IS8332A - Nítróoxýafleiður lósartans, valsartans, kandesartans, telmisartans, eprósartans og ólmesartans sem angíótensín-II viðtakatálmar til að meðhöndla hjarta- og æðasjúkdóma - Google Patents

Nítróoxýafleiður lósartans, valsartans, kandesartans, telmisartans, eprósartans og ólmesartans sem angíótensín-II viðtakatálmar til að meðhöndla hjarta- og æðasjúkdóma

Info

Publication number: IS8332A
Authority: IS; Iceland
Prior art keywords: olmesartan; eprosartan; telmisartan; candesartan; valsartan
Prior art date: 2003-07-31

Application number

IS8332A

Other languages

English (en)

Other versions

IS2534B (is

Inventor

Almirante Nicoletta

Del Soldato Piero

Ongini Ennio

Original Assignee

Nicox S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-31

Filing date

2006-02-27

Publication date

2006-02-27

2006-02-27 Application filed by Nicox S.A. filed Critical Nicox S.A.

2006-02-27 Publication of IS8332A publication Critical patent/IS8332A/is

2009-08-15 Publication of IS2534B publication Critical patent/IS2534B/is

Links

RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 title 2
102000008873 Angiotensin II receptor Human genes 0.000 title 1
108050000824 Angiotensin II receptor Proteins 0.000 title 1
239000002083 C09CA01 - Losartan Substances 0.000 title 1
239000002080 C09CA02 - Eprosartan Substances 0.000 title 1
239000004072 C09CA03 - Valsartan Substances 0.000 title 1
239000002053 C09CA06 - Candesartan Substances 0.000 title 1
239000005537 C09CA07 - Telmisartan Substances 0.000 title 1
208000024172 Cardiovascular disease Diseases 0.000 title 1
239000005480 Olmesartan Substances 0.000 title 1
229960000932 candesartan Drugs 0.000 title 1
SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 title 1
229960004563 eprosartan Drugs 0.000 title 1
OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229960004773 losartan Drugs 0.000 title 1
125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 title 1
229960005117 olmesartan Drugs 0.000 title 1
VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 title 1
229960005187 telmisartan Drugs 0.000 title 1
229960004699 valsartan Drugs 0.000 title 1
SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IS8332A 2003-07-31 2006-02-27 Nítróoxýafleiður lósartans, valsartans, kandesartans, telmisartans, eprósartans og ólmesartans sem angíótensín-II viðtakatálmar til að meðhöndla hjarta- og æðasjúkdóma IS2534B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03102379		2003-07-31
PCT/EP2004/051550 WO2005011646A2 (en)	2003-07-31	2004-07-20	Nitrooxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-ii receptor blockers for the treatment of cardiovascular diseases

Publications (2)

Publication Number	Publication Date
IS8332A true IS8332A (is)	2006-02-27
IS2534B IS2534B (is)	2009-08-15

Family

ID=34112476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8332A IS2534B (is)	2003-07-31	2006-02-27	Nítróoxýafleiður lósartans, valsartans, kandesartans, telmisartans, eprósartans og ólmesartans sem angíótensín-II viðtakatálmar til að meðhöndla hjarta- og æðasjúkdóma

Country Status (29)

Country	Link
US (1)	US20060276523A1 (is)
EP (1)	EP1653950B1 (is)
JP (1)	JP2007500684A (is)
KR (1)	KR20060056352A (is)
CN (1)	CN100496490C (is)
AR (1)	AR045145A1 (is)
AT (1)	ATE383155T1 (is)
AU (1)	AU2004260830B2 (is)
BR (1)	BRPI0413028A (is)
CA (1)	CA2534451A1 (is)
CY (1)	CY1110447T1 (is)
DE (1)	DE602004011230T2 (is)
DK (1)	DK1653950T3 (is)
EC (1)	ECSP066334A (is)
ES (1)	ES2299861T3 (is)
HR (1)	HRP20060084A2 (is)
IL (1)	IL172703A0 (is)
IS (1)	IS2534B (is)
MA (1)	MA27987A1 (is)
MX (1)	MXPA06001263A (is)
NO (1)	NO20060900L (is)
NZ (1)	NZ544463A (is)
PL (2)	PL379420A1 (is)
PT (1)	PT1653950E (is)
RU (1)	RU2374240C2 (is)
SI (1)	SI1653950T1 (is)
UA (1)	UA87983C2 (is)
WO (1)	WO2005011646A2 (is)
ZA (1)	ZA200600856B (is)

