IT1396003B1 - Ialuronidasi extracellulare da streptomyces koganeiensis - Google Patents

Ialuronidasi extracellulare da streptomyces koganeiensis

Info

Publication number
IT1396003B1
IT1396003B1 ITMI2009A000831A ITMI20090831A IT1396003B1 IT 1396003 B1 IT1396003 B1 IT 1396003B1 IT MI2009A000831 A ITMI2009A000831 A IT MI2009A000831A IT MI20090831 A ITMI20090831 A IT MI20090831A IT 1396003 B1 IT1396003 B1 IT 1396003B1
Authority
IT
Italy
Prior art keywords
ialuronidase
extracellular
streptomyces koganeiensis
koganeiensis
streptomyces
Prior art date
Application number
ITMI2009A000831A
Other languages
English (en)
Inventor
Giovanni Gennari
Salvatore Caruso
Luciano Messina
Susanna Vaccaro
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US13/318,476 priority Critical patent/US20120219554A2/en
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Priority to ITMI2009A000831A priority patent/IT1396003B1/it
Priority to RU2011150814/10A priority patent/RU2553205C2/ru
Priority to DK10718616.5T priority patent/DK2432874T3/en
Priority to PCT/EP2010/056596 priority patent/WO2010130810A1/en
Priority to HRP20141251TT priority patent/HRP20141251T1/hr
Priority to PL10718616T priority patent/PL2432874T3/pl
Priority to HK12106088.6A priority patent/HK1165487B/en
Priority to HUE10718616A priority patent/HUE024101T2/hu
Priority to CA2759373A priority patent/CA2759373C/en
Priority to EP10718616.5A priority patent/EP2432874B1/en
Priority to CN201080021089.XA priority patent/CN102439144B/zh
Priority to ES10718616.5T priority patent/ES2527618T3/es
Priority to SI201030842T priority patent/SI2432874T1/sl
Publication of ITMI20090831A1 publication Critical patent/ITMI20090831A1/it
Application granted granted Critical
Publication of IT1396003B1 publication Critical patent/IT1396003B1/it
Priority to SM201500006T priority patent/SMT201500006B/it
Priority to US15/226,593 priority patent/US10208300B2/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/924Hydrolases (3) acting on glycosyl compounds (3.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
ITMI2009A000831A 2009-05-14 2009-05-14 Ialuronidasi extracellulare da streptomyces koganeiensis IT1396003B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ITMI2009A000831A IT1396003B1 (it) 2009-05-14 2009-05-14 Ialuronidasi extracellulare da streptomyces koganeiensis
US13/318,476 US20120219554A2 (en) 2009-05-14 2009-05-14 Extracellular yaluronidase from streptomyces koganeiensis
CN201080021089.XA CN102439144B (zh) 2009-05-14 2010-05-12 来源于链霉菌考干尼西斯的胞外透明质酸酶
PCT/EP2010/056596 WO2010130810A1 (en) 2009-05-14 2010-05-12 Extracellular yaluronidase from streptomyces koganeiensis
HRP20141251TT HRP20141251T1 (hr) 2009-05-14 2010-05-12 Ekstracelularna hijaluronidaza iz streptomyces koganeiensis
PL10718616T PL2432874T3 (pl) 2009-05-14 2010-05-12 Pozakomórkowa hialuronidaza z Streptomyces koganeiensis
HK12106088.6A HK1165487B (en) 2009-05-14 2010-05-12 Extracellular yaluronidase from streptomyces koganeiensis
HUE10718616A HUE024101T2 (hu) 2009-05-14 2010-05-12 Extracelluláris Streptomyces koganeinsis hialuronidáz
RU2011150814/10A RU2553205C2 (ru) 2009-05-14 2010-05-12 ВНЕКЛЕТОЧНАЯ ГИАЛУРОНИДАЗА ИЗ Streptomyces koganeiensis
EP10718616.5A EP2432874B1 (en) 2009-05-14 2010-05-12 Extracellular yaluronidase from streptomyces koganeiensis
DK10718616.5T DK2432874T3 (en) 2009-05-14 2010-05-12 Extracellular hyaluronidase from Streptomyces KOGANEIENSIS
ES10718616.5T ES2527618T3 (es) 2009-05-14 2010-05-12 Hialuronidasa extracelular de Streptomyces koganeiensis
SI201030842T SI2432874T1 (sl) 2009-05-14 2010-05-12 Ekstracelularna hialuronidaza iz streptomyces koganeiensis
CA2759373A CA2759373C (en) 2009-05-14 2010-05-12 Extracellular hyaluronidase from streptomyces koganeiensis
SM201500006T SMT201500006B (it) 2009-05-14 2015-01-08 Ialuronidasi extracellulare da streptomyces koganeiensis
US15/226,593 US10208300B2 (en) 2009-05-14 2016-08-02 Extracellular hyaluronidase from Streptomyces koganeiensis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A000831A IT1396003B1 (it) 2009-05-14 2009-05-14 Ialuronidasi extracellulare da streptomyces koganeiensis

Publications (2)

Publication Number Publication Date
ITMI20090831A1 ITMI20090831A1 (it) 2010-11-15
IT1396003B1 true IT1396003B1 (it) 2012-11-09

Family

ID=41319602

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A000831A IT1396003B1 (it) 2009-05-14 2009-05-14 Ialuronidasi extracellulare da streptomyces koganeiensis

Country Status (14)

Country Link
US (2) US20120219554A2 (it)
EP (1) EP2432874B1 (it)
CN (1) CN102439144B (it)
CA (1) CA2759373C (it)
DK (1) DK2432874T3 (it)
ES (1) ES2527618T3 (it)
HR (1) HRP20141251T1 (it)
HU (1) HUE024101T2 (it)
IT (1) IT1396003B1 (it)
PL (1) PL2432874T3 (it)
RU (1) RU2553205C2 (it)
SI (1) SI2432874T1 (it)
SM (1) SMT201500006B (it)
WO (1) WO2010130810A1 (it)

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* Cited by examiner, † Cited by third party
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US20120219554A2 (en) * 2009-05-14 2012-08-30 Fidia Farmaceutici S.P.A. Extracellular yaluronidase from streptomyces koganeiensis
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
ES2665556T3 (es) 2012-02-21 2018-04-26 Bloomage Freda Biopharm Co., Ltd. Bacillus, enzima de ácido hialurónico y usos de los mismos
CZ303879B6 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ2012664A3 (cs) 2012-09-27 2013-11-13 Contipro Biotech S.R.O. Enzym hyaluronan-lyáza, zpusob jeho výroby, pouzití a zpusob prípravy nízkomolekulárního hyaluronanu
KR101454646B1 (ko) * 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
ITMI20130992A1 (it) 2013-06-17 2014-12-18 Fidia Farmaceutici Ialuronidasi batterica e metodo per la sua produzione
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
WO2017055462A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Multi chamber syringe unit and method of preparing a multi chamber syringe
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
RU2658605C2 (ru) * 2016-07-01 2018-06-21 Наталья Владимировна Глазова Способ получения гиалуронидазы из семенников крупного рогатого скота
WO2019118921A1 (en) 2017-12-14 2019-06-20 Flodesign Sonics, Inc. Acoustic transducer drive and controller
RU2692061C1 (ru) * 2018-06-21 2019-06-20 Федеральное государственное бюджетное образовательное учреждение высшего образования Санкт-Петербургская государственная академия ветеринарной медицины ФГБОУ ВО СПбГАВМ Способ лечения хронического мастита у коров с помощью медицинских пиявок
CN109880758B (zh) * 2019-03-05 2020-11-10 山东安华生物医药股份有限公司 一种植物乳杆菌诱变菌株及其诱变方法和应用
CN115671267A (zh) * 2021-07-23 2023-02-03 上海宝济药业有限公司 一种皮下抗生素药物组合物

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JPS6033474B2 (ja) * 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼbmp−8231およびその製造法
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ITPD20060219A1 (it) * 2006-05-31 2007-12-01 Fidia Farmaceutici Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
WO2009037566A2 (en) * 2007-06-19 2009-03-26 Uvarkina Tamara P Hyaluronidase and method of use thereof
US20120219554A2 (en) * 2009-05-14 2012-08-30 Fidia Farmaceutici S.P.A. Extracellular yaluronidase from streptomyces koganeiensis

Also Published As

Publication number Publication date
WO2010130810A1 (en) 2010-11-18
CA2759373C (en) 2018-06-12
RU2553205C2 (ru) 2015-06-10
US20120219554A2 (en) 2012-08-30
DK2432874T3 (en) 2015-01-19
SMT201500006B (it) 2015-03-05
US20170101634A1 (en) 2017-04-13
ES2527618T3 (es) 2015-01-27
US10208300B2 (en) 2019-02-19
HK1165487A1 (en) 2012-10-05
PL2432874T3 (pl) 2015-03-31
HRP20141251T1 (hr) 2015-04-24
EP2432874A1 (en) 2012-03-28
CN102439144A (zh) 2012-05-02
ITMI20090831A1 (it) 2010-11-15
HUE024101T2 (hu) 2016-02-29
CN102439144B (zh) 2014-05-21
US20120070441A1 (en) 2012-03-22
CA2759373A1 (en) 2010-11-18
SI2432874T1 (sl) 2015-03-31
RU2011150814A (ru) 2013-06-20
EP2432874B1 (en) 2014-10-29

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