IT1244873B - Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali - Google Patents

Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali

Info

Publication number: IT1244873B
Authority: IT; Italy
Prior art keywords: aminosalicylic acid; pct; asa; therapy; derivatives
Prior art date: 1990-09-12

Application number

IT02144390A

Other languages

English (en)

Other versions

IT9021443A1 (it

IT9021443A0 (it

Inventor

Roberto Pellicciari

Aaron Garzon

Carlo Clerici

Camillo Maria Francesc Palazzi

Original Assignee

Depha Team Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-12

Filing date

1990-09-12

Publication date

1994-09-12

1990-09-12 Application filed by Depha Team Srl filed Critical Depha Team Srl

1990-09-12 Publication of IT9021443A0 publication Critical patent/IT9021443A0/it

1990-09-12 Priority to IT02144390A priority Critical patent/IT1244873B/it

1991-09-10 Priority to CA002091459A priority patent/CA2091459A1/en

1991-09-10 Priority to PCT/EP1991/001718 priority patent/WO1992004369A1/en

1991-09-10 Priority to AU85308/91A priority patent/AU8530891A/en

1991-09-10 Priority to AT91916335T priority patent/ATE105841T1/de

1991-09-10 Priority to JP3515457A priority patent/JPH06500787A/ja

1991-09-10 Priority to US07/984,575 priority patent/US5424292A/en

1991-09-10 Priority to EP91916335A priority patent/EP0548177B1/en

1991-09-10 Priority to DK91916335.2T priority patent/DK0548177T3/da

1991-09-10 Priority to ES91916335T priority patent/ES2052391T3/es

1991-09-10 Priority to DE69102069T priority patent/DE69102069T2/de

1992-03-12 Publication of IT9021443A1 publication Critical patent/IT9021443A1/it

1994-09-12 Application granted granted Critical

1994-09-12 Publication of IT1244873B publication Critical patent/IT1244873B/it

Links

KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical class NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 title abstract 4
229960004963 mesalazine Drugs 0.000 title abstract 2
206010061218 Inflammation Diseases 0.000 title 1
230000001684 chronic effect Effects 0.000 title 1
230000000968 intestinal effect Effects 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
235000003704 aspartic acid Nutrition 0.000 abstract 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
235000013922 glutamic acid Nutrition 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT02144390A 1990-09-12 1990-09-12 Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali IT1244873B (it)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
IT02144390A IT1244873B (it)	1990-09-12	1990-09-12	Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali
US07/984,575 US5424292A (en)	1990-09-12	1991-09-10	5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases
PCT/EP1991/001718 WO1992004369A1 (en)	1990-09-12	1991-09-10	5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases
AU85308/91A AU8530891A (en)	1990-09-12	1991-09-10	5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases
AT91916335T ATE105841T1 (de)	1990-09-12	1991-09-10	5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen.
JP3515457A JPH06500787A (ja)	1990-09-12	1991-09-10	慢性炎症性腸疾患治療のための５―アミノサリチル酸誘導体
CA002091459A CA2091459A1 (en)	1990-09-12	1991-09-10	5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases
EP91916335A EP0548177B1 (en)	1990-09-12	1991-09-10	5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases
DK91916335.2T DK0548177T3 (da)	1990-09-12	1991-09-10	5-Aminosalicylsyrederivater til terapi af kroniske inflammatoriske tarmsygdomme
ES91916335T ES2052391T3 (es)	1990-09-12	1991-09-10	Derivados de acido 5-aminosalicilico para la terapia de enfermedades inflamatorias cronicas del intestino.
DE69102069T DE69102069T2 (de)	1990-09-12	1991-09-10	5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02144390A IT1244873B (it)	1990-09-12	1990-09-12	Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali

Publications (3)

Publication Number	Publication Date
IT9021443A0 IT9021443A0 (it)	1990-09-12
IT9021443A1 IT9021443A1 (it)	1992-03-12
IT1244873B true IT1244873B (it)	1994-09-12

Family

ID=11181864

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT02144390A IT1244873B (it)	1990-09-12	1990-09-12	Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali

Country Status (11)

