IT1317832B1 - Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche. - Google Patents
Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche.Info
- Publication number
- IT1317832B1 IT1317832B1 IT2000MI000246A ITMI20000246A IT1317832B1 IT 1317832 B1 IT1317832 B1 IT 1317832B1 IT 2000MI000246 A IT2000MI000246 A IT 2000MI000246A IT MI20000246 A ITMI20000246 A IT MI20000246A IT 1317832 B1 IT1317832 B1 IT 1317832B1
- Authority
- IT
- Italy
- Prior art keywords
- procedure
- preparation
- therapeutic applications
- collagen
- powdered
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title abstract 4
- 108010035532 Collagen Proteins 0.000 title abstract 4
- 229920001436 collagen Polymers 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000004500 asepsis Methods 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
- C08J2389/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08J2389/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000246A IT1317832B1 (it) | 2000-02-15 | 2000-02-15 | Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche. |
| ES01915198T ES2243465T3 (es) | 2000-02-15 | 2001-02-07 | Procedimiento para la preparacion de colageno micronizado y aplicaciones terapeuticas. |
| PCT/EP2001/001283 WO2001060922A1 (en) | 2000-02-15 | 2001-02-07 | Process for the preparation of micronised collagen, and its therapeutic applications |
| JP2001560296A JP2003523438A (ja) | 2000-02-15 | 2001-02-07 | 超微粉コラーゲンの製造方法およびその治療的応用 |
| US10/169,857 US20030012741A1 (en) | 2000-02-15 | 2001-02-07 | Process for the preparation of micronised collagen, and its therapeutic applications |
| AT01915198T ATE296859T1 (de) | 2000-02-15 | 2001-02-07 | Verfahren zur herstellung von mikronisiertem kollagen, und therapeutische verwendungen |
| ES05101795T ES2313210T3 (es) | 2000-02-15 | 2001-02-07 | Proceso para la prepparacion de colageno micronizado y sus aplicaciones terapeuticas. |
| DE60136300T DE60136300D1 (de) | 2000-02-15 | 2001-02-07 | Verfahren zur Herstellung von mikronisiertem Kollagen, und therapeutische Verwendungen |
| EP05101795A EP1541634B1 (en) | 2000-02-15 | 2001-02-07 | Process for the preparation of micronised collagen, and its therapeutic applications |
| EP01915198A EP1263884B1 (en) | 2000-02-15 | 2001-02-07 | Process for the preparation of micronised collagen, and its therapeutic applications |
| DE60111192T DE60111192T2 (de) | 2000-02-15 | 2001-02-07 | Verfahren zur herstellung von mikronisiertem kollagen, und therapeutische verwendungen |
| CA002395709A CA2395709C (en) | 2000-02-15 | 2001-02-07 | Process for the preparation of micronised collagen, and its therapeutic applications |
| US11/747,765 US20070253912A1 (en) | 2000-02-15 | 2007-05-11 | Process for the preparation of micronised collagen, and its therapeutic applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000246A IT1317832B1 (it) | 2000-02-15 | 2000-02-15 | Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI20000246A0 ITMI20000246A0 (it) | 2000-02-15 |
| ITMI20000246A1 ITMI20000246A1 (it) | 2001-08-15 |
| IT1317832B1 true IT1317832B1 (it) | 2003-07-15 |
Family
ID=11444011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2000MI000246A IT1317832B1 (it) | 2000-02-15 | 2000-02-15 | Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20030012741A1 (it) |
| EP (2) | EP1541634B1 (it) |
| JP (1) | JP2003523438A (it) |
| AT (1) | ATE296859T1 (it) |
| CA (1) | CA2395709C (it) |
| DE (2) | DE60136300D1 (it) |
| ES (2) | ES2313210T3 (it) |
| IT (1) | IT1317832B1 (it) |
