IS8129A - Samsetningar paroxetíns og 4-(S)-(4-asetýl-píperasín-1-ýl)-2-(R)-(4-flúor-2-metýl-fenýl)-píperídín-1-karboxýlsýru [1-(R)-(3,5-bis-tríflúormetýl-fenýl)etýl]-metýlamíðs til að meðhöndla þunglyndi og/eða kvíða - Google Patents

Samsetningar paroxetíns og 4-(S)-(4-asetýl-píperasín-1-ýl)-2-(R)-(4-flúor-2-metýl-fenýl)-píperídín-1-karboxýlsýru [1-(R)-(3,5-bis-tríflúormetýl-fenýl)etýl]-metýlamíðs til að meðhöndla þunglyndi og/eða kvíða

Info

Publication number: IS8129A
Authority: IS; Iceland
Prior art keywords: phenyl; methylamide; paroxetine; piperazin; anxiety
Prior art date: 2003-04-17

Application number

IS8129A

Other languages

English (en)

Inventor

Melotto Sergio

Corsi Mauro

Carletti Renzo

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-17

Filing date

2005-11-15

Publication date

2005-11-15

2005-11-15 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2005-11-15 Publication of IS8129A publication Critical patent/IS8129A/is

Links

AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title 1
208000019901 Anxiety disease Diseases 0.000 title 1
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title 1
230000036506 anxiety Effects 0.000 title 1
XGGTZCKQRWXCHW-WMTVXVAQSA-N casopitant Chemical compound C1([C@H]2C[C@H](CCN2C(=O)N(C)[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N2CCN(CC2)C(C)=O)=CC=C(F)C=C1C XGGTZCKQRWXCHW-WMTVXVAQSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229960002296 paroxetine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

IS8129A 2003-04-17 2005-11-15 Samsetningar paroxetíns og 4-(S)-(4-asetýl-píperasín-1-ýl)-2-(R)-(4-flúor-2-metýl-fenýl)-píperídín-1-karboxýlsýru [1-(R)-(3,5-bis-tríflúormetýl-fenýl)etýl]-metýlamíðs til að meðhöndla þunglyndi og/eða kvíða IS8129A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0308968.7A GB0308968D0 (en)	2003-04-17	2003-04-17	Medicaments
PCT/EP2004/004122 WO2004091616A1 (en)	2003-04-17	2004-04-16	Combinations of paroxetine and 4- (s) - (4-acetyl-piperazin-1-yl) -2- (r)- (4-fluoro-2-methyl-phenyl -piperidine-1-carboxylic acid [1- (r) -(3,5-bis-trifluoromethyl-phenyl) -ethyl] methylamide for treatment of depression and / or anxiety

Publications (1)

Publication Number	Publication Date
IS8129A true IS8129A (is)	2005-11-15

Family

ID=9956996

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IS8128A IS8128A (is)	2003-04-17	2005-11-15	Samsetningar sem fela í sér paroxetín og 2-(S)-(4-flúor-2-metýl-fenýl)-píperasín-1-karboxýlsýru[1-(R)-(3,5-bis-tríflúor-2-metýl-fenýl)-etýl]-metýl-amíð til að meðhöndla þunglyndi og/eða kvíða
IS8129A IS8129A (is)	2003-04-17	2005-11-15	Samsetningar paroxetíns og 4-(S)-(4-asetýl-píperasín-1-ýl)-2-(R)-(4-flúor-2-metýl-fenýl)-píperídín-1-karboxýlsýru [1-(R)-(3,5-bis-tríflúormetýl-fenýl)etýl]-metýlamíðs til að meðhöndla þunglyndi og/eða kvíða

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IS8128A IS8128A (is)	2003-04-17	2005-11-15	Samsetningar sem fela í sér paroxetín og 2-(S)-(4-flúor-2-metýl-fenýl)-píperasín-1-karboxýlsýru[1-(R)-(3,5-bis-tríflúor-2-metýl-fenýl)-etýl]-metýl-amíð til að meðhöndla þunglyndi og/eða kvíða

Country Status (18)

