IT1274351B - Uso di alcuni glicosaminoglicani nella dialisi peritoneale. - Google Patents

Uso di alcuni glicosaminoglicani nella dialisi peritoneale.

Info

Publication number: IT1274351B
Authority: IT; Italy
Prior art keywords: peritoneal; sulodexide; subjected; molecular weight; low molecular
Prior art date: 1994-10-06

Application number

ITBO940436A

Other languages

English (en)

Inventor

Bruno Baggio

Giorgio Bazzato

Agostino Fracasso

Giovanni Gambaro

Egidio Marchi

Gianfranco Tamagnone

Original Assignee

Alfa Wassermann Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-06

Filing date

1994-10-06

Publication date

1997-07-17

1994-10-06 Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa

1994-10-06 Publication of ITBO940436A0 publication Critical patent/ITBO940436A0/it

1994-10-06 Priority to ITBO940436A priority Critical patent/IT1274351B/it

1995-09-04 Priority to DE69521388T priority patent/DE69521388T2/de

1995-09-04 Priority to EP95113868A priority patent/EP0710483B1/en

1995-09-04 Priority to AT95113868T priority patent/ATE202282T1/de

1995-09-04 Priority to DK95113868T priority patent/DK0710483T3/da

1995-09-04 Priority to PT95113868T priority patent/PT710483E/pt

1995-09-04 Priority to ES95113868T priority patent/ES2157277T3/es

1995-09-19 Priority to US08/530,597 priority patent/US5686432A/en

1996-04-06 Publication of ITBO940436A1 publication Critical patent/ITBO940436A1/it

1997-07-17 Application granted granted Critical

1997-07-17 Publication of IT1274351B publication Critical patent/IT1274351B/it

2001-06-29 Priority to GR20010401009T priority patent/GR3036158T3/el

Links

238000000502 dialysis Methods 0.000 title abstract 2
GRYSXUXXBDSYRT-WOUKDFQISA-N (2r,3r,4r,5r)-2-(hydroxymethyl)-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol Chemical compound C1=NC=2C(NC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OC GRYSXUXXBDSYRT-WOUKDFQISA-N 0.000 abstract 2
229920000439 Sulodexide Polymers 0.000 abstract 2
208000020832 chronic kidney disease Diseases 0.000 abstract 2
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 abstract 2
238000007912 intraperitoneal administration Methods 0.000 abstract 2
229960003491 sulodexide Drugs 0.000 abstract 2
229920000045 Dermatan sulfate Polymers 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
241000700159 Rattus Species 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
229940109239 creatinine Drugs 0.000 abstract 1
AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 1
229940051593 dermatan sulfate Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003055 low molecular weight heparin Substances 0.000 abstract 1
229940127215 low-molecular weight heparin Drugs 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000032258 transport Effects 0.000 abstract 1
238000000108 ultra-filtration Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Cell Biology (AREA)
Immunology (AREA)
Physiology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Developmental Biology & Embryology (AREA)
Nutrition Science (AREA)
Virology (AREA)
Zoology (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
External Artificial Organs (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ITBO940436A 1994-10-06 1994-10-06 Uso di alcuni glicosaminoglicani nella dialisi peritoneale. IT1274351B (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
ITBO940436A IT1274351B (it)	1994-10-06	1994-10-06	Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
DK95113868T DK0710483T3 (da)	1994-10-06	1995-09-04	Anvendelse af visse glycosaminoglycaner til fremstillingen af et lægemiddel til behandlingen af kronisk nyresvigt
EP95113868A EP0710483B1 (en)	1994-10-06	1995-09-04	Use of some glycosaminoglycans for the manufacture of a medicament for the treatment of chronic renal failure
AT95113868T ATE202282T1 (de)	1994-10-06	1995-09-04	Verwendung von glycosaminoglycanen zur herstellung eines arzneimittels zur behandlung des chronischen nierenversagens
DE69521388T DE69521388T2 (de)	1994-10-06	1995-09-04	Verwendung von Glycosaminoglycanen zur Herstellung eines Arzneimittels zur Behandlung des chronischen Nierenversagens
PT95113868T PT710483E (pt)	1994-10-06	1995-09-04	Utilizacao de alguns glicosaminoglicanos para a producao de um medicamento para o tratamento da insuficiencia renal cronica
ES95113868T ES2157277T3 (es)	1994-10-06	1995-09-04	Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica.
US08/530,597 US5686432A (en)	1994-10-06	1995-09-19	Use of some glycosaminoglycans in the peritoneal dialysis
GR20010401009T GR3036158T3 (en)	1994-10-06	2001-06-29	Use of some glycosaminoglycans for the manufacture of a medicament for the treatment of chronic renal failure

