IT1397246B1 - Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica - Google Patents

Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica

Info

Publication number: IT1397246B1
Authority: IT; Italy
Prior art keywords: cithocinic; inhabiting; activating; activity; hyaluronic acid
Prior art date: 2009-05-14

Application number

ITPD2009A000134A

Other languages

English (en)

Inventor

Giovanni Gennari

Este Matteo D

Original Assignee

Fidia Farmaceutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-14

Filing date

2009-05-14

Publication date

2013-01-04

2009-05-14 Priority to ITPD2009A000134A priority Critical patent/IT1397246B1/it

2009-05-14 Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici

2010-05-14 Priority to ES18185228T priority patent/ES2808575T3/es

2010-05-14 Priority to HUE10721126A priority patent/HUE030673T2/hu

2010-05-14 Priority to US13/320,000 priority patent/US20120121572A1/en

2010-05-14 Priority to HRP20161574TT priority patent/HRP20161574T1/hr

2010-05-14 Priority to PCT/EP2010/003050 priority patent/WO2010130468A1/en

2010-05-14 Priority to SM20200522T priority patent/SMT202000522T1/it

2010-05-14 Priority to PL10721126T priority patent/PL2429515T3/pl

2010-05-14 Priority to EP18185228.6A priority patent/EP3417855B1/en

2010-05-14 Priority to SM20190015T priority patent/SMT201900015T1/it

2010-05-14 Priority to ES10721126.0T priority patent/ES2601681T3/es

2010-05-14 Priority to CA2761628A priority patent/CA2761628C/en

2010-05-14 Priority to EP16178620.7A priority patent/EP3103449B1/en

2010-05-14 Priority to CN201080020708.3A priority patent/CN102427808B/zh

2010-05-14 Priority to PT107211260T priority patent/PT2429515T/pt

2010-05-14 Priority to SI201031318A priority patent/SI2429515T1/sl

2010-05-14 Priority to LTEP10721126.0T priority patent/LT2429515T/lt

2010-05-14 Priority to US13/320,000 priority patent/US9504708B2/en

2010-05-14 Priority to ES16178620T priority patent/ES2704921T3/es

2010-05-14 Priority to EP10721126.0A priority patent/EP2429515B1/en

2010-05-14 Priority to CA2995610A priority patent/CA2995610C/en

2010-05-14 Priority to RU2011145992/15A priority patent/RU2543354C2/ru

2010-11-15 Publication of ITPD20090134A1 publication Critical patent/ITPD20090134A1/it

2013-01-04 Application granted granted Critical

2013-01-04 Publication of IT1397246B1 publication Critical patent/IT1397246B1/it

2014-11-21 Priority to RU2014146977A priority patent/RU2673661C2/ru

2014-11-21 Priority to RU2014146985A priority patent/RU2673066C2/ru

2016-10-27 Priority to US15/336,498 priority patent/US10435483B2/en

2016-12-14 Priority to SM201600455T priority patent/SMT201600455B/it

2019-08-26 Priority to US16/550,810 priority patent/US11198741B2/en

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
230000003213 activating effect Effects 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
230000000694 effects Effects 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
- A61Q1/06—Lipsticks
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Birds (AREA)
Zoology (AREA)
Oral & Maxillofacial Surgery (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Rheumatology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Diabetes (AREA)

ITPD2009A000134A 2009-05-14 2009-05-14 Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica IT1397246B1 (it)

Priority Applications (27)

