IS8506A - Nógó-A hlutleysandi ónæmisglóbúlín fyrir meðhöndlun á taugasjúkdómum - Google Patents

Nógó-A hlutleysandi ónæmisglóbúlín fyrir meðhöndlun á taugasjúkdómum

Info

Publication number
IS8506A
IS8506A IS8506A IS8506A IS8506A IS 8506 A IS8506 A IS 8506A IS 8506 A IS8506 A IS 8506A IS 8506 A IS8506 A IS 8506A IS 8506 A IS8506 A IS 8506A
Authority
IS
Iceland
Prior art keywords
nogo
treatment
neurological disorders
neutralizing immunoglobulin
immunoglobulin
Prior art date
Application number
IS8506A
Other languages
English (en)
Other versions
IS2739B (is
Inventor
Ellis Jonathan Henry
Eon-Duval Alexandre
Grundy Robert Ian
Hussain Farhana
Mcadam Ruth
Plumpton Christopher
Prinjha Rabinder Kumar
Wilson Paul Alexander
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329684A external-priority patent/GB0329684D0/en
Priority claimed from GB0329711A external-priority patent/GB0329711D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IS8506A publication Critical patent/IS8506A/is
Publication of IS2739B publication Critical patent/IS2739B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IS8506A 2003-12-22 2006-06-12 Nógó@@@hlutleysandi@ónæmisglóbúlín@fyrir@meðhöndlun@á@taugasjúkdómum IS2739B (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0329684A GB0329684D0 (en) 2003-12-22 2003-12-22 Method
GB0329711A GB0329711D0 (en) 2003-12-22 2003-12-22 Antibodies
PCT/GB2004/005325 WO2005061544A2 (en) 2003-12-22 2004-12-20 Nogo-a neutralising immunoglobulins for treatment of neurological diseases

Publications (2)

Publication Number Publication Date
IS8506A true IS8506A (is) 2006-06-12
IS2739B IS2739B (is) 2011-06-15

Family

ID=34712703

Family Applications (1)

Application Number Title Priority Date Filing Date
IS8506A IS2739B (is) 2003-12-22 2006-06-12 Nógó@@@hlutleysandi@ónæmisglóbúlín@fyrir@meðhöndlun@á@taugasjúkdómum

Country Status (27)

Country Link
US (4) US7988964B2 (is)
EP (3) EP1706426A2 (is)
JP (2) JP4901480B2 (is)
KR (1) KR101150548B1 (is)
AR (1) AR048912A1 (is)
AT (1) ATE440866T1 (is)
AU (1) AU2004303585B2 (is)
BR (1) BRPI0417959A (is)
CA (1) CA2549956C (is)
CY (1) CY1110530T1 (is)
DE (1) DE602004022871D1 (is)
DK (1) DK1711530T3 (is)
ES (1) ES2330444T3 (is)
HR (1) HRP20090527T1 (is)
IL (1) IL176206A (is)
IS (1) IS2739B (is)
MA (1) MA28289A1 (is)
MX (1) MXPA06007190A (is)
MY (1) MY144612A (is)
NO (1) NO20062767L (is)
NZ (1) NZ548013A (is)
PL (1) PL1711530T3 (is)
PT (1) PT1711530E (is)
RU (1) RU2362780C2 (is)
SI (1) SI1711530T1 (is)
TW (1) TWI329649B (is)
WO (2) WO2005061544A2 (is)

