IT1079103B - Derivati del 9-ossido-alo-prostanoico acido - Google Patents

Derivati del 9-ossido-alo-prostanoico acido

Info

Publication number: IT1079103B
Authority: IT; Italy
Prior art keywords: alkyl; alkoxy; antihypertensives; oxido; vasodilators
Prior art date: 1977-01-14

Application number

IT1928377A

Other languages

English (en)

Inventor

Carmelo Gandolfi

Carlo Passarotti

Alessandro Andreoni

Angelo Fumagalli

Franco Faustini

Roberto Ceserani

Maria Maddalena Usardi

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-01-14

Filing date

1977-01-14

Publication date

1985-05-08

1977-01-14 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1977-01-14 Priority to IT1928377A priority Critical patent/IT1079103B/it

1977-12-13 Priority to FI773757A priority patent/FI71138C/fi

1977-12-15 Priority to AU31642/77A priority patent/AU525965B2/en

1977-12-15 Priority to NZ185986A priority patent/NZ185986A/xx

1977-12-18 Priority to IL53630A priority patent/IL53630A0/xx

1977-12-21 Priority to GB53226/77A priority patent/GB1599280A/en

1977-12-22 Priority to GR55028A priority patent/GR66057B/el

1977-12-24 Priority to DE19772757919 priority patent/DE2757919A1/de

1977-12-28 Priority to JP15758977A priority patent/JPS5384959A/ja

1977-12-29 Priority to DK586077A priority patent/DK586077A/da

1977-12-30 Priority to HU77EA181A priority patent/HU182725B/hu

1977-12-30 Priority to NO774524A priority patent/NO153689C/no

1977-12-30 Priority to YU03166/77A priority patent/YU316677A/xx

1977-12-30 Priority to FR7739879A priority patent/FR2376147A1/fr

1977-12-30 Priority to NL7714613A priority patent/NL7714613A/xx

1977-12-30 Priority to AT944277A priority patent/AT376429B/de

1977-12-30 Priority to BE183997A priority patent/BE862514A/xx

1977-12-30 Priority to SE7714948A priority patent/SE437268B/sv

1978-01-03 Priority to CH4978A priority patent/CH636096A5/de

1978-06-29 Priority to US05/920,166 priority patent/US4297368A/en

1978-07-28 Priority to US05/928,809 priority patent/US4328240A/en

1978-12-01 Priority to US05/965,267 priority patent/US4277491A/en

1979-02-26 Priority to US05/015,148 priority patent/US4230721A/en

1979-04-13 Priority to US06/029,924 priority patent/US4271183A/en

1979-04-13 Priority to US06/029,925 priority patent/US4303670A/en

1979-04-13 Priority to US06/029,921 priority patent/US4242508A/en

1979-04-13 Priority to US06/029,922 priority patent/US4259244A/en

1979-06-08 Priority to CA000329306A priority patent/CA1183839A/en

1979-06-08 Priority to CA000329309A priority patent/CA1183840A/en

1979-06-18 Priority to US06/049,326 priority patent/US4262016A/en

1979-06-18 Priority to US06/049,118 priority patent/US4254137A/en

1979-11-01 Priority to US06/090,305 priority patent/US4250188A/en

1979-11-30 Priority to US06/098,963 priority patent/US4271184A/en

1979-12-03 Priority to AT764979A priority patent/AT376430B/de

1980-12-10 Priority to CA000366521A priority patent/CA1183841A/en

1982-01-25 Priority to CA000394875A priority patent/CA1183842A/en

1982-03-17 Priority to KE3196A priority patent/KE3196A/xx

1982-06-30 Priority to HK29082A priority patent/HK29082A/xx

1982-12-30 Priority to MY265/82A priority patent/MY8200265A/xx

1985-05-08 Application granted granted Critical

1985-05-08 Publication of IT1079103B publication Critical patent/IT1079103B/it

Links

229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title abstract 2
239000002220 antihypertensive agent Substances 0.000 title abstract 2
229940030600 antihypertensive agent Drugs 0.000 title abstract 2
229940124549 vasodilator Drugs 0.000 title abstract 2
239000003071 vasodilator agent Substances 0.000 title abstract 2
239000003705 antithrombocytic agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000003545 alkoxy group Chemical group 0.000 abstract 3
-1 1H-tetrazol-5-yl Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 1
PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
229960000711 alprostadil Drugs 0.000 abstract 1
239000003699 antiulcer agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
239000000168 bronchodilator agent Substances 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 1
229960002986 dinoprostone Drugs 0.000 abstract 1
125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000130 luteolytic agent Substances 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
239000002863 oxytocic agent Substances 0.000 abstract 1
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 1
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 1
CBOMORHDRONZRN-QLOYDKTKSA-N prostaglandin E3 Chemical compound CC\C=C/C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O CBOMORHDRONZRN-QLOYDKTKSA-N 0.000 abstract 1
150000003180 prostaglandins Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002731 stomach secretion inhibitor Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IT1928377A 1976-12-31 1977-01-14 Derivati del 9-ossido-alo-prostanoico acido IT1079103B (it)

