IT1276207B1 - Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone - Google Patents
Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattoneInfo
- Publication number
- IT1276207B1 IT1276207B1 IT95RM000652A ITRM950652A IT1276207B1 IT 1276207 B1 IT1276207 B1 IT 1276207B1 IT 95RM000652 A IT95RM000652 A IT 95RM000652A IT RM950652 A ITRM950652 A IT RM950652A IT 1276207 B1 IT1276207 B1 IT 1276207B1
- Authority
- IT
- Italy
- Prior art keywords
- butyrolactone
- gamma
- hydroxy
- procedure
- preparation
- Prior art date
Links
- FUDDLSHBRSNCBV-UHFFFAOYSA-N (+)-(R)-3-hydroxytetrahydrofuranone Natural products OC1COC(=O)C1 FUDDLSHBRSNCBV-UHFFFAOYSA-N 0.000 abstract 1
- FUDDLSHBRSNCBV-VKHMYHEASA-N (4s)-4-hydroxyoxolan-2-one Chemical compound O[C@@H]1COC(=O)C1 FUDDLSHBRSNCBV-VKHMYHEASA-N 0.000 abstract 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- PHIQHXFUZVPYII-LURJTMIESA-N (S)-carnitine Chemical compound C[N+](C)(C)C[C@@H](O)CC([O-])=O PHIQHXFUZVPYII-LURJTMIESA-N 0.000 abstract 1
- 229960001518 levocarnitine Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Seasonings (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95RM000652A IT1276207B1 (it) | 1995-09-29 | 1995-09-29 | Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone |
| CA002181012A CA2181012A1 (en) | 1995-09-29 | 1996-07-11 | Process for the preparation of (s)-.beta.-hydroxy-gamma-butyrolactone |
| US08/678,684 US5714619A (en) | 1995-09-29 | 1996-07-11 | Process for the preparation of (S)-β-hydroxy-γ-butyrolactone |
| EP96111567A EP0765876B1 (en) | 1995-09-29 | 1996-07-18 | Process for the preparation of (s)-beta-hydroxy-gamma-butyrolactone |
| DK96111567T DK0765876T3 (da) | 1995-09-29 | 1996-07-18 | Fremgangsmåde til fremstilling af (S)-beta-hydroxy-gamma-butyrolacton |
| ES96111567T ES2126969T3 (es) | 1995-09-29 | 1996-07-18 | Procedimiento para la preparacion de (s)-beta-hidroxi-gamma-butirolactona. |
| DE69601116T DE69601116T2 (de) | 1995-09-29 | 1996-07-18 | Verfahren zur Herstellung von (s)-Beta-hydroxy-gamma-butirolactone |
| AT96111567T ATE174333T1 (de) | 1995-09-29 | 1996-07-18 | Verfahren zur herstellung von (s)-beta-hydroxy- gamma-butirolactone |
| KR1019960029667A KR100407645B1 (ko) | 1995-09-29 | 1996-07-23 | (S)-β-하이드록시-γ-부티로락톤의제조방법 |
| JP20355396A JP4012588B2 (ja) | 1995-09-29 | 1996-08-01 | (S)−β−ヒドロキシ−γ−ブチロラクトンの製法 |
| ZA968127A ZA968127B (en) | 1995-09-29 | 1996-09-27 | Process for the preparation of (s)-beta-hydroxy-gamma-butyrolactone |
| GR990400632T GR3029537T3 (en) | 1995-09-29 | 1999-03-01 | Process for the preparation of (s)-beta-hydroxy-gamma-butyrolactone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95RM000652A IT1276207B1 (it) | 1995-09-29 | 1995-09-29 | Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM950652A0 ITRM950652A0 (it) | 1995-09-29 |
| ITRM950652A1 ITRM950652A1 (it) | 1997-03-29 |
| IT1276207B1 true IT1276207B1 (it) | 1997-10-27 |
Family
ID=11403592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95RM000652A IT1276207B1 (it) | 1995-09-29 | 1995-09-29 | Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5714619A (it) |