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GB0321997D0 (en) * 2003-09-19 2003-10-22 Novartis Ag Organic compound
NZ548013A (en) 2003-12-22 2009-04-30 Glaxo Group Ltd Immunoglobulins
CA2614076A1 (en) * 2005-07-05 2007-01-11 Glaxo Group Limited Humanised antibodies specific for nogo-a and pharmaceutical uses thereof
CN101277974A (zh) 2005-09-30 2008-10-01 阿伯特有限及两合公司 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途
RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
GB0525662D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Immunoglobulins
US8663635B2 (en) 2006-03-21 2014-03-04 The Regents Of The University Of California N-cadherin: target for cancer diagnosis and therapy
WO2008002594A2 (en) * 2006-06-27 2008-01-03 Neuroprotection For Life Corp. Neuronal circuit-dependent neuroprotection by interaction between nicotinic receptors
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
MX2009006034A (es) * 2006-12-07 2009-10-12 Novartis Ag Anticuerpos antagonistas contra ephb3.
US8895004B2 (en) * 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
WO2009026117A2 (en) * 2007-08-16 2009-02-26 Glaxo Group Limited Novel compounds
CA2704357C (en) 2007-11-02 2016-06-21 Novartis Ag Improved nogo-a binding molecules and pharmaceutical use thereof
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
EA201001603A1 (ru) * 2008-04-04 2011-06-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Антитела против кадгерина, блокирующие рост опухоли, ангиогенез и метастазирование
CA2730473A1 (en) * 2008-07-11 2010-01-14 Glaxo Group Limited Novel treatment
US10266585B2 (en) 2009-08-28 2019-04-23 The Board Of Regents Of The Univerity Of Texas System Methods of treating brain injury
PH12012501070A1 (en) 2009-12-08 2017-08-23 Abbott Gmbh & Co Kg Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
WO2011130377A2 (en) 2010-04-15 2011-10-20 Abbott Laboratories Amyloid-beta binding proteins
US8828390B2 (en) 2010-07-09 2014-09-09 Universitat Zurich Uses of NOGO-A inhibitors and related methods
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
CA2817973C (en) 2010-10-15 2019-06-25 The Board Of Regents Of The University Of Texas System Antibodies that bind amyloid oligomers
CA2815277A1 (en) 2010-10-29 2012-05-03 Immunogen, Inc. Novel egfr-binding molecules and immunoconjugates thereof
JP5828902B2 (ja) 2010-10-29 2015-12-09 イミュノジェン, インコーポレイテッド 非拮抗性egfr結合分子およびその免疫複合体
JP2014533954A (ja) 2011-11-21 2014-12-18 イミュノジェン, インコーポレイテッド Egfr抗体細胞傷害性薬物複合体による、egfr療法に耐性である腫瘍の治療方法
US20140050720A1 (en) 2012-01-09 2014-02-20 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
AU2013211939C1 (en) 2012-01-27 2018-06-07 AbbVie Deutschland GmbH & Co. KG Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
IN2014KN02952A (is) 2012-07-05 2015-05-08 Glaxo Group Ltd
BR112017023872A2 (pt) 2015-05-04 2018-07-24 Cytomx Therapeutics Inc anticorpos anti-cd166, anticorpos anti-cd166 ativáveis e métodos de uso dos mesmos
US20180362660A1 (en) * 2016-05-09 2018-12-20 Schickwann Tsai Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes
US11220544B2 (en) * 2017-07-14 2022-01-11 Cytomx Therapeutics, Inc. Anti-CD166 antibodies and uses thereof
TW201946654A (zh) 2018-03-05 2019-12-16 比利時商健生藥品公司 抗PHF-Tau抗體及其用途
JP2022501319A (ja) * 2018-09-25 2022-01-06 アカデミア シニカAcademia Sinica 抗Siglec抗体、それを備える薬学的組成物及びその使用
BR112022006534A2 (pt) 2019-10-24 2022-07-05 Novago Therapeutics Ag Anticorpos anti-nogo-a
CN116635718A (zh) * 2020-12-02 2023-08-22 安捷伦科技有限公司 用于在免疫组织化学(ihc)方案中使用以诊断癌症的抗人cd10抗体
WO2024041450A1 (zh) * 2022-08-22 2024-02-29 舒泰神(北京)生物制药股份有限公司 特异性识别Nogo-A的抗体及其应用
CN116693672B (zh) * 2023-06-15 2025-08-08 郑州伊美诺生物技术有限公司 抗3型人副流感病毒单克隆抗体及其制备方法和应用
WO2025006549A2 (en) * 2023-06-28 2025-01-02 University Of Connecticut Antibodies against immune checkpoint molecules and methods of use
WO2026041734A1 (en) 2024-08-22 2026-02-26 Novago Therapeutics Ag Methods for treating neurological disorders using anti-nogo-a antibodies

