IT1226301B - Processo per la preparazione di intermedi per la sintesi del diltiazem. - Google Patents

Processo per la preparazione di intermedi per la sintesi del diltiazem.

Info

Publication number: IT1226301B
Authority: IT; Italy
Prior art keywords: diltiazem; synthesis; intermediates; preparation; dimethylaminoethanol
Prior art date: 1988-07-26

Application number

IT8821479A

Other languages

English (en)

Other versions

IT8821479A0 (it

Inventor

Silvia Cavicchioli

Maurizio Paiocchi

Claudio Giordano

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-26

Filing date

1988-07-26

Publication date

1990-12-27

1988-07-26 Application filed by Zambon Spa filed Critical Zambon Spa

1988-07-26 Priority to IT8821479A priority Critical patent/IT1226301B/it

1988-07-26 Publication of IT8821479A0 publication Critical patent/IT8821479A0/it

1989-07-18 Priority to DE68914211T priority patent/DE68914211T2/de

1989-07-18 Priority to EP89113136A priority patent/EP0355395B1/en

1989-07-18 Priority to ES89113136T priority patent/ES2061819T3/es

1989-07-18 Priority to AT89113136T priority patent/ATE103598T1/de

1989-07-25 Priority to US07/384,730 priority patent/US4937334A/en

1989-07-26 Priority to JP01193818A priority patent/JP3101819B2/ja

1990-12-27 Application granted granted Critical

1990-12-27 Publication of IT1226301B publication Critical patent/IT1226301B/it

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
229960004166 diltiazem Drugs 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000007126 N-alkylation reaction Methods 0.000 abstract 1
UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT8821479A 1988-07-26 1988-07-26 Processo per la preparazione di intermedi per la sintesi del diltiazem. IT1226301B (it)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
IT8821479A IT1226301B (it)	1988-07-26	1988-07-26	Processo per la preparazione di intermedi per la sintesi del diltiazem.
DE68914211T DE68914211T2 (de)	1988-07-26	1989-07-18	Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem.
EP89113136A EP0355395B1 (en)	1988-07-26	1989-07-18	Process for the preparation of intermediates for the synthesis of diltiazem
ES89113136T ES2061819T3 (es)	1988-07-26	1989-07-18	Procedimiento para la preparacion de intermediarios para la sintesis de diltiazem.
AT89113136T ATE103598T1 (de)	1988-07-26	1989-07-18	Verfahren zur herstellung von zwischenprodukten in der synthese von diltiazem.
US07/384,730 US4937334A (en)	1988-07-26	1989-07-25	Process for the preparation of intermediates for the synthesis of diltiazem
JP01193818A JP3101819B2 (ja)	1988-07-26	1989-07-26	（２ｓ，３ｓ）（＋）―３―ヒドロキシ―２，３―ジヒドロ―２―（４―メトキシフェニル）―５―（２―ジメチルアミノエチル）―１，５―ベンゾチアゼピン―４（５ｈ）―オンの製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8821479A IT1226301B (it)	1988-07-26	1988-07-26	Processo per la preparazione di intermedi per la sintesi del diltiazem.

Publications (2)

Publication Number	Publication Date
IT8821479A0 IT8821479A0 (it)	1988-07-26
IT1226301B true IT1226301B (it)	1990-12-27

Family

ID=11182442

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8821479A IT1226301B (it)	1988-07-26	1988-07-26	Processo per la preparazione di intermedi per la sintesi del diltiazem.

