IT1301965B1 - Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. - Google Patents

Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica.

Info

Publication number
IT1301965B1
IT1301965B1 IT1998MI001748A ITMI981748A IT1301965B1 IT 1301965 B1 IT1301965 B1 IT 1301965B1 IT 1998MI001748 A IT1998MI001748 A IT 1998MI001748A IT MI981748 A ITMI981748 A IT MI981748A IT 1301965 B1 IT1301965 B1 IT 1301965B1
Authority
IT
Italy
Prior art keywords
benzothiazepine
pyrol
antipsychotic
atypical activity
compounds
Prior art date
Application number
IT1998MI001748A
Other languages
English (en)
Inventor
Giuseppe Campiani
Vito Nacci
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITMI981748A0 publication Critical patent/ITMI981748A0/it
Priority to IT1998MI001748A priority Critical patent/IT1301965B1/it
Priority to KR1020017001214A priority patent/KR100642730B1/ko
Priority to PT99936971T priority patent/PT1100803E/pt
Priority to EP99936971A priority patent/EP1100803B1/en
Priority to JP2000562378A priority patent/JP4523160B2/ja
Priority to HK01105573.3A priority patent/HK1036793B/en
Priority to ES99936971T priority patent/ES2185384T3/es
Priority to AU51933/99A priority patent/AU762021B2/en
Priority to CA002338651A priority patent/CA2338651C/en
Priority to DE69903321T priority patent/DE69903321T2/de
Priority to SI9930110T priority patent/SI1100803T1/xx
Priority to AT99936971T priority patent/ATE225352T1/de
Priority to DK99936971T priority patent/DK1100803T3/da
Priority to PCT/IT1999/000240 priority patent/WO2000006579A2/en
Publication of ITMI981748A1 publication Critical patent/ITMI981748A1/it
Application granted granted Critical
Publication of IT1301965B1 publication Critical patent/IT1301965B1/it
Priority to US09/769,740 priority patent/US6391870B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyrrole Compounds (AREA)
IT1998MI001748A 1998-07-28 1998-07-28 Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica. IT1301965B1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT1998MI001748A IT1301965B1 (it) 1998-07-28 1998-07-28 Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica.
CA002338651A CA2338651C (en) 1998-07-28 1999-07-27 Pyrrolo[2,1-b][1,3]benzothiazepines with atypical antipsychotic activity
SI9930110T SI1100803T1 (en) 1998-07-28 1999-07-27 Pyrrolo (2,1-b) (1,3)benzothiazepines with atypical antipsychotic activity
EP99936971A EP1100803B1 (en) 1998-07-28 1999-07-27 Pyrrolo [2,1-b] [1,3]benzothiazepines with atypical antipsychotic activity
JP2000562378A JP4523160B2 (ja) 1998-07-28 1999-07-27 非定型抗精神病薬活性を有するピロロ［２，１−ｂ］［１，３］ベンゾチアゼピン
HK01105573.3A HK1036793B (en) 1998-07-28 1999-07-27 Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity
ES99936971T ES2185384T3 (es) 1998-07-28 1999-07-27 Pirrolo(2,1-b)(1,3)benzodiazepinas con actividad antipsicotica atipica.
AU51933/99A AU762021B2 (en) 1998-07-28 1999-07-27 Pyrrolo(2,1-B)(1,3)benzothiazepines with atypical antipsychotic activity
KR1020017001214A KR100642730B1 (ko) 1998-07-28 1999-07-27 비정형적인 향정신성 작용을 갖는피롤로[2,1-ｂ][1,3]벤조티아제핀
DE69903321T DE69903321T2 (de) 1998-07-28 1999-07-27 Pyrrolo[2,1-b][1,3]benzothiazepine mit atypisch antipsychotischer wirkung
PT99936971T PT1100803E (pt) 1998-07-28 1999-07-27 Pirrolo¬2,1-b|¬1,3|benzotiazepinas com actividade antipsicotica atipica
AT99936971T ATE225352T1 (de) 1998-07-28 1999-07-27 Pyrrolo(2,1-b)(1,3)benzothiazepine mit atypisch antipsychotischer wirkung
DK99936971T DK1100803T3 (da) 1998-07-28 1999-07-27 Pyrrolo[2,1-b][1,3]benzothiazepiner med atypisk antipsykotisk aktivitet
PCT/IT1999/000240 WO2000006579A2 (en) 1998-07-28 1999-07-27 Pyrrolo[2,1-b][1,3]benzothiazepines with atypical antipsychotic activity
US09/769,740 US6391870B2 (en) 1998-07-28 2001-01-26 Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI001748A IT1301965B1 (it) 1998-07-28 1998-07-28 Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica.

Publications (3)

Publication Number Publication Date
ITMI981748A0 ITMI981748A0 (it) 1998-07-28
ITMI981748A1 ITMI981748A1 (it) 2000-01-28
IT1301965B1 true IT1301965B1 (it) 2000-07-20

Family

ID=11380538

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI001748A IT1301965B1 (it) 1998-07-28 1998-07-28 Pirrolo (2,1-b)(1,3) benzotiazepine con attivita' antipsicoticaatipica.

Country Status (13)

Country Link
US (1) US6391870B2 (it)
EP (1) EP1100803B1 (it)
JP (1) JP4523160B2 (it)
KR (1) KR100642730B1 (it)
AT (1) ATE225352T1 (it)
AU (1) AU762021B2 (it)
CA (1) CA2338651C (it)
DE (1) DE69903321T2 (it)
DK (1) DK1100803T3 (it)
ES (1) ES2185384T3 (it)
IT (1) IT1301965B1 (it)
PT (1) PT1100803E (it)
WO (1) WO2000006579A2 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317886B1 (it) 2000-08-01 2003-07-15 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di 9,10-diidro-pirrolo (2,1-b)(1,3)benzotiazepine 9-ammino sostituite.
IT1317884B1 (it) 2000-08-01 2003-07-15 Sigma Tau Ind Farmaceuti Pirrolo (2,1-b)(1,3)benzotiazepine e loro uso per la preparazione dimedicamenti ad attivita' antipsicotica classica.
ITRM20040178A1 (it) * 2004-04-07 2004-07-07 Sigma Tau Ind Farmaceuti Composti ad attivita' antipsicotica atipica.
ITRM20040222A1 (it) * 2004-05-07 2004-08-07 Sigma Tau Ind Farmaceuti Derivati dealchilati di pirrolo[2,1-b]benzotiazepine ad attivita' antipsicotica atipica.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines

Also Published As

Publication number Publication date
WO2000006579A3 (en) 2000-05-04
DK1100803T3 (da) 2002-12-30
US6391870B2 (en) 2002-05-21
AU5193399A (en) 2000-02-21
WO2000006579A2 (en) 2000-02-10
ITMI981748A1 (it) 2000-01-28
US20020006921A1 (en) 2002-01-17
AU762021B2 (en) 2003-06-19
CA2338651A1 (en) 2000-02-10
EP1100803A2 (en) 2001-05-23
HK1036793A1 (en) 2002-01-18
JP4523160B2 (ja) 2010-08-11
PT1100803E (pt) 2003-02-28
DE69903321T2 (de) 2003-06-18
ES2185384T3 (es) 2003-04-16
KR100642730B1 (ko) 2006-11-03
CA2338651C (en) 2009-05-19
ATE225352T1 (de) 2002-10-15
ITMI981748A0 (it) 1998-07-28
KR20010072090A (ko) 2001-07-31
JP2002521485A (ja) 2002-07-16
DE69903321D1 (de) 2002-11-07
EP1100803B1 (en) 2002-10-02

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