IT1281886B1 - Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro - Google Patents

Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro

Info

Publication number: IT1281886B1
Authority: IT; Italy
Prior art keywords: preparation; hyaluronic acid; ultraviolet irradiation; chemical derivatives; hydrogels obtained
Prior art date: 1995-05-22

Application number

IT95PD000101A

Other languages

English (en)

Inventor

Davide Bellini

Lanfranco Callegaro

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-22

Filing date

1995-05-22

Publication date

1998-03-03

1995-05-22 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

1995-05-22 Priority to IT95PD000101A priority Critical patent/IT1281886B1/it

1995-05-22 Publication of ITPD950101A0 publication Critical patent/ITPD950101A0/it

1996-05-22 Priority to AU60012/96A priority patent/AU6001296A/en

1996-05-22 Priority to PCT/EP1996/002270 priority patent/WO1996037519A1/en

1996-11-22 Publication of ITPD950101A1 publication Critical patent/ITPD950101A1/it

1998-03-03 Application granted granted Critical

1998-03-03 Publication of IT1281886B1 publication Critical patent/IT1281886B1/it

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
239000000017 hydrogel Substances 0.000 title 1
239000000126 substance Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Materials Engineering (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Dermatology (AREA)
Birds (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Polymers & Plastics (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Inorganic Chemistry (AREA)
Surgery (AREA)
Vascular Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Materials For Medical Uses (AREA)

IT95PD000101A 1995-05-22 1995-05-22 Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro IT1281886B1 (it)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
IT95PD000101A IT1281886B1 (it)	1995-05-22	1995-05-22	Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
AU60012/96A AU6001296A (en)	1995-05-22	1996-05-22	A polysaccharide hydrogel material, a process for its prepar ation and its use in medicine, surgery, cosmetics and for th e preparation of health care products
PCT/EP1996/002270 WO1996037519A1 (en)	1995-05-22	1996-05-22	A polysaccharide hydrogel material, a process for its preparation and its use in medicine, surgery, cosmetics and for the preparation of health care products

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT95PD000101A IT1281886B1 (it)	1995-05-22	1995-05-22	Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro

Publications (3)

Publication Number	Publication Date
ITPD950101A0 ITPD950101A0 (it)	1995-05-22
ITPD950101A1 ITPD950101A1 (it)	1996-11-22
IT1281886B1 true IT1281886B1 (it)	1998-03-03

Family

ID=11391062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT95PD000101A IT1281886B1 (it)	1995-05-22	1995-05-22	Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro

Country Status (3)

Country	Link
AU (1)	AU6001296A (it)
IT (1)	IT1281886B1 (it)
WO (1)	WO1996037519A1 (it)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6610669B1 (en)	1987-09-18	2003-08-26	Genzyme Corporation	Water insoluble derivatives of polyanionic polysaccharides
IT1282207B1 (it) *	1995-11-20	1998-03-16	Fidia Advanced Biopolymers Srl	Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
IT1293484B1 (it) *	1997-06-11	1999-03-01	Fidia Advanced Biopolymers Srl	Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile
IT1296689B1 (it) *	1997-11-06	1999-07-14	Fidia Advanced Biopolymers Srl	Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
FR2781677B1 (fr) *	1998-07-31	2000-10-20	Brothier Lab	Dispositif de traitement de plaies et procede de fabrication de ce dispositif
KR100501584B1 (ko) *	2000-02-03	2005-07-18	(주)케이비피	저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품
FR2811671B1 (fr) *	2000-07-17	2003-02-28	Corneal Ind	Hydrogel de polymere(s), resistant a la biodegration, preparation et utilisation a titre de support de regeneration tissulaire
EP1465596A1 (en) *	2002-01-18	2004-10-13	Control Delivery Systems, Inc.	Polymeric gel system for the controlled delivery of codrugs
ITPD20020064A1 (it)	2002-03-12	2003-09-12	Fidia Advanced Biopolymers Srl	Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US7332179B2 (en)	2003-12-12	2008-02-19	Kimberly-Clark Worldwide, Inc.	Tissue products comprising a cleansing composition
CA2572297A1 (en) *	2004-06-30	2006-01-12	Covalon Technologies Inc.	Non-adhesive hydrogels
US7642395B2 (en)	2004-12-28	2010-01-05	Kimberly-Clark Worldwide, Inc.	Composition and wipe for reducing viscosity of viscoelastic bodily fluids
US8367109B2 (en) *	2008-04-09	2013-02-05	Brookhaven Science Associates, Llc	Microbes encapsulated within crosslinkable polymers
WO2010028025A1 (en)	2008-09-02	2010-03-11	Gurtner Geoffrey C	Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
WO2010132857A1 (en) *	2009-05-14	2010-11-18	Central Michigan University	Composition and method of preparation of polysaccharide gel-based artificial, biodegradable skin scaffolds
CA2797017A1 (en)	2010-04-22	2011-10-27	Teijin Limited	Hydrogel
CZ2014451A3 (cs)	2014-06-30	2016-01-13	Contipro Pharma A.S.	Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs)	2015-03-09	2022-08-10	Contipro A.S.	Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ2015398A3 (cs)	2015-06-15	2017-02-08	Contipro A.S.	Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs)	2015-06-26	2017-04-26	Contipro A.S.	Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs)	2016-06-27	2020-01-08	Contipro A.S.	Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
EP3512500A1 (en) *	2016-09-14	2019-07-24	Ecole Polytechnique Federale de Lausanne (EPFL)	Hydrogels based on functionalized polysaccharides
EP3600441A1 (en)	2017-03-22	2020-02-05	Genentech, Inc.	Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1203814B (it) *	1986-06-30	1989-02-23	Fidia Farmaceutici	Esteri dell'acido alginico
IT1198449B (it) *	1986-10-13	1988-12-21	F I D I Farmaceutici Italiani	Esteri di alcoli polivalenti di acido ialuronico
WO1993009176A2 (en) *	1991-10-29	1993-05-13	Clover Consolidated, Limited	Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
IT1260154B (it) *	1992-07-03	1996-03-28	Lanfranco Callegaro	Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)

