IT1127225B - 5-(2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazione - Google Patents
5-(2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazioneInfo
- Publication number
- IT1127225B IT1127225B IT27284/79A IT2728479A IT1127225B IT 1127225 B IT1127225 B IT 1127225B IT 27284/79 A IT27284/79 A IT 27284/79A IT 2728479 A IT2728479 A IT 2728479A IT 1127225 B IT1127225 B IT 1127225B
- Authority
- IT
- Italy
- Prior art keywords
- aminopyrimidines
- imidazolin
- replaced
- preparation
- replaced aminopyrimidines
- Prior art date
Links
- 150000005005 aminopyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2849537A DE2849537C2 (de) | 1978-11-15 | 1978-11-15 | Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE19792937023 DE2937023A1 (de) | 1979-09-13 | 1979-09-13 | Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7927284A0 IT7927284A0 (it) | 1979-11-14 |
| IT1127225B true IT1127225B (it) | 1986-05-21 |
Family
ID=25776489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT27284/79A IT1127225B (it) | 1978-11-15 | 1979-11-14 | 5-(2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazione |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4323570A (it) |
| AT (1) | AT374197B (it) |
| AU (1) | AU541305B1 (it) |
| CA (1) | CA1138454A (it) |
| CH (1) | CH642965A5 (it) |
| DK (1) | DK150142C (it) |
| ES (1) | ES486349A1 (it) |
| FR (1) | FR2441625A1 (it) |
| GB (1) | GB2039275B (it) |
| IT (1) | IT1127225B (it) |
| NL (2) | NL190553C (it) |
| SE (1) | SE440079B (it) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2146986B (en) * | 1983-09-23 | 1987-06-17 | Lilly Co Eli | Process for preparing 5-substituted pyrimidines |
| DE3729299A1 (de) * | 1987-09-02 | 1989-03-23 | Beiersdorf Ag | Transdermales therapeutisches system |
| DE3739779A1 (de) * | 1987-11-24 | 1989-06-08 | Beiersdorf Ag | Pharmazeutische praeparate |
| DE3904795C2 (de) * | 1989-02-17 | 2000-10-12 | Lilly Pharma Produktion Gmbh & | Pharmazeutisches Präparat und dessen Verwendung |
| US5972948A (en) * | 1994-07-01 | 1999-10-26 | Solvay Pharmaceuticals Gmbh | Method of inhibiting hyperglycemia and pharmaceutical composition for use therein |
| DE4423177A1 (de) * | 1994-07-01 | 1996-01-04 | Kali Chemie Pharma Gmbh | Antihyperglykämisch wirksame Arzneimittel |
| US5977121A (en) * | 1995-02-28 | 1999-11-02 | Eli Lilly And Company | Use of moxonidine for the treatment of atherosclerosis |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| IL118544A (en) * | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
| CA2182851A1 (en) * | 1995-08-15 | 1997-02-16 | August Masaru Watanabe | Method for treating substance abuse withdrawal |
| KR20000016406A (ko) * | 1996-06-06 | 2000-03-25 | 피터 지. 스트링거 | 울혈성 심장 마비 치료용 제제 및 방법_ |
| IL123232A0 (en) * | 1997-02-11 | 1999-11-30 | Lilly Co Eli | Medicament for inhibiting glucose metabolism deterioration |
| DE19722322A1 (de) * | 1997-05-28 | 1998-12-03 | Solvay Pharm Gmbh | Nephroprotektives Arzneimittel |
| WO1999011269A1 (en) * | 1997-09-03 | 1999-03-11 | Eli Lilly And Company | Pyrimidine derivatives |
| DE19911371A1 (de) | 1999-03-15 | 2000-09-21 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen |
| WO2004000312A2 (de) * | 2002-06-19 | 2003-12-31 | Solvay Pharmaceuticals Gmbh | Arzneimittel zur behandlung von eine inhibition oder aktivitätsverminderung von ph-wert-regulierenden bikarbonat-transporter-proteinen erfordernden erkrangungen |
| CA2637292A1 (en) * | 2006-01-27 | 2007-08-16 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of cns disorders |
| EP1894926A1 (en) * | 2006-06-26 | 2008-03-05 | Chemagis Ltd. | Polymorphs of moxonidine and processes for preparation therefor |
| ES2369113T3 (es) | 2006-06-26 | 2011-11-25 | Chemagis Ltd. | Procedimiento mejorado para producir moxonidina. |
| EP1873152B1 (en) * | 2006-06-26 | 2008-10-15 | Chemagis Ltd. | Novel purification process of moxonidine |
| WO2008020425A1 (en) * | 2006-08-17 | 2008-02-21 | Chemagis Ltd. | Crystalline moxonidine comprising single tautomer and preparation process therefor |
| EP1894927B1 (en) * | 2006-08-31 | 2010-11-10 | Chemagis Ltd. | The use of moxonidine salts for purification of moxonidine |
| AU2007312389B2 (en) * | 2006-10-19 | 2012-02-23 | F. Hoffmann-La Roche Ag | Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors |
| RU2009112496A (ru) * | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-4-имидазолы |
| CA2668454A1 (en) * | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles |
| JP2010510184A (ja) * | 2006-11-16 | 2010-04-02 | エフ．ホフマン−ラ ロシュ アーゲー | 置換４−イミダゾール類 |
| WO2008073125A1 (en) * | 2006-12-12 | 2008-06-19 | Chemagis Ltd. | Moxonidine analogs, preparation processes and uses therefor |
| CA2672617A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2-imidazoles as ligands for trace amine associated receptors (taar) |
| US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| CN101600700B (zh) * | 2007-02-02 | 2013-08-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体用于cns病症的新的2-氨基噁唑啉 |
| KR101222412B1 (ko) * | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ1 리간드로서의 2-아미노옥사졸린 |
| CN101687812A (zh) | 2007-07-02 | 2010-03-31 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物 |
| CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
| CA2694362A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
| CN101765425A (zh) * | 2007-08-02 | 2010-06-30 | 弗·哈夫曼-拉罗切有限公司 | 苯甲酰胺衍生物用于治疗cns障碍的用途 |
| JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
| CN102083805A (zh) * | 2008-07-24 | 2011-06-01 | 弗·哈夫曼-拉罗切有限公司 | 4,5-二氢-唑-2-基衍生物 |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| EP2586779A1 (en) | 2011-10-24 | 2013-05-01 | Hetero Research Foundation | Process for the preparation of moxonidine |
| DE102012215896A1 (de) | 2012-09-07 | 2014-03-13 | Wörwag Pharma GmbH & Co.KG | Moxonidinsynthese mit Hilfe organischer Basen |
| EP2738165B1 (en) | 2012-12-03 | 2016-10-12 | WÖRWAG PHARMA GmbH & Co. KG | Method by means of phase transfer catalysis |
| EP2765131B1 (en) | 2013-02-08 | 2016-11-23 | Arevipharma GmbH | Process for the production of Moxonidine |
| WO2014140034A1 (en) * | 2013-03-14 | 2014-09-18 | Farmak, A.S. | Improved process for the manufacture of moxonidine |
| EP2829540A1 (en) | 2013-07-26 | 2015-01-28 | Abbott Healthcare Products B.V. | Synthesis of substituted aminopyridines |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| CN108713019B (zh) | 2016-03-17 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物 |
| WO2022101435A1 (en) | 2020-11-12 | 2022-05-19 | 3Z Ehf | Novel treatments of attention deficit/hyperactivity disorder |
| GB202103400D0 (en) * | 2021-03-11 | 2021-04-28 | 3Z Ehf | Novel treatments |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754832A (fr) | 1969-08-14 | 1971-02-15 | Beecham Group Ltd | Iminazolines |
| GB1319840A (en) * | 1970-08-27 | 1973-06-13 | Beecham Group Ltd | Substituted 5-amino imidazoles |
| BE795636A (fr) * | 1972-02-19 | 1973-08-20 | Schering Ag | Nitroimidazolylpyrimidines, et leur procede de preparation |
| US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| DE2220906A1 (de) * | 1972-04-28 | 1973-11-15 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung |
| BE503170A (it) * | 1975-09-02 |
-
1979
- 1979-11-07 US US06/092,134 patent/US4323570A/en not_active Expired - Lifetime
- 1979-11-08 NL NLAANVRAGE7908192,A patent/NL190553C/xx not_active IP Right Cessation
- 1979-11-14 CA CA000339844A patent/CA1138454A/en not_active Expired
- 1979-11-14 AT AT0727079A patent/AT374197B/de not_active IP Right Cessation
- 1979-11-14 SE SE7909392A patent/SE440079B/sv not_active IP Right Cessation
- 1979-11-14 GB GB7939460A patent/GB2039275B/en not_active Expired
- 1979-11-14 ES ES486349A patent/ES486349A1/es not_active Expired
- 1979-11-14 DK DK481879A patent/DK150142C/da not_active IP Right Cessation
- 1979-11-14 IT IT27284/79A patent/IT1127225B/it active
- 1979-11-15 AU AU52873/79A patent/AU541305B1/en not_active Expired
- 1979-11-15 CH CH1021679A patent/CH642965A5/de not_active IP Right Cessation
- 1979-11-15 FR FR7928169A patent/FR2441625A1/fr active Granted
-
1994
- 1994-06-27 NL NL940011C patent/NL940011I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL190553C (nl) | 1994-04-18 |
| FR2441625B1 (it) | 1981-12-31 |
| DK150142B (da) | 1986-12-15 |
| GB2039275A (en) | 1980-08-06 |
| NL940011I2 (nl) | 1998-05-06 |
| FR2441625A1 (fr) | 1980-06-13 |
| SE440079B (sv) | 1985-07-15 |
| ES486349A1 (es) | 1980-06-16 |
| CH642965A5 (de) | 1984-05-15 |
| AU541305B1 (en) | 1985-01-03 |
| NL7908192A (nl) | 1980-05-19 |
| DK150142C (da) | 1987-06-01 |
| US4323570A (en) | 1982-04-06 |
| DK481879A (da) | 1980-05-16 |
| IT7927284A0 (it) | 1979-11-14 |
| NL190553B (nl) | 1993-11-16 |
| SE7909392L (sv) | 1980-05-16 |
| NL940011I1 (nl) | 1994-08-01 |
| CA1138454A (en) | 1982-12-28 |
| GB2039275B (en) | 1982-11-17 |
| ATA727079A (de) | 1983-08-15 |
| AT374197B (de) | 1984-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971126 |