IT1201436B - Formulazioni topiche a lento rilascio - Google Patents
Formulazioni topiche a lento rilascioInfo
- Publication number
- IT1201436B IT1201436B IT21654/85A IT2165485A IT1201436B IT 1201436 B IT1201436 B IT 1201436B IT 21654/85 A IT21654/85 A IT 21654/85A IT 2165485 A IT2165485 A IT 2165485A IT 1201436 B IT1201436 B IT 1201436B
- Authority
- IT
- Italy
- Prior art keywords
- slow release
- release formulations
- salts
- topical
- topical slow
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 201000004384 Alopecia Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 abstract 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229920000388 Polyphosphate Polymers 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 229960003632 minoxidil Drugs 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 229920000447 polyanionic polymer Polymers 0.000 abstract 1
- 239000001205 polyphosphate Substances 0.000 abstract 1
- 235000011176 polyphosphates Nutrition 0.000 abstract 1
- 239000011970 polystyrene sulfonate Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21654/85A IT1201436B (it) | 1985-07-19 | 1985-07-19 | Formulazioni topiche a lento rilascio |
| DE198686109454T DE211268T1 (de) | 1985-07-19 | 1986-07-10 | Topische praeparate mit verzoegerter freigabe. |
| AT86109454T ATE67488T1 (de) | 1985-07-19 | 1986-07-10 | Topische praeparate mit verzoegerter freigabe. |
| EP86109454A EP0211268B1 (en) | 1985-07-19 | 1986-07-10 | Slow-release topical formulations |
| DE8686109454T DE3681529D1 (de) | 1985-07-19 | 1986-07-10 | Topische praeparate mit verzoegerter freigabe. |
| JP61170714A JPS6236367A (ja) | 1985-07-19 | 1986-07-18 | ミノキシジル塩、その製法およびそれを有効成分とする外用剤または化粧料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21654/85A IT1201436B (it) | 1985-07-19 | 1985-07-19 | Formulazioni topiche a lento rilascio |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8521654A0 IT8521654A0 (it) | 1985-07-19 |
| IT1201436B true IT1201436B (it) | 1989-02-02 |
Family
ID=11184897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21654/85A IT1201436B (it) | 1985-07-19 | 1985-07-19 | Formulazioni topiche a lento rilascio |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0211268B1 (it) |
| JP (1) | JPS6236367A (it) |
| AT (1) | ATE67488T1 (it) |
| DE (2) | DE3681529D1 (it) |
| IT (1) | IT1201436B (it) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU86547A1 (fr) * | 1986-08-07 | 1988-03-02 | Oreal | Suspension pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de la pyrimidine |
| US4828837A (en) * | 1987-03-30 | 1989-05-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition, its production and application |
| JPS63186560A (ja) * | 1987-05-15 | 1988-08-02 | Toshiba Corp | 電圧共振形高周波スイッチング回路 |
| LU86958A1 (fr) * | 1987-07-31 | 1989-03-08 | Oreal | Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie |
| EP0330453A1 (en) * | 1988-02-26 | 1989-08-30 | Minnesota Mining And Manufacturing Company | Scalp treatment composition |
| DE3816995A1 (de) * | 1988-05-19 | 1989-11-23 | Hoechst Ag | Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen |
| JP2744853B2 (ja) * | 1991-03-29 | 1998-04-28 | 品川白煉瓦株式会社 | スライドバルブ装置用プレート煉瓦カートリッジ及び該カートリッジを用いたスライドバルブ装置 |
| US6077822A (en) * | 1993-09-14 | 2000-06-20 | Dumex-Alpharma A/S | Drug salts |
| EP0764169B1 (en) * | 1994-06-10 | 1998-09-23 | Dumex-Alpharma A/S | Drug salts |
| AUPP310798A0 (en) * | 1998-04-22 | 1998-05-14 | Soltec Research Pty Ltd | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
| DE102005060690B4 (de) * | 2005-12-15 | 2008-09-25 | Capsulution Nanoscience Ag | Salze von Clopidogrel mit Polyanionen und ihre Verwendung zur Herstellung pharmazeutischer Formulierungen |
| JP5323324B2 (ja) * | 2007-04-13 | 2013-10-23 | 大正製薬株式会社 | ミノキシジル配合育毛剤の着色防止方法及びミノキシジル配合育毛剤が充填された容器 |
| EP2611852B1 (de) | 2010-08-31 | 2014-07-30 | Basf Se | Verzweigte polyester auf basis von zitronensäure sowie deren herstellung und verwendung |
| WO2017032651A1 (de) | 2015-08-21 | 2017-03-02 | Basf Se | Salze von wirkstoffen mit polymeren gegenionen |
| JP6914916B2 (ja) | 2015-08-21 | 2021-08-04 | ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ | Ｎ−ビニルピロリドン及びアクリル酸をベースとした水溶性ポリマーの医薬助剤としての使用 |
| MX390288B (es) * | 2018-02-06 | 2025-03-20 | Centro Int De Cosmiatria S A P I De C V | Formulación y método para el tratamiento de la alopecia androgénica. |
| CN118908900B (zh) * | 2024-10-10 | 2025-01-28 | 山东则正医药技术有限公司 | 一种米诺地尔乳酸盐晶型及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE560809A (it) * | ||||
| CA935092A (en) * | 1968-09-03 | 1973-10-09 | S. Banker Gilbert | Molecular drug entrapment process and compositions |
| WO1983002558A1 (en) * | 1981-11-09 | 1983-08-04 | Gail Sansone Bazzano | The use of retinoids and minoxidil (2,4,-diamino-6-piperidino-pyrimidine-3-oxide) to increase the rate of growth of human scalp hair and to treat certain types of alopecias |
| NZ214397A (en) * | 1984-12-21 | 1989-04-26 | Richardson Vicks Inc | Minoxidil and acrylate polymer topical compositions |
-
1985
- 1985-07-19 IT IT21654/85A patent/IT1201436B/it active
-
1986
- 1986-07-10 DE DE8686109454T patent/DE3681529D1/de not_active Expired - Lifetime
- 1986-07-10 DE DE198686109454T patent/DE211268T1/de active Pending
- 1986-07-10 AT AT86109454T patent/ATE67488T1/de active
- 1986-07-10 EP EP86109454A patent/EP0211268B1/en not_active Expired - Lifetime
- 1986-07-18 JP JP61170714A patent/JPS6236367A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6236367A (ja) | 1987-02-17 |
| EP0211268A3 (en) | 1988-01-20 |
| EP0211268B1 (en) | 1991-09-18 |
| IT8521654A0 (it) | 1985-07-19 |
| ATE67488T1 (de) | 1991-10-15 |
| DE211268T1 (de) | 1987-08-13 |
| EP0211268A2 (en) | 1987-02-25 |
| DE3681529D1 (de) | 1991-10-24 |
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