ATE190067T1 - Peptide modifiziert durch eine phosphin gruppe zur markierung mit 99mtc und 186-188re oder paramagnetische agentien - Google Patents

Peptide modifiziert durch eine phosphin gruppe zur markierung mit 99mtc und 186-188re oder paramagnetische agentien

Info

Publication number
ATE190067T1
ATE190067T1 AT94120079T AT94120079T ATE190067T1 AT E190067 T1 ATE190067 T1 AT E190067T1 AT 94120079 T AT94120079 T AT 94120079T AT 94120079 T AT94120079 T AT 94120079T AT E190067 T1 ATE190067 T1 AT E190067T1
Authority
AT
Austria
Prior art keywords
99mtc
labeling
phosphine group
paramagnetic agents
peptides modified
Prior art date
Application number
AT94120079T
Other languages
English (en)
Inventor
Ulderico Mazzi
Fabio Lunghi
Original Assignee
Nycomed Amersham Sorin S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Amersham Sorin S R L filed Critical Nycomed Amersham Sorin S R L
Application granted granted Critical
Publication of ATE190067T1 publication Critical patent/ATE190067T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94120079T 1993-12-21 1994-12-19 Peptide modifiziert durch eine phosphin gruppe zur markierung mit 99mtc und 186-188re oder paramagnetische agentien ATE190067T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO930974A IT1261386B (it) 1993-12-21 1993-12-21 Peptidi modificati con gruppo fosfinico per la marcatura con 99m-tc e 186-188-re o agenti paramagnetici.
US08/494,105 US5635158A (en) 1993-12-21 1995-06-23 Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents

Publications (1)

Publication Number Publication Date
ATE190067T1 true ATE190067T1 (de) 2000-03-15

Family

ID=26332240

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94120079T ATE190067T1 (de) 1993-12-21 1994-12-19 Peptide modifiziert durch eine phosphin gruppe zur markierung mit 99mtc und 186-188re oder paramagnetische agentien

Country Status (6)

Country Link
US (1) US5635158A (de)
EP (1) EP0659764B1 (de)
AT (1) ATE190067T1 (de)
DE (1) DE69423192T2 (de)
ES (1) ES2145088T3 (de)
IT (1) IT1261386B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5855867A (en) * 1995-03-29 1999-01-05 The Curators Of The University Of Missouri Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
EP1809339A2 (de) * 2004-10-07 2007-07-25 Koninklijke Philips Electronics N.V. Verbindungen, kits und verfahren zur verwendung in der medizinischen bilddarstellung
WO2007039864A2 (en) * 2005-10-04 2007-04-12 Koninklijke Philips Electronics N.V. The staudinger reaction in imaging and therapy and kits for use in imaging and therapy
US8350014B2 (en) 2008-11-17 2013-01-08 Wisconsin Alumni Research Foundation Preparation of diazo and diazonium compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
GB9116925D0 (en) * 1991-08-06 1991-09-18 Antisoma Ltd Novel reagent for tumour imaging and therapy
WO1993008839A1 (en) * 1991-11-08 1993-05-13 Curators Of The University Of Missouri Multifunctional ligands for potential use in the design of therapeutic or diagnostic radiopharmaceutical imaging agents

Also Published As

Publication number Publication date
DE69423192D1 (de) 2000-04-06
EP0659764A2 (de) 1995-06-28
US5635158A (en) 1997-06-03
ITTO930974A1 (it) 1995-06-21
ES2145088T3 (es) 2000-07-01
IT1261386B (it) 1996-05-20
DE69423192T2 (de) 2000-07-06
EP0659764A3 (de) 1996-10-16
ITTO930974A0 (it) 1993-12-21
EP0659764B1 (de) 2000-03-01

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties