ATE115123T1 - Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. - Google Patents

Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Info

Publication number: ATE115123T1
Authority: AT; Austria
Prior art keywords: formula; compound; oxazoline; oxazoline compound; pct
Prior art date: 1990-10-25

Application number

AT91920162T

Other languages

English (en)

Inventor

Jon E Clark

Doris P Schumacher

Guang-Zhong Wu

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-25

Filing date

1991-10-23

Publication date

1994-12-15

1991-10-23 Application filed by Schering Corp filed Critical Schering Corp

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115123T1 publication Critical patent/ATE115123T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 3
IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 title 1
229960003760 florfenicol Drugs 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
-1 oxazoline compound Chemical class 0.000 abstract 10
150000001875 compounds Chemical class 0.000 abstract 3
239000003153 chemical reaction reagent Substances 0.000 abstract 2
239000012025 fluorinating agent Substances 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Compounds Of Unknown Constitution (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)

AT91920162T 1990-10-25 1991-10-23 Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. ATE115123T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US60357590A	1990-10-25	1990-10-25

Publications (1)

Publication Number	Publication Date
ATE115123T1 true ATE115123T1 (de)	1994-12-15

Family

ID=24416027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91920162T ATE115123T1 (de)	1990-10-25	1991-10-23	Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Country Status (19)

Country	Link
US (1)	US5382673A (de)
EP (1)	EP0555340B1 (de)
JP (1)	JPH0645580B2 (de)
KR (1)	KR960008665B1 (de)
AT (1)	ATE115123T1 (de)
AU (1)	AU646910B2 (de)
CA (1)	CA2094810C (de)
CZ (1)	CZ286239B6 (de)
DE (1)	DE69105752T2 (de)
DK (1)	DK0555340T3 (de)
ES (1)	ES2067958T3 (de)
GR (1)	GR3015221T3 (de)
HK (1)	HK185496A (de)
HU (2)	HU212617B (de)
NZ (2)	NZ240319A (de)
PL (1)	PL166385B1 (de)
RU (1)	RU2071468C1 (de)
SK (1)	SK281740B6 (de)
WO (1)	WO1992007824A1 (de)