Application Number	Priority Date	Filing Date	Title
ITPD2009A000134A IT1397246B1 (it)	2009-05-14	2009-05-14	Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
SI201031318A SI2429515T1 (sl)	2009-05-14	2010-05-14	Nova zdravila za topično uporabo na osnovi sulfatirane hialuronske kisline kot sredstvo za aktiviranje ali inhibiranje citokinske aktivnosti
US13/320,000 US20120121572A1 (en)	2009-05-14	2010-05-14	New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
HRP20161574TT HRP20161574T1 (hr)	2009-05-14	2010-05-14	Novi lijekovi za topikalnu primjenu temeljeni na sulfatiranoj hijaluronskoj kiselini kao sredstvu za aktiviranje ili inhibiciju aktivnosti citokina
PCT/EP2010/003050 WO2010130468A1 (en)	2009-05-14	2010-05-14	New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
SM20200522T SMT202000522T1 (it)	2009-05-14	2010-05-14	Composizioni farmaceutiche per uso topico a base di acido ialuronico solfatato come promotore dell'assorbimento cutaneo
PL10721126T PL2429515T3 (pl)	2009-05-14	2010-05-14	Nowe leki do stosowania miejscowego oparte na siarczanowanym kwasie hialuronowym jako środku aktywującym lub inhibitującym aktywność cytokin
EP18185228.6A EP3417855B1 (en)	2009-05-14	2010-05-14	Pharmaceutical compositions for topical use based on sulfated hyaluronic acid as skin absorption promoter
SM20190015T SMT201900015T1 (it)	2009-05-14	2010-05-14	Medicamento per uso topico a base di acido ialuronico solfatato per il trattamento dei coaguli di fibrina e dei trombi
ES10721126.0T ES2601681T3 (es)	2009-05-14	2010-05-14	Nuevos medicamentos de uso tópico basados en ácido hialurónico sulfatado como agente de activación o inhibición de la actividad de las citoquinas
CA2761628A CA2761628C (en)	2009-05-14	2010-05-14	New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
EP16178620.7A EP3103449B1 (en)	2009-05-14	2010-05-14	Medicines for topical use based on sulfated hyaluronic acid for the treatment of clots of fibrin and thrombi
ES18185228T ES2808575T3 (es)	2009-05-14	2010-05-14	Composiciones farmacéuticas para uso tópico basadas en ácido hialurónico sulfatado como promotor de absorción de la piel
PT107211260T PT2429515T (pt)	2009-05-14	2010-05-14	Novos medicamentos para uso tópico à base de ácido hialurónico sulfatado como agente de ativação ou inibição da atividade citoquínica
US13/320,000 US9504708B2 (en)	2009-05-14	2010-05-14	Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
CA2995610A CA2995610C (en)	2009-05-14	2010-05-14	New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
LTEP10721126.0T LT2429515T (lt)	2009-05-14	2010-05-14	Nauji vaistai, skirti vietiniam naudojimui sulfatuotos hialurono rūgšties, kaip citokinų aktyvumą aktyvuojančio arba inhibuojančio agento, pagrindu
ES16178620T ES2704921T3 (es)	2009-05-14	2010-05-14	Medicamentos para uso tópico basados en ácido hialurónico sulfatado para el tratamiento de coágulos de fibrina y trombos
EP10721126.0A EP2429515B1 (en)	2009-05-14	2010-05-14	New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
HUE10721126A HUE030673T2 (hu)	2009-05-14	2010-05-14	Szulfatált hialuronsav alapú helyi alkalmazású új gyógyszerek mint citokin aktivitást aktiváló vagy gátló szerek
RU2011145992/15A RU2543354C2 (ru)	2009-05-14	2010-05-14	Новые лекарственные средства для местного применения на основе сульфатированной гиалуроновой кислоты в качестве стимуляторов или ингибиторов цитокиновой активности
CN201080020708.3A CN102427808B (zh)	2009-05-14	2010-05-14	基于作为细胞因子活性的活化剂或抑制剂的硫酸化透明质酸的新的用于局部应用的药剂
RU2014146977A RU2673661C2 (ru)	2009-05-14	2014-11-21	Новые лекарственные средства для местного применения на основе сульфатированной гиалуроновой кислоты в качестве стимуляторов или ингибиторов цитокиновой активности
RU2014146985A RU2673066C2 (ru)	2009-05-14	2014-11-21	Новые лекарственные средства для местного применения на основе сульфатированной гиалуроновой кислоты в качестве стимуляторов или ингибиторов цитокиновой активности
US15/336,498 US10435483B2 (en)	2009-05-14	2016-10-27	Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
SM201600455T SMT201600455B (it)	2009-05-14	2016-12-14	Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attività citochinica
US16/550,810 US11198741B2 (en)	2009-05-14	2019-08-26	Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITPD2009A000134A IT1397246B1 (it)	2009-05-14	2009-05-14	Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica

