IT1282736B1 - Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative - Google Patents

Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative

Info

Publication number
IT1282736B1
IT1282736B1 IT96MI001013A ITMI961013A IT1282736B1 IT 1282736 B1 IT1282736 B1 IT 1282736B1 IT 96MI001013 A IT96MI001013 A IT 96MI001013A IT MI961013 A ITMI961013 A IT MI961013A IT 1282736 B1 IT1282736 B1 IT 1282736B1
Authority
IT
Italy
Prior art keywords
treatment
pharmaceutical compositions
neurodegenerative diseases
compositions useful
prepare pharmaceutical
Prior art date
Application number
IT96MI001013A
Other languages
English (en)
Italian (it)
Inventor
Mario Pinza
Mario Brufani
Claudio Milanese
Original Assignee
Angelini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angelini Ricerche Spa filed Critical Angelini Ricerche Spa
Publication of ITMI961013A0 publication Critical patent/ITMI961013A0/it
Priority to IT96MI001013A priority Critical patent/IT1282736B1/it
Priority to IL12704497A priority patent/IL127044A/xx
Priority to NZ333232A priority patent/NZ333232A/xx
Priority to AU30923/97A priority patent/AU723004B2/en
Priority to SI9730612T priority patent/SI0946162T1/xx
Priority to CZ19983749A priority patent/CZ295875B6/cs
Priority to ES97925950T priority patent/ES2208909T3/es
Priority to US09/147,280 priority patent/US6043285A/en
Priority to EA199801028A priority patent/EA003251B1/ru
Priority to HU9904027A priority patent/HU225536B1/hu
Priority to AT97925950T priority patent/ATE252897T1/de
Priority to TR1998/02384T priority patent/TR199802384T2/xx
Priority to DE69725879T priority patent/DE69725879T2/de
Priority to DK97925950T priority patent/DK0946162T3/da
Priority to JP09541586A priority patent/JP2000510859A/ja
Priority to PCT/EP1997/002708 priority patent/WO1997044020A1/en
Priority to PT97925950T priority patent/PT946162E/pt
Priority to EP97925950A priority patent/EP0946162B1/en
Priority to SK1598-98A priority patent/SK284860B6/sk
Priority to ZA9704387A priority patent/ZA974387B/xx
Publication of ITMI961013A1 publication Critical patent/ITMI961013A1/it
Application granted granted Critical
Publication of IT1282736B1 publication Critical patent/IT1282736B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT96MI001013A 1996-05-21 1996-05-21 Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative IT1282736B1 (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT96MI001013A IT1282736B1 (it) 1996-05-21 1996-05-21 Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative
AT97925950T ATE252897T1 (de) 1996-05-21 1997-05-15 Verwendung von p-aminophenolderivaten zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von neurodegenerativen erkrankungen
DE69725879T DE69725879T2 (de) 1996-05-21 1997-05-15 VERWENDUNG VON p-AMINOPHENOLDERIVATEN ZUR HERSTELLUNG VON PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
AU30923/97A AU723004B2 (en) 1996-05-21 1997-05-15 Use of P-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
SI9730612T SI0946162T1 (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
CZ19983749A CZ295875B6 (cs) 1996-05-21 1997-05-15 Použití p-aminofenolového derivátu pro výrobu léčiva pro léčení neurodegenerativních chorob
ES97925950T ES2208909T3 (es) 1996-05-21 1997-05-15 Utilizacion de derivados del p-aminofenol para la preparacion de composiciones farmaceuticas utiles en el tratamiento de las enfermedades neurodegenerativas.
US09/147,280 US6043285A (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
EA199801028A EA003251B1 (ru) 1996-05-21 1997-05-15 ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ п-АМИНОФЕНОЛА ДЛЯ ПРИГОТОВЛЕНИЯ ФАРМАЦЕВТИЧЕСКИХ КОМПОЗИЦИЙ, ИСПОЛЬЗУЕМЫХ ПРИ ЛЕЧЕНИИ НЕЙРОДЕГЕНЕРАТИВНЫХ ЗАБОЛЕВАНИЙ
HU9904027A HU225536B1 (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
IL12704497A IL127044A (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenertive diseases
TR1998/02384T TR199802384T2 (xx) 1996-05-21 1997-05-15 N�rodejeneratif hastal�klar�n tedavisinde yararl� farmas�tik bile�imlerin haz�rlanmas� i�in P-Aminofenol t�revlerinin kullan�m�.
NZ333232A NZ333232A (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives (paracetamol) to treat neurodegenerative disease
DK97925950T DK0946162T3 (da) 1996-05-21 1997-05-15 Anvendelse af p-aminophenol-derivater til fremstilling af farmaceutiske præparater, som er nyttige til behandlingen af neurodegenerative sygdomme
JP09541586A JP2000510859A (ja) 1996-05-21 1997-05-15 神経変性疾患の治療に有用な医薬組成物の調製のためのｐ―アミノフェノール誘導体類の利用
PCT/EP1997/002708 WO1997044020A1 (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
PT97925950T PT946162E (pt) 1996-05-21 1997-05-15 Utilizacao de derivados do p-aminofenol para a preparacao de composicoes farmaceuticas uteis no tratamento de doencas neurodegenerativas
EP97925950A EP0946162B1 (en) 1996-05-21 1997-05-15 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases
SK1598-98A SK284860B6 (sk) 1996-05-21 1997-05-15 Použitie p-aminofenolového derivátu na výrobu liečiva na liečenie neurodegeneratívnych chorôb
ZA9704387A ZA974387B (en) 1996-05-21 1997-05-20 Use of p-aminophenol derivatives for the preparation of pharmaceutical compositions useful in the treatment of neurodegenerative diseases.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001013A IT1282736B1 (it) 1996-05-21 1996-05-21 Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative

Publications (3)

Publication Number Publication Date
ITMI961013A0 ITMI961013A0 (da) 1996-05-21
ITMI961013A1 ITMI961013A1 (it) 1997-11-21
IT1282736B1 true IT1282736B1 (it) 1998-03-31

Family

ID=11374289

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001013A IT1282736B1 (it) 1996-05-21 1996-05-21 Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative

Country Status (19)

Country Link
US (1) US6043285A (da)
EP (1) EP0946162B1 (da)
JP (1) JP2000510859A (da)
AT (1) ATE252897T1 (da)
AU (1) AU723004B2 (da)
CZ (1) CZ295875B6 (da)
DE (1) DE69725879T2 (da)
DK (1) DK0946162T3 (da)
EA (1) EA003251B1 (da)
ES (1) ES2208909T3 (da)
HU (1) HU225536B1 (da)
IL (1) IL127044A (da)
IT (1) IT1282736B1 (da)
NZ (1) NZ333232A (da)
PT (1) PT946162E (da)
SK (1) SK284860B6 (da)
TR (1) TR199802384T2 (da)
WO (1) WO1997044020A1 (da)
ZA (1) ZA974387B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI962356A1 (it) * 1996-11-13 1998-05-13 Uni Degli Studi Di Brescia D I Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di
DE19911626A1 (de) * 1999-03-16 2000-09-28 Strathmann Ag & Co Induktion antiinflammatorisch wirkender Proteine durch Ammoniumionen bzw. Amino-Reste
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
US6664297B1 (en) * 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
WO2004034963A2 (en) * 2002-05-17 2004-04-29 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
GB0310300D0 (en) * 2003-05-06 2003-06-11 Univ Belfast Nanocomposite drug delivery composition
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) * 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
ES2670407T3 (es) * 2006-09-03 2018-05-30 Techfields Biochem Co. Ltd Profármacos de acetaminofén solubles en agua cargados positivamente y compuestos relacionados con una tasa de penetración de la piel muy rápida
KR20150058566A (ko) * 2007-06-04 2015-05-28 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도
EP2291084A4 (en) 2008-05-20 2012-04-25 Neurogesx Inc CARBONATE PRODRUGS AND METHOD FOR THEIR USE
JP5757864B2 (ja) 2008-05-20 2015-08-05 ニューロジェシックス， インコーポレイテッド 水溶性アセトアミノフェン類似体
BR122021011394B1 (pt) 2008-12-04 2021-09-28 Chongxi Yu Composição de alta penetração de um fármaco principal, e uso de uma hpc
CN111012914A (zh) 2012-01-18 2020-04-17 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
JP5855599B2 (ja) * 2013-04-30 2016-02-09 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
JP5997658B2 (ja) * 2013-05-08 2016-09-28 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
JP6165816B2 (ja) * 2015-10-01 2017-07-19 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
CN115835862B (zh) * 2020-07-10 2026-01-02 广东横琴新创益生物医药有限公司 治疗阿尔茨海默病的莫达非尼组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
US5472983A (en) * 1994-04-14 1995-12-05 Centaur Pharmaceuticals, Inc. Benzamide-containing pharmaceutical compositions
US5643960A (en) * 1994-04-15 1997-07-01 Duke University Method of delaying onset of alzheimer's disease symptoms
US5756548A (en) * 1995-04-03 1998-05-26 Centaur Pharmaceuticals, Inc. Acetamidobenzamide compounds for neurodegenerative disorders

Also Published As

Publication number Publication date
SK284860B6 (sk) 2006-01-05
ZA974387B (en) 1997-12-23
EP0946162B1 (en) 2003-10-29
AU3092397A (en) 1997-12-09
EA199801028A1 (ru) 1999-06-24
ATE252897T1 (de) 2003-11-15
SK159898A3 (en) 2000-04-10
HUP9904027A3 (en) 2000-07-28
DE69725879T2 (de) 2004-09-02
CZ295875B6 (cs) 2005-11-16
DE69725879D1 (de) 2003-12-04
HU225536B1 (en) 2007-02-28
CZ374998A3 (cs) 1999-04-14
DK0946162T3 (da) 2004-03-01
TR199802384T2 (xx) 1999-03-22
EA003251B1 (ru) 2003-02-27
NZ333232A (en) 2000-08-25
AU723004B2 (en) 2000-08-17
ITMI961013A1 (it) 1997-11-21
IL127044A (en) 2001-03-19
HUP9904027A2 (hu) 2000-05-28
ITMI961013A0 (da) 1996-05-21
WO1997044020A1 (en) 1997-11-27
ES2208909T3 (es) 2004-06-16
JP2000510859A (ja) 2000-08-22
EP0946162A1 (en) 1999-10-06
US6043285A (en) 2000-03-28
PT946162E (pt) 2004-03-31
IL127044A0 (en) 1999-09-22

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