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US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
DE69531458T2 (de) 1994-05-27 2004-08-05 Glaxosmithkline S.P.A. Chinolinderivate als tachykinin nk3 rezeptor antagonisten
SK287323B6 (sk) * 1998-11-06 2010-07-07 University Of Z�Rich Nogo proteín, jeho purifikovaný fragment, chimérny proteín a purifikovaná molekula s jeho obsahom, izolovaná nukleová kyselina, vektor s jej obsahom, rekombinantná bunka, spôsob produkcie rekombinantného proteínu a jeho použitie
FR2792199B3 (fr) * 1999-04-13 2001-05-18 Sanofi Sa Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur
US20030113891A1 (en) * 2000-02-11 2003-06-19 Lawrence Blatt Method and reagent for the inhibition of NOGO and NOGO receptor genes
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EP1575482A2 (en) * 2002-04-17 2005-09-21 Pharmacia & Upjohn Company LLC Compositions and method of treating alzheimer's disease
GB0228832D0 (en) 2002-12-10 2003-01-15 Novartis Ag Organic compound
CN1832752A (zh) * 2003-04-16 2006-09-13 耶鲁大学 治疗淀粉样蛋白斑相关性病症的nogo-受体拮抗剂
GB0318727D0 (en) 2003-08-08 2003-09-10 Smithkline Beecham Corp Novel compounds
GB0321997D0 (en) 2003-09-19 2003-10-22 Novartis Ag Organic compound
NZ548013A (en) * 2003-12-22 2009-04-30 Glaxo Group Ltd Immunoglobulins

Also Published As

Publication number Publication date
US20110054149A1 (en) 2011-03-03
WO2005061545A2 (en) 2005-07-07
EP2213684A3 (en) 2011-05-18
IS2739B (is) 2011-06-15
CY1110530T1 (el) 2015-04-29
KR101150548B1 (ko) 2012-07-06
AR048912A1 (es) 2006-06-14
HRP20090527T1 (hr) 2009-11-30
EP1711530A2 (en) 2006-10-18
JP2007537145A (ja) 2007-12-20
DK1711530T3 (da) 2009-12-14
BRPI0417959A (pt) 2007-03-27
TW200533680A (en) 2005-10-16
CA2549956C (en) 2016-04-12
ATE440866T1 (de) 2009-09-15
US20140147435A1 (en) 2014-05-29
DE602004022871D1 (de) 2009-10-08
WO2005061544A2 (en) 2005-07-07
US20060029603A1 (en) 2006-02-09
JP4901480B2 (ja) 2012-03-21
CA2549956A1 (en) 2005-07-07
IL176206A0 (en) 2006-10-05
ES2330444T3 (es) 2009-12-10
MY144612A (en) 2011-10-14
MA28289A1 (fr) 2006-11-01
HK1100144A1 (en) 2007-09-07
TWI329649B (en) 2010-09-01
SI1711530T1 (sl) 2010-01-29
US20070065430A1 (en) 2007-03-22
EP1706426A2 (en) 2006-10-04
IL176206A (en) 2012-02-29
US7780964B2 (en) 2010-08-24
AU2004303585B2 (en) 2010-12-23
PL1711530T3 (pl) 2010-01-29
US7988964B2 (en) 2011-08-02
NO20062767L (no) 2006-09-20
RU2362780C2 (ru) 2009-07-27
WO2005061544A3 (en) 2005-08-18
PT1711530E (pt) 2009-10-22
RU2006123481A (ru) 2008-01-27
JP2008504220A (ja) 2008-02-14
WO2005061545A3 (en) 2005-08-18
EP2213684A2 (en) 2010-08-04
EP1711530B1 (en) 2009-08-26
NZ548013A (en) 2009-04-30
MXPA06007190A (es) 2006-08-23
AU2004303585A1 (en) 2005-07-07
KR20060129290A (ko) 2006-12-15

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