Priority Applications (39)

Application Number	Priority Date	Filing Date	Title
IT1928377A IT1079103B (it)	1977-01-14	1977-01-14	Derivati del 9-ossido-alo-prostanoico acido
FI773757A FI71138C (fi)	1976-12-31	1977-12-13	Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
AU31642/77A AU525965B2 (en)	1976-12-31	1977-12-15	Bicyclic prostaglandin derivatives
NZ185986A NZ185986A (en)	1976-12-31	1977-12-15	2-oxa-bicyclic prostag-landins and pharmaceutical compositions
IL53630A IL53630A0 (en)	1976-12-31	1977-12-18	Bicyclic prostaglandins and process for their preparation
GB53226/77A GB1599280A (en)	1976-12-31	1977-12-21	5,9-or 6,9-epoxyprostaglandins
GR55028A GR66057B (it)	1976-12-31	1977-12-22
DE19772757919 DE2757919A1 (de)	1976-12-31	1977-12-24	Bicyclische prostaglandine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische oder veterinaer-zubereitung
JP15758977A JPS5384959A (en)	1976-12-31	1977-12-28	Bicyclic prostaglandin and method for its production
DK586077A DK586077A (da)	1976-12-31	1977-12-29	Bicykliske prostaglandiner samt fremgangsmaade til fremstilling deraf
NO774524A NO153689C (no)	1976-12-31	1977-12-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive bicykliske prostaglandiner.
YU03166/77A YU316677A (en)	1976-12-31	1977-12-30	Process for obtaining bicyclic prostaglandin
FR7739879A FR2376147A1 (fr)	1976-12-31	1977-12-30	Prostaglandines bicycliques, utiles notamment comme anti-agglutinants des plaquettes sanguines et leur procede de preparation
NL7714613A NL7714613A (nl)	1976-12-31	1977-12-30	Werkwijze ter bereiding van bicyclische pros- taglandinen, alsmede farmaceutische en veteri- naire preparaten.
AT944277A AT376429B (de)	1977-01-14	1977-12-30	Verfahren zur herstellung von neuen bicyclischen prostaglandinen und von deren salzen
BE183997A BE862514A (fr)	1976-12-31	1977-12-30	Prostaglandines bicycliques et leur procede de preparation
SE7714948A SE437268B (sv)	1976-12-31	1977-12-30	Forfarande for framstellning av 2-oxa-bicykliska prostaglandiner
HU77EA181A HU182725B (en)	1976-12-31	1977-12-30	Process for producing dihydric-prostacyclin-derivatives
CH4978A CH636096A5 (de)	1976-12-31	1978-01-03	Bicyclische prostaglandine, verfahren zu ihrer herstellung und pharmazeutische praeparate.
US05/920,166 US4297368A (en)	1976-12-31	1978-06-29	Pharmaceutically useful 5,6-saturated PGI compounds
US05/928,809 US4328240A (en)	1976-12-31	1978-07-28	Certain PGI1 compounds and their pharmaceutical composition and methods
US05/965,267 US4277491A (en)	1976-12-31	1978-12-01	Bicyclic prostaglandins
US05/015,148 US4230721A (en)	1976-12-31	1979-02-26	Bicyclic prostaglandins
US06/029,925 US4303670A (en)	1976-12-31	1979-04-13	Bicyclic prostaglandins and process for their preparation
US06/029,921 US4242508A (en)	1976-12-31	1979-04-13	Certain thiacyclic PGI compounds
US06/029,922 US4259244A (en)	1976-12-31	1979-04-13	Certain 13,14-didehydro-PGI1 compounds
US06/029,924 US4271183A (en)	1976-12-31	1979-04-13	Bicyclic prostaglandins
CA000329309A CA1183840A (en)	1976-12-31	1979-06-08	Bicyclic prostaglandins and process for their preparation
CA000329306A CA1183839A (en)	1976-12-31	1979-06-08	Bicyclic prostaglandins and process for their preparation
US06/049,326 US4262016A (en)	1976-12-31	1979-06-18	Bicyclic prostaglandins and process for their preparation
US06/049,118 US4254137A (en)	1976-12-31	1979-06-18	Bicyclic prostaglandins and process for their preparation
US06/090,305 US4250188A (en)	1976-12-31	1979-11-01	Certain PGI1 compounds and pharmaceutical compositions containing them
US06/098,963 US4271184A (en)	1976-12-31	1979-11-30	Bicyclic prostaglandins
AT764979A AT376430B (de)	1976-12-31	1979-12-03	Verfahren zur herstellung von neuen und bekannten bicyclischen prostaglandinen und deren salzen und isomeren
CA000366521A CA1183841A (en)	1976-12-31	1980-12-10	Bicyclic prostaglandins and process for their preparation
CA000394875A CA1183842A (en)	1976-12-31	1982-01-25	Bicyclic prostaglandins and process for their preparation
KE3196A KE3196A (en)	1976-12-31	1982-03-17	5,9-or 6,9-epoxyprostaglandins
HK29082A HK29082A (en)	1976-12-31	1982-06-30	5,9-or 6,9-epoxyprostaglandins
MY265/82A MY8200265A (en)	1976-12-31	1982-12-30	5,9-or 6,9-epoxyprostaglandins

