IT1261386B - Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici. - Google Patents

Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici.

Info

Publication number
IT1261386B
IT1261386B ITTO930974A ITTO930974A IT1261386B IT 1261386 B IT1261386 B IT 1261386B IT TO930974 A ITTO930974 A IT TO930974A IT TO930974 A ITTO930974 A IT TO930974A IT 1261386 B IT1261386 B IT 1261386B
Authority
IT
Italy
Prior art keywords
marking
modified peptides
paramagnetic agents
phosphinic group
phosphinic
Prior art date
Application number
ITTO930974A
Other languages
English (en)
Inventor
Ulderico Mazzi
Fabio Lunghi
Original Assignee
Sorin Biomedica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sorin Biomedica Spa filed Critical Sorin Biomedica Spa
Priority to ITTO930974A priority Critical patent/IT1261386B/it
Publication of ITTO930974A0 publication Critical patent/ITTO930974A0/it
Priority to ES94120079T priority patent/ES2145088T3/es
Priority to EP94120079A priority patent/EP0659764B1/en
Priority to AT94120079T priority patent/ATE190067T1/de
Priority to DE69423192T priority patent/DE69423192T2/de
Publication of ITTO930974A1 publication Critical patent/ITTO930974A1/it
Priority to US08/494,105 priority patent/US5635158A/en
Application granted granted Critical
Publication of IT1261386B publication Critical patent/IT1261386B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Sono descritti peptidi modificati con gruppo fosfinico utili per la marcatura con 99mTc e 186-188Re o agenti paramagnetici per l'impiego di diagnosi e radioterapia; in particolare sono descritti composti chelanti che presentano i set coordinativi PN2X, dove X è -S, -O, COO-, PN3, P2N3 e P2N2.
ITTO930974A 1993-12-21 1993-12-21 Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici. IT1261386B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITTO930974A IT1261386B (it) 1993-12-21 1993-12-21 Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici.
ES94120079T ES2145088T3 (es) 1993-12-21 1994-12-19 Peptidos modificados mediante un grupo fosfino para marcar con tc99m y re186-188 o agentes paramagneticos.
EP94120079A EP0659764B1 (en) 1993-12-21 1994-12-19 Peptides modified by the phosphine group for marking with 99mTC and 186-188Re or paramagnetic agents
AT94120079T ATE190067T1 (de) 1993-12-21 1994-12-19 Peptide modifiziert durch eine phosphin gruppe zur markierung mit 99mtc und 186-188re oder paramagnetische agentien
DE69423192T DE69423192T2 (de) 1993-12-21 1994-12-19 Peptide modifiziert durch eine Phosphin Gruppe zur Markierung mit 99mTC und 186-188Re oder paramagnetische Agentien
US08/494,105 US5635158A (en) 1993-12-21 1995-06-23 Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO930974A IT1261386B (it) 1993-12-21 1993-12-21 Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici.
US08/494,105 US5635158A (en) 1993-12-21 1995-06-23 Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents

Publications (3)

Publication Number Publication Date
ITTO930974A0 ITTO930974A0 (it) 1993-12-21
ITTO930974A1 ITTO930974A1 (it) 1995-06-21
IT1261386B true IT1261386B (it) 1996-05-20

Family

ID=26332240

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO930974A IT1261386B (it) 1993-12-21 1993-12-21 Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici.

Country Status (6)

Country Link
US (1) US5635158A (it)
EP (1) EP0659764B1 (it)
AT (1) ATE190067T1 (it)
DE (1) DE69423192T2 (it)
ES (1) ES2145088T3 (it)
IT (1) IT1261386B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5855867A (en) * 1995-03-29 1999-01-05 The Curators Of The University Of Missouri Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
EP1799273A2 (en) * 2004-10-07 2007-06-27 Koninklijke Philips Electronics N.V. Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy
US20080274057A1 (en) * 2005-10-04 2008-11-06 Koninklijke Philips Electronics, N.V. Staudinger Reaction in Imaging and Therapy and Kits for Use in Imaging and Therapy
WO2010057220A1 (en) 2008-11-17 2010-05-20 Wisconsin Alumni Research Foundation Preparation of diazo and diazonium compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
GB9116925D0 (en) * 1991-08-06 1991-09-18 Antisoma Ltd Novel reagent for tumour imaging and therapy
WO1993008839A1 (en) * 1991-11-08 1993-05-13 Curators Of The University Of Missouri Multifunctional ligands for potential use in the design of therapeutic or diagnostic radiopharmaceutical imaging agents

Also Published As

Publication number Publication date
DE69423192D1 (de) 2000-04-06
ATE190067T1 (de) 2000-03-15
EP0659764A2 (en) 1995-06-28
ITTO930974A1 (it) 1995-06-21
ES2145088T3 (es) 2000-07-01
EP0659764A3 (en) 1996-10-16
DE69423192T2 (de) 2000-07-06
EP0659764B1 (en) 2000-03-01
ITTO930974A0 (it) 1993-12-21
US5635158A (en) 1997-06-03

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961231