Country	Link
US (1)	US5424292A (it)
EP (1)	EP0548177B1 (it)
JP (1)	JPH06500787A (it)
AT (1)	ATE105841T1 (it)
AU (1)	AU8530891A (it)
CA (1)	CA2091459A1 (it)
DE (1)	DE69102069T2 (it)
DK (1)	DK0548177T3 (it)
ES (1)	ES2052391T3 (it)
IT (1)	IT1244873B (it)
WO (1)	WO1992004369A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5484605A (en) *	1988-11-25	1996-01-16	Henning Berlin Gmbh Chemie-Und Pharmawerk	Agent for treating chronically inflammatory intestinal diseases
EP1001764A4 (en) *	1997-05-29	2005-08-24	Merck & Co Inc	HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION
US6903075B1 (en)	1997-05-29	2005-06-07	Merck & Co., Inc.	Heterocyclic amide compounds as cell adhesion inhibitors
US6716452B1 (en) *	2000-08-22	2004-04-06	New River Pharmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
US8394813B2 (en)	2000-11-14	2013-03-12	Shire Llc	Active agent delivery systems and methods for protecting and administering active agents
US20060014697A1 (en) *	2001-08-22	2006-01-19	Travis Mickle	Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) *	2003-09-30	2007-01-30	New River Pharmaceuticals Inc.	Compounds and compositions for prevention of overdose of oxycodone
KR101159477B1 (ko) *	2003-05-29	2012-07-02	샤이어 엘엘씨	남용 방지성 암페타민 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7008620A (it) *	1969-06-25	1970-12-29
NL7008623A (it) *	1969-06-25	1970-12-29
JPS5569549A (en) *	1978-11-16	1980-05-26	Nitto Boseki Co Ltd	Novel substrate for determination of enzyme activity
WO1981002672A1 (en) *	1980-03-20	1981-10-01	Ferring Farma Lab	Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease
US4505898A (en) *	1982-04-21	1985-03-19	Marks Robert E	Derivatives of acetylsalicylic acid and substituted phenylacetic acids and compositions containing them
IT1196348B (it) *	1984-11-29	1988-11-16	Italfarmaco Spa	Composti ad attivita'antiinfiammatoria
US5120306A (en) *	1990-03-21	1992-06-09	Gosselin Leon F	Direct delivery of anti-inflammatories to the proximal small bowel

1990
- 1990-09-12 IT IT02144390A patent/IT1244873B/it active IP Right Grant
1991
- 1991-09-10 CA CA002091459A patent/CA2091459A1/en not_active Abandoned
- 1991-09-10 DE DE69102069T patent/DE69102069T2/de not_active Expired - Fee Related
- 1991-09-10 JP JP3515457A patent/JPH06500787A/ja active Pending
- 1991-09-10 US US07/984,575 patent/US5424292A/en not_active Expired - Fee Related
- 1991-09-10 ES ES91916335T patent/ES2052391T3/es not_active Expired - Lifetime
- 1991-09-10 AU AU85308/91A patent/AU8530891A/en not_active Abandoned
- 1991-09-10 DK DK91916335.2T patent/DK0548177T3/da active
- 1991-09-10 EP EP91916335A patent/EP0548177B1/en not_active Expired - Lifetime
- 1991-09-10 WO PCT/EP1991/001718 patent/WO1992004369A1/en not_active Ceased
- 1991-09-10 AT AT91916335T patent/ATE105841T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU8530891A (en)	1992-03-30
DE69102069T2 (de)	1994-09-01
DE69102069D1 (de)	1994-06-23
US5424292A (en)	1995-06-13
JPH06500787A (ja)	1994-01-27
ES2052391T3 (es)	1994-07-01
IT9021443A1 (it)	1992-03-12
EP0548177B1 (en)	1994-05-18
DK0548177T3 (da)	1994-08-22
IT9021443A0 (it)	1990-09-12
WO1992004369A1 (en)	1992-03-19
CA2091459A1 (en)	1992-03-13
EP0548177A1 (en)	1993-06-30
ATE105841T1 (de)	1994-06-15

Legal Events

Date	Code	Title	Description
1994-09-12	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970729

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DK1025124T3 (da)	2008-10-06	Human interferon-alfa-analoge med lav toksicitet
ES511408A0 (es)	1983-08-01	"procedimiento de preparar amidoaminoacidos n-substituidos".
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MY115211A (en)	2003-04-30	Novel amino acid derivatives, their preparation and use
DK482185D0 (da)	1985-10-21	Peptider, deres fremstilling og anvendelse som laegemidler
DK0548177T3 (da)	1994-08-22	5-Aminosalicylsyrederivater til terapi af kroniske inflammatoriske tarmsygdomme
DK0561846T3 (da)	1995-08-21	4,5-dihydroxy- og 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracencarboxylsyre-dicarbonater og -urethaner med terapeutisk virkning
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AU8230187A (en)	1988-05-25	N,n'-bis-amino acid-l-cystine-peptide-containing amino acid preparations for oral and parenteral administration
IT9086204A0 (it)	1990-05-31	Metodo per la cura dell'impotenza erettiva maschile
ATE175971T1 (de)	1999-02-15	Wasserlösliche retinoide
MX9205978A (es)	1993-04-01	Nuevas proteinas inhibidoras de trombina de garrapatas.
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NO960048L (no)	1996-03-05	Difluorstaton-analoger
GR3024353T3 (en)	1997-11-28	Glycosyl amides of 2-aminoacylamino-2-deoxy sugars
EP0671935A4 (en)	1997-12-17	AMINIC ACID CONJUGATES OF AMINE CYCLOHEXAPEPTIDES.
ITMI910729V0 (it)	1991-08-02	Orologio di polso incorporato in bracciale in corrispondenza dell'articolazione carpo-radiale
IT8705181A0 (it)	1987-05-22	Limitatore dell'angolo di deviazione per giunti cardanici.
MX9702895A (es)	1997-07-31	Composiciones para el suministro de antigenos.
IT8322398V0 (it)	1983-07-19	Giunto per l'applicazione alle usuali cannucce per bibite, di oggetto decorativi, pubblicitari ed altro.