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CN100581550C (zh) *	2001-12-05	2010-01-20	杜拉美德药物有限公司	预防怀孕和减少经期前症状的口服避孕药
WO2003077828A2 (en) *	2002-03-08	2003-09-25	Schering-Plough, Ltd.	Novel florfenicol-type antibiotics
US7439268B2 (en) *	2003-07-18	2008-10-21	Idexx Laboratories	Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) *	2003-08-27	2005-03-03	Idexx Laboratories, Inc.	Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en)	2003-10-06	2006-10-24	Aurobindo Pharma Limited	Process for preparing florfenicol
JP4792032B2 (ja)	2004-08-13	2011-10-12	シェーリング−プラウ・リミテッド	抗生物質、トリアゾールおよびコルチコステロイドを含む薬学的処方物
AU2005286723A1 (en)	2004-09-23	2006-03-30	Schering-Plough Pty. Limited	Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
DE602005017419D1 (de) *	2004-11-19	2009-12-10	Schering Plough Ltd	Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
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CA2609574A1 (en) *	2005-06-09	2006-12-21	Schering-Plough Ltd.	Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
CN1331849C (zh) *	2005-08-12	2007-08-15	中国科学院上海有机化学研究所	甲砜霉素和氟苯尼考的新合成方法及其关键中间体
US8119667B2 (en) *	2005-12-29	2012-02-21	Schering-Plough Animal Health Corporation	Carbonates of fenicol antibiotics
US7518017B2 (en)	2006-02-17	2009-04-14	Idexx Laboratories	Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) *	2006-04-10	2007-10-11	Winzenberg Kevin N	N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101605756A (zh) *	2006-12-13	2009-12-16	先灵-普劳有限公司	氟苯尼考及其类似物的水溶性前药
CA2672795A1 (en) *	2006-12-13	2008-06-26	Schering-Plough Ltd.	Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CN101686956A (zh) *	2007-04-27	2010-03-31	谢尔英·普劳有限公司	用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
ES2549731T3 (es)	2007-06-27	2015-11-02	E. I. Du Pont De Nemours And Company	Método para el control de plagas en animales
US7550625B2 (en) *	2007-10-19	2009-06-23	Idexx Laboratories	Esters of florfenicol
PL2217207T3 (pl) *	2007-11-09	2019-05-31	Intervet Int Bv	Preparat o szybkim uwalnianiu w postaci stałej, jego przygotowanie i zastosowanie
TWI401023B (zh)	2008-02-06	2013-07-11	Du Pont	中離子農藥
CN102131772B (zh) *	2008-07-30	2015-03-11	英特威国际有限公司	用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA110924C2 (uk)	2009-08-05	2016-03-10	Е. І. Дю Пон Де Немур Енд Компані	Мезоіонні пестициди
UA107804C2 (xx)	2009-08-05	2015-02-25	Du Pont	Суміші мезоіонних пестицидів
AU2010279574A1 (en)	2009-08-05	2012-02-09	E. I. Du Pont De Nemours And Company	Mesoionic pesticides
MX2012001646A (es)	2009-08-05	2012-03-21	Du Pont	Pesticidas mesoionicos.
BRPI1002023A2 (pt)	2010-03-01	2011-10-25	Nanocore Biotecnologia S A	forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
RS54677B1 (sr)	2010-05-27	2016-08-31	E. I. Du Pont De Nemours And Company	Kristalni oblici 4-[5-[3-hloro-5-(trifluorometil)fenil]-4,5 -dihidro-5-(trifluorometil)-3-izoksazolil]-n-[2-okso-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenkarboksamida
WO2012087630A1 (en)	2010-12-20	2012-06-28	E.I. Du Pont De Nemours And Company	Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en)	2012-04-17	2013-10-24	E. I. Du Pont De Nemours And Company	Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) *	2012-10-31	2014-07-02	绍兴民生医药有限公司	(4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103980167B (zh) *	2014-04-17	2016-06-08	天津大学	一种无定形氟苯尼考及其制备方法
CN105218474B (zh) *	2015-10-22	2017-12-05	山东国邦药业股份有限公司	(4r,5r)‑2‑二氯甲基‑4,5‑二氢‑5‑(4‑甲砜基苯基)‑4‑恶唑甲醇的合成方法
CN106278964B (zh) *	2016-07-31	2018-01-16	浙江润康药业有限公司	氟苯尼考的制备方法
CN109678811B (zh) *	2019-01-25	2020-12-29	湖北中牧安达药业有限公司	一种氟苯尼考中间体环合物的不对称制备方法
CN110330463B (zh) *	2019-08-02	2021-05-14	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法
CN113264892B (zh) *	2021-04-05	2022-12-20	复旦大学	一种使用微反应系统连续制备氟苯尼考关键中间体的方法
CN113185473B (zh) *	2021-06-30	2021-10-08	山东国邦药业有限公司	一种氟苯尼考中间体氟甲砜噁唑的制备方法
CN113185474B (zh) *	2021-07-02	2021-11-05	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法

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1991
- 1991-10-23 CZ CZ1993710A patent/CZ286239B6/cs not_active IP Right Cessation
- 1991-10-23 HU HU9301182A patent/HU212617B/hu unknown
- 1991-10-23 JP JP4500718A patent/JPH0645580B2/ja not_active Expired - Lifetime
- 1991-10-23 NZ NZ240319A patent/NZ240319A/en not_active IP Right Cessation
- 1991-10-23 RU RU9193040370A patent/RU2071468C1/ru active
- 1991-10-23 US US08/039,450 patent/US5382673A/en not_active Expired - Lifetime
- 1991-10-23 DE DE69105752T patent/DE69105752T2/de not_active Expired - Lifetime
- 1991-10-23 PL PL91299059A patent/PL166385B1/pl unknown
- 1991-10-23 AU AU89279/91A patent/AU646910B2/en not_active Expired
- 1991-10-23 CA CA002094810A patent/CA2094810C/en not_active Expired - Lifetime
- 1991-10-23 EP EP91920162A patent/EP0555340B1/de not_active Expired - Lifetime
- 1991-10-23 ES ES91920162T patent/ES2067958T3/es not_active Expired - Lifetime
- 1991-10-23 AT AT91920162T patent/ATE115123T1/de not_active IP Right Cessation
- 1991-10-23 SK SK377-93A patent/SK281740B6/sk not_active IP Right Cessation
- 1991-10-23 DK DK91920162.4T patent/DK0555340T3/da active
- 1991-10-23 WO PCT/US1991/007608 patent/WO1992007824A1/en not_active Ceased
- 1991-10-23 HU HU931182A patent/HU9301182D0/hu unknown
- 1991-10-23 NZ NZ250394A patent/NZ250394A/en not_active IP Right Cessation
1993
- 1993-04-24 KR KR93701226A patent/KR960008665B1/ko not_active Expired - Lifetime
1995
- 1995-02-28 GR GR950400425T patent/GR3015221T3/el unknown
1996
- 1996-10-03 HK HK185496A patent/HK185496A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0555340A1 (de)	1993-08-18
SK281740B6 (sk)	2001-07-10
SK37793A3 (en)	1993-10-06
DK0555340T3 (da)	1995-03-06
KR960008665B1 (en)	1996-06-28
JPH0645580B2 (ja)	1994-06-15
AU8927991A (en)	1992-05-26
CA2094810A1 (en)	1992-04-26
AU646910B2 (en)	1994-03-10
GR3015221T3 (en)	1995-05-31
CA2094810C (en)	2002-06-04
HK185496A (en)	1996-10-11
CZ286239B6 (cs)	2000-02-16
HUT65402A (en)	1994-06-28
CZ71093A3 (en)	1994-02-16
ES2067958T3 (es)	1995-04-01
DE69105752T2 (de)	1995-05-11
HU9301182D0 (en)	1993-08-30
US5382673A (en)	1995-01-17
JPH05507289A (ja)	1993-10-21
HU212617B (en)	1996-09-30
NZ240319A (en)	1994-10-26
WO1992007824A1 (en)	1992-05-14
EP0555340B1 (de)	1994-12-07
PL166385B1 (en)	1995-05-31
RU2071468C1 (ru)	1997-01-10
DE69105752D1 (de)	1995-01-19
NZ250394A (en)	1994-10-26