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EP1778617A1 (en) *	2004-07-20	2007-05-02	NicOx S.A.	Process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates, intermediates useful in said process and preparation thereof
WO2006079610A1 (en) *	2005-01-31	2006-08-03	Nicox S.A.	Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
RU2306930C1 (ru) *	2005-12-28	2007-09-27	Михаил Владимирович Покровский	Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
CN101024643A (zh)	2006-02-20	2007-08-29	上海艾力斯医药科技有限公司	咪唑－5－羧酸类衍生物、制备方法及其应用
TW200821303A (en) *	2006-08-08	2008-05-16	Speedel Experimenta Ag	Organic compounds
WO2008076245A2 (en) *	2006-12-13	2008-06-26	Merck & Co., Inc.	Nitroderivatives as angiotensin ii receptor antagonists
EP2081892A4 (en)	2006-11-17	2014-03-05	Donald F Weaver	COMPOUNDS AND METHOD FOR THE TREATMENT OF PROTEIN DISAPPEARANCE
AU2006351517B8 (en) *	2006-12-06	2012-01-19	Shenzhen Salubris Pharmaceuticals Co., Ltd.	The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
TW200831079A (en) *	2006-12-13	2008-08-01	Merck & Co Inc	Angiotensin II receptor antagonists
CN101214242A (zh) *	2007-01-05	2008-07-09	上海艾力斯医药科技有限公司	新的药用组合物
EP1980559A1 (en) *	2007-04-10	2008-10-15	CTG Pharma S.r.l.	Cardiovascular agents
CN101317842A (zh)	2007-06-07	2008-12-10	上海艾力斯医药科技有限公司	一种咪唑-5-羧酸衍生物的治疗用途
CN101407511B (zh) *	2007-10-11	2013-01-09	上海艾力斯生物医药有限公司	一种结晶型的咪唑-5-羧酸衍生物
AR069340A1 (es) *	2007-11-26	2010-01-13	Merck & Co Inc	Antagonistas del receptor de angiotensina ii
ES2394589T3 (es)	2007-12-14	2013-02-04	Aerodesigns, Inc	Suministro de productos alimenticios transformables en aerosol
US7947664B2 (en) *	2008-01-24	2011-05-24	Merck Sharp & Dohme Corp.	Angiotensin II receptor antagonists
JP2011511079A (ja) *	2008-02-08	2011-04-07	メルク・シャープ・エンド・ドーム・コーポレイション	アンジオテンシンｉｉ受容体アンタゴニスト
EP2250158A2 (en) *	2008-02-26	2010-11-17	Nicox S.A.	Angiotensin ii receptor antagonists
JP2011513269A (ja) *	2008-02-26	2011-04-28	ニコックスエスエイ	新規アンジオテンシンｉｉレセプターブロッカー誘導体
EP2291076A4 (en) *	2008-05-15	2012-03-21	Merck Sharp & Dohme	Angiotensin-II Receptor Antagonists
CN101596189A (zh) *	2008-06-05	2009-12-09	上海艾力斯生物医药有限公司	含有咪唑-5-羧酸类衍生物的药用组合物
WO2009150007A1 (en) *	2008-06-09	2009-12-17	Nicox S.A.	Angiotensin ii receptor antagonists
AR073259A1 (es) *	2008-07-29	2010-10-28	Merck & Co Inc	Derivados de furosemida utiles como diureticos
WO2010015447A1 (en) *	2008-08-08	2010-02-11	Nicox S.A.	Angiotensin ii receptor antagonists
EP2194048A1 (en)	2008-12-02	2010-06-09	Dirk Sartor	Nitrate esters for the treatment of vascular and metabolic diseases
EP2373630A1 (en) *	2008-12-05	2011-10-12	Merck Sharp & Dohme Corp.	Nitrooxy derivatives as angiotensin ii receptor antagonists
JP5658172B2 (ja)	2009-01-23	2015-01-21	ハンミ・サイエンス・カンパニー・リミテッド	アムロジピン及びロサルタンを含む固形薬剤学的組成物及びその製造方法
KR20130075740A (ko)	2010-04-19	2013-07-05	카르디올린크스 아게	혈관 질환 및 대사성 질환을 치료하기 위한 산화질소 공여체를 갖는 발사르탄 유도체
EP2560634A1 (en) *	2010-04-23	2013-02-27	Piramal Enterprises Limited	Nitric oxide releasing prodrugs of therapeutic agents
WO2011160974A2 (en)	2010-06-21	2011-12-29	Nicox S.A.	Statin derivatives
JO3350B1 (ar)	2011-03-07	2019-03-13	Merck Sharp & Dohme	مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
WO2014111957A1 (en)	2013-01-21	2014-07-24	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents
CN103275074B (zh) *	2013-06-21	2016-08-10	黄冈鲁班药业股份有限公司	一种奥美沙坦衍生物及其制备方法
CN105820125B (zh) *	2015-01-09	2018-12-07	北京中医药大学	一种用于治疗高血压的化合物及其制备方法和用途
CN108349911B (zh)	2015-09-07	2022-05-13	浙江华海药业股份有限公司	可释放一氧化氮的前药分子
CN106800537B (zh)	2017-01-18	2019-02-01	广东隆赋药业股份有限公司	丁苯酞-替米沙坦杂合物及其制备方法和用途
CN108892624B (zh) *	2018-06-20	2020-12-15	重庆威鹏药业有限公司	沙库巴曲硝基氧衍生物及其制备方法和应用
CN114105881B (zh) *	2020-08-31	2024-01-26	沈阳海诺威医药科技有限公司	血小板聚集抑制剂及其制备方法和用途

