IT1173213B - Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi - Google Patents

Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi

Info

Publication number
IT1173213B
IT1173213B IT19435/84A IT1943584A IT1173213B IT 1173213 B IT1173213 B IT 1173213B IT 19435/84 A IT19435/84 A IT 19435/84A IT 1943584 A IT1943584 A IT 1943584A IT 1173213 B IT1173213 B IT 1173213B
Authority
IT
Italy
Prior art keywords
fenyl
propandiol
intermediates
fluorine
derivatives
Prior art date
Application number
IT19435/84A
Other languages
English (en)
Other versions
IT8419435A0 (it
Inventor
Giancarlo Jommi
Dario Chiarino
Roberto Pagliarin
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT8419435A0 publication Critical patent/IT8419435A0/it
Priority to IT19435/84A priority Critical patent/IT1173213B/it
Priority to EP95201522A priority patent/EP0677511A3/en
Priority to EP84200772A priority patent/EP0130633B1/en
Priority to EP95201523A priority patent/EP0678506A3/en
Priority to AT84200772T priority patent/ATE143953T1/de
Priority to DE3486438T priority patent/DE3486438T2/de
Priority to ES533355A priority patent/ES533355A0/es
Priority to JP59113774A priority patent/JPH0819085B2/ja
Priority to US06/697,568 priority patent/US4743700A/en
Application granted granted Critical
Publication of IT1173213B publication Critical patent/IT1173213B/it
Priority to US07/870,777 priority patent/US5153328A/en
Priority to US08/065,521 priority patent/US5332835A/en
Priority to US08/240,432 priority patent/US5567844A/en
Priority to JP7287772A priority patent/JP2721959B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT19435/84A 1983-06-02 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi IT1173213B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT19435/84A IT1173213B (it) 1984-02-03 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
EP95201522A EP0677511A3 (en) 1983-06-02 1984-05-29 Intermediates for the production of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
EP84200772A EP0130633B1 (en) 1983-06-02 1984-05-29 Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
EP95201523A EP0678506A3 (en) 1983-06-02 1984-05-29 Intermediates for the production of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
AT84200772T ATE143953T1 (de) 1983-06-02 1984-05-29 Verfahren zur herstellung von 1-(phenyl)-1- hydroxy-2-amino-3-fluor-propan-derivaten
DE3486438T DE3486438T2 (de) 1983-06-02 1984-05-29 Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten
ES533355A ES533355A0 (es) 1983-06-02 1984-06-01 Procedimiento para la preparacion de derivados de 1-(fenil)-1-hidroxi-2-amino-3-fluoro-propano
JP59113774A JPH0819085B2 (ja) 1983-06-02 1984-06-02 １−（フエニル）−１−ヒドロキシ−２−アミノ−３−フルオロプロパン誘導体製造用中間体
US06/697,568 US4743700A (en) 1984-02-03 1985-02-01 Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds
US07/870,777 US5153328A (en) 1984-02-03 1992-04-21 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines
US08/065,521 US5332835A (en) 1984-02-03 1993-05-24 Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US08/240,432 US5567844A (en) 1984-02-03 1994-05-10 Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols
JP7287772A JP2721959B2 (ja) 1983-06-02 1995-09-29 １−（フェニル）−１−ヒドロキシー２−アミノー３−フルオロプロパン誘導体製造用中間体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19435/84A IT1173213B (it) 1984-02-03 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi

Publications (2)

Publication Number Publication Date
IT8419435A0 IT8419435A0 (it) 1984-02-03
IT1173213B true IT1173213B (it) 1987-06-18

Family

ID=11157919

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19435/84A IT1173213B (it) 1983-06-02 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi

Country Status (2)

Country Link
US (1) US4743700A (it)
IT (1) IT1173213B (it)

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US5243056A (en) * 1983-06-02 1993-09-07 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
US5332835A (en) * 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US5153328A (en) * 1984-02-03 1992-10-06 Zambon S.P.A. 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
IT1240676B (it) * 1990-04-24 1993-12-17 Agrimont Spa Composizioni ad attivita' erbicida
CZ286239B6 (cs) * 1990-10-25 2000-02-16 Schering Corporation Způsob přípravy florfenikolu, jeho analogy a oxazolinové meziprodukty
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
CZ2003837A3 (cs) * 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
WO2003077828A2 (en) * 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
JP4792032B2 (ja) 2004-08-13 2011-10-12 シェーリング−プラウ・リミテッド 抗生物質、トリアゾールおよびコルチコステロイドを含む薬学的処方物
EP1836162A2 (en) * 2004-09-02 2007-09-26 IDEXX Laboratories Inc Antibacterial agents
AU2005286723A1 (en) 2004-09-23 2006-03-30 Schering-Plough Pty. Limited Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
DE602005017419D1 (de) * 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
MX2007007528A (es) * 2004-12-21 2007-10-08 Intervet Int Bv Composicion veterinaria inyectable.
CA2609574A1 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CN101605756A (zh) * 2006-12-13 2009-12-16 先灵-普劳有限公司 氟苯尼考及其类似物的水溶性前药
CN101686956A (zh) * 2007-04-27 2010-03-31 谢尔英·普劳有限公司 用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
ES2549731T3 (es) 2007-06-27 2015-11-02 E. I. Du Pont De Nemours And Company Método para el control de plagas en animales
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
PL2217207T3 (pl) * 2007-11-09 2019-05-31 Intervet Int Bv Preparat o szybkim uwalnianiu w postaci stałej, jego przygotowanie i zastosowanie
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA107804C2 (xx) 2009-08-05 2015-02-25 Du Pont Суміші мезоіонних пестицидів
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
RS54677B1 (sr) 2010-05-27 2016-08-31 E. I. Du Pont De Nemours And Company Kristalni oblici 4-[5-[3-hloro-5-(trifluorometil)fenil]-4,5 -dihidro-5-(trifluorometil)-3-izoksazolil]-n-[2-okso-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenkarboksamida
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
EP2768798A1 (en) * 2011-10-17 2014-08-27 Zoetis LLC Novel phenicol antibacterials
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965085B (zh) * 2014-04-17 2016-02-24 上海恒晟药业有限公司 一种取代1,2-氨基醇药物的制备方法

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Also Published As

Publication number Publication date
IT8419435A0 (it) 1984-02-03
US4743700A (en) 1988-05-10

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