IS8217A - Bætt framleiðsla rósúvastatínkalsíumsalts - Google Patents

Bætt framleiðsla rósúvastatínkalsíumsalts

Info

Publication number
IS8217A
IS8217A IS8217A IS8217A IS8217A IS 8217 A IS8217 A IS 8217A IS 8217 A IS8217 A IS 8217A IS 8217 A IS8217 A IS 8217A IS 8217 A IS8217 A IS 8217A
Authority
IS
Iceland
Prior art keywords
calcium salt
improved production
rosuvastatin calcium
rosuvastatin
production
Prior art date
Application number
IS8217A
Other languages
English (en)
Other versions
IS2751B (is
Inventor
Norman Crabb Jeffrey
Horbury John
Philip Taylor Nigel
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33512687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS8217(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of IS8217A publication Critical patent/IS8217A/is
Publication of IS2751B publication Critical patent/IS2751B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IS8217A 2003-06-05 2006-01-02 Bætt@framleiðsla@rósúvastatínkalsíumsalts IS2751B (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0312896.4A GB0312896D0 (en) 2003-06-05 2003-06-05 Chemical process
GBGB0324793.9A GB0324793D0 (en) 2003-06-05 2003-10-24 Chemical process
PCT/GB2004/002373 WO2004108691A1 (en) 2003-06-05 2004-06-03 Improved production of rosuvastatin calcium salt

Publications (2)

Publication Number Publication Date
IS8217A true IS8217A (is) 2006-01-02
IS2751B IS2751B (is) 2011-09-15

Family

ID=33512687

Family Applications (1)

Application Number Title Priority Date Filing Date
IS8217A IS2751B (is) 2003-06-05 2006-01-02 Bætt@framleiðsla@rósúvastatínkalsíumsalts

Country Status (25)

Country Link
US (1) US8063213B2 (is)
EP (1) EP1633727B1 (is)
JP (1) JP4651615B2 (is)
KR (1) KR101099934B1 (is)
CN (1) CN100422157C (is)
AR (1) AR044773A1 (is)
AT (1) ATE464297T1 (is)
AU (1) AU2004245291B2 (is)
BR (1) BRPI0410922B8 (is)
CA (1) CA2527314C (is)
CO (1) CO5640116A2 (is)
DE (1) DE602004026576D1 (is)
ES (1) ES2341858T3 (is)
GB (2) GB0312896D0 (is)
IL (1) IL172075A (is)
IS (1) IS2751B (is)
MX (1) MXPA05013128A (is)
MY (1) MY140820A (is)
NO (1) NO332971B1 (is)
NZ (1) NZ543962A (is)
RU (1) RU2361864C2 (is)
SA (1) SA04250223B1 (is)
TW (1) TWI341310B (is)
UY (1) UY28341A1 (is)
WO (1) WO2004108691A1 (is)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
KR100888408B1 (ko) 2001-07-13 2009-03-13 아스트라제네카 유케이 리미티드 아미노피리미딘 화합물의 제조 방법
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
DE60330050D1 (de) 2002-12-16 2009-12-24 Astrazeneca Uk Ltd Verfahren zur herstellung von pyrimidinverbindungen
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
EP1737828A1 (en) * 2004-01-19 2007-01-03 Ranbaxy Laboratories Limited Amorphous magnesium salts of rosuvastatin
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
TWI345562B (en) * 2005-02-22 2011-07-21 Teva Pharma Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
ES2564807T5 (es) 2005-06-24 2019-02-26 Lek Pharmaceuticals Proceso para preparación de rosuvastatina de calcio amorfa pura
CZ299215B6 (cs) * 2005-06-29 2008-05-21 Zentiva, A. S. Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
KR20070062996A (ko) 2005-08-16 2007-06-18 테바 파마슈티컬 인더스트리즈 리미티드 결정성 로수바스타틴 중간체
EP1919880A2 (en) * 2005-08-16 2008-05-14 Teva Pharmaceutical Industries Ltd. Rosuvastatin calcium with a low salt by-product content
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
SI2024341T1 (sl) 2006-05-03 2016-04-29 Msn Laboratories Private Limited Novi postopek za statine in njihove farmacevtsko sprejemljive soli
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
HU230981B1 (hu) * 2007-10-12 2019-08-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás rosuvastatin só előállítására
EP2298745B1 (en) 2008-05-27 2014-09-03 Changzhou Pharmaceutical Factory Preparation method of rosuvastatin calcium and its intermediates
EA024554B1 (ru) 2008-06-27 2016-09-30 Крка, Товарна Здравил, Д.Д., Ново Место Твердая лекарственная форма, содержащая розувастатин, и способ ее получения
EP2138165A1 (en) 2008-06-27 2009-12-30 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
CN102186843A (zh) * 2008-09-09 2011-09-14 拜康有限公司 用于制备瑞舒伐他汀缩丙酮钙的方法
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
US8487105B2 (en) 2009-01-19 2013-07-16 Msn Laboratories Limited Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
CA2796964A1 (en) 2010-04-23 2011-10-27 Ranbaxy Laboratories Limited Intermediates for the preparation of hmg-coa reductase inhibitors
WO2012011129A2 (en) * 2010-07-22 2012-01-26 Msn Laboratories Limited Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt
CN105753834B (zh) * 2016-03-25 2018-08-21 河南师范大学 一种瑞舒伐他汀钙关键手性中间体的合成方法