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CA1338238C (en) *	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DK0403159T3 (da) *	1989-06-14	2000-08-14	Smithkline Beecham Corp	Imidazolylalkensyrer
HU217958B (hu) *	1989-06-30	2000-05-28	E. I. Du Pont De Nemours And Co.	Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
RU2067581C1 (ru) *	1989-06-30	1996-10-10	Е.И.Дюпон Де Немур Энд Компани	Аралкилзамещенные имидазолы, обладающие противогипертоническим действием, способ их получения и фармацевтический состав, обладающий ингибирующей активностью в отношении ангиотензина ii
AT398202B (de) *	1991-10-04	1994-10-25	Chem Pharm Forsch Gmbh	Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
FR2725987B1 (fr) *	1994-10-19	1997-01-10	Sanofi Sa	Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
IT1311924B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
CA2420055C (en) *	2000-08-25	2010-06-01	Takeda Chemical Industries, Ltd.	Fibrinogen-lowering agent
ITMI20011744A1 (it) *	2001-08-09	2003-02-09	Nicox Sa	Farmaci per le vasculopatie

2004
- 2004-07-20 PL PL379420A patent/PL379420A1/pl not_active Application Discontinuation
- 2004-07-20 PT PT04766269T patent/PT1653950E/pt unknown
- 2004-07-20 JP JP2006521571A patent/JP2007500684A/ja active Pending
- 2004-07-20 UA UAA200600273A patent/UA87983C2/ru unknown
- 2004-07-20 NZ NZ544463A patent/NZ544463A/en unknown
- 2004-07-20 HR HR20060084A patent/HRP20060084A2/hr not_active Application Discontinuation
- 2004-07-20 CN CNB200480022483XA patent/CN100496490C/zh not_active Expired - Fee Related
- 2004-07-20 MX MXPA06001263A patent/MXPA06001263A/es active IP Right Grant
- 2004-07-20 AU AU2004260830A patent/AU2004260830B2/en not_active Ceased
- 2004-07-20 CA CA002534451A patent/CA2534451A1/en not_active Abandoned
- 2004-07-20 BR BRPI0413028-6A patent/BRPI0413028A/pt not_active IP Right Cessation
- 2004-07-20 SI SI200430655T patent/SI1653950T1/sl unknown
- 2004-07-20 PL PL04766269T patent/PL1653950T3/pl unknown
- 2004-07-20 DK DK04766269T patent/DK1653950T3/da active
- 2004-07-20 RU RU2006105804/04A patent/RU2374240C2/ru not_active IP Right Cessation
- 2004-07-20 KR KR1020067001893A patent/KR20060056352A/ko not_active Ceased
- 2004-07-20 WO PCT/EP2004/051550 patent/WO2005011646A2/en not_active Ceased
- 2004-07-20 EP EP04766269A patent/EP1653950B1/en not_active Expired - Lifetime
- 2004-07-20 AT AT04766269T patent/ATE383155T1/de not_active IP Right Cessation
- 2004-07-20 US US10/566,292 patent/US20060276523A1/en not_active Abandoned
- 2004-07-20 ES ES04766269T patent/ES2299861T3/es not_active Expired - Lifetime
- 2004-07-20 DE DE602004011230T patent/DE602004011230T2/de not_active Expired - Lifetime
- 2004-07-28 AR ARP040102685A patent/AR045145A1/es unknown
2005
- 2005-12-20 IL IL172703A patent/IL172703A0/en not_active IP Right Cessation
2006
- 2006-01-30 ZA ZA200600856A patent/ZA200600856B/en unknown
- 2006-01-30 EC EC2006006334A patent/ECSP066334A/es unknown
- 2006-02-13 MA MA28789A patent/MA27987A1/fr unknown
- 2006-02-24 NO NO20060900A patent/NO20060900L/no not_active Application Discontinuation
- 2006-02-27 IS IS8332A patent/IS2534B/is unknown
2008
- 2008-04-07 CY CY20081100385T patent/CY1110447T1/el unknown

