IT1115898B - Picolilamidi di acdio isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la loro preparazione - Google Patents

Picolilamidi di acdio isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la loro preparazione

Info

Publication number
IT1115898B
IT1115898B IT50896/77A IT5089677A IT1115898B IT 1115898 B IT1115898 B IT 1115898B IT 50896/77 A IT50896/77 A IT 50896/77A IT 5089677 A IT5089677 A IT 5089677A IT 1115898 B IT1115898 B IT 1115898B
Authority
IT
Italy
Prior art keywords
thrombinic
picolylamids
agulant
acd
aggregating
Prior art date
Application number
IT50896/77A
Other languages
English (en)
Inventor
Giovanni Orzalesi
Franco Innocenti
Ivo Volpato
Original Assignee
Manetti & Roberts Italo Brit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manetti & Roberts Italo Brit filed Critical Manetti & Roberts Italo Brit
Priority to IT50896/77A priority Critical patent/IT1115898B/it
Priority to GB7834450A priority patent/GB2005251B/en
Priority to US05/937,732 priority patent/US4294833A/en
Priority to JP53109027A priority patent/JPS6042791B2/ja
Priority to CA310,663A priority patent/CA1108616A/en
Priority to CH932678A priority patent/CH636086A5/de
Priority to DE2838837A priority patent/DE2838837C3/de
Priority to FR7825680A priority patent/FR2401922A1/fr
Application granted granted Critical
Publication of IT1115898B publication Critical patent/IT1115898B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT50896/77A 1977-09-06 1977-09-06 Picolilamidi di acdio isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la loro preparazione IT1115898B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT50896/77A IT1115898B (it) 1977-09-06 1977-09-06 Picolilamidi di acdio isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la loro preparazione
GB7834450A GB2005251B (en) 1977-09-06 1978-08-24 Isophthalic acid derivatives
US05/937,732 US4294833A (en) 1977-09-06 1978-08-29 Substituted 4-hydroxy-isophthalic acid picolylamides having a pharmaceutical activity in thromboembolic disorders
JP53109027A JPS6042791B2 (ja) 1977-09-06 1978-09-05 置換４−ヒドロキシ−イソフタル酸ピコリルアミド、同製造法および医薬組成物
CA310,663A CA1108616A (en) 1977-09-06 1978-09-05 Substituted 4-hydroxy-isophtalic acid picolylamides having a pharmaceutical activity in thromboembolic disorders and a process for their production
CH932678A CH636086A5 (de) 1977-09-06 1978-09-05 4-hydroxy- und 4-alkoxy-isophthalsaeure-picolylamide, verfahren zu deren herstellung und sie enthaltende arzneimittel.
DE2838837A DE2838837C3 (de) 1977-09-06 1978-09-06 4-Hydroxyisophthalsäure-bis-picolylamide, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
FR7825680A FR2401922A1 (fr) 1977-09-06 1978-09-06 Picolylamides d'acides 4-hydroxy-isophtaliques substitues, leur preparation et leurs utilisations therapeutiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT50896/77A IT1115898B (it) 1977-09-06 1977-09-06 Picolilamidi di acdio isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la loro preparazione

Publications (1)

Publication Number Publication Date
IT1115898B true IT1115898B (it) 1986-02-10

Family

ID=11274050

Family Applications (1)

Application Number Title Priority Date Filing Date
IT50896/77A IT1115898B (it) 1977-09-06 1977-09-06 Picolilamidi di acdio isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la loro preparazione

Country Status (8)

Country Link
US (1) US4294833A (it)
JP (1) JPS6042791B2 (it)
CA (1) CA1108616A (it)
CH (1) CH636086A5 (it)
DE (1) DE2838837C3 (it)
FR (1) FR2401922A1 (it)
GB (1) GB2005251B (it)
IT (1) IT1115898B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1214915B (it) * 1985-10-10 1990-01-31 Manetti & Roberts Italo Brit Derivato dell'acido 4-metossiisoftalico con attivita'farmacologica in disordini tromboembolici e procedimento per la sua preparazione
US5227492A (en) * 1988-01-20 1993-07-13 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
ES2286089T3 (es) * 2001-06-21 2007-12-01 Cesare Casagrande Compuesto para el tratamiento de estados patologicos ateroesclerotico-tromboticos.
US6525078B1 (en) 2002-06-25 2003-02-25 Cesare Casagrande Compound for the treatment of atherosclerotic-thrombotic pathological conditions
JP2007145816A (ja) * 2005-10-27 2007-06-14 Sumitomo Chemical Co Ltd アミド化合物及びその用途
JP2007145817A (ja) * 2005-10-27 2007-06-14 Sumitomo Chemical Co Ltd アミド化合物及びその用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1016005B (it) * 1970-07-01 1977-05-30 Manetti & Roberts Italo Brit Picolilamidi dell acido 4 idrossi isoftalico e suoi derivati e relativo procedimento di prepara zione
US3923820A (en) * 1974-04-08 1975-12-02 Made Labor Sa Method of obtaining 3,5 di-methylbenzamid substitutes
US3973026A (en) * 1975-02-05 1976-08-03 Societa Italo-Britannica L. Manetti-H. Roberts & C. Inhibitor of blood plate aggregation
DE2506209C2 (de) * 1975-02-14 1986-01-16 Società Italo-Britannica L. Manetti - H. Roberts & C., Florenz/Firenze Verwendung von N,N'-Bis(3-picolyl)-4-methoxy-isophtalamid zur Verhinderung der Blutplättchenaggregation

Also Published As

Publication number Publication date
DE2838837A1 (de) 1979-03-08
CA1108616A (en) 1981-09-08
CH636086A5 (de) 1983-05-13
JPS6042791B2 (ja) 1985-09-25
FR2401922A1 (fr) 1979-03-30
GB2005251A (en) 1979-04-19
DE2838837B2 (de) 1981-05-21
FR2401922B1 (it) 1982-07-02
DE2838837C3 (de) 1982-04-08
JPS54103874A (en) 1979-08-15
US4294833A (en) 1981-10-13
GB2005251B (en) 1982-04-07

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