IT1271421B - Derivati di tioalchiltio carbacefalosporina e loro uso come antibiotici - Google Patents

Derivati di tioalchiltio carbacefalosporina e loro uso come antibiotici

Info

Publication number
IT1271421B
IT1271421B ITMI932073A ITMI932073A IT1271421B IT 1271421 B IT1271421 B IT 1271421B IT MI932073 A ITMI932073 A IT MI932073A IT MI932073 A ITMI932073 A IT MI932073A IT 1271421 B IT1271421 B IT 1271421B
Authority
IT
Italy
Prior art keywords
thioalkyltio
carbacephalosporin
antibiotics
derivatives
acyl
Prior art date
Application number
ITMI932073A
Other languages
English (en)
Inventor
Kubota Tadatoshi
Kume Masaharu
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of ITMI932073A0 publication Critical patent/ITMI932073A0/it
Publication of ITMI932073A1 publication Critical patent/ITMI932073A1/it
Application granted granted Critical
Publication of IT1271421B publication Critical patent/IT1271421B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composto della formula I: (FORMULA I) in cui Acil è C1-C12 acile; Het è un gruppo eteroaromatico monociclico opzionalmente sostituito contenente uno o più etero atomi; R1 è un legame singolo o un C1-C4 alchilene; R2 è un C1-C4 alchilene lineare o ramificato; e Y è un atomo di idrogeno o un gruppo metossi, o un sale farmaceuticamente accettabile o un derivato protetto con ammino, carbossi e/o idrossi protetto, che ha una potente attività antibiotica.
ITMI932073A 1992-09-30 1993-09-29 Derivati di tioalchiltio carbacefalosporina e loro uso come antibiotici IT1271421B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26147892A JP3238209B2 (ja) 1992-09-30 1992-09-30 チオメチルチオカルバセファロスポリン誘導体

Publications (3)

Publication Number Publication Date
ITMI932073A0 ITMI932073A0 (it) 1993-09-29
ITMI932073A1 ITMI932073A1 (it) 1995-03-29
IT1271421B true IT1271421B (it) 1997-05-28

Family

ID=17362465

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI932073A IT1271421B (it) 1992-09-30 1993-09-29 Derivati di tioalchiltio carbacefalosporina e loro uso come antibiotici

Country Status (8)

Country Link
US (1) US5362724A (it)
JP (1) JP3238209B2 (it)
BE (1) BE1007544A3 (it)
CH (1) CH687205A5 (it)
ES (1) ES2103222B1 (it)
FR (1) FR2696179B1 (it)
GB (1) GB2271564B (it)
IT (1) IT1271421B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0133937B1 (ko) * 1989-02-22 1998-04-18 말키 예후다 상이 박힌 비누 제조방법
US5565445A (en) * 1995-02-22 1996-10-15 Merck & Co., Inc. 3-thioheteroaryl 1-carba-1-dethiacephalosporin compounds, compositions and methods of use
CN101835777A (zh) 2007-10-25 2010-09-15 尔察祯有限公司 碳头孢烯β-内酰胺抗生素
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics
WO2010030811A2 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. CARBACEPHEM β-LACTAM ANTIBIOTICS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA766941B (en) * 1975-11-21 1978-06-28 Merck & Co Inc 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd ３位置換カルバセフエム化合物
JPH0653739B2 (ja) * 1984-11-15 1994-07-20 協和醗酵工業株式会社 ３位置換カルバセフエム化合物
DE3803169A1 (de) * 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
IE65926B1 (en) * 1990-07-19 1995-11-29 Shionogi & Co Thioalkylthio cephalosporin derivatives
US5077287A (en) * 1991-01-18 1991-12-31 Eli Lilly And Company 3-thiazolylthio carbacephem antibacterial agents

Also Published As

Publication number Publication date
CH687205A5 (fr) 1996-10-15
ITMI932073A0 (it) 1993-09-29
FR2696179B1 (fr) 1996-01-05
GB9319338D0 (en) 1993-11-03
JPH06107660A (ja) 1994-04-19
FR2696179A1 (fr) 1994-04-01
ES2103222B1 (es) 1998-06-16
BE1007544A3 (fr) 1995-08-01
GB2271564A (en) 1994-04-20
GB2271564B (en) 1996-03-06
ITMI932073A1 (it) 1995-03-29
US5362724A (en) 1994-11-08
ES2103222A1 (es) 1997-09-01
JP3238209B2 (ja) 2001-12-10

Similar Documents

Publication Publication Date Title
NO20013379D0 (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
YU49312B (sh) Kristalni hidratni derivati 3,4,4-trisupstituisanih - peperidinil-n-alkilkarboksilata, njihovi intermedijari i postupak za dobijanje
TR200200129T2 (tr) Hepatit C inhibitörü tri-peptidler
ATE204275T1 (de) Indolderivate als 5-ht1-like agonisten
NO20014317D0 (no) Pyrimidinforbindelser
EA200000683A1 (ru) Производные ряда 4-(2-кето-1-бензимидазолинил)пиперидина в качестве агонистов orl1-рецептора
ATE211139T1 (de) Tetrahydroimidazopyridoindoldione als cgmp spezifische pde hemmer
TR200200099T2 (tr) Th2 farklılaşma inhibitörleri
EA004302B9 (ru) β-КАРБОЛИНОВЫЕ ЛЕКАРСТВЕННЫЕ ПРОДУКТЫ
PT1086178E (pt) Antraquinona e seus derivados
NO20020176D0 (no) Sykliske peptidderivater som inhibitorer for intergrin <alfa>v<beta>6
IL163625A0 (en) Alkoxy-pyridine derivatives and pharmaceutical compositions containing the same
CA2047347A1 (en) Thioalkylthio cephalosporins derivatives
CO4750666A1 (es) Compuestos de 7-acilamino-3-(imino)metil cefalosporina utiles como antibioticos
GEP20053626B (en) Substituted 8-Arylquinoline Phosphodiesterase-4 Inhibitors, Pharmaceutical Composition Containing Them and Use Thereof
CO5560589A2 (es) 6,7-dihidro-5h-pirazol[1,2-a]pirazol-1-onas que controlan citosinas inflamatorias
DE69834271D1 (de) Steroid-3-o-sulfamat-derivate als estronsulfatase-hemmer
IT1301968B1 (it) Derivati di eritromicina ad attivita' antibiotica
TR199800813T2 (xx) Nitrik oksit sintaz�n�n �nleyicileri olarak amidin, isot�re t�revleri.
KR920701240A (ko) 글루타티온 유도체
MXPA04009421A (es) Compuestos de tiazol-2-ilimina como inhibidores de la pde-7.
ES2072386T3 (es) Derivados del penciclovir para el tratamiento de las infecciones de hepatitis-b.
HUP9800550A2 (hu) Benzotiofénszármazékok alkalmazása környezeti ösztrogének inhibiálására szolgáló gyógyszerkészítmények előállítására
DK113289A (da) Cephemforbindelser
ES2103222A1 (es) Derivados tioalquiltiocarbacefalosporina.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970926