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITBO940436A IT1274351B (it)	1994-10-06	1994-10-06	Uso di alcuni glicosaminoglicani nella dialisi peritoneale.

Publications (3)

Publication Number	Publication Date
ITBO940436A0 ITBO940436A0 (it)	1994-10-06
ITBO940436A1 ITBO940436A1 (it)	1996-04-06
IT1274351B true IT1274351B (it)	1997-07-17

Family

ID=11340040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITBO940436A IT1274351B (it)	1994-10-06	1994-10-06	Uso di alcuni glicosaminoglicani nella dialisi peritoneale.

Country Status (9)

Country	Link
US (1)	US5686432A (it)
EP (1)	EP0710483B1 (it)
AT (1)	ATE202282T1 (it)
DE (1)	DE69521388T2 (it)
DK (1)	DK0710483T3 (it)
ES (1)	ES2157277T3 (it)
GR (1)	GR3036158T3 (it)
IT (1)	IT1274351B (it)
PT (1)	PT710483E (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL127896A0 (en) *	1998-12-31	1999-10-28	Gail Laster	A novel treatment for preeclampsia and related diseases
EP1192187A1 (en) *	1999-06-30	2002-04-03	Hamilton Civic Hospitals Research Development, Inc.	Heparin compositions that inhibit clot associated coagulation factors
ITMI991503A1 (it) *	1999-07-08	2001-01-08	Bidifarm S R L	Uso di metaboliti oligosaccaridici di proteoglicani come maker in fluidi biologici di diagnosi del biabete e delle complicanze patologiche c
US7259152B2 (en) *	2000-06-07	2007-08-21	Alfa Wasserman, Inc.	Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US20040038932A1 (en) *	2000-09-08	2004-02-26	Jack Hirsh	Antithrombotic compositions
US20030008844A1 (en) *	2001-05-17	2003-01-09	Keryx Biopharmaceuticals, Inc.	Use of sulodexide for the treatment of inflammatory bowel disease
EP1406640A2 (en) *	2001-06-12	2004-04-14	Keryx Biopharmceuticals Inc.	Use of glycosaminoglycans for the treatment of hiv-associated nephropathy
PE20030263A1 (es) *	2001-07-31	2003-04-17	Novartis Ag	Composicion farmaceutica oftalmica
US8367731B2 (en)	2005-05-30	2013-02-05	Fresenius Medical Care Deutschland Gmbh	Peritoneal dialysis fluid
ES2352801T3 (es)	2005-12-22	2011-02-23	Kiacta Sàrl	Tratamiento de nefropatía diabética.
US20070155672A1 (en) *	2006-01-05	2007-07-05	Markus Voges	Sterilized peritoneal dialysis solutions containing heparin
JP5320296B2 (ja) *	2007-10-01	2013-10-23	生化学工業株式会社	新規な低分子化コンドロイチン硫酸およびその用途
CN101632686A (zh) *	2008-04-04	2010-01-27	马斯特里赫特大学	糖胺聚糖用于修复糖萼的用途
IT1401253B1 (it)	2010-04-23	2013-07-18	Uni Degli Studi Carlo Bo Urbino	Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1245907B (it) *	1991-05-17	1994-10-25	Alfa Wassermann Spa	Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.
IT1270846B (it) *	1993-05-10	1997-05-13	Alfa Wassermann Spa	Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
PL177245B1 (pl) *	1993-09-30	1999-10-29	Seikagaku Kogyo Co Ltd	Środek przeciwzakrzepowy

