MA27987A1 - Derives nitro-oxy de losartan, valsatan, candesartan, telmisartan, eprosartan et olmesartan comme bloqueurs des recepteurs de l'angiontensine-ii pour le traitement des maladies cardiovasculaires. - Google Patents
Derives nitro-oxy de losartan, valsatan, candesartan, telmisartan, eprosartan et olmesartan comme bloqueurs des recepteurs de l'angiontensine-ii pour le traitement des maladies cardiovasculaires.Info
- Publication number
- MA27987A1 MA27987A1 MA28789A MA28789A MA27987A1 MA 27987 A1 MA27987 A1 MA 27987A1 MA 28789 A MA28789 A MA 28789A MA 28789 A MA28789 A MA 28789A MA 27987 A1 MA27987 A1 MA 27987A1
- Authority
- MA
- Morocco
- Prior art keywords
- valsatan
- olmesartan
- eprosartan
- telmisartan
- candesartan
- Prior art date
Links
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical class CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 title abstract 4
- -1 VALSATAN Chemical class 0.000 title abstract 3
- 239000002083 C09CA01 - Losartan Substances 0.000 title abstract 2
- 239000002080 C09CA02 - Eprosartan Chemical class 0.000 title abstract 2
- 239000002053 C09CA06 - Candesartan Substances 0.000 title abstract 2
- 239000005537 C09CA07 - Telmisartan Chemical class 0.000 title abstract 2
- 239000005480 Olmesartan Substances 0.000 title abstract 2
- 229960000932 candesartan Drugs 0.000 title abstract 2
- SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical class CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004563 eprosartan Drugs 0.000 title abstract 2
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical class C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 title abstract 2
- 229960004773 losartan Drugs 0.000 title abstract 2
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical class CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005117 olmesartan Drugs 0.000 title abstract 2
- 229960005187 telmisartan Drugs 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 102000008873 Angiotensin II receptor Human genes 0.000 abstract 1
- 108050000824 Angiotensin II receptor Proteins 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 abstract 1
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Dérivés nitrooxy des bloqueurs des récepteurs pour l'angiotensine II losartan, valsatan, candésartan, telmisartan, éprosartan et olmésartan et les composés y relatifs de formule (I) : R-(Y-ONO2)8 dans laquelle R est de formule (II) ou (III) : R0 est ex. : et R1 est : (IIa), (IIb), (IIc), (IId) ou (IIe).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03102379 | 2003-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27987A1 true MA27987A1 (fr) | 2006-07-03 |
Family
ID=34112476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28789A MA27987A1 (fr) | 2003-07-31 | 2006-02-13 | Derives nitro-oxy de losartan, valsatan, candesartan, telmisartan, eprosartan et olmesartan comme bloqueurs des recepteurs de l'angiontensine-ii pour le traitement des maladies cardiovasculaires. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20060276523A1 (fr) |
| EP (1) | EP1653950B1 (fr) |
| JP (1) | JP2007500684A (fr) |
| KR (1) | KR20060056352A (fr) |
| CN (1) | CN100496490C (fr) |
| AR (1) | AR045145A1 (fr) |
| AT (1) | ATE383155T1 (fr) |
| AU (1) | AU2004260830B2 (fr) |
| BR (1) | BRPI0413028A (fr) |
| CA (1) | CA2534451A1 (fr) |
| CY (1) | CY1110447T1 (fr) |
| DE (1) | DE602004011230T2 (fr) |
| DK (1) | DK1653950T3 (fr) |
| EC (1) | ECSP066334A (fr) |
| ES (1) | ES2299861T3 (fr) |
| HR (1) | HRP20060084A2 (fr) |
| IL (1) | IL172703A0 (fr) |
| IS (1) | IS2534B (fr) |
| MA (1) | MA27987A1 (fr) |
| MX (1) | MXPA06001263A (fr) |
| NO (1) | NO20060900L (fr) |
| NZ (1) | NZ544463A (fr) |
| PL (2) | PL379420A1 (fr) |
| PT (1) | PT1653950E (fr) |
| RU (1) | RU2374240C2 (fr) |