| WO (1) | WO2001060922A1 (it) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3805654B2 (ja) * | 2001-08-29 | 2006-08-02 | 株式会社ネクスト | 止血・癒着防止性のバイオポリマーの微細粒子 |
| US7923431B2 (en) * | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
| US7955288B2 (en) * | 2002-12-11 | 2011-06-07 | Ferrosan Medical Devices A/S | Gelatine-based materials as swabs |
| CA2554994C (en) * | 2004-01-30 | 2015-05-19 | Ferrosan A/S | Haemostatic sprays and compositions |
| KR20070046093A (ko) * | 2004-07-09 | 2007-05-02 | 훼로산 아크티에 셀스카브 | 히알루론산을 포함하는 지혈 조성물 |
| CA2716872C (en) * | 2008-02-29 | 2015-02-10 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| US20100111841A1 (en) * | 2008-10-31 | 2010-05-06 | Searete Llc | Compositions and methods for surface abrasion with frozen particles |
| US9072799B2 (en) * | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US20100111857A1 (en) * | 2008-10-31 | 2010-05-06 | Boyden Edward S | Compositions and methods for surface abrasion with frozen particles |
| US9072688B2 (en) | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US9050070B2 (en) * | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US9060934B2 (en) * | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US9060931B2 (en) * | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for delivery of frozen particle adhesives |
| US8551505B2 (en) * | 2008-10-31 | 2013-10-08 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US9050317B2 (en) * | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8793075B2 (en) * | 2008-10-31 | 2014-07-29 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8603494B2 (en) * | 2008-10-31 | 2013-12-10 | The Invention Science Fund I, Llc | Compositions and methods for administering compartmentalized frozen particles |
| US8545857B2 (en) * | 2008-10-31 | 2013-10-01 | The Invention Science Fund I, Llc | Compositions and methods for administering compartmentalized frozen particles |
| US9060926B2 (en) | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8731841B2 (en) * | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US20100111831A1 (en) * | 2008-10-31 | 2010-05-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Compositions and methods for surface abrasion with frozen particles |
| US8409376B2 (en) | 2008-10-31 | 2013-04-02 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US8731840B2 (en) * | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8788211B2 (en) * | 2008-10-31 | 2014-07-22 | The Invention Science Fund I, Llc | Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition |
| US8762067B2 (en) | 2008-10-31 | 2014-06-24 | The Invention Science Fund I, Llc | Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data |
| US8613937B2 (en) * | 2008-10-31 | 2013-12-24 | The Invention Science Fund I, Llc | Compositions and methods for biological remodeling with frozen particle compositions |
| US8725420B2 (en) * | 2008-10-31 | 2014-05-13 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US20100111836A1 (en) * | 2008-10-31 | 2010-05-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Compositions and methods for therapeutic delivery with frozen particles |
| US8603495B2 (en) * | 2008-10-31 | 2013-12-10 | The Invention Science Fund I, Llc | Compositions and methods for biological remodeling with frozen particle compositions |
| US8721583B2 (en) * | 2008-10-31 | 2014-05-13 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US20100111835A1 (en) * | 2008-10-31 | 2010-05-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Compositions and methods for therapeutic delivery with frozen particles |
