IS7453A - Trópan afleiður sem CCR5 stillar - Google Patents

Trópan afleiður sem CCR5 stillar

Info

Publication number: IS7453A
Authority: IS; Iceland
Prior art keywords: tropon; ccr5; derivatives set; derivatives; tropon derivatives
Prior art date: 2002-04-08

Application number

IS7453A

Other languages

English (en)

Other versions

IS2577B (is

Inventor

Ann Basford Patricia

Thomas Stephenson Peter

Colin John Taylor Stefan

Wood Anthony

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-08

Filing date

2004-09-16

Publication date

2004-09-16

2002-04-08 Priority claimed from GBGB0208071.1A external-priority patent/GB0208071D0/en

2003-01-23 Priority claimed from GB0301575A external-priority patent/GB0301575D0/en

2004-09-16 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2004-09-16 Publication of IS7453A publication Critical patent/IS7453A/is

2010-02-15 Publication of IS2577B publication Critical patent/IS2577B/is

Links

102100035875 C-C chemokine receptor type 5 Human genes 0.000 title 1
101710149870 C-C chemokine receptor type 5 Proteins 0.000 title 1
QVWDCTQRORVHHT-UHFFFAOYSA-N tropone Chemical class O=C1C=CC=CC=C1 QVWDCTQRORVHHT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Child & Adolescent Psychology (AREA)

IS7453A 2002-04-08 2004-09-16 Trópan afleiður sem CCR5 stillar IS2577B (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0208071.1A GB0208071D0 (en)	2002-04-08	2002-04-08	Tropane derivatives useful in therapy
GB0301575A GB0301575D0 (en)	2003-01-23	2003-01-23	Tropane derivatives useful in therapy
PCT/IB2003/001220 WO2003084954A1 (en)	2002-04-08	2003-03-31	Tropane derivatives as ccr5 modulators

Publications (2)

Publication Number	Publication Date
IS7453A true IS7453A (is)	2004-09-16
IS2577B IS2577B (is)	2010-02-15

Family

ID=28793308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7453A IS2577B (is)	2002-04-08	2004-09-16	Trópan afleiður sem CCR5 stillar

Country Status (40)

Country	Link
EP (1)	EP1492789B1 (is)
JP (2)	JP3793200B2 (is)
KR (1)	KR100734685B1 (is)
CN (1)	CN1324025C (is)
AP (1)	AP1789A (is)
AR (1)	AR039383A1 (is)
AT (1)	ATE328882T1 (is)
AU (1)	AU2003214503B2 (is)
BR (1)	BR0309118A (is)
CA (1)	CA2481482C (is)
CR (1)	CR7514A (is)
CU (1)	CU23282A3 (is)
CY (1)	CY1106114T1 (is)
DE (1)	DE60305903T2 (is)
DK (1)	DK1492789T3 (is)
DO (1)	DOP2003000624A (is)
EA (1)	EA007590B1 (is)
ES (1)	ES2263960T3 (is)
GE (1)	GEP20074210B (is)
HN (1)	HN2003000114A (is)
HR (1)	HRP20040940A2 (is)
IL (1)	IL164261A0 (is)
IS (1)	IS2577B (is)
MA (1)	MA27190A1 (is)
MX (1)	MXPA04009220A (is)
MY (1)	MY134223A (is)
NI (1)	NI200300053A (is)
NO (1)	NO329674B1 (is)
NZ (1)	NZ535452A (is)
OA (1)	OA12798A (is)
PA (1)	PA8570801A1 (is)
PE (1)	PE20040082A1 (is)
PL (1)	PL372968A1 (is)
PT (1)	PT1492789E (is)
RS (1)	RS51550B (is)
SI (1)	SI1492789T1 (is)
TN (1)	TNSN04194A1 (is)
TW (1)	TWI280130B (is)
UY (1)	UY27752A1 (is)
WO (1)	WO2003084954A1 (is)

Families Citing this family (31)