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645858A (en) 1982-03-22 1987-02-24 G. D. Searle & Co. Pentanedioic acid derivatives
DE3741509A1 (de) 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
WO1990003973A1 (en) 1988-10-06 1990-04-19 Sandoz Ag Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them
US5026698A (en) 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5278313A (en) 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
SG44830A1 (en) 1992-07-02 1997-12-19 Hoechst Ag Process for preparing tert-butyl 93R,5S) -6 Hydroxy-3,5-O-Isopropylidene-3, 5-Dihydroxyhexanoate
BR9609872A (pt) 1995-07-17 1999-03-23 Warner Lambert Co Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino
US6278001B1 (en) 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
DE69719755T2 (de) 1996-06-24 2003-11-20 Novartis Ag, Basel Polymorphe verbindungen
WO2000034264A1 (en) 1998-12-10 2000-06-15 Kaneka Corporation Process for producing simvastatin
GB9900339D0 (en) * 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds
GB9903472D0 (en) * 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
WO2001022962A1 (en) 1999-09-30 2001-04-05 Merck & Co., Inc. Anti-hypercholesterolemic drug combination
SI1535613T1 (sl) 1999-11-17 2010-12-31 Teva Pharma Postopek za pripravo polimorfne oblike atorvastatin kalcija
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
AU2000254249A1 (en) 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
GB0011163D0 (en) 2000-05-10 2000-06-28 Astrazeneca Ab Chemical compound
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
HRP20030347A2 (en) 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
HRP20030454A2 (en) 2000-11-16 2005-10-31 Teva Pharmaceutical Industries Ltd. Hydrolysis of [r(r*,r*)]-2-(4-fluorophenyl)-(3,6-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
IN190564B (is) 2001-04-11 2003-08-09 Cadila Heathcare Ltd
HUP0401724A2 (hu) 2001-06-06 2004-12-28 Bristol-Myers Squibb Co. Eljárás királis diol-szulfon és dihidroxi-sav típusú HMG CoA reduktáz inhibitorok előállítására
KR100888408B1 (ko) * 2001-07-13 2009-03-13 아스트라제네카 유케이 리미티드 아미노피리미딘 화합물의 제조 방법
CA2450820C (en) 2001-08-16 2011-03-15 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
KR20040026705A (ko) 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
EP1423365A1 (en) 2001-08-22 2004-06-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives
JP2005512516A (ja) 2001-09-24 2005-05-12 メルク エンド カムパニー インコーポレーテッド スタチン薬物の組合せのスクリーニング方法および選択方法
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EA200401533A1 (ru) 2002-05-21 2005-06-30 Ранбакси Лабораторис Лимитед Способ получения росувастатина
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US7566782B2 (en) 2002-12-10 2009-07-28 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
DE60330050D1 (de) * 2002-12-16 2009-12-24 Astrazeneca Uk Ltd Verfahren zur herstellung von pyrimidinverbindungen
CA2520740C (en) 2003-04-11 2012-06-05 Lek Pharmaceuticals D.D. Process for the preparation of amorphous calcium salt of atorvastatin
WO2004103977A2 (en) 2003-05-21 2004-12-02 Ciba Specialty Chemicals Holding Inc. Process for the preparation of pyrimidine derivatives
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2005005384A1 (en) 2003-07-15 2005-01-20 Eos Eczacibasi Ozgun Kimyasal Urunler Sanyi Ve Ticaret A.S. Process for the preparation of amortphous atorvastatin calcium without interconversion of any crystalline form
US7396927B2 (en) 2003-08-28 2008-07-08 Teva Pharmaceutical Industries Ltd. Process for preparation of rosuvastatin calcium
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
EP1678148A1 (en) 2003-10-22 2006-07-12 Ranbaxy Laboratories Limited Process for the preparation of amorphous rosuvastatin calcium
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
DE10352659B4 (de) 2003-11-11 2007-09-13 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren
WO2005051921A1 (en) 2003-11-24 2005-06-09 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
WO2005077916A1 (en) 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
CN1894221B (zh) 2003-12-02 2012-08-08 特瓦制药工业有限公司 用于表征罗苏伐他汀的参照标准品
WO2005054207A1 (en) 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives
CA2645396A1 (en) 2003-12-24 2005-07-14 Teva Pharmaceutical Industries, Ltd Process for preparation of statins with high syn to anti ratio
CZ200486A3 (cs) 2004-01-16 2005-08-17 Zentiva, A.S. Způsob výroby hemivápenaté soli (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenové kyseliny
EP1737828A1 (en) 2004-01-19 2007-01-03 Ranbaxy Laboratories Limited Amorphous magnesium salts of rosuvastatin
US7241800B2 (en) 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
GB0406757D0 (en) 2004-03-26 2004-04-28 Avecia Ltd Process and compounds
US7161004B2 (en) 2004-06-21 2007-01-09 Dr. Reddy's Laboratories Limited Processes to produce intermediates for rosuvastatin
WO2006017357A1 (en) 2004-07-13 2006-02-16 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
WO2006035277A2 (en) 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
JP2008528542A (ja) 2005-01-31 2008-07-31 チバ ホールディング インコーポレーテッド ロスバスタチンカルシウム塩の結晶形
CA2498978A1 (en) 2005-02-28 2006-08-28 Apotex Pharmachem Inc. An improved process for the preparation of atorvastatin and intermediates
GB0514078D0 (en) 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
IL172075A (en) 2011-06-30
TW200510337A (en) 2005-03-16
JP4651615B2 (ja) 2011-03-16
MY140820A (en) 2010-01-29
RU2005138370A (ru) 2006-07-10
CN100422157C (zh) 2008-10-01
CA2527314A1 (en) 2004-12-16
EP1633727A1 (en) 2006-03-15
DE602004026576D1 (de) 2010-05-27
CO5640116A2 (es) 2006-05-31
ES2341858T3 (es) 2010-06-29
GB0324793D0 (en) 2003-11-26
SA04250223B1 (ar) 2008-12-23
GB0312896D0 (en) 2003-07-09
MXPA05013128A (es) 2006-03-16
NO20055730L (no) 2005-12-27
WO2004108691A1 (en) 2004-12-16
EP1633727B1 (en) 2010-04-14
KR20060017848A (ko) 2006-02-27
AU2004245291A1 (en) 2004-12-16
US8063213B2 (en) 2011-11-22
UY28341A1 (es) 2005-01-31
CA2527314C (en) 2012-02-21
AU2004245291B2 (en) 2008-02-14
NO332971B1 (no) 2013-02-11
IS2751B (is) 2011-09-15
RU2361864C2 (ru) 2009-07-20
TWI341310B (en) 2011-05-01
US20080221323A1 (en) 2008-09-11
JP2006526602A (ja) 2006-11-24
KR101099934B1 (ko) 2011-12-28
CN1798741A (zh) 2006-07-05
NZ543962A (en) 2008-09-26
NO20055730D0 (no) 2005-12-05
BRPI0410922A (pt) 2006-06-27
ATE464297T1 (de) 2010-04-15
HK1087405A1 (en) 2006-10-13
BRPI0410922B1 (pt) 2016-02-23
BRPI0410922B8 (pt) 2021-05-25
AR044773A1 (es) 2005-10-05