Country Status (7)

Country	Link
US (1)	US4937334A (it)
EP (1)	EP0355395B1 (it)
JP (1)	JP3101819B2 (it)
AT (1)	ATE103598T1 (it)
DE (1)	DE68914211T2 (it)
ES (1)	ES2061819T3 (it)
IT (1)	IT1226301B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1244878B (it) *	1990-12-11	1994-09-12	Lusochimica Spa	Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
TW438787B (en)	1997-02-27	2001-06-07	Tanabe Seiyaku Co	Process for preparing optically active trans-3-substituted glycidic acid ester
FR3033701B1 (fr)	2015-03-19	2021-01-15	Univ Claude Bernard Lyon	Nouvelles compositions antivirales pour le traitement de la grippe
US12594280B2 (en)	2015-03-19	2026-04-07	Universite Claude Bernard Lyon 1	Antiviral compositions for treating the flu

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
JPS5899471A (ja) *	1981-12-07	1983-06-13	Tanabe Seiyaku Co Ltd	ベンゾチアゼピン誘導体の新規製造法
US4567175A (en) *	1983-06-03	1986-01-28	Tanabe Seiyaku Co., Ltd.	8-Chloro-1,5-benzothiazepine derivatives
HU195795B (en) *	1985-11-06	1988-07-28	Richter Gedeon Vegyeszet	Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

1988
- 1988-07-26 IT IT8821479A patent/IT1226301B/it active
1989
- 1989-07-18 ES ES89113136T patent/ES2061819T3/es not_active Expired - Lifetime
- 1989-07-18 EP EP89113136A patent/EP0355395B1/en not_active Expired - Lifetime
- 1989-07-18 AT AT89113136T patent/ATE103598T1/de not_active IP Right Cessation
- 1989-07-18 DE DE68914211T patent/DE68914211T2/de not_active Expired - Fee Related
- 1989-07-25 US US07/384,730 patent/US4937334A/en not_active Expired - Lifetime
- 1989-07-26 JP JP01193818A patent/JP3101819B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE68914211T2 (de)	1994-07-07
DE68914211D1 (de)	1994-05-05
JPH0278673A (ja)	1990-03-19
US4937334A (en)	1990-06-26
EP0355395B1 (en)	1994-03-30
EP0355395A1 (en)	1990-02-28
IT8821479A0 (it)	1988-07-26
JP3101819B2 (ja)	2000-10-23
ES2061819T3 (es)	1994-12-16
ATE103598T1 (de)	1994-04-15

Publication	Publication Date	Title
ES2088537T3 (es)	1996-08-16	Derivados de piranil cianoguanidina.
ATE112285T1 (de)	1994-10-15	Adenosin-derivate, die eine aktivität gegen bluthochdruck haben.
FI906045A0 (fi)	1990-12-07	Kvaevehaltiga spirocykliska foereningar.
ES2188661T3 (es)	2003-07-01	Preparacion de un derivado de camptothecin por ciclacion intramolecular.
NO307379B1 (no)	2000-03-27	3-merkapto-1-(1,3-tiazolin-2-yl)azetidin-derivater
HUT52043A (en)	1990-06-28	Process for producing intermediates for producing substituted indolinon derivatives
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CA1273957C (it)	1990-09-11
DE60333733D1 (en)	2010-09-23	Clohexancarbonsäurederivats
ITMI931012A1 (it)	1994-11-18	Composti spiro-piranici dotati di caratteristiche fotocromatiche
FI955954A0 (fi)	1995-12-12	Thiolyhdisteitä
DE69915413D1 (de)	2004-04-15	Verfahren zur Herstellung von 4-phenyl-1,2,3,6-tetrahydropyridin-derivaten und die dafür verwendeten Zwischenprodukte
DE68914211D1 (de)	1994-05-05	Verfahren zur Herstellung von Zwischenprodukten in der Synthese von Diltiazem.
ES2053707T3 (es)	1994-08-01	Procedimiento para la preparacion de amidas de acidos 3,3-diaril-acrilicos.
BR9401346A (pt)	1994-11-01	Processo para a preparação de derivados de 4-amino-3-oxo-2,3,4,5-tetraidro-1,2,4-triazina e processo para a preparação de um composto
BR9405302A (pt)	1995-10-17	Processo para a preparação de um composto e o referido composto
ATE169909T1 (de)	1998-09-15	Benzyl- und benzhydryl alkohole
IT1198237B (it)	1988-12-21	Intermedi per la sintesi di composti organici
ES2164258T3 (es)	2002-02-16	Procedimiento de preparacion de derivados de carbamoilmetilurea.