| EP (1) | EP0765876B1 (it) |
| JP (1) | JP4012588B2 (it) |
| KR (1) | KR100407645B1 (it) |
| AT (1) | ATE174333T1 (it) |
| CA (1) | CA2181012A1 (it) |
| DE (1) | DE69601116T2 (it) |
| DK (1) | DK0765876T3 (it) |
| ES (1) | ES2126969T3 (it) |
| GR (1) | GR3029537T3 (it) |
| IT (1) | IT1276207B1 (it) |
| ZA (1) | ZA968127B (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1297120B1 (it) * | 1997-12-16 | 1999-08-03 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina |
| US7183423B1 (en) | 1998-12-11 | 2007-02-27 | Daicel Chemical Industries, Ltd. | Process for the preparation of organic compounds with imide catalysts |
| KR20000065995A (ko) * | 1999-04-12 | 2000-11-15 | 박영구 | 키랄 3-히드록시-γ-부티로락톤의 제조방법 |
| CN104961711B (zh) * | 2015-07-23 | 2017-03-08 | 沧州那瑞化学科技有限公司 | (s)‑3‑羟基四氢呋喃和(r)‑3‑羟基四氢呋喃的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3087325B2 (ja) * | 1991-02-21 | 2000-09-11 | チッソ株式会社 | 光学活性化合物とその製造法 |
| IT1256705B (it) * | 1992-12-21 | 1995-12-12 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. |
| IT1261230B (it) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione. |
| IT1261231B (it) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. |
| IT1261489B (it) * | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
| US5473104A (en) * | 1994-09-13 | 1995-12-05 | Neurocrine Biosciences, Inc. | Process for the preparation of L-carnitine |
-
1995
- 1995-09-29 IT IT95RM000652A patent/IT1276207B1/it active IP Right Grant
-
1996
- 1996-07-11 US US08/678,684 patent/US5714619A/en not_active Expired - Fee Related
- 1996-07-11 CA CA002181012A patent/CA2181012A1/en not_active Abandoned
- 1996-07-18 DE DE69601116T patent/DE69601116T2/de not_active Expired - Fee Related
- 1996-07-18 DK DK96111567T patent/DK0765876T3/da active
- 1996-07-18 AT AT96111567T patent/ATE174333T1/de not_active IP Right Cessation
- 1996-07-18 EP EP96111567A patent/EP0765876B1/en not_active Expired - Lifetime
- 1996-07-18 ES ES96111567T patent/ES2126969T3/es not_active Expired - Lifetime
- 1996-07-23 KR KR1019960029667A patent/KR100407645B1/ko not_active Expired - Fee Related
- 1996-08-01 JP JP20355396A patent/JP4012588B2/ja not_active Expired - Fee Related
- 1996-09-27 ZA ZA968127A patent/ZA968127B/xx unknown
-
1999
- 1999-03-01 GR GR990400632T patent/GR3029537T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69601116D1 (de) | 1999-01-21 |
| EP0765876B1 (en) | 1998-12-09 |
| EP0765876A1 (en) | 1997-04-02 |
| DE69601116T2 (de) | 1999-05-06 |
| KR970015583A (ko) | 1997-04-28 |
| ES2126969T3 (es) | 1999-04-01 |
| JPH09110851A (ja) | 1997-04-28 |
| ITRM950652A0 (it) | 1995-09-29 |
| GR3029537T3 (en) | 1999-06-30 |
| ATE174333T1 (de) | 1998-12-15 |
| JP4012588B2 (ja) | 2007-11-21 |
| US5714619A (en) | 1998-02-03 |
| CA2181012A1 (en) | 1997-03-30 |
| KR100407645B1 (ko) | 2004-03-18 |
| ZA968127B (en) | 1997-04-21 |
| ITRM950652A1 (it) | 1997-03-29 |
| DK0765876T3 (da) | 1999-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |