IT1235153B - Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento - Google Patents

Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento

Info

Publication number: IT1235153B
Authority: IT; Italy
Prior art keywords: treatment; carnitine; acetyl; cataract; pharmaceutical compositions
Prior art date: 1988-11-15

Application number

IT8848558A

Other languages

English (en)

Other versions

IT8848558A0 (it

Inventor

Claudio Cavazza

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-15

Filing date

1988-11-15

Publication date

1992-06-22

1988-11-15 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1988-11-15 Priority to IT8848558A priority Critical patent/IT1235153B/it

1988-11-15 Publication of IT8848558A0 publication Critical patent/IT8848558A0/it

1989-11-13 Priority to AT89830491T priority patent/ATE99172T1/de

1989-11-13 Priority to ES89830491T priority patent/ES2062100T3/es

1989-11-13 Priority to EP89830491A priority patent/EP0375628B1/en

1989-11-13 Priority to DE89830491T priority patent/DE68911891T2/de

1989-11-14 Priority to US07/436,203 priority patent/US5037851A/en

1989-11-14 Priority to ZA898667A priority patent/ZA898667B/xx

1989-11-15 Priority to JP1298729A priority patent/JPH02180820A/ja

1992-06-22 Application granted granted Critical

1992-06-22 Publication of IT1235153B publication Critical patent/IT1235153B/it

Links

RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title abstract 3
208000002177 Cataract Diseases 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT8848558A 1988-11-15 1988-11-15 Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento IT1235153B (it)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
IT8848558A IT1235153B (it)	1988-11-15	1988-11-15	Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento
AT89830491T ATE99172T1 (de)	1988-11-15	1989-11-13	Verwendung von acetyl-l-carnitin zur behandlung von katarakt, sowie pharmazeutische zusammensetzungen fuer eine derartige behandlung.
ES89830491T ES2062100T3 (es)	1988-11-15	1989-11-13	Empleo de acetil l-carnitina en el tratamiento terapeutico de cataratas y composiciones farmaceuticas utiles en este tratamiento.
EP89830491A EP0375628B1 (en)	1988-11-15	1989-11-13	Use of acetyl L-carnitine in the therapeutic treatment of cataract, and pharmaceutical compositions useful in such treatment
DE89830491T DE68911891T2 (de)	1988-11-15	1989-11-13	Verwendung von Acetyl-L-carnitin zur Behandlung von Katarakt, sowie pharmazeutische Zusammensetzungen für eine derartige Behandlung.
US07/436,203 US5037851A (en)	1988-11-15	1989-11-14	Use of acetyl l-carnitine in the therapeutic treatment of cataract, and pharmaceutical compositions useful in such treatment
ZA898667A ZA898667B (en)	1988-11-15	1989-11-14	Use of acetyl l-carnitine in the therapeutic treatment of cataract and pharmaceutical compositions useful in such treatment
JP1298729A JPH02180820A (ja)	1988-11-15	1989-11-15	アセチル―ｌ―カルニチン白内障処置剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8848558A IT1235153B (it)	1988-11-15	1988-11-15	Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento

Publications (2)

Publication Number	Publication Date
IT8848558A0 IT8848558A0 (it)	1988-11-15
IT1235153B true IT1235153B (it)	1992-06-22

Family

ID=11267312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8848558A IT1235153B (it)	1988-11-15	1988-11-15	Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento

Country Status (8)