| US9050251B2 (en) * | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for delivery of frozen particle adhesives |
| US8545855B2 (en) * | 2008-10-31 | 2013-10-01 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US8858912B2 (en) * | 2008-10-31 | 2014-10-14 | The Invention Science Fund I, Llc | Frozen compositions and methods for piercing a substrate |
| US8414356B2 (en) * | 2008-10-31 | 2013-04-09 | The Invention Science Fund I, Llc | Systems, devices, and methods for making or administering frozen particles |
| US20100178038A1 (en) * | 2009-01-12 | 2010-07-15 | Mediatek Inc. | Video player |
| US20130011451A1 (en) * | 2011-07-06 | 2013-01-10 | Diversified Glogal Technologies, Llc | Footbed with non-denatured collagen |
| EP2773690A1 (en) * | 2011-10-31 | 2014-09-10 | Shell Internationale Research Maatschappij B.V. | Hydrocarbon fluid compatible micronized polymers |
| CN104159527B (zh) | 2012-03-06 | 2017-04-12 | 弗罗桑医疗设备公司 | 包含止血糊剂的压力容器 |
| RU2636240C2 (ru) | 2012-06-12 | 2017-11-21 | Ферросан Медикал Дивайсиз А/С | Сухая гемостатическая композиция |
| CA2910748C (en) | 2013-05-15 | 2021-03-30 | Euroresearch S.R.L. | Collagen powder, composition and use |
| JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー/エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
| BR112016013322B1 (pt) | 2013-12-11 | 2020-07-21 | Ferrosan Medical Devices A/S | métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit |
| BR112017007466B1 (pt) | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca |
| RU2705905C2 (ru) | 2014-12-24 | 2019-11-12 | Ферросан Медикал Дивайсиз А/С | Шприц для удерживания и смешивания первого и второго веществ |
| FR3033697B1 (fr) * | 2015-03-17 | 2020-03-27 | Universite Pierre Et Marie Curie (Paris 6) | Suspensions de collagene injectables, leur procede de preparation et leurs utilisations, notamment pour la formation de matrices denses de collagene |
| US12290599B2 (en) | 2015-06-19 | 2025-05-06 | Global Health Solutions Llc | Oil-based wound care compositions and methods |
| EP3310392A4 (en) | 2015-06-19 | 2019-03-27 | Global Health Solutions, LLC | PETROLATUM-BASED DISTRIBUTION SYSTEMS AND FOR ACTIVE SUBSTANCES |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| EP3337923B2 (en) | 2015-09-21 | 2023-01-04 | Modern Meadow, Inc. | Fiber reinforced tissue composites |
| JP7109882B2 (ja) | 2016-02-15 | 2022-08-01 | モダン メドウ,インコーポレイテッド | コラーゲンフィブリルを含むバイオファブリケーテッド材料を作製するための方法 |
| US10980740B2 (en) | 2017-09-12 | 2021-04-20 | Shilpa Medicare Limited | Tranexamic acid spray for knee arthroplasty |
| AU2018253595A1 (en) | 2017-11-13 | 2019-05-30 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
| EP4321182A3 (en) | 2018-05-09 | 2024-05-29 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
| AU2020209847B2 (en) | 2019-01-17 | 2024-10-17 | Modern Meadow, Inc. | Layered collagen materials and methods of making the same |
| US12246126B2 (en) | 2019-02-28 | 2025-03-11 | Cook Biotech Incorporated | Powder spray dispenser for comminuted ECM |
| WO2021051028A1 (en) * | 2019-09-12 | 2021-03-18 | Global Health Solutions Llc | Oil-based wound care compositions and methods |
| EP4143258A4 (en) | 2020-05-01 | 2024-05-22 | Modern Meadow, Inc. | PROTEIN POLYURETHANE ALLOYS AND LAYERING MATERIALS |
| IT202100018647A1 (it) * | 2021-07-14 | 2023-01-14 | Typeone Biomaterials S R L | Polvere di collagene, procedimento per la sua preparazione e suoi usi. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2352894B2 (de) * | 1973-10-22 | 1981-04-16 | Aktieselskabet Niro Atomizer, Soeborg | Verfahren zur Herstellung von Pulver aus Milch oder ähnlichen Flüssigkeiten |
| DK210679A (da) * | 1979-05-22 | 1980-11-23 | Niro Atomizer As | Fremgangsmaade ved spraytoerring af et vaeskeformigt produkt og spraytoerringsanlaeg til brug ved udoevelse af fremgangsmaaden |
| DE3314903A1 (de) * | 1982-04-28 | 1983-11-03 | Edward Julius Bromyard Herefordshire Bals | Spruehvorrichtung |
| DK157053B (da) * | 1982-06-14 | 1989-11-06 | Niro Atomizer As | Fremgangsmaade til fremstilling af et agglomereret, pulverformet maelkeprodukt |
| EP0239970A3 (en) * | 1986-03-31 | 1988-04-20 | Toa Nenryo Kogyo Kabushiki Kaisha | Assemblage of hydroxyl apatite particles and liquid chromatography column using the same |
| IT1214505B (it) * | 1987-03-12 | 1990-01-18 | Gentili Ist Spa | Procedimento per la preparazione di collageno e prodotti cosi'ottenuto. |
| JP2789115B2 (ja) * | 1989-09-07 | 1998-08-20 | 株式会社高研 | 可溶性コラーゲンパウダーを担体とする粒状医薬徐放剤の製造方法 |
| US5196185A (en) * | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
| GB2274458A (en) * | 1993-01-20 | 1994-07-27 | Laporte B S D Limited | Production of soluble collagen by hydrolysis and spray-drying |
| DE69325595T2 (de) * | 1993-11-17 | 2000-03-16 | Niro Holding A/S | Verfahren und sprühtrocknungsgerät zum erzeugen von agglomeriertem pulver |
| DE69404045T2 (de) * | 1994-03-11 | 1998-02-05 | Niro Holding As | Sprühtrocknungsvorrichtung |
| DE4414755C2 (de) * | 1994-04-27 | 2000-11-16 | Lohmann Therapie Syst Lts | Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung |
| JPH0827035A (ja) * | 1994-07-18 | 1996-01-30 | Hokuyo Kk | 新規な粉末コラーゲンおよびその製造方法 |
| RO111787B1 (ro) * | 1995-07-26 | 1997-01-30 | Gabriel Lucian Radu | Procedeu biotehnologic de obținere a hidrolizatelor de colagen |
-
2000
- 2000-02-15 IT IT2000MI000246A patent/IT1317832B1/it active
-
2001
- 2001-02-07 WO PCT/EP2001/001283 patent/WO2001060922A1/en not_active Ceased
- 2001-02-07 EP EP05101795A patent/EP1541634B1/en not_active Expired - Lifetime
- 2001-02-07 DE DE60136300T patent/DE60136300D1/de not_active Expired - Lifetime
- 2001-02-07 ES ES05101795T patent/ES2313210T3/es not_active Expired - Lifetime
- 2001-02-07 ES ES01915198T patent/ES2243465T3/es not_active Expired - Lifetime
- 2001-02-07 US US10/169,857 patent/US20030012741A1/en not_active Abandoned
- 2001-02-07 CA CA002395709A patent/CA2395709C/en not_active Expired - Lifetime
- 2001-02-07 JP JP2001560296A patent/JP2003523438A/ja not_active Withdrawn
- 2001-02-07 EP EP01915198A patent/EP1263884B1/en not_active Expired - Lifetime
- 2001-02-07 DE DE60111192T patent/DE60111192T2/de not_active Expired - Lifetime
- 2001-02-07 AT AT01915198T patent/ATE296859T1/de not_active IP Right Cessation
-
2007
- 2007-05-11 US US11/747,765 patent/US20070253912A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1263884A1 (en) | 2002-12-11 |
| ITMI20000246A1 (it) | 2001-08-15 |
| EP1263884B1 (en) | 2005-06-01 |
| CA2395709A1 (en) | 2001-08-23 |
| EP1541634B1 (en) | 2008-10-22 |
| ES2243465T3 (es) | 2005-12-01 |
| JP2003523438A (ja) | 2003-08-05 |
| DE60111192D1 (de) | 2005-07-07 |
| US20070253912A1 (en) | 2007-11-01 |
| CA2395709C (en) | 2009-09-22 |
| EP1541634A1 (en) | 2005-06-15 |
| ITMI20000246A0 (it) | 2000-02-15 |
| DE60111192T2 (de) | 2006-04-27 |
| ES2313210T3 (es) | 2009-03-01 |
| WO2001060922A1 (en) | 2001-08-23 |
| ATE296859T1 (de) | 2005-06-15 |
| DE60136300D1 (de) | 2008-12-04 |
| US20030012741A1 (en) | 2003-01-16 |
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