IT1244878B - Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato - Google Patents

Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato

Info

Publication number: IT1244878B
Authority: IT; Italy
Prior art keywords: benzothiazepin; dihydro; cis; pct; acetoxy
Prior art date: 1990-12-11

Application number

IT02234090A

Other languages

English (en)

Other versions

IT9022340A0 (it

IT9022340A1 (it

Inventor

Elso Manghisi

Bruno Perego

Original Assignee

Lusochimica Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-11

Filing date

1990-12-11

Publication date

1994-09-12

1990-12-11 Application filed by Lusochimica Spa filed Critical Lusochimica Spa

1990-12-11 Publication of IT9022340A0 publication Critical patent/IT9022340A0/it

1990-12-11 Priority to IT02234090A priority Critical patent/IT1244878B/it

1991-12-09 Priority to ES92900248T priority patent/ES2070622T3/es

1991-12-09 Priority to DE69108410T priority patent/DE69108410T2/de

1991-12-09 Priority to EP92900248A priority patent/EP0561861B1/en

1991-12-09 Priority to AT92900248T priority patent/ATE120192T1/de

1991-12-09 Priority to US08/074,841 priority patent/US5382663A/en

1991-12-09 Priority to CA002098114A priority patent/CA2098114C/en

1991-12-09 Priority to AU90366/91A priority patent/AU9036691A/en

1991-12-09 Priority to JP50037292A priority patent/JP3152658B2/ja

1991-12-09 Priority to PCT/EP1991/002353 priority patent/WO1992010485A1/en

1992-06-11 Publication of IT9022340A1 publication Critical patent/IT9022340A1/it

1994-09-12 Application granted granted Critical

1994-09-12 Publication of IT1244878B publication Critical patent/IT1244878B/it

Links

ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 title 2
-1 ACETOXY Chemical class 0.000 title 1
QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
LHBHZALHFIQJGJ-CABCVRRESA-N (2s,3s)-3-hydroxy-2-(4-methoxyphenyl)-3,5-dihydro-2h-1,5-benzothiazepin-4-one Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](O)C(=O)NC2=CC=CC=C2S1 LHBHZALHFIQJGJ-CABCVRRESA-N 0.000 abstract 1
WQMAANNAZKNUDL-UHFFFAOYSA-N 2-dimethylaminoethyl chloride Chemical compound CN(C)CCCl WQMAANNAZKNUDL-UHFFFAOYSA-N 0.000 abstract 1
238000007126 N-alkylation reaction Methods 0.000 abstract 1
230000021736 acetylation Effects 0.000 abstract 1
238000006640 acetylation reaction Methods 0.000 abstract 1
239000003444 phase transfer catalyst Substances 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
235000015320 potassium carbonate Nutrition 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

IT02234090A 1990-12-11 1990-12-11 Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato IT1244878B (it)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
IT02234090A IT1244878B (it)	1990-12-11	1990-12-11	Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
AT92900248T ATE120192T1 (de)	1990-12-11	1991-12-09	Verfahren zur herstellung von diltiazem.
DE69108410T DE69108410T2 (de)	1990-12-11	1991-12-09	Verfahren zur herstellung von diltiazem.
EP92900248A EP0561861B1 (en)	1990-12-11	1991-12-09	A process for the preparation of diltiazem
ES92900248T ES2070622T3 (es)	1990-12-11	1991-12-09	Un procedimiento para la preparacion de diltiazem.
US08/074,841 US5382663A (en)	1990-12-11	1991-12-09	Process for the preparation of diltiazem
CA002098114A CA2098114C (en)	1990-12-11	1991-12-09	A process for the preparation of diltiazem
AU90366/91A AU9036691A (en)	1990-12-11	1991-12-09	A process for the preparation of diltiazem
JP50037292A JP3152658B2 (ja)	1990-12-11	1991-12-09	ジルチアゼムの製造方法
PCT/EP1991/002353 WO1992010485A1 (en)	1990-12-11	1991-12-09	A process for the preparation of diltiazem

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02234090A IT1244878B (it)	1990-12-11	1990-12-11	Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato

Publications (3)

Publication Number	Publication Date
IT9022340A0 IT9022340A0 (it)	1990-12-11
IT9022340A1 IT9022340A1 (it)	1992-06-11
IT1244878B true IT1244878B (it)	1994-09-12

Family

ID=11194922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT02234090A IT1244878B (it)	1990-12-11	1990-12-11	Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato

Country Status (10)

Country	Link
US (1)	US5382663A (it)
EP (1)	EP0561861B1 (it)
JP (1)	JP3152658B2 (it)
AT (1)	ATE120192T1 (it)
AU (1)	AU9036691A (it)
CA (1)	CA2098114C (it)
DE (1)	DE69108410T2 (it)
ES (1)	ES2070622T3 (it)
IT (1)	IT1244878B (it)
WO (1)	WO1992010485A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6938825B1 (en)	1989-04-24	2005-09-06	Ultracard, Inc.	Data system
IT1255545B (it) *	1992-10-23	1995-11-09		Procedimento per la preparazione di diltiazem
ES2118292T3 (es) *	1994-09-16	1998-09-16	Orion Corp Fermion	Metodo para la preparacion de 3-hidroxi-5-(2-dimetilamino)-etil)-2,3-dihidro-4-(metoxifenil)-1,5-benzotiazepin-4(5h)-ona y uso del producto para elaborar compuestos farmaceuticamente activos.
FI97725C (fi) *	1995-02-17	1997-02-10	Orion Yhtymae Oy	Menetelmä diltiatseemin valmistamiseksi
WO1996038429A1 (en) *	1995-06-01	1996-12-05	Acic (Canada) Inc.	Method for the manufacture of benzothiazepine derivatives
US6871787B1 (en)	1998-07-10	2005-03-29	Ultracard, Inc.	Data storage card having a glass substrate and data surface region and method for using same
US7487908B1 (en)	1999-10-23	2009-02-10	Ultracard, Inc.	Article having an embedded accessible storage member, apparatus and method for using same
US8397998B1 (en)	1999-10-23	2013-03-19	Ultracard, Inc.	Data storage device, apparatus and method for using same
US7036739B1 (en)	1999-10-23	2006-05-02	Ultracard, Inc.	Data storage device apparatus and method for using same
US6969006B1 (en)	2000-09-15	2005-11-29	Ultracard, Inc.	Rotable portable card having a data storage device, apparatus and method for using same
US12594280B2 (en)	2015-03-19	2026-04-07	Universite Claude Bernard Lyon 1	Antiviral compositions for treating the flu
FR3033701B1 (fr)	2015-03-19	2021-01-15	Univ Claude Bernard Lyon	Nouvelles compositions antivirales pour le traitement de la grippe
CN116143723A (zh) *	2022-12-07	2023-05-23	海南锦瑞制药有限公司	一种盐酸地尔硫卓的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3562257A (en)	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
IL71538A (en) *	1984-04-13	1987-07-31	Abic Ltd	Process for the preparation of benzothiazepine derivatives
US4902684A (en) *	1988-06-20	1990-02-20	E. R. Squibb & Sons, Inc.	Benzazepine and benzothiazepine derivatives
IT1226301B (it) *	1988-07-26	1990-12-27	Zambon Spa	Processo per la preparazione di intermedi per la sintesi del diltiazem.

1990
- 1990-12-11 IT IT02234090A patent/IT1244878B/it active IP Right Grant
1991
- 1991-12-09 US US08/074,841 patent/US5382663A/en not_active Expired - Lifetime
- 1991-12-09 CA CA002098114A patent/CA2098114C/en not_active Expired - Lifetime
- 1991-12-09 JP JP50037292A patent/JP3152658B2/ja not_active Expired - Lifetime
- 1991-12-09 DE DE69108410T patent/DE69108410T2/de not_active Expired - Lifetime
- 1991-12-09 ES ES92900248T patent/ES2070622T3/es not_active Expired - Lifetime
- 1991-12-09 AT AT92900248T patent/ATE120192T1/de not_active IP Right Cessation
- 1991-12-09 AU AU90366/91A patent/AU9036691A/en not_active Abandoned
- 1991-12-09 WO PCT/EP1991/002353 patent/WO1992010485A1/en not_active Ceased
- 1991-12-09 EP EP92900248A patent/EP0561861B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP3152658B2 (ja)	2001-04-03
US5382663A (en)	1995-01-17
ES2070622T3 (es)	1995-06-01
AU9036691A (en)	1992-07-08
JPH06503317A (ja)	1994-04-14
CA2098114A1 (en)	1992-06-11
CA2098114C (en)	2002-06-25
EP0561861B1 (en)	1995-03-22
IT9022340A0 (it)	1990-12-11
DE69108410T2 (de)	1995-08-10
IT9022340A1 (it)	1992-06-11
WO1992010485A1 (en)	1992-06-25
EP0561861A1 (en)	1993-09-29
ATE120192T1 (de)	1995-04-15
DE69108410D1 (de)	1995-04-27

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Legal Events

Date	Code	Title	Description
1994-09-12	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19951227