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1928377A IT1079103B (it)	1977-01-14	1977-01-14	Derivati del 9-ossido-alo-prostanoico acido

Publications (1)

Publication Number	Publication Date
IT1079103B true IT1079103B (it)	1985-05-08

Family

ID=11156388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT1928377A IT1079103B (it)	1976-12-31	1977-01-14	Derivati del 9-ossido-alo-prostanoico acido

Country Status (2)

Country	Link
AT (1)	AT376429B (it)
IT (1)	IT1079103B (it)

1977
- 1977-01-14 IT IT1928377A patent/IT1079103B/it active
- 1977-12-30 AT AT944277A patent/AT376429B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA944277A (de)	1984-04-15
AT376429B (de)	1984-11-26

Publication	Publication Date	Title
GB1394373A (en)	1975-05-14	Control of plant diseases
ES449162A1 (es)	1977-12-16	Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.
JPS5444639A (en)	1979-04-09	Prostaglandin analog and its preparation
FR2294696A1 (fr)	1976-07-16	Nouveaux analogues de prostaglandines, leur procede de preparation et leurs applications
ES436117A1 (es)	1977-05-01	Procedimiento para la preparacion de nuevos compuestos ana- logos de acidos prostanoicos que no se presentan en la natu-raleza.
ES420643A1 (es)	1976-09-01	Procedimiento para la obtencion de sulfuros organicos.
IT1075678B (it)	1985-04-22	15-idrossi-bicicliche prostaglandine
IT1115636B (it)	1986-02-03	13,14-deidro-bicicliche prostaglandine
IT1085878B (it)	1985-05-28	Bicilicli ossiranici 15-cheto-prostenoici acidi
IT1079103B (it)	1985-05-08	Derivati del 9-ossido-alo-prostanoico acido
IT1072541B (it)	1985-04-10	6(9)-ossido-prostenoici acidi
GB1484591A (en)	1977-09-01	Prostaglandin compositions
ES439322A1 (es)	1977-02-16	Procedimiento para la preparacion de nuevos derivados de a- cido prostanoico.
IE41535L (en)	1975-10-22	Prostanoic acid derivatives
GB1496845A (en)	1978-01-05	(dl)-13-substituted sulphinyl-prostaglandin-like compounds and methods of making
CA1262140C (en)	1989-10-03	7-OXABICYCLOHEPTANE PROSTAGLANDIN SUBSTITUTE ALCOHOLS
GB1506302A (en)	1978-04-05	1-alkyl-2-(phenoxymethyl)-5-nitro-imidazoles and processes for their preparation
GB1530154A (en)	1978-10-25	Prostaglandin analogues
FR2316925A1 (fr)	1977-02-04	Dimethyl-16, 16 prostaglandines et procede de leur preparation
ES422831A1 (es)	1976-09-16	Procedimiento para la obtencion de derivados de ciclopenta-no.
FR2013922A1 (en)	1970-04-10	Prostaglandins
JPS5573678A (en)	1980-06-03	Simultated compound of thio-prostaglandin i1, its preparation and drug composition containing it as active ingredient
JPS5340742A (en)	1978-04-13	Prostagilandin analogues, their preparation and medical composition containing the same as active constituents
FR2157899A1 (en)	1973-06-08	16-mono and di-lower alkyl prostaglandin compsns - - for treatment of peptic ulcers
FR2134673A1 (en)	1972-12-08	Novel optically active isomers of prostaglandin analoguesof natural configuration useful as hypotensive agents, diuretics,contraceptives, for treating gastric ulcer and asthma, and forinhibiting platelet aggregation