IT1270846B - Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica. - Google Patents

Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.

Info

Publication number
IT1270846B
IT1270846B ITBO930205A ITBO930205A IT1270846B IT 1270846 B IT1270846 B IT 1270846B IT BO930205 A ITBO930205 A IT BO930205A IT BO930205 A ITBO930205 A IT BO930205A IT 1270846 B IT1270846 B IT 1270846B
Authority
IT
Italy
Prior art keywords
sulodexide
contain
treatment
diabetic nephropathy
specialties
Prior art date
Application number
ITBO930205A
Other languages
English (en)
Inventor
Egidio Marchi
Gianfranco Tamagnone
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO930205A0 publication Critical patent/ITBO930205A0/it
Priority to ITBO930205A priority Critical patent/IT1270846B/it
Priority to CA002120062A priority patent/CA2120062C/en
Priority to US08/227,502 priority patent/US5496807A/en
Priority to JP6091713A priority patent/JP2702400B2/ja
Priority to KR1019940009102A priority patent/KR0165567B1/ko
Priority to ES94107051T priority patent/ES2152272T3/es
Priority to AT94107051T priority patent/ATE198278T1/de
Priority to DK94107051T priority patent/DK0624374T3/da
Priority to EP94107051A priority patent/EP0624374B1/en
Priority to DE69426471T priority patent/DE69426471T2/de
Priority to PT94107051T priority patent/PT624374E/pt
Publication of ITBO930205A1 publication Critical patent/ITBO930205A1/it
Application granted granted Critical
Publication of IT1270846B publication Critical patent/IT1270846B/it
Priority to GR20010400047T priority patent/GR3035231T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'oggetto della presente invenzione è costituito dall'uso di sulodexide, glicosaminoglicano di origine naturale estratto da mucosa intestinale di mammifero, e di specialità medicinali che lo contengono nel trattamento di pazienti affetti da nefropatia di origine diabetica.L'efficacia del sulodexide è stata dimostrata dalla significativa diminuzione dell'albumina in pazienti diabetici microalbuminurici trattati con composizioni farmaceutiche somministrate per via orale contenenti quantità terapeuticamente efficaci di farmaco;/
ITBO930205A 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica. IT1270846B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITBO930205A IT1270846B (it) 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
CA002120062A CA2120062C (en) 1993-05-10 1994-03-28 Use of sulodexide and of medicines containing it in the treatment of diabetic nephropathy
US08/227,502 US5496807A (en) 1993-05-10 1994-04-14 Method of treatment of diabetic nephropathy by means of sulodexide of medicines containing it
JP6091713A JP2702400B2 (ja) 1993-05-10 1994-04-28 糖尿病性腎症治療用スロデキサイド含有医薬
KR1019940009102A KR0165567B1 (ko) 1993-05-10 1994-04-28 술로덱사이드를 함유하는 당뇨성 신장병증 치료약
AT94107051T ATE198278T1 (de) 1993-05-10 1994-05-05 Verwendung von sulodexid und von arzneimitteln, die dieses enthalten, zur behandlung der diabetischen nephropathie
ES94107051T ES2152272T3 (es) 1993-05-10 1994-05-05 Uso de sulodexide y de medicamentos que lo contienen para el tratamiento de la nefropatia diabetica.
DK94107051T DK0624374T3 (da) 1993-05-10 1994-05-05 Anvendelse af sulodexid og medicin, som indeholder dette, til behandlingen af diabetisk nephropati
EP94107051A EP0624374B1 (en) 1993-05-10 1994-05-05 Use of sulodexide and of medicines containing it for the treatment of diabetic nephropathy
DE69426471T DE69426471T2 (de) 1993-05-10 1994-05-05 Verwendung von Sulodexid und von Arzneimitteln, die dieses enthalten, zur Behandlung der diabetischen Nephropathie
PT94107051T PT624374E (pt) 1993-05-10 1994-05-05 Utilizacao de sulodexida e de medicamentos que contem tal composto para o tratamento de nefropatia diabetica
GR20010400047T GR3035231T3 (en) 1993-05-10 2001-01-11 Use of sulodexide and of medicines containing it for the treatment of diabetic nephropathy.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO930205A IT1270846B (it) 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.