Country	Link
US (4)	US20060241143A1 (is)
EP (4)	EP1653956A1 (is)
JP (4)	JP2006523651A (is)
KR (2)	KR20060003876A (is)
CN (2)	CN1809355A (is)
AU (2)	AU2004229181A1 (is)
BR (2)	BRPI0409377A (is)
CA (2)	CA2522311A1 (is)
CO (1)	CO5700753A2 (is)
GB (1)	GB0308968D0 (is)
IS (2)	IS8128A (is)
MA (2)	MA27731A1 (is)
MX (2)	MXPA05011064A (is)
NO (2)	NO20055367L (is)
PL (2)	PL377858A1 (is)
RU (2)	RU2005135647A (is)
WO (4)	WO2004091616A1 (is)
ZA (2)	ZA200508067B (is)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0203020D0 (en) *	2002-02-08	2002-03-27	Glaxo Group Ltd	Chemical compounds
GB0403149D0 (en) *	2004-02-12	2004-03-17	Glaxo Group Ltd	Medicament
GB0409098D0 (en) *	2004-04-23	2004-05-26	Glaxo Group Ltd	Medicament
GB0426942D0 (en) *	2004-12-08	2005-01-12	Glaxo Group Ltd	Medicament
WO2007012968A2 (en) *	2005-07-29	2007-02-01	Aurobindo Pharma Ltd	Stable dosage form of an antidepressant
GB0621229D0 (en) *	2006-10-20	2006-12-06	Glaxo Group Ltd	Novel use
US8093268B2 (en)	2007-01-24	2012-01-10	Glaxo Group Limited	Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
WO2012175434A1 (en) *	2011-06-20	2012-12-27	Glaxo Group Limited	Pharmaceutical formulations comprising vestipitant
CN103446066B (zh) *	2013-09-16	2014-12-24	南通丝乡丝绸有限公司	帕罗西汀冻干粉针及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IS4208A (is) *	1993-09-22	1995-03-23	Glaxo Group Limited	3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
US6117855A (en) *	1996-10-07	2000-09-12	Merck Sharp & Dohme Ltd.	Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
AU735760B2 (en) *	1997-04-24	2001-07-12	Merck Sharp & Dohme Limited	Use of a NK-1 receptor antagonist and an SSRI for treating obesity
GB9923748D0 (en) *	1999-10-07	1999-12-08	Glaxo Group Ltd	Chemical compounds
JP2003522739A (ja) *	1999-12-17	2003-07-29	シェーリングコーポレイション	選択的ニューロキニンアンタゴニスト
US6436928B1 (en) *	1999-12-17	2002-08-20	Schering Corporation	Selective neurokinin antagonists
GT200100147A (es) *	2000-07-31	2002-06-25		Derivados de imidazol
GB0025354D0 (en) *	2000-10-17	2000-11-29	Glaxo Group Ltd	Chemical compounds
GB0119797D0 (en) *	2001-08-14	2001-10-03	Glaxo Group Ltd	Chemical compounds
EP1451153B1 (en) *	2001-11-13	2007-09-26	Schering Corporation	Nk1 antagonists
GB0203020D0 (en) *	2002-02-08	2002-03-27	Glaxo Group Ltd	Chemical compounds

2003
- 2003-04-17 GB GBGB0308968.7A patent/GB0308968D0/en not_active Ceased
2004
- 2004-04-16 JP JP2006505187A patent/JP2006523651A/ja active Pending
- 2004-04-16 CN CNA2004800171620A patent/CN1809355A/zh active Pending
- 2004-04-16 US US10/552,870 patent/US20060241143A1/en not_active Abandoned
- 2004-04-16 KR KR1020057019521A patent/KR20060003876A/ko not_active Withdrawn
- 2004-04-16 US US10/552,982 patent/US20060287325A1/en not_active Abandoned
- 2004-04-16 AU AU2004229181A patent/AU2004229181A1/en not_active Abandoned
- 2004-04-16 WO PCT/EP2004/004122 patent/WO2004091616A1/en not_active Ceased
- 2004-04-16 EP EP04727896A patent/EP1653956A1/en not_active Withdrawn
- 2004-04-16 WO PCT/EP2004/004126 patent/WO2004091624A1/en not_active Ceased
- 2004-04-16 CA CA002522311A patent/CA2522311A1/en not_active Abandoned
- 2004-04-16 WO PCT/EP2004/004121 patent/WO2004091615A1/en not_active Ceased
- 2004-04-16 JP JP2006505188A patent/JP2006523652A/ja active Pending
- 2004-04-16 AU AU2004229179A patent/AU2004229179A1/en not_active Abandoned
- 2004-04-16 MX MXPA05011064A patent/MXPA05011064A/es unknown
- 2004-04-16 EP EP04739086A patent/EP1615642A1/en not_active Withdrawn
- 2004-04-16 BR BRPI0409377-1A patent/BRPI0409377A/pt not_active Application Discontinuation
- 2004-04-16 JP JP2006505186A patent/JP2006523650A/ja active Pending
- 2004-04-16 EP EP04739085A patent/EP1615641A1/en not_active Withdrawn
- 2004-04-16 PL PL377858A patent/PL377858A1/pl not_active Application Discontinuation
- 2004-04-16 EP EP04727895A patent/EP1613325A1/en not_active Withdrawn
- 2004-04-16 CA CA002522313A patent/CA2522313A1/en not_active Abandoned
- 2004-04-16 RU RU2005135647/15A patent/RU2005135647A/ru not_active Application Discontinuation
- 2004-04-16 RU RU2005135649/15A patent/RU2005135649A/ru not_active Application Discontinuation
- 2004-04-16 US US10/552,869 patent/US20060241124A1/en not_active Abandoned
- 2004-04-16 US US10/552,871 patent/US20060217395A1/en not_active Abandoned
- 2004-04-16 KR KR1020057019520A patent/KR20060003875A/ko not_active Withdrawn
- 2004-04-16 MX MXPA05011063A patent/MXPA05011063A/es unknown
- 2004-04-16 JP JP2006505185A patent/JP2006523649A/ja active Pending
- 2004-04-16 BR BRPI0409379-8A patent/BRPI0409379A/pt not_active Application Discontinuation
- 2004-04-16 PL PL377857A patent/PL377857A1/pl not_active Application Discontinuation
- 2004-04-16 WO PCT/EP2004/004124 patent/WO2004091617A1/en not_active Ceased
- 2004-04-16 CN CNA2004800172252A patent/CN1809359A/zh active Pending
2005
- 2005-10-06 ZA ZA200508067A patent/ZA200508067B/en unknown
- 2005-10-06 ZA ZA200508068A patent/ZA200508068B/en unknown
- 2005-10-14 CO CO05105292A patent/CO5700753A2/es not_active Application Discontinuation
- 2005-10-19 MA MA28562A patent/MA27731A1/fr unknown
- 2005-10-19 MA MA28561A patent/MA27730A1/fr unknown
- 2005-11-14 NO NO20055367A patent/NO20055367L/no not_active Application Discontinuation
- 2005-11-14 NO NO20055368A patent/NO20055368L/no not_active Application Discontinuation
- 2005-11-15 IS IS8128A patent/IS8128A/is unknown
- 2005-11-15 IS IS8129A patent/IS8129A/is unknown

Also Published As

Publication number	Publication date
GB0308968D0 (en)	2003-05-28
EP1615642A1 (en)	2006-01-18
CN1809359A (zh)	2006-07-26
JP2006523652A (ja)	2006-10-19
WO2004091617A1 (en)	2004-10-28
IS8128A (is)	2005-11-15
PL377857A1 (pl)	2006-02-20
US20060241124A1 (en)	2006-10-26
CA2522313A1 (en)	2004-10-28
CA2522311A1 (en)	2004-10-28
MXPA05011064A (es)	2006-04-18
MA27731A1 (fr)	2006-01-02
EP1613325A1 (en)	2006-01-11
NO20055367L (no)	2005-11-14
US20060217395A1 (en)	2006-09-28
AU2004229181A1 (en)	2004-10-28
US20060241143A1 (en)	2006-10-26
WO2004091624A1 (en)	2004-10-28
JP2006523649A (ja)	2006-10-19
US20060287325A1 (en)	2006-12-21
EP1615641A1 (en)	2006-01-18
WO2004091616A1 (en)	2004-10-28
ZA200508067B (en)	2007-02-28
JP2006523651A (ja)	2006-10-19
CO5700753A2 (es)	2006-11-30
MA27730A1 (fr)	2006-01-02
BRPI0409379A (pt)	2006-04-25
BRPI0409377A (pt)	2006-04-25
EP1653956A1 (en)	2006-05-10
ZA200508068B (en)	2007-02-28
CN1809355A (zh)	2006-07-26
JP2006523650A (ja)	2006-10-19
KR20060003876A (ko)	2006-01-11
WO2004091615A1 (en)	2004-10-28
AU2004229179A1 (en)	2004-10-28
MXPA05011063A (es)	2005-12-12
RU2005135647A (ru)	2006-06-10
KR20060003875A (ko)	2006-01-11
NO20055368L (no)	2005-11-14
PL377858A1 (pl)	2006-02-20
RU2005135649A (ru)	2006-03-20