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EA007590B1 (ru) *	2002-04-08	2006-12-29	Пфайзер Инк.	Производные тропана в качестве модуляторов ccr5
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
CA2579609A1 (en)	2003-09-10	2005-03-17	Virochem Pharma Inc.	Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
GB0323236D0 (en) *	2003-10-03	2003-11-05	Pfizer Ltd	Chemical compounds
ES2295924T3 (es) *	2003-10-03	2008-04-16	Pfizer, Inc.	Derivados de tropano imidazopirina sustituidos con actividad antagonista de los receptores ccr5 para el tratamiento de vih y de la inflamacion.
TW200533348A (en)	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8131026B2 (en)	2004-04-16	2012-03-06	Validity Sensors, Inc.	Method and apparatus for fingerprint image reconstruction
DE602005022900D1 (de)	2004-10-04	2010-09-23	Validity Sensors Inc	Fingerabdruckerfassende konstruktionen mit einem substrat
WO2006064340A2 (en) *	2004-12-13	2006-06-22	Pfizer Limited	Process for the preparation of n-acyl beta-aminoaldehydes
WO2008063600A2 (en) *	2006-11-17	2008-05-29	Concert Pharmaceuticals Inc.	Triazolyl tropane derivatives
MX2009011063A (es)	2007-04-13	2009-10-30	Dong Wha Pharm Co Ltd	Aspartato de acido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-dia za-espiro[3.4]oct-6-il)-4-oxo-1,4-dihidro-[1,8]naftiridin-3-carbo xilico, metodo para preparar el mismo y composicion farmaceutica antimicrobiana que comprende el mismo.
US7947710B2 (en)	2007-08-27	2011-05-24	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
CN101712679B (zh) *	2008-10-08	2013-04-10	中国科学院上海药物研究所	一种酰胺类化合物、其药物组合物及其制备方法和用途
WO2011061243A1 (en) *	2009-11-21	2011-05-26	F. Hoffmann-La Roche Ag	Heterocyclic antiviral compounds
CN102822163B (zh)	2009-12-23	2016-01-20	艾恩伍德医药品股份有限公司	Crth2调节剂
MX2012011415A (es)	2010-04-02	2013-02-26	Phivco 1 Llc	Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico.
US20130259830A1 (en)	2010-07-12	2013-10-03	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
WO2012009137A1 (en)	2010-07-12	2012-01-19	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
HUE047354T2 (hu)	2011-05-18	2020-04-28	Vertex Pharmaceuticals Europe Ltd	Ivacaftor deuterizált származékai
WO2013024022A1 (en)	2011-08-12	2013-02-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
CN103159754A (zh) *	2011-12-19	2013-06-19	中国科学院上海药物研究所	一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
JP6146990B2 (ja) *	2012-11-16	2017-06-14	コンサートファーマシューティカルズインコーポレイテッド	重水素化されたｃｆｔｒ増強物質
GB201321749D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
GB201321748D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US10196384B2 (en)	2015-03-31	2019-02-05	Vertex Pharmaceuticals (Europe) Limited	Deuterated CFTR modulators
HK1258473A1 (zh)	2015-09-25	2019-11-15	Vertex Pharmaceuticals (Europe) Limited	氘代cftr增效剂
JP2017105824A (ja) *	2017-02-10	2017-06-15	コンサートファーマシューティカルズインコーポレイテッド	重水素化されたｃｆｔｒ増強物質
WO2019109021A1 (en)	2017-12-01	2019-06-06	Vertex Pharmaceuticals Incorporated	Processes for making modulators of cystic fibrosis transmembrane conductance regulator
EP3768256A4 (en)	2018-03-19	2021-11-24	Emory University	PAN-TROPICAL ENTRANCE INHIBITORS
JP6654223B2 (ja) *	2018-08-13	2020-02-26	バーテックスファーマシューティカルズ（ヨーロッパ）リミテッド	重水素化されたｃｆｔｒ増強物質
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
WO2001080106A1 (en) *	2000-04-19	2001-10-25	Satoshi Yamazaki	Advertising-tool distribution method and magnetic recorded medium for the software
EP1526134B1 (en) *	2000-05-26	2008-09-03	Pfizer Limited	Triazolyl tropane derivatives as ccr5 modulators
EA007590B1 (ru) *	2002-04-08	2006-12-29	Пфайзер Инк.	Производные тропана в качестве модуляторов ccr5

