IT201700100116A1 - Composti a struttura benzo[a]carbazolica e loro usi - Google Patents

Composti a struttura benzo[a]carbazolica e loro usi

Info

Publication number
IT201700100116A1
IT201700100116A1 IT102017000100116A IT201700100116A IT201700100116A1 IT 201700100116 A1 IT201700100116 A1 IT 201700100116A1 IT 102017000100116 A IT102017000100116 A IT 102017000100116A IT 201700100116 A IT201700100116 A IT 201700100116A IT 201700100116 A1 IT201700100116 A1 IT 201700100116A1
Authority
IT
Italy
Prior art keywords
carbazolica
composition
benzo structure
benzo
Prior art date
Application number
IT102017000100116A
Other languages
English (en)
Inventor
Armando Rossello
Elisa Nuti
Elisabetta Orlandini
Susanna Nencetti
Claudia Martini
Barbara Costa
Chiara Giacomelli
Simona Daniele
Original Assignee
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa filed Critical Univ Pisa
Priority to IT102017000100116A priority Critical patent/IT201700100116A1/it
Priority to US16/645,267 priority patent/US20200299306A1/en
Priority to EP18782191.3A priority patent/EP3679044A1/en
Priority to PCT/IB2018/056737 priority patent/WO2019049024A1/en
Publication of IT201700100116A1 publication Critical patent/IT201700100116A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102017000100116A 2017-09-07 2017-09-07 Composti a struttura benzo[a]carbazolica e loro usi IT201700100116A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102017000100116A IT201700100116A1 (it) 2017-09-07 2017-09-07 Composti a struttura benzo[a]carbazolica e loro usi
US16/645,267 US20200299306A1 (en) 2017-09-07 2018-09-04 Compounds with a benzo[a]carbazole structure and use thereof
EP18782191.3A EP3679044A1 (en) 2017-09-07 2018-09-04 Compounds with a benzo[a]carbazole structure and use thereof
PCT/IB2018/056737 WO2019049024A1 (en) 2017-09-07 2018-09-04 COMPOUNDS HAVING A BENZO [A] CARBAZOLE STRUCTURE AND THEIR USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000100116A IT201700100116A1 (it) 2017-09-07 2017-09-07 Composti a struttura benzo[a]carbazolica e loro usi

Publications (1)

Publication Number Publication Date
IT201700100116A1 true IT201700100116A1 (it) 2019-03-07

Family

ID=60991352

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000100116A IT201700100116A1 (it) 2017-09-07 2017-09-07 Composti a struttura benzo[a]carbazolica e loro usi

Country Status (4)

Country Link
US (1) US20200299306A1 (it)
EP (1) EP3679044A1 (it)
IT (1) IT201700100116A1 (it)
WO (1) WO2019049024A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022080812A1 (ko) * 2020-10-13 2022-04-21 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조 방법
IT202100020582A1 (it) * 2021-07-30 2023-01-30 Universita’ Di Pisa Composti a struttura benzo[a]carbazolica per uso nella prevenzione e/o nel trattamento di malattie infettive
KR20240101561A (ko) 2021-10-14 2024-07-02 인사이트 코포레이션 Kras의 저해제로서의 퀴놀린 화합물
CN118146234A (zh) * 2022-11-30 2024-06-07 浙江我武翼方药业有限公司 6,5,7,6-四环衍生物、其制备方法和应用
CN118146221B (zh) * 2024-05-13 2024-10-25 南京市鸿舜医药科技有限公司 一种吡咯并[3,2-b]吡啶类拓扑异构酶抑制剂、制法及其药物组合物和应用
CN118221674B (zh) * 2024-05-27 2025-01-28 南京市鸿舜医药科技有限公司 一种吡咯并[3,2-b]吡啶类Top/HDAC双靶点抑制剂、制法及其药物组合物和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007009120A2 (en) * 2005-07-14 2007-01-18 Irm Llc Heterotetracyclic compounds as tpo mimetics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007009120A2 (en) * 2005-07-14 2007-01-18 Irm Llc Heterotetracyclic compounds as tpo mimetics

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ERWIN VON ANGERER ET AL: "Benzo[a]carbazole derivatives. Synthesis, estrogen receptor binding affinities, and mammary tumor inhibiting activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 3, 1 March 1986 (1986-03-01), pages 380 - 386, XP055468926, ISSN: 0022-2623, DOI: 10.1021/jm00153a013 *
GABRIELA MARTIN ET AL: "Antitumoral activity of a new series of 5,6-dihydrobenzo( a)carbazoles", JOURNAL OF EXPERIMENTAL THERAPEUTICS AND ONCOLOGY, vol. 2, no. 2, 1 March 2002 (2002-03-01), GB, pages 77 - 84, XP055468932, ISSN: 1359-4117, DOI: 10.1046/j.1359-4117.2002.01013.x *
MARYAM BASHIR ET AL: "Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review", MOLECULES, vol. 20, no. 8, 1 January 2015 (2015-01-01), pages 13496 - 13517, XP055468959, DOI: 10.3390/molecules200813496 *
ROSSELLO A ET AL: "Synthesis and antimicrobial activity of new 7@b-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins", IL FAR, ELSEVIER FRANCE * EDITIONS SCIENTIFIQUES ET MEDICALES, FR, vol. 59, no. 9, 1 September 2004 (2004-09-01), pages 691 - 696, XP004547501, ISSN: 0014-827X, DOI: 10.1016/J.FARMAC.2004.05.001 *

Also Published As

Publication number Publication date
EP3679044A1 (en) 2020-07-15
WO2019049024A1 (en) 2019-03-14
US20200299306A1 (en) 2020-09-24

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