Country	Link
US (1)	US5037851A (it)
EP (1)	EP0375628B1 (it)
JP (1)	JPH02180820A (it)
AT (1)	ATE99172T1 (it)
DE (1)	DE68911891T2 (it)
ES (1)	ES2062100T3 (it)
IT (1)	IT1235153B (it)
ZA (1)	ZA898667B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5668117A (en) *	1991-02-22	1997-09-16	Shapiro; Howard K.	Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
IT1254314B (it) *	1992-03-27	1995-09-14	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
IT1263004B (it) *	1992-10-08	1996-07-23	Sigma Tau Ind Farmaceuti	Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti.
IT1276225B1 (it) *	1995-10-17	1997-10-27	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it)	1995-12-15	1997-10-27	Sigma Tau Ind Farmaceuti	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1291113B1 (it) *	1997-03-20	1998-12-29	Sigma Tau Ind Farmaceuti	Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US6090848A (en) *	1997-12-01	2000-07-18	Sigma-Tau Healthscience S.P.A.	Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US5863940A (en)	1997-12-01	1999-01-26	Sigma-Tau Healthscience S.P.A.	Medicament and therapeutical method for treating idiopathic asthenozoospermia
DK0951909T4 (da)	1998-03-19	2011-01-24	Sigma Tau Ind Farmaceuti	Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
PT1100589E (pt) *	1998-07-30	2005-05-31	Sigma Tau Ind Farmaceuti	Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena
EP1341813B1 (en) *	2000-12-15	2006-09-13	Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.	Use of l-carnitine as stabilizing agent of proteins
US8569367B2 (en)	2004-11-16	2013-10-29	Allergan, Inc.	Ophthalmic compositions and methods for treating eyes
CA2611909C (en) *	2005-07-01	2014-01-07	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Composition for treatment of corneal disease
RS52735B (sr)	2005-07-08	2013-08-30	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Primena kombinacije koja sadrži l-karnitin ili alkanoil l-karnitin, benzokvinon rastvorljiv u mastima i omega-3-polinezasićenu masnu kiselinu za pripremu dodataka ishrani ili leka za lečenje oboljenja rožnjače
US20110015154A1 (en) *	2009-07-20	2011-01-20	Kellermann Gottfried H	Supporting acetylcholine function
US20110098265A1 (en) *	2009-10-28	2011-04-28	Neuroscience, Inc.	Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
EP2363126A1 (en)	2010-03-04	2011-09-07	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Composition comprising as active ingredient L-carnitine in combination with hydroxykynurenine-O-beta-DL-glucoside, for the prevention and/or treatment of pathologies of the eye due to ultraviolet radiation
EP2642991A1 (en)	2010-11-22	2013-10-02	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Therapeutical method for the treatment of the leber optic
US9907826B2 (en)	2011-12-07	2018-03-06	Allergan, Inc.	Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
EP2783695A1 (en)	2013-03-28	2014-10-01	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Physiological supplement or medicament for ophthalmic use containing L-carnitine or alkanoyl L-carnitines in combination with eledoisin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1184655B (it) *	1985-10-14	1987-10-28	Sigma Tau Ind Farmaceuti	Imiego di acetil l-carnitina nel trattamento terapeutico degli stati di shock

1988
- 1988-11-15 IT IT8848558A patent/IT1235153B/it active
1989
- 1989-11-13 DE DE89830491T patent/DE68911891T2/de not_active Expired - Fee Related
- 1989-11-13 EP EP89830491A patent/EP0375628B1/en not_active Expired - Lifetime
- 1989-11-13 ES ES89830491T patent/ES2062100T3/es not_active Expired - Lifetime
- 1989-11-13 AT AT89830491T patent/ATE99172T1/de not_active IP Right Cessation
- 1989-11-14 US US07/436,203 patent/US5037851A/en not_active Expired - Lifetime
- 1989-11-14 ZA ZA898667A patent/ZA898667B/xx unknown
- 1989-11-15 JP JP1298729A patent/JPH02180820A/ja active Pending

Also Published As

Publication number	Publication date
EP0375628A2 (en)	1990-06-27
ATE99172T1 (de)	1994-01-15
EP0375628B1 (en)	1993-12-29
ES2062100T3 (es)	1994-12-16
IT8848558A0 (it)	1988-11-15
US5037851A (en)	1991-08-06
JPH02180820A (ja)	1990-07-13
EP0375628A3 (en)	1991-08-14
DE68911891T2 (de)	1994-04-21
DE68911891D1 (de)	1994-02-10
ZA898667B (en)	1990-10-31

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19931014