Similar Documents

Publication Publication Date Title
NO20055730D0 (no) Forbedret produksjon av rosuvastatin kalsiumsalt
IS7728A (is) Aðferð til að framleiða kalsíumsalt rósuvastatíns
NL301158I2 (nl) Relugolix of een zout daarvan
NL350091I2 (nl) Cyantraniliprole of een zout daarvan
NO20041082L (no) Fremgangsmater for fremstilling av kalsiumsaltformer av statiner
NL300885I2 (nl) Irinotecansucrosofaatzout
MA28802B1 (fr) Utilisations therapeutiques d'inhibiteurs de rtp801
FIC20150014I1 (fi) Fluralaneeri tai sen suola
IL173858A0 (en) Process for preparation of rosuvastatin calcium
EP1788874A4 (en) 5-AZACYTIDINE SALTS
ATE428701T1 (de) Kristalline form von bisä(e)-7-ä4-(4-fluorphenyl)-6-isopropyl-2-
DE602005027308D1 (de) Stabile salze von olanzapin
EP1660436A4 (en) cathepsin inhibitors
NO20050118D0 (no) Substituerte fenylsulfonamidinhibitorer av beta-amyolid produksjon
NO20052474D0 (no) Amort form av esomeprazolsalter
DE502004011575D1 (de) Verwendung von Dioldimerfettsäureestern
HRP20150163T1 (xx) Postupak za proizvodnju n-supstituiranih 2-cijanopirolidina
PL371629A1 (pl) Sposób wytwarzania kombrestatyn
EP1764075A4 (en) HAMMER OF TISSUE FACTORING
IS8399A (is) Form fjölgervings 3-fenýlsúlfónýl-8-píperasín-1-ýl-kínólíns
IS8321A (is) Stöðug afbrigði tegaseródvetnismaleats
ATE499348T1 (de) Stabiler polymorph von bifeprunoxmesilat
IS7477A (is) Aðferð við framleiðslu sýrusalts af gemifloxasíni
FR2864109B1 (fr) Croissance organisee de nano-structures
DE602004022100D1 (de) Stimulationshilfe