1994
- 1994-10-06 IT ITBO940436A patent/IT1274351B/it active IP Right Grant
1995
- 1995-09-04 PT PT95113868T patent/PT710483E/pt unknown
- 1995-09-04 DE DE69521388T patent/DE69521388T2/de not_active Expired - Lifetime
- 1995-09-04 EP EP95113868A patent/EP0710483B1/en not_active Expired - Lifetime
- 1995-09-04 AT AT95113868T patent/ATE202282T1/de active
- 1995-09-04 DK DK95113868T patent/DK0710483T3/da active
- 1995-09-04 ES ES95113868T patent/ES2157277T3/es not_active Expired - Lifetime
- 1995-09-19 US US08/530,597 patent/US5686432A/en not_active Expired - Lifetime
2001
- 2001-06-29 GR GR20010401009T patent/GR3036158T3/el unknown

Also Published As

Publication number	Publication date
EP0710483A1 (en)	1996-05-08
DE69521388T2 (de)	2001-10-11
EP0710483B1 (en)	2001-06-20
ITBO940436A0 (it)	1994-10-06
ITBO940436A1 (it)	1996-04-06
DK0710483T3 (da)	2001-09-03
US5686432A (en)	1997-11-11
ATE202282T1 (de)	2001-07-15
DE69521388D1 (de)	2001-07-26
GR3036158T3 (en)	2001-09-28
PT710483E (pt)	2001-09-28
ES2157277T3 (es)	2001-08-16

Legal Events

Date	Code	Title	Description
1997-07-17	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970716

Publication	Publication Date	Title
IT1274351B (it)	1997-07-17	Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
Taylor et al.	1991	Erythropoietin and spontaneous platelet aggregation in haemodialysis patients
Malorca et al.	1989	Is CAPD competitive with haemodialysis for long-term treatment of uraemic patients?
Khan et al.	1996	Hypokalemia in peritoneal dialysis patients
Mistry et al.	1990	Kinetic and Clinical Studies of β2Microglobulin in Continuous Ambulatory Peritoneal Dialysis: Influence of Renal and Enhanced Peritoneal Clearances Using Glucose Polymer
Falk et al.	1983	Iron removal during continuous ambulatory peritoneal dialysis using deferoxamine
IT9040161A0 (it)	1990-12-07	Impianto ad alto rendimento per la attuazione di emodialisi, emofiltrazione plasmaferesi, emodiafiltrazione
Odlind et al.	1980	Diuretic resistance: reduced bioavailability and effect of oral frusemide
Silvester et al.	1998	Continuous versus intermittent renal replacement theory in the critically ill
Wynckel et al.	1991	Guidelines to the use of enoxaparin in slow continuous hemodialysis
Gross et al.	1983	Ceftizoxime elimination kinetics in continuous ambulatory peritoneal dialysis
Koup et al.	1986	Ceftriaxone pharmacokinetics during peritoneal dialysis
Wise et al.	1985	The pharmacokinetics of cefotaxime and ceftriaxone in renal and hepatic dysfunction
Nensel et al.	1994	Dialyzer permeability for low-molecular-weight proteins: comparison between polysulfone, polyamide and cuprammonium-rayon dialyzers
Schrader et al.	1986	Long-term intraperitoneal application of low molecular weight heparin in a continuous ambulatory peritoneal dialysis patient with deep vein thrombosis
Brown et al.	1981	Peritoneal clearance of theophylline
Kessler et al.	1992	Dialysis pruritus and sensitization
Banyai et al.	2000	Pharmacokinetics of cefpirome during continuous venovenous hemofiltration: Rationale for an 8‐hour dosing interval
Haag-Weber et al.	1989	Neutrophil activation during hemodialysis
Hyneck et al.	1981	Cimetidine clearance during intermittent and chronic peritoneal dialysis
Von Herrath et al.	1988	Good biocompatibility of the polyamide hemofilter
Albertioni et al.	1994	Protein binding of 2-chloro 2′-deoxyadenosine (cladribine) in healthy subjects and in patients with leukaemia
RU96113786A (ru)	1999-02-20	Антикоагулянтное средство
LEE et al.	1997	Clinical Significances of Scrum Protein C and S in Chronic Renal Failure
Leichter et al.	1990	The optimal dialysis regimen for children Undergoing different continuous cycling peritoneal dialysis protocols