Publications (2)

Publication Number	Publication Date
ITPD20090134A1 ITPD20090134A1 (it)	2010-11-15
IT1397246B1 true IT1397246B1 (it)	2013-01-04

Family

ID=41226841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITPD2009A000134A IT1397246B1 (it)	2009-05-14	2009-05-14	Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica

Country Status (15)

Country	Link
US (4)	US9504708B2 (it)
EP (3)	EP3103449B1 (it)
CN (1)	CN102427808B (it)
CA (2)	CA2995610C (it)
ES (3)	ES2704921T3 (it)
HR (1)	HRP20161574T1 (it)
HU (1)	HUE030673T2 (it)
IT (1)	IT1397246B1 (it)
LT (1)	LT2429515T (it)
PL (1)	PL2429515T3 (it)
PT (1)	PT2429515T (it)
RU (3)	RU2543354C2 (it)
SI (1)	SI2429515T1 (it)
SM (3)	SMT201900015T1 (it)
WO (1)	WO2010130468A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2719666C (en)	2008-04-04	2016-08-16	Glenn Prestwich	Alkylated semi-synthetic glycosaminoglycosan ethers, and methods for making and using thereof
US8343942B2 (en) *	2008-04-04	2013-01-01	University Of Utah Research Foundation	Methods for treating interstitial cystitis
IT1397247B1 (it) *	2009-05-14	2013-01-04	Fidia Farmaceutici	Nuovi agenti regolatori dell'attivita' citochinica
US20130209531A1 (en)	2010-06-08	2013-08-15	University Of Utah Research Foundation	Applications of partially and fully sulfated hyaluronan
WO2012129461A1 (en)	2011-03-23	2012-09-27	University Of Utah Research Foundation	Methods for treating or preventing urological inflammation
EP3206673B1 (en)	2014-10-17	2024-08-21	Fidia Farmaceutici S.p.A.	Dermal therapeutic system with high adhesivity
ITUB20155623A1 (it) *	2015-11-16	2017-05-16	Fidia Farm Spa	Processo migliorato per la produzione di HA solfatato di elevata purezza
AU2017255833B2 (en) *	2016-04-25	2022-09-01	Mizhou Hui	Application of small-molecule hyaluronic acid fragment
US11337994B2 (en)	2016-09-15	2022-05-24	University Of Utah Research Foundation	In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
IT201600117042A1 (it) *	2016-11-18	2018-05-18	Fidia Farm Spa	Acidi ialuronici solfatati funzionalizzati con dopamina
CN111228653A (zh)	2018-11-13	2020-06-05	格莱科米拉治疗公司	用电离辐射加强癌症治疗的方法
IT201900003887A1 (it)	2019-03-18	2020-09-18	Fidia Farm Spa	Sistemi di stabilizzazione e di rilascio controllato di farmaci instabili alla sterilizzazione
WO2021133000A1 (ko) *	2019-12-23	2021-07-01	주식회사 엘지화학	항염 또는 항혈관신생용 약제학적 조성물
WO2023080886A1 (en) *	2020-09-29	2023-05-11	Ziropa, Inc.	Compositions and methods for pain relief and numbing
CN113754795B (zh) *	2021-10-19	2023-03-10	澳门大学	磺酸化透明质酸类化合物、其制备方法及其应用
WO2024164213A1 (zh) *	2023-02-09	2024-08-15	谢彦晖	聚乙二醇修饰的白介素2、糖皮质激素和透明质酸用于治疗特应性皮炎

