0316755A (pt) 2005-10-25
EP1569937A4 (en) 2007-08-08
MXPA05006164A (es) 2005-08-26
CA2509650C (en) 2007-10-30
PL377517A1 (pl) 2006-02-06
WO2004054514A3 (en) 2004-10-07
CO5570660A2 (es) 2005-10-31
RU2356903C2 (ru) 2009-05-27
KR20050084242A (ko) 2005-08-26
RU2005120650A (ru) 2006-01-20
ZA200504507B (en) 2006-08-30
AU2003300877B2 (en) 2010-02-18
UA80591C2 (en) 2007-10-10
KR101073801B1 (ko) 2011-10-13
NO20052733D0 (no) 2005-06-07
JP2006509826A (ja) 2006-03-23
JP4511367B2 (ja) 2010-07-28
NZ540338A (en) 2008-05-30
RS20050441A (sr) 2007-04-10
HRP20050535A2 (en) 2005-12-31
EP1569937A2 (en) 2005-09-07
AU2003300877A1 (en) 2004-07-09
CN1726216A (zh) 2006-01-25

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