BE1003313A3 - Procede de purification de produits intermediaires pour la preparation du diltiazem. - Google Patents

Procede de purification de produits intermediaires pour la preparation du diltiazem. Download PDF

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Publication number
BE1003313A3
BE1003313A3 BE9000707A BE9000707A BE1003313A3 BE 1003313 A3 BE1003313 A3 BE 1003313A3 BE 9000707 A BE9000707 A BE 9000707A BE 9000707 A BE9000707 A BE 9000707A BE 1003313 A3 BE1003313 A3 BE 1003313A3
Authority
BE
Belgium
Prior art keywords
diltiazem
purification
preparation
intermediate products
benzothiazepin
Prior art date
Application number
BE9000707A
Other languages
English (en)
Inventor
Claudio Giordano
Dario Tentorio
Laura Russo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of BE1003313A3 publication Critical patent/BE1003313A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procédé de purification de produits intermédiaires pour la préparation de diltiazem, comprenant la cristallisation d'un mélange énantiomériquement enrichi en (2S,3S)-2,3,dihydro-3-hydroxy-2-(4-méthoxyphényl)-1,5-benzothiazépin-4(5H)-one.
BE9000707A 1989-07-12 1990-07-11 Procede de purification de produits intermediaires pour la preparation du diltiazem. BE1003313A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921166A IT1234387B (it) 1989-07-12 1989-07-12 Processo di purificazione di intermedi utili nella preparazione del diltiazem

Publications (1)

Publication Number Publication Date
BE1003313A3 true BE1003313A3 (fr) 1992-02-25

Family

ID=11177746

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9000707A BE1003313A3 (fr) 1989-07-12 1990-07-11 Procede de purification de produits intermediaires pour la preparation du diltiazem.

Country Status (13)

Country Link
US (1) US5315005A (fr)
JP (1) JP2979240B2 (fr)
AT (1) AT401649B (fr)
BE (1) BE1003313A3 (fr)
CA (1) CA2020158C (fr)
CH (1) CH680219A5 (fr)
DE (1) DE4021999C2 (fr)
ES (1) ES2020722A6 (fr)
FR (1) FR2649706B1 (fr)
GB (1) GB2233646B (fr)
IT (1) IT1234387B (fr)
NL (1) NL9001515A (fr)
SE (1) SE509636C2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559229A (en) * 1995-06-01 1996-09-24 Acic (Canada) Inc. Method for the manufacture of benzothiazepine
US7513937B2 (en) 2005-07-08 2009-04-07 Refined Global Solutions, Inc. Oil reconditioning device and associated methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
FR2360124A1 (fr) * 1976-07-30 1978-02-24 Amiens Const Electro Mecan Procede de controle de commutation de la puissance de chauffage dans un appareil electrodomestique a programmateur et dispositif pour la mise en oeuvre dudit procede
EP0059335B1 (fr) * 1981-02-27 1985-05-15 Tanabe Seiyaku Co., Ltd. Procédé pour la préparation des esters de l'acide thréo-hydroxy-2 (méthoxy-4 phényl)-3 (nitro-2 phénylthio)-3 propionique
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
IT1217988B (it) * 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
FR2642425A1 (fr) * 1989-01-30 1990-08-03 Sanofi Sa Procede de preparation de derives de benzothiazepine-1,5 one-4
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
ES2069003T3 (es) * 1989-04-28 1995-05-01 Tanabe Seiyaku Co Procedimiento para preparar derivados de 1,5-benzotiazepina.
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HELVETICA CHIMICA ACTA, vol. 67, no. 3, 2 mai 1984, pages 916-926, Bâle, CH; B. KOJIC-PRODIC et al.: "Absolute conformation and configuration of (2S,3S)-3-acetoxy-5-(dimethylaminoethyl)-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one chloride (dilthiazem hydrochloride)" *

Also Published As

Publication number Publication date
NL9001515A (nl) 1991-02-01
CA2020158A1 (fr) 1991-01-13
GB2233646A (en) 1991-01-16
AT401649B (de) 1996-10-25
NL194274B (fr) 2001-07-02
SE9002410D0 (sv) 1990-07-11
NL194274C (fr) 2001-11-05
DE4021999A1 (de) 1991-01-17
CA2020158C (fr) 1997-03-04
JPH0348671A (ja) 1991-03-01
ES2020722A6 (es) 1991-09-01
GB9014799D0 (en) 1990-08-22
IT1234387B (it) 1992-05-18
FR2649706B1 (fr) 1994-10-07
US5315005A (en) 1994-05-24
DE4021999C2 (de) 2002-08-29
GB2233646B (en) 1993-01-27
ATA147690A (de) 1996-03-15
JP2979240B2 (ja) 1999-11-15
FR2649706A1 (fr) 1991-01-18
IT8921166A0 (it) 1989-07-12
SE509636C2 (sv) 1999-02-15
CH680219A5 (fr) 1992-07-15
SE9002410L (sv) 1991-01-13

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Effective date: 20050731