| SI (1) | SI1653950T1 (fr) |
| UA (1) | UA87983C2 (fr) |
| WO (1) | WO2005011646A2 (fr) |
| ZA (1) | ZA200600856B (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1778617A1 (fr) * | 2004-07-20 | 2007-05-02 | NicOx S.A. | Procede destine a la preparation d'esters nitro-oxy, de thioesters nitro-oxy, de carbonates nitro-oxy et de thiocarbonates nitro-oxy, produits intermediaires utiles dans ce procede et leur preparation |
| WO2006079610A1 (fr) * | 2005-01-31 | 2006-08-03 | Nicox S.A. | Derives de sartane nitrooxy en tant que bloqueurs d'un recepteur d'angiotensine ii pour le traitement de maladies cardio-vasculaires et inflammatoires |
| RU2306930C1 (ru) * | 2005-12-28 | 2007-09-27 | Михаил Владимирович Покровский | Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота |
| CN101024643A (zh) | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
| WO2008076245A2 (fr) * | 2006-12-13 | 2008-06-26 | Merck & Co., Inc. | Antagonistes des récepteurs de l'angiotensine ii |
| EP2081892A4 (fr) | 2006-11-17 | 2014-03-05 | Donald F Weaver | Composés et procédés pour traiter des troubles de repliement de protéine |
| AU2006351517B8 (en) * | 2006-12-06 | 2012-01-19 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof |
| TW200831079A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
| CN101214242A (zh) * | 2007-01-05 | 2008-07-09 | 上海艾力斯医药科技有限公司 | 新的药用组合物 |
| EP1980559A1 (fr) * | 2007-04-10 | 2008-10-15 | CTG Pharma S.r.l. | Agents cardiovasculaires |
| CN101317842A (zh) | 2007-06-07 | 2008-12-10 | 上海艾力斯医药科技有限公司 | 一种咪唑-5-羧酸衍生物的治疗用途 |
| CN101407511B (zh) * | 2007-10-11 | 2013-01-09 | 上海艾力斯生物医药有限公司 | 一种结晶型的咪唑-5-羧酸衍生物 |
| AR069340A1 (es) * | 2007-11-26 | 2010-01-13 | Merck & Co Inc | Antagonistas del receptor de angiotensina ii |
| ES2394589T3 (es) | 2007-12-14 | 2013-02-04 | Aerodesigns, Inc | Suministro de productos alimenticios transformables en aerosol |
| US7947664B2 (en) * | 2008-01-24 | 2011-05-24 | Merck Sharp & Dohme Corp. | Angiotensin II receptor antagonists |
| JP2011511079A (ja) * | 2008-02-08 | 2011-04-07 | メルク・シャープ・エンド・ドーム・コーポレイション | アンジオテンシンｉｉ受容体アンタゴニスト |
| EP2250158A2 (fr) * | 2008-02-26 | 2010-11-17 | Nicox S.A. | Antagonistes vis-à-vis des récepteurs de l'angiotensine ii |
| JP2011513269A (ja) * | 2008-02-26 | 2011-04-28 | ニコックス エス エイ | 新規アンジオテンシンｉｉレセプターブロッカー誘導体 |
| EP2291076A4 (fr) * | 2008-05-15 | 2012-03-21 | Merck Sharp & Dohme | Antagonistes du récepteur de l'angiotensine ll |
| CN101596189A (zh) * | 2008-06-05 | 2009-12-09 | 上海艾力斯生物医药有限公司 | 含有咪唑-5-羧酸类衍生物的药用组合物 |
| WO2009150007A1 (fr) * | 2008-06-09 | 2009-12-17 | Nicox S.A. | Antagonistes des récepteurs de l’angiotensine ii |
| AR073259A1 (es) * | 2008-07-29 | 2010-10-28 | Merck & Co Inc | Derivados de furosemida utiles como diureticos |
| WO2010015447A1 (fr) * | 2008-08-08 | 2010-02-11 | Nicox S.A. | Antagonistes des récepteurs de l'angiotensine ii |
| EP2194048A1 (fr) | 2008-12-02 | 2010-06-09 | Dirk Sartor | Esters de nitrate pour le traitement de maladies vasculaires et métaboliques |
| EP2373630A1 (fr) * | 2008-12-05 | 2011-10-12 | Merck Sharp & Dohme Corp. | Dérivés nitrooxy en tant qu'antagonistes du récepteur de l'angiotensine ii |
| JP5658172B2 (ja) | 2009-01-23 | 2015-01-21 | ハンミ・サイエンス・カンパニー・リミテッド | アムロジピン及びロサルタンを含む固形薬剤学的組成物及びその製造方法 |
| KR20130075740A (ko) | 2010-04-19 | 2013-07-05 | 카르디올린크스 아게 | 혈관 질환 및 대사성 질환을 치료하기 위한 산화질소 공여체를 갖는 발사르탄 유도체 |
| EP2560634A1 (fr) * | 2010-04-23 | 2013-02-27 | Piramal Enterprises Limited | Promédicaments d'agents thérapeutiques libérant de l'oxyde nitrique |
| WO2011160974A2 (fr) | 2010-06-21 | 2011-12-29 | Nicox S.A. | Dérivés de statines |
| JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
| WO2014111957A1 (fr) | 2013-01-21 | 2014-07-24 | Apparao Satyam | Promédicaments d'agents thérapeutiques libérant de l'oxyde nitrique |
| CN103275074B (zh) * | 2013-06-21 | 2016-08-10 | 黄冈鲁班药业股份有限公司 | 一种奥美沙坦衍生物及其制备方法 |
| CN105820125B (zh) * | 2015-01-09 | 2018-12-07 | 北京中医药大学 | 一种用于治疗高血压的化合物及其制备方法和用途 |
| CN108349911B (zh) | 2015-09-07 | 2022-05-13 | 浙江华海药业股份有限公司 | 可释放一氧化氮的前药分子 |
| CN106800537B (zh) | 2017-01-18 | 2019-02-01 | 广东隆赋药业股份有限公司 | 丁苯酞-替米沙坦杂合物及其制备方法和用途 |
| CN108892624B (zh) * | 2018-06-20 | 2020-12-15 | 重庆威鹏药业有限公司 | 沙库巴曲硝基氧衍生物及其制备方法和应用 |
| CN114105881B (zh) * | 2020-08-31 | 2024-01-26 | 沈阳海诺威医药科技有限公司 | 血小板聚集抑制剂及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1338238C (fr) * | 1988-01-07 | 1996-04-09 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens |
| DK0403159T3 (da) * | 1989-06-14 | 2000-08-14 | Smithkline Beecham Corp | Imidazolylalkensyrer |
| HU217958B (hu) * | 1989-06-30 | 2000-05-28 | E. I. Du Pont De Nemours And Co. | Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
| RU2067581C1 (ru) * | 1989-06-30 | 1996-10-10 | Е.И.Дюпон Де Немур Энд Компани | Аралкилзамещенные имидазолы, обладающие противогипертоническим действием, способ их получения и фармацевтический состав, обладающий ингибирующей активностью в отношении ангиотензина ii |
| AT398202B (de) * | 1991-10-04 | 1994-10-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| FR2725987B1 (fr) * | 1994-10-19 | 1997-01-10 | Sanofi Sa | Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| CA2420055C (fr) * | 2000-08-25 | 2010-06-01 | Takeda Chemical Industries, Ltd. | Agent de reduction du fibrinogene |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
-
2004
- 2004-07-20 PL PL379420A patent/PL379420A1/pl not_active Application Discontinuation
- 2004-07-20 PT PT04766269T patent/PT1653950E/pt unknown
- 2004-07-20 JP JP2006521571A patent/JP2007500684A/ja active Pending
- 2004-07-20 UA UAA200600273A patent/UA87983C2/ru unknown
- 2004-07-20 NZ NZ544463A patent/NZ544463A/en unknown
- 2004-07-20 HR HR20060084A patent/HRP20060084A2/hr not_active Application Discontinuation
- 2004-07-20 CN CNB200480022483XA patent/CN100496490C/zh not_active Expired - Fee Related
- 2004-07-20 MX MXPA06001263A patent/MXPA06001263A/es active IP Right Grant
- 2004-07-20 AU AU2004260830A patent/AU2004260830B2/en not_active Ceased
- 2004-07-20 CA CA002534451A patent/CA2534451A1/fr not_active Abandoned
- 2004-07-20 BR BRPI0413028-6A patent/BRPI0413028A/pt not_active IP Right Cessation
- 2004-07-20 SI SI200430655T patent/SI1653950T1/sl unknown
- 2004-07-20 PL PL04766269T patent/PL1653950T3/pl unknown
- 2004-07-20 DK DK04766269T patent/DK1653950T3/da active
- 2004-07-20 RU RU2006105804/04A patent/RU2374240C2/ru not_active IP Right Cessation
- 2004-07-20 KR KR1020067001893A patent/KR20060056352A/ko not_active Ceased
- 2004-07-20 WO PCT/EP2004/051550 patent/WO2005011646A2/fr not_active Ceased
- 2004-07-20 EP EP04766269A patent/EP1653950B1/fr not_active Expired - Lifetime
- 2004-07-20 AT AT04766269T patent/ATE383155T1/de not_active IP Right Cessation
- 2004-07-20 US US10/566,292 patent/US20060276523A1/en not_active Abandoned
- 2004-07-20 ES ES04766269T patent/ES2299861T3/es not_active Expired - Lifetime
- 2004-07-20 DE DE602004011230T patent/DE602004011230T2/de not_active Expired - Lifetime
- 2004-07-28 AR ARP040102685A patent/AR045145A1/es unknown
-
2005
- 2005-12-20 IL IL172703A patent/IL172703A0/en not_active IP Right Cessation
-
2006
- 2006-01-30 ZA ZA200600856A patent/ZA200600856B/en unknown
- 2006-01-30 EC EC2006006334A patent/ECSP066334A/es unknown
- 2006-02-13 MA MA28789A patent/MA27987A1/fr unknown
- 2006-02-24 NO NO20060900A patent/NO20060900L/no not_active Application Discontinuation
- 2006-02-27 IS IS8332A patent/IS2534B/is unknown
-
2008
- 2008-04-07 CY CY20081100385T patent/CY1110447T1/el unknown
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