IT1249677B - Agenti bloccanti neuromuscolari e procedimento di preparazione - Google Patents

Agenti bloccanti neuromuscolari e procedimento di preparazione

Info

Publication number
IT1249677B
IT1249677B ITRM910518A ITRM910518A IT1249677B IT 1249677 B IT1249677 B IT 1249677B IT RM910518 A ITRM910518 A IT RM910518A IT RM910518 A ITRM910518 A IT RM910518A IT 1249677 B IT1249677 B IT 1249677B
Authority
IT
Italy
Prior art keywords
neuromuscular blocking
cis
blocking agents
preparation procedure
geometric
Prior art date
Application number
ITRM910518A
Other languages
English (en)
Inventor
Derek Anthony Hill
Geoffrey Lloyd Turner
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ITRM910518A0 publication Critical patent/ITRM910518A0/it
Publication of ITRM910518A1 publication Critical patent/ITRM910518A1/it
Application granted granted Critical
Publication of IT1249677B publication Critical patent/IT1249677B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Led Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'isomero 1R-cis, 1'R-cis di un sale di 2', 2'-(3, 11-diosso-4, 10-diossatridecilen)-bis-(1, 2, 3, 4-tetraidro-6, 7-dimetossi-2-metil-1-veratrilisochinolinio) sostanzialmente privo di altri suoi isomeri geometrici ed ottici. L'isomero 1R-cis, 1'R-cis ha dimostrato di avere una vantaggiosa combinazione di proprietà farmacologiche, in particolare una maggiore potenza bloccante neuromuscolare, una ridotta potenza di rilascio di istamina e, ad equivalenti livelli di blocco neuromuscolare, minori effetti negativi potenziali sul sistema nervoso autonomo (blocco simpatetico e parasimpatetico). In confronto con il noto miscuglio di isomeri geometrici ed ottici.
ITRM910518A 1990-07-13 1991-07-12 Agenti bloccanti neuromuscolari e procedimento di preparazione IT1249677B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015473A GB9015473D0 (en) 1990-07-13 1990-07-13 Neuromuscular blocking agents

Publications (3)

Publication Number Publication Date
ITRM910518A0 ITRM910518A0 (it) 1991-07-12
ITRM910518A1 ITRM910518A1 (it) 1993-01-12
IT1249677B true IT1249677B (it) 1995-03-09

Family

ID=10679071

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910518A IT1249677B (it) 1990-07-13 1991-07-12 Agenti bloccanti neuromuscolari e procedimento di preparazione

Country Status (40)

Country Link
EP (1) EP0539470B1 (it)
JP (3) JP2823356B2 (it)
KR (1) KR0174284B1 (it)
AT (1) ATE138369T1 (it)
AU (2) AU8190491A (it)
BE (1) BE1003407A3 (it)
CA (1) CA2087104C (it)
CH (1) CH683427A5 (it)
CY (1) CY1985A (it)
CZ (1) CZ284645B6 (it)
DE (2) DE69119768T2 (it)
DK (2) DK0539470T3 (it)
ES (2) ES2083315B1 (it)
FI (2) FI982342A7 (it)
FR (1) FR2665701B1 (it)
GB (2) GB9015473D0 (it)
GE (1) GEP19981163B (it)
GR (1) GR3020792T3 (it)
HK (1) HK80196A (it)
HU (2) HU218766B (it)
IE (1) IE912440A1 (it)
IL (1) IL98814A (it)
IT (1) IT1249677B (it)
LT (1) LT3317B (it)
LU (1) LU88198A1 (it)
LV (1) LV10432B (it)
MX (1) MX9203220A (it)
MY (1) MY113017A (it)
NL (1) NL9120017A (it)
NZ (1) NZ238964A (it)
PA (1) PA8401801A1 (it)
PL (1) PL167302B1 (it)
PT (1) PT98306B (it)
RU (1) RU2104005C1 (it)
SA (1) SA91120073B1 (it)
SE (1) SE9300052D0 (it)
SK (1) SK279907B6 (it)
UA (1) UA32536C2 (it)
WO (1) WO1992000965A1 (it)
ZA (1) ZA915468B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
CN1203061C (zh) 1997-03-25 2005-05-25 艾弗拉药品公司 取代异喹啉类，其制备方法，药物组合物及其制药用途
AU2008222298A1 (en) 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US8293912B2 (en) 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CA2702535A1 (en) 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
IT1396543B1 (it) 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
WO2010128518A2 (en) * 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate
CN107056700A (zh) * 2017-04-18 2017-08-18 哈尔滨医科大学 一种四氢异喹啉类化合物外消旋体的半量拆分法
CN112939862B (zh) * 2021-02-03 2023-01-10 江苏诚信药业有限公司 一种苯磺顺阿曲库铵杂质h的分离制备方法及其应用
CN115850169B (zh) * 2022-10-17 2025-04-04 上海医药集团(本溪)北方药业有限公司 苯磺顺阿曲库铵杂质及其中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
GB1579822A (en) * 1976-10-29 1980-11-26 Wellcome Found Tetrahydroisoquinolinium muscle relaxants
ES454090A1 (es) * 1976-12-09 1978-01-16 Wellcome Found Un metodo para preparar compuestos heterociclicos.
DE3328664A1 (de) * 1983-08-09 1985-02-21 Robert Bosch Gmbh, 7000 Stuttgart Zuckerziehmaschine
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
US9524531B2 (en) 2011-05-09 2016-12-20 Microsoft Technology Licensing, Llc Extensibility features for electronic communications

