IT1193190B - 2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito - Google Patents

2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito

Info

Publication number
IT1193190B
IT1193190B IT24165/79A IT2416579A IT1193190B IT 1193190 B IT1193190 B IT 1193190B IT 24165/79 A IT24165/79 A IT 24165/79A IT 2416579 A IT2416579 A IT 2416579A IT 1193190 B IT1193190 B IT 1193190B
Authority
IT
Italy
Prior art keywords
tetraidro
benzazepine
mercapto
replaced
benzazepine mercapto
Prior art date
Application number
IT24165/79A
Other languages
English (en)
Other versions
IT7924165A0 (it
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of IT7924165A0 publication Critical patent/IT7924165A0/it
Application granted granted Critical
Publication of IT1193190B publication Critical patent/IT1193190B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IT24165/79A 1978-07-07 1979-07-06 2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito IT1193190B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92261378A 1978-07-07 1978-07-07

Publications (2)

Publication Number Publication Date
IT7924165A0 IT7924165A0 (it) 1979-07-06
IT1193190B true IT1193190B (it) 1988-06-02

Family

ID=25447325

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24165/79A IT1193190B (it) 1978-07-07 1979-07-06 2,3,4,5-tetraidro-1h-3-benzazepine mercapto-sostituito

Country Status (24)

Country Link
EP (2) EP0080012B1 (it)
JP (1) JPS5511584A (it)
AR (1) AR222828A1 (it)
AU (1) AU525789B2 (it)
CA (1) CA1115271A (it)
CS (1) CS213381B2 (it)
DD (1) DD147355A5 (it)
DE (1) DE2964530D1 (it)
DK (1) DK156001C (it)
ES (3) ES482276A1 (it)
FI (1) FI67215C (it)
GR (1) GR69675B (it)
HU (1) HU179315B (it)
IE (1) IE48654B1 (it)
IL (1) IL57532A (it)
IT (1) IT1193190B (it)
JO (1) JO1273B1 (it)
NO (1) NO152213C (it)
NZ (1) NZ190745A (it)
PH (1) PH15754A (it)
PL (1) PL216908A1 (it)
PT (1) PT69855A (it)
SU (1) SU1029827A3 (it)
ZA (1) ZA792785B (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) * 1984-08-23 1987-03-24 Smithkline Beckman Corporation Azidobenzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US6384079B1 (en) 1986-12-23 2002-05-07 Tristrata Technology, Incorporated Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
US5942250A (en) * 1986-12-23 1999-08-24 Tristrata Technology, Inc. Compositions and methods for enhancing the topical effects of sunscreen agents
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
SK4782001A3 (en) * 1998-10-08 2001-11-06 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
ES2264003T3 (es) 2002-10-07 2006-12-16 Glaxo Group Limited Derivados de sulfonamida como agentges antipsicoticos.
MXPA05013364A (es) 2003-06-17 2006-03-17 Arena Pharm Inc Procedimiento para preparar 3-benzazepinas.
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
EA011011B1 (ru) * 2004-02-25 2008-12-30 Эли Лилли Энд Компани 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT
BRPI0519726B8 (pt) 2004-12-21 2021-05-25 Arena Pharm Inc composto de hemidrato de (r)-8-cloro-1-metil-2,3,4,5-tetraidro-1h-3-benzazepina, composição compreendendo o referido composto e seus usos
BRPI0515862A2 (pt) 2004-12-23 2011-10-11 Arena Pharm Inc uso de fentermina e agonista seletivo do receptor de 5ht-2c na preparação de composições, composições moduladoras do receptor de 5ht-2c e forma de dosagem unitária compreendendo as mesmas
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
JP5404414B2 (ja) 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
CA2886875A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
CN116655892B (zh) * 2023-05-18 2026-03-31 常州大学 一种交联聚合物有机电极材料及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520264A (en) * 1947-08-26 1950-08-29 Maltbie Lab Inc Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
GB1268243A (en) * 1968-03-11 1972-03-22 Wallace & Tiernan Inc 0,2,4,5,-tetrahydro-3h,3-benzazepines
US3671519A (en) * 1969-07-14 1972-06-20 American Home Prod N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en) 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en) 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

Also Published As

Publication number Publication date
JO1273B1 (en) 1986-11-30
DD147355A5 (de) 1981-04-01
IL57532A (en) 1982-08-31
ES482281A1 (es) 1980-04-01
HU179315B (en) 1982-09-28
DK156001C (da) 1989-11-06
NO152213B (no) 1985-05-13
PT69855A (en) 1979-08-01
FI67215B (fi) 1984-10-31
AR222828A1 (es) 1981-06-30
ES482276A1 (es) 1980-04-01
EP0080012A1 (en) 1983-06-01
AU4861379A (en) 1980-02-07
AU525789B2 (en) 1982-12-02
NZ190745A (en) 1981-01-23
NO152213C (no) 1985-08-28
GR69675B (it) 1982-07-07
NO792267L (no) 1980-01-08
JPS5511584A (en) 1980-01-26
DK278379A (da) 1980-01-08
IT7924165A0 (it) 1979-07-06
ZA792785B (en) 1980-08-27
FI67215C (fi) 1985-02-11
EP0007070A1 (en) 1980-01-23
JPH0153271B2 (it) 1989-11-13
PL216908A1 (it) 1980-08-11
EP0007070B1 (en) 1983-01-19
IL57532A0 (en) 1979-10-31
PH15754A (en) 1983-03-18
IE48654B1 (en) 1985-04-03
SU1029827A3 (ru) 1983-07-15
EP0080012B1 (en) 1986-04-09
CA1115271A (en) 1981-12-29
IE791276L (en) 1980-01-07
FI792125A7 (fi) 1980-01-08
DE2964530D1 (en) 1983-02-24
CS213381B2 (en) 1982-04-09
ES482282A1 (es) 1980-04-01
DK156001B (da) 1989-06-12

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