Also Published As

Publication number	Publication date
PT1653950E (pt)	2008-04-11
WO2005011646A2 (en)	2005-02-10
AR045145A1 (es)	2005-10-19
RU2374240C2 (ru)	2009-11-27
US20060276523A1 (en)	2006-12-07
CY1110447T1 (el)	2015-04-29
CN100496490C (zh)	2009-06-10
KR20060056352A (ko)	2006-05-24
BRPI0413028A (pt)	2006-10-03
AU2004260830B2 (en)	2010-04-29
IS2534B (is)	2009-08-15
PL1653950T3 (pl)	2008-08-29
CN1832742A (zh)	2006-09-13
ES2299861T3 (es)	2008-06-01
MXPA06001263A (es)	2006-04-11
MA27987A1 (fr)	2006-07-03
NO20060900L (no)	2006-02-24
EP1653950B1 (en)	2008-01-09
NZ544463A (en)	2009-10-30
ECSP066334A (es)	2006-07-28
RU2006105804A (ru)	2007-09-20
UA87983C2 (ru)	2009-09-10
SI1653950T1 (sl)	2008-06-30
DK1653950T3 (da)	2008-05-26
AU2004260830A1 (en)	2005-02-10
ZA200600856B (en)	2007-05-30
JP2007500684A (ja)	2007-01-18
HRP20060084A2 (hr)	2006-04-30
CA2534451A1 (en)	2005-02-10
EP1653950A2 (en)	2006-05-10
PL379420A1 (pl)	2006-09-04
HK1095093A1 (zh)	2007-04-27
WO2005011646A3 (en)	2005-04-21
DE602004011230T2 (de)	2009-01-02
ATE383155T1 (de)	2008-01-15
DE602004011230D1 (de)	2008-02-21
IL172703A0 (en)	2006-04-10

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IL176630A0 (en)	2006-10-31	Benzimidazole derivatives
IL188486A0 (en)	2008-04-13	Benzimidazole derivatives as 5-ht6,5-ht24
CL2004000379A1 (es)	2005-01-21	Uso de una combinacion farmaceutica de lercanidipina con un bloqueador de los receptores de angiotensina ii, seleccionado de olmesartan, irbesartan, valsartan, telmisartan y losartan, para tratar la hipertension.
IL176140A0 (en)	2006-10-05	Candesartan cilexetil polymorphs
ZA200703495B (en)	2008-10-29	Process for the preparation of irbesartan hydrochloride
EP1778650A4 (en)	2009-12-02	PROCESS OF MANUFACTURING CANDÉSARTAN CILEXÉTIL
EP1984356A4 (en)	2010-11-24	IMPROVED PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL
WO2006063578A3 (de)	2006-10-12	Verfahren zur herstellung von candesartan
ZA200808598B (en)	2009-12-30	Pyrrolopyrimidine derivatives used as HSP90 inhibitors
ZA200800892B (en)	2009-04-29	Activator of peroxisome proliferator activated receptor δ
ZA200709002B (en)	2009-01-28	Benzimidazole derivative and use as angiotensin II antagonist