Publication	Publication Date	Title
EA200700117A1 (ru)	2007-06-29	N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
ATE536353T1 (de)	2011-12-15	2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren
PE20120252A1 (es)	2012-04-13	Compuestos heteroaril-aril-ureas como inhibidores de la quinasa
MX2010006238A (es)	2010-08-11	Formulaciones del acido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5 -il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico.
WO2004046120A3 (en)	2004-08-12	Diaminotriazoles useful as inhibitors of protein kinases
NO20051100L (no)	2005-05-02	Pyrazolsammensetninger anvendelige som GSK-3-inhibitorer
UA100364C2 (xx)	2012-12-25	Сукцинат біфеніл-2-ілкарбамінової кислоти 1-$2-(2-хлор-4-{$(r)-2-гідрокси-2-(8-гідроксі-2-оксо-1,2-дигідрохінолін-5-іл)етиламіно]метил]}-5-метоксифенілкарбамоїл)етил]піперидин-4-іл-естеру та його застосування для лікування легеневих розладів
ATE466580T1 (de)	2010-05-15	Azolylaminoazine als proteinkinasehemmer
ATE468336T1 (de)	2010-06-15	Azolylaminoazine als proteinkinasehemmer
DE60327999D1 (de)	2009-07-30	Azolylaminoazine als inhibitoren von proteinkinasen
ATE365733T1 (de)	2007-07-15	Zusammensetzungen brauchbar als protein-kinase- inhibitoren
IL183526A0 (en)	2007-09-20	4-(4-(imidazol-4-yl)pyrimidin-2-ylamino)benzamides as cdk inhibitors
MA27192A1 (fr)	2005-01-03	Derives de n- (phenyl(piperidin-2-yl)methyl) benzamide, leur preparation et leur application en therapeutique
IL188942A0 (en)	2008-04-13	Benzimidazole derivatives and pharmaceutical compositions containing the same
IL205697A0 (en)	2010-11-30	4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazole-2-yl)benzenesulfon-amide derivatives, compositions comprising the same and uses thereof
DE60329330D1 (de)	2009-10-29	Piperidin- und pyrrolidin-derivate alsantagonisten des histamin-h3-rezeptors
EP1786428A4 (en)	2009-08-05	PDE5 INHIBITOR COMPOSITIONS AND METHOD FOR TREATING DISEASE
DE602005009255D1 (de)	2008-10-02	Amid-prodrug von gemcitabin, zusammensetzungen und verwendung damit
ATE471315T1 (de)	2010-07-15	Piperidin- und piperazinacetamide als inhibitoren der 17beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
NO20085052L (no)	2008-12-04	4-((fluorofenoksyl)fenylmetyl)piperidin metansulfonat: anvendelser, synteseprosess og farmasoytiske sammensetninger
ATE471326T1 (de)	2010-07-15	Substituierte thienopyrrolcarbonsäureamide, pyrrolothiazolcarbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i- epsilon
ATE435858T1 (de)	2009-07-15	Prodrugs von als erk-proteinkinase-inhibitoren wirkenden pyrrolylpyrimidinen
MXPA05011064A (es)	2006-04-18	Combinaciones de paroxetina y [1-(r)-(3, 5-bis-trifluorometi l-fenil)-etil] -metilamida del acido 4-(s)- (4-acetil-piperazin -1-il)-2- (r)-(4-fluoro -2-metil- fenil)-piperidin -1-carboxilico para tratamiento de depresion y/o ansiedad.
FR2862968B1 (fr)	2006-08-04	Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
NO20070371L (no)	2007-03-08	N-substituerte piperidiner og anvendelse derav som farmasoytiske preparater