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4303676A (en) *	1980-03-21	1981-12-01	Balazs Endre A	Hyaluronate based compositions and cosmetic formulations containing same
US5639738A (en) *	1992-02-20	1997-06-17	Hyal Pharmaceutical Corporation	Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
ITPD940054A1 (it)	1994-03-23	1995-09-23	Fidia Advanced Biopolymers Srl	Polisaccaridi solfatati
DE69621528T2 (de)	1995-02-07	2003-01-16	Shiseido Co. Ltd., Tokio/Tokyo	Anti-inflamatorische agenzien
GB2317182B (en) *	1996-09-11	2000-11-01	Johnson & Johnson Medical	Sulfated polysaccharides and uses thereof in medical treatment
JPH10195107A (ja) *	1997-01-10	1998-07-28	Shiseido Co Ltd	オリゴ硫酸化ヒアルロン酸
DE69809892T2 (de) *	1997-04-04	2003-08-28	Fidia Advanced Biopolymers S.R.L., Brindisi	N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
DE19813234A1 (de) *	1998-03-26	1999-09-30	Knoell Hans Forschung Ev	Verfahren zur Herstellung hochsulfatierter Hyaluronsäuren
JPH11279042A (ja) *	1998-03-30	1999-10-12	Shiseido Co Ltd	皮膚外用剤
CN1116044C (zh) *	1998-06-24	2003-07-30	凌沛学	含有透明质酸钠的防粘连颗粒剂和粉雾剂及其制作方法
JP2000178196A (ja) *	1998-12-11	2000-06-27	Seikagaku Kogyo Co Ltd	新規ヒアルロニダーゼ阻害剤及び外用剤
EP1140199B1 (de) *	1998-12-23	2003-07-23	Esparma GmbH	Hyaluronatlyase als penetrationsförderer in topischen mitteln
WO2000069917A1 (fr) *	1999-05-18	2000-11-23	Maruho Kabushikikaisha	Compositions medicinales destinees a inhiber le systeme kallikreine-kinine ou la phospholipase a¿2?
JP2001163789A (ja) *	1999-12-13	2001-06-19	Maruho Co Ltd	マトリックスメタロプロテアーゼ阻害用医薬組成物
WO2001074781A1 (en) *	2000-03-21	2001-10-11	Astion Development Aps	Chemical complex comprising a substituted pyridine carboxy derivative and a glucosaminoglycan
IL137559A (en) *	2000-07-27	2006-12-31	Amnon Sintov	A system for administering drugs through the skin
DE10053053A1 (de)	2000-10-19	2002-05-16	Knoell Hans Forschung Ev	Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden
US20030162732A1 (en) *	2001-07-05	2003-08-28	Astion Development A/S	Combination of aminosugars and cysteine or cysteine derivatives
ITMI20020756A1 (it) *	2002-04-09	2003-10-09	Sinclair Pharma S R L	Composizioni farmaceutiche topiche per il trattamento delle dermatiti
MXPA05000186A (es) *	2002-07-03	2005-08-17	Pericor Science Inc	Composiciones de acido hialuronico y metodos de uso.
RU2329037C2 (ru) *	2003-02-14	2008-07-20	Комбинаторкс, Инкорпорейтед	Комбинированная терапия для лечения иммуновоспалительных заболеваний
DE102004002001A1 (de) *	2004-01-14	2005-08-11	Reinmüller, Johannes, Dr.med.	Mittel zur Behandlung von entzündlichen Erkrankungen
GB0411165D0 (en) *	2004-05-19	2004-06-23	Bionovate Ltd	Hyaluronic acid containing pharmaceutical or veterinary compounds
ITPD20050168A1 (it) *	2005-06-01	2006-12-02	Fidia Advanced Biopolymers Srl	Formulazioni di acido lipoico ed acido ialuronico e o suoi derivati e loro impiego in campo farmaceutico e cosmetico
RU2302231C1 (ru) *	2006-02-08	2007-07-10	Александр Егорович Петренко	Глазные капли для лечения синдрома сухого глаза
ITPD20060219A1 (it) *	2006-05-31	2007-12-01	Fidia Farmaceutici	Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
ITMI20071724A1 (it) *	2007-09-05	2009-03-06	Fidia Farmaceutici	Formulazioni topiche antivirali in forma di gel bioadesivo
IT1397247B1 (it) *	2009-05-14	2013-01-04	Fidia Farmaceutici	Nuovi agenti regolatori dell'attivita' citochinica