2003
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- 2003-03-31 PT PT03710080T patent/PT1492789E/pt unknown
- 2003-03-31 JP JP2003582151A patent/JP3793200B2/ja not_active Expired - Lifetime
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- 2003-04-04 NI NI200300053A patent/NI200300053A/es unknown
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- 2003-04-07 AR ARP030101205A patent/AR039383A1/es unknown
- 2003-04-07 HN HN2003000114A patent/HN2003000114A/es unknown
- 2003-04-08 PA PA20038570801A patent/PA8570801A1/es unknown
2004
- 2004-09-16 IS IS7453A patent/IS2577B/is unknown
- 2004-09-29 MA MA27883A patent/MA27190A1/fr unknown
- 2004-10-06 TN TNP2004000194A patent/TNSN04194A1/fr unknown
- 2004-10-07 CU CU20040219A patent/CU23282A3/es unknown
- 2004-10-07 CR CR7514A patent/CR7514A/es unknown
- 2004-10-26 NO NO20044615A patent/NO329674B1/no not_active IP Right Cessation
2006
- 2006-02-03 JP JP2006027537A patent/JP4571078B2/ja not_active Expired - Lifetime
- 2006-07-04 CY CY20061100919T patent/CY1106114T1/el unknown

Also Published As

Publication number	Publication date
JP2006182784A (ja)	2006-07-13
ES2263960T3 (es)	2006-12-16
AU2003214503B2 (en)	2008-08-07
DE60305903T2 (de)	2007-03-08
HN2003000114A (es)	2004-05-05
RS51550B (sr)	2011-06-30
AP2004003147A0 (en)	2004-09-30
NO20044615L (no)	2004-10-26
TWI280130B (en)	2007-05-01
EP1492789B1 (en)	2006-06-07
CY1106114T1 (el)	2011-06-08
SI1492789T1 (sl)	2006-10-31
PA8570801A1 (es)	2004-11-26
JP4571078B2 (ja)	2010-10-27
NZ535452A (en)	2006-11-30
NI200300053A (es)	2005-11-01
IS2577B (is)	2010-02-15
DK1492789T3 (da)	2006-09-11
WO2003084954A1 (en)	2003-10-16
KR20040099420A (ko)	2004-11-26
MA27190A1 (fr)	2005-01-03
CN1646526A (zh)	2005-07-27
EP1492789A1 (en)	2005-01-05
TW200403242A (en)	2004-03-01
PE20040082A1 (es)	2004-03-20
UY27752A1 (es)	2003-11-28
CA2481482A1 (en)	2003-10-16
DOP2003000624A (es)	2003-10-15
AP1789A (en)	2007-10-05
MXPA04009220A (es)	2005-09-30
PL372968A1 (en)	2005-08-08
HRP20040940A2 (en)	2005-04-30
MY134223A (en)	2007-11-30
PT1492789E (pt)	2006-09-29
JP3793200B2 (ja)	2006-07-05
RS88804A (sr)	2006-12-15
EA200401167A1 (ru)	2005-04-28
CA2481482C (en)	2009-11-10
GEP20074210B (en)	2007-10-10
AR039383A1 (es)	2005-02-16
EA007590B1 (ru)	2006-12-29
OA12798A (en)	2006-07-10
AU2003214503A1 (en)	2003-10-20
CN1324025C (zh)	2007-07-04
KR100734685B1 (ko)	2007-07-02
NO329674B1 (no)	2010-11-29
CU23282A3 (es)	2008-06-30
CR7514A (es)	2004-11-08
BR0309118A (pt)	2005-02-01
HK1076102A1 (en)	2006-01-06
TNSN04194A1 (fr)	2007-03-12
DE60305903D1 (de)	2006-07-20
ATE328882T1 (de)	2006-06-15
IL164261A0 (en)	2005-12-18
JP2005532285A (ja)	2005-10-27

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IS7942A (is)	2005-07-18	Nýjar píperídínafleiður sem stillar flakkboðaviðtaka CCR5
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FIU20020073U0 (fi)	2002-02-25	Liitoskappale