1995
- 1995-05-22 IT IT95PD000101A patent/IT1281886B1/it active IP Right Grant
1996
- 1996-05-22 WO PCT/EP1996/002270 patent/WO1996037519A1/en not_active Ceased
- 1996-05-22 AU AU60012/96A patent/AU6001296A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1996037519A1 (en)	1996-11-28
ITPD950101A0 (it)	1995-05-22
ITPD950101A1 (it)	1996-11-22
AU6001296A (en)	1996-12-11

Legal Events

Date	Code	Title	Description
1998-03-03	0001	Granted

Publication	Publication Date	Title
IT1281886B1 (it)	1998-03-03	Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
IT1254915B (it)	1995-10-11	Derivati di adenosina ad attivita' a2 agonista
IT1268954B1 (it)	1997-03-18	Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
EP1008655A4 (en)	2003-07-16	METHOD FOR THE PRODUCTION OF MALONIC ACID DERIVATIVES.
DZ1923A1 (fr)	2002-02-17	Sels d'un derivé d'indole anti-migraineux, son Procédé de production et composition pharmaceutique le contenant.
ITPD930164A0 (it)	1993-07-30	Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
NO961970D0 (no)	1996-05-14	Fremgangsmåte for fremstilling av klor
FR2704861B1 (fr)	1995-07-28	Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
IT1217658B (it)	1990-03-30	Processo perfezionato per la produzione di perfluoropolieteri costituiti sostanzialmente da unita' perfludossietilenche e perfluoroossipropileniche
IT1173336B (it)	1987-06-24	Derivati dell'acido benzochinolizin carbossilico,e processo per la preparazione di essi
ITMI962545A0 (it)	1996-12-04	Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1269961B (it)	1997-04-16	Processo per la produzione di derivati orto-isopropil-fenoli
BR9605759A (pt)	1998-08-25	Processo contínuo para preparação de 4-mino-2,2,6,6-tetrametilpiperidina
IT1251182B (it)	1995-05-04	Oligosaccaridi di dermatan solfato, processo per la loro produzione e relative composizioni farmaceutiche.
ITMI920350A1 (it)	1993-08-18	Processo per la produzione di pezzi smaltati
IT1232310B (it)	1992-01-28	Processo per la preparazione di un prodotto contenente glucano a partire da candida albicans bmm-12
IT9020349A0 (it)	1990-05-17	Processo per la risoluzione di derivati glicidici
ITMI951612A0 (it)	1995-07-25	Processo per la produzione di agenti contrastografici iodurati
DE69218865D1 (de)	1997-05-15	Verfahren und Vorrichtung zur Herstellung von Glasgegenständen nach dem Pressblasverfahren
ITMI950973A0 (it)	1995-05-12	Procedimento fotochimico per la preparazione dell'acido 13-cis-retinoico
ITMI951297A0 (it)	1995-06-16	Processo per la preparazione di derivati dell'acido-metil-2- tiofeneacetico
IT1256236B (it)	1995-11-29	Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
BR9100294A (pt)	1991-10-22	Derivados substituidos do acido beta-pirimidiniloxi(tio)e beta-triaziniloxi(tio)-cicloalquilcarboxilico;compostos;processo para sua fabricacao;agente com efeito herbicida,fungicida e regulador do crescimento de plantas;aplicacao destes agentes;processo de fabricacao destes agentes
ITMI951556A0 (it)	1995-07-19	Processo per la preparazione di fluorossi- o clorossi- perfluoroacilfluoruri
ITMI911052A1 (it)	1992-10-16	Processo per la preparazione dell'acido 2, 4 -diclorofenossiacetico