2009
- 2009-05-14 IT ITPD2009A000134A patent/IT1397246B1/it active
2010
- 2010-05-14 EP EP16178620.7A patent/EP3103449B1/en active Active
- 2010-05-14 HU HUE10721126A patent/HUE030673T2/hu unknown
- 2010-05-14 ES ES16178620T patent/ES2704921T3/es active Active
- 2010-05-14 PT PT107211260T patent/PT2429515T/pt unknown
- 2010-05-14 CA CA2995610A patent/CA2995610C/en active Active
- 2010-05-14 US US13/320,000 patent/US9504708B2/en active Active
- 2010-05-14 US US13/320,000 patent/US20120121572A1/en active Granted
- 2010-05-14 SM SM20190015T patent/SMT201900015T1/it unknown
- 2010-05-14 PL PL10721126T patent/PL2429515T3/pl unknown
- 2010-05-14 ES ES18185228T patent/ES2808575T3/es active Active
- 2010-05-14 CN CN201080020708.3A patent/CN102427808B/zh active Active
- 2010-05-14 EP EP18185228.6A patent/EP3417855B1/en active Active
- 2010-05-14 HR HRP20161574TT patent/HRP20161574T1/hr unknown
- 2010-05-14 ES ES10721126.0T patent/ES2601681T3/es active Active
- 2010-05-14 RU RU2011145992/15A patent/RU2543354C2/ru active
- 2010-05-14 CA CA2761628A patent/CA2761628C/en active Active
- 2010-05-14 SI SI201031318A patent/SI2429515T1/sl unknown
- 2010-05-14 SM SM20200522T patent/SMT202000522T1/it unknown
- 2010-05-14 EP EP10721126.0A patent/EP2429515B1/en active Active
- 2010-05-14 WO PCT/EP2010/003050 patent/WO2010130468A1/en not_active Ceased
- 2010-05-14 LT LTEP10721126.0T patent/LT2429515T/lt unknown
2014
- 2014-11-21 RU RU2014146985A patent/RU2673066C2/ru active
- 2014-11-21 RU RU2014146977A patent/RU2673661C2/ru active
2016
- 2016-10-27 US US15/336,498 patent/US10435483B2/en active Active
- 2016-12-14 SM SM201600455T patent/SMT201600455B/it unknown
2019
- 2019-08-26 US US16/550,810 patent/US11198741B2/en active Active