Publications (3)

Publication Number Publication Date
ITBO930205A0 ITBO930205A0 (it) 1993-05-10
ITBO930205A1 ITBO930205A1 (it) 1994-11-10
IT1270846B true IT1270846B (it) 1997-05-13

Family

ID=11339016

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO930205A IT1270846B (it) 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.

Country Status (12)

Country Link
US (1) US5496807A (it)
EP (1) EP0624374B1 (it)
JP (1) JP2702400B2 (it)
KR (1) KR0165567B1 (it)
AT (1) ATE198278T1 (it)
CA (1) CA2120062C (it)
DE (1) DE69426471T2 (it)
DK (1) DK0624374T3 (it)
ES (1) ES2152272T3 (it)
GR (1) GR3035231T3 (it)
IT (1) IT1270846B (it)
PT (1) PT624374E (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274351B (it) * 1994-10-06 1997-07-17 Alfa Wassermann Spa Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
IT1299969B1 (it) * 1998-04-15 2000-04-04 Alfa Wassermann Spa Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della retinopatia diabetica.
IL127896A0 (en) * 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US20030013680A1 (en) * 2001-06-12 2003-01-16 Keryx Methods using glycosaminoglycans for the treatment of nephropathy
EP1804810A4 (en) * 2004-10-01 2008-02-27 Keryx Biopharmaceuticals Inc METHODS OF TREATING RENALE DISEASE USING GLYCOSAMINOGLYCANS
US8029829B2 (en) 2005-02-03 2011-10-04 Taiyo Kagaku Co., Ltd. Preventive, relieving or therapeutic composition for diabetes mellitus and/or diabetic nephropathy
JP2008540448A (ja) * 2005-05-05 2008-11-20 ケリク ビオファルマセウチカルス インコーポレーテッド 糖尿病性腎症の治療において、スロデキシド及び血圧低下薬を用いた併用療法
MX2008008213A (es) * 2005-12-22 2008-09-03 Neurochem Int Ltd Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias.
WO2008016171A1 (en) * 2006-08-04 2008-02-07 Ajinomoto Co., Inc. Prophylactic/therapeutic agent for renal dysfunction
WO2008070778A2 (en) * 2006-12-06 2008-06-12 Nephrogenex Inc. Pyridoxamine and low molecular weight heparinoids for diabetic kidney disease
EP2120905A1 (en) * 2006-12-22 2009-11-25 BELLUS Health (International) Limited Methods, compounds, and compositions for treating metabolic disorders and diabetes
CN101632686A (zh) * 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
MX2011011757A (es) 2009-05-04 2012-01-25 Prometic Biosciences Inc Compuestos aromaticos substituidos y usos farmaceuticos.
US9475750B2 (en) 2010-10-27 2016-10-25 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
CN112930171B (zh) 2018-07-13 2023-01-03 迈阿密大学 治疗肾脏障碍的方法
US20200085810A1 (en) 2018-07-26 2020-03-19 Hoffmann-La Roche Inc. Compounds for use in treating kidney disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245761B (it) * 1991-01-30 1994-10-14 Alfa Wassermann Spa Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
IT1245907B (it) * 1991-05-17 1994-10-25 Alfa Wassermann Spa Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.

Also Published As

Publication number Publication date
EP0624374B1 (en) 2000-12-27
ES2152272T3 (es) 2001-02-01
ITBO930205A0 (it) 1993-05-10
ATE198278T1 (de) 2001-01-15
DE69426471T2 (de) 2001-05-03
DK0624374T3 (da) 2001-01-29
EP0624374A1 (en) 1994-11-17
ITBO930205A1 (it) 1994-11-10
PT624374E (pt) 2001-04-30
GR3035231T3 (en) 2001-04-30
KR0165567B1 (ko) 1999-01-15
JP2702400B2 (ja) 1998-01-21
DE69426471D1 (de) 2001-02-01
JPH06329541A (ja) 1994-11-29
CA2120062A1 (en) 1994-11-11
CA2120062C (en) 1999-05-25
US5496807A (en) 1996-03-05

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970423