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2012-01-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE115123T1 (de)	1994-12-15	Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.
KR840005083A (ko)	1984-11-03	항고혈압제로서 유용한 아미노산유도체의 제조방법
KR910021366A (ko)	1991-12-20	4-(4-알콕시페닐)-2-부틸아민 유도체 및 그의 제조방법
ATE8047T1 (de)	1984-07-15	(2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthioessigs[ure, ihre salze und ester, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE69312566D1 (de)	1997-09-04	Verfahren zur Herstellung von Alkylpolyglukosiden
ATE42283T1 (de)	1989-05-15	Verfahren zur verminderung von nebenproduktanteilen bei der herstellung von carbendazim.
ATE84074T1 (de)	1993-01-15	Verfahren zur fermentativen herstellung von 2-(4- hydroxiphenoxi-)propionsaeure.
ATE49402T1 (de)	1990-01-15	Verfahren zur herstellung von zirkoniumcarboxylat.
DE68903570D1 (de)	1993-01-07	Verfahren zur herstellung von hydroxyalkylierungsmitteln, die erhaltenen mittel und deren verwendung.
ATE1707T1 (de)	1982-11-15	Verfahren zur herstellung von thiochlorformiaten.
IT1237529B (it)	1993-06-08	Composti spiro-indolino-ossazine con caratteristiche fotocromatiche e fotosensibilizzatrici e procedimento per la loro preparazione
ATE23989T1 (de)	1986-12-15	Verfahren zur herstellung von n,n'-bis(2hydroxyethyl)oxamid.
DE69024999D1 (de)	1996-03-07	Verfahren zur Herstellung von 2-Oxindol-1-carboxamiden
DE68917160D1 (de)	1994-09-08	Herstellung von Aminosäure-Derivaten.
ES8101889A1 (es)	1980-12-16	Procedimiento para la obtencion de pastas endoparasiticidas para caballos
KR920016441A (ko)	1992-09-24	글리세르알데하이드-3-펜타나이드 및 이의 제조방법
IT1099589B (it)	1985-09-18	Processo per la preparazione di derivati dell'acido benzoxazolil propionico
KR840007591A (ko)	1984-12-08	니자티딘의 합성법
ATE93845T1 (de)	1993-09-15	Verfahren zur herstellung von 4,4'-bis-(4aminophenoxy)-diphenylsulfon.
JPS5735932A (en)	1982-02-26	Emulsifier composition
ATE19872T1 (de)	1986-06-15	Verfahren zur herstellung von 2,4,6-triisocyanato-toluol.
KR830001203A (ko)	1983-04-29	N-(1-메틸-2-필로리디닐-메틸)-2,3-디메톡시-5-메틸설파모일 벤즈아미드의 제조방법
JPS53101382A (en)	1978-09-04	Tetrahydroisoquinoline-3-acetic acids and process for their preparation
ATE132865T1 (de)	1996-01-15	3-anilino-2-hydroxycarbonyl-4-thiophenessigsäur n
DE59101665D1 (de)	1994-06-23	Verfahren zur Herstellung von staubfreiem Silbernitrat.