Also Published As

Publication number Publication date
EP0539470B1 (en) 1996-05-22
IL98814A0 (en) 1992-07-15
ITRM910518A0 (it) 1991-07-12
ES2083315A1 (es) 1996-04-01
SK383392A3 (en) 1999-05-07
GB9224764D0 (en) 1993-02-03
FR2665701A1 (fr) 1992-02-14
AU1134695A (en) 1995-03-30
JP2823356B2 (ja) 1998-11-11
PA8401801A1 (es) 1997-01-03
LV10432B (en) 1995-08-20
IL98814A (en) 1995-12-08
HU218766B (hu) 2000-11-28
PT98306B (pt) 1999-01-29
AU8190491A (en) 1992-02-04
BE1003407A3 (fr) 1992-03-17
MY113017A (en) 2001-11-30
LV10432A (lv) 1995-02-20
DE4191541T1 (de) 1993-05-13
FI982342A0 (fi) 1998-10-28
GB9015473D0 (en) 1990-08-29
LTIP274A (en) 1994-10-25
SE9300052L (sv) 1993-01-12
DK149692A (da) 1992-12-14
HU9300052D0 (en) 1993-04-28
EP0539470A1 (en) 1993-05-05
DK149692D0 (da) 1992-12-14
FI982342L (fi) 1998-10-28
FI103507B1 (fi) 1999-07-15
ZA915468B (en) 1993-03-31
JPH05508648A (ja) 1993-12-02
WO1992000965A1 (en) 1992-01-23
JPH10139763A (ja) 1998-05-26
SA91120073B1 (ar) 2002-10-26
SE9300052D0 (sv) 1993-01-12
FI925894L (fi) 1992-12-28
PL297606A1 (it) 1992-07-13
CA2087104C (en) 1998-08-18
CZ284645B6 (cs) 1999-01-13
NZ238964A (en) 1992-06-25
LT3317B (en) 1995-06-26
GEP19981163B (en) 1998-07-06
HK80196A (en) 1996-05-17
FI103507B (fi) 1999-07-15
CH683427A5 (fr) 1994-03-15
DK0539470T3 (da) 1996-08-05
FI982342A7 (fi) 1998-10-28
ATE138369T1 (de) 1996-06-15
PT98306A (pt) 1992-06-30
RU2104005C1 (ru) 1998-02-10
GB2260763A (en) 1993-04-28
ES2083315B1 (es) 1997-11-16
JP2001058981A (ja) 2001-03-06
GR3020792T3 (en) 1996-11-30
UA32536C2 (uk) 2001-02-15
JP3462165B2 (ja) 2003-11-05
FR2665701B1 (fr) 1995-03-03
ES2088009T3 (es) 1996-08-01
KR0174284B1 (ko) 1999-02-18
IE912440A1 (en) 1992-01-15
NL9120017A (nl) 1993-04-01
DE69119768D1 (de) 1996-06-27
CZ383392A3 (en) 1994-02-16
DE69119768T2 (de) 1996-10-02
HUT67613A (en) 1995-04-28
HU211169A9 (en) 1995-11-28
CY1985A (en) 1997-09-05
AU687481B2 (en) 1998-02-26
SK279907B6 (sk) 1999-05-07
CA2087104A1 (en) 1992-01-14
ITRM910518A1 (it) 1993-01-12
GB2260763B (en) 1994-01-05
LU88198A1 (fr) 1993-05-17
MX9203220A (es) 1992-07-01
FI925894A0 (fi) 1992-12-28
PL167302B1 (en) 1995-08-31

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970730