Also Published As

Publication number	Publication date
SMT201900015T1 (it)	2019-02-28
SMT201600455B (it)	2017-01-10
HRP20161574T1 (hr)	2016-12-30
US10435483B2 (en)	2019-10-08
EP2429515A1 (en)	2012-03-21
EP3103449A2 (en)	2016-12-14
CA2761628C (en)	2018-04-10
RU2543354C2 (ru)	2015-02-27
PL2429515T3 (pl)	2017-02-28
RU2673661C2 (ru)	2018-11-29
EP3103449A3 (en)	2017-02-15
RU2014146977A3 (it)	2018-06-05
EP3417855B1 (en)	2020-07-01
US11198741B2 (en)	2021-12-14
EP3417855A1 (en)	2018-12-26
US9504708B2 (en)	2016-11-29
SMT202000522T1 (it)	2020-11-10
US20170107303A1 (en)	2017-04-20
CA2995610C (en)	2020-04-28
RU2673066C2 (ru)	2018-11-22
ES2704921T3 (es)	2019-03-20
CA2995610A1 (en)	2010-11-18
HUE030673T2 (hu)	2017-05-29
ITPD20090134A1 (it)	2010-11-15
RU2014146977A (ru)	2016-06-10
ES2808575T3 (es)	2021-03-01
LT2429515T (lt)	2016-12-12
US20200010573A1 (en)	2020-01-09
SI2429515T1 (sl)	2016-12-30
RU2014146985A (ru)	2016-06-10
PT2429515T (pt)	2016-11-10
US20120121572A1 (en)	2012-05-17
RU2014146985A3 (it)	2018-06-05
RU2011145992A (ru)	2013-06-20
CN102427808A (zh)	2012-04-25
CN102427808B (zh)	2020-05-19
WO2010130468A1 (en)	2010-11-18
CA2761628A1 (en)	2010-11-18
EP3103449B1 (en)	2018-10-17
ES2601681T3 (es)	2017-02-15
EP2429515B1 (en)	2016-09-07

Publication	Publication Date	Title
IT1397246B1 (it)	2013-01-04	Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
SMT201500196B (it)	2015-10-30	Derivati dell'acido idrossammico
BRPI1014876A2 (pt)	2016-04-12	"diamidas de azetidinila como inibidores de monoacilglicerol lipase."
FR2957244B1 (fr)	2012-04-13	Implant d'arthrodese
IT1402901B1 (it)	2013-09-27	Struttura modulare, particolarmente per l'edilizia.
BR112013013409A2 (pt)	2016-09-06	"método de reduzir a emissão de formaldeído de um produto de fibra mineral, e produto de fibra mineral com emissão de formaldeído reduzida"
IT1402907B1 (it)	2013-09-27	Composizioni topiche per mantenere o ripristinare l'integrita' delle mucose.
BRPI1015327A2 (pt)	2019-09-24	"microcápsula, composição química, uso das microcápsulas, uso de uma composição química, e, artigo."
EP2614815A4 (en)	2014-03-19	Foamable aerosol composition
BRPI1009392A2 (pt)	2016-03-08	"formulação farmacêutica, e, uso de uma quantidade farmaceuticamente eficaz de uma formulação farmacêutica."
EP2608694A4 (en)	2014-01-08	COMPUTER CASE
LT2429533T (lt)	2016-12-12	Sulfatuotos hialorono rūgštys, kaip citokinų aktyvumą reguliuojantys agentai
EP2598985A4 (en)	2015-01-07	APPLICATION INSTRUMENT AND QUERY MEMORY FOR THIS
FR2944062B1 (fr)	2011-06-03	Injecteur d'ergols
BR112012018402A2 (pt)	2018-08-07	"produto refratário com elevado teor de zircônio".
EP2596111A4 (en)	2015-09-23	PREPARATION OF ARABITOL
EP2591195A4 (en)	2016-06-01	METHOD, ARRANGEMENT AND USE FOR MARKING OBJECTS
FR2939766B1 (fr)	2011-01-14	Pylone central d'aeronef.
IT1399609B1 (it)	2013-04-26	Ifi16 extracellulare come agente terapeutico
ITMI20051416A1 (it)	2007-01-23	Composizioni cosmetiche contenenti acido ialuronico e colostro
ITMI20062254A1 (it)	2008-05-25	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
FR2962712B1 (fr)	2013-03-29	Structure d'aeronef integrant des supports de systemes.
BRPI0905875A2 (pt)	2015-06-30	"composição, método de preparação de uma composição farmacêutica e uso de uma composição"
UA19583S (uk)	2009-10-12	Печиво «поліно»
UA21365S (uk)	2011-01-25	Сухарі «панчос»