IT8520872A0 - Mercaptocicloalchilcarbonil e mercaptoarilcarbonil dipeptidi adattivita' antiipertensiva e relative composizioni farmaceutiche. - Google Patents

Mercaptocicloalchilcarbonil e mercaptoarilcarbonil dipeptidi adattivita' antiipertensiva e relative composizioni farmaceutiche.

Info

Publication number
IT8520872A0
IT8520872A0 IT8520872A IT2087285A IT8520872A0 IT 8520872 A0 IT8520872 A0 IT 8520872A0 IT 8520872 A IT8520872 A IT 8520872A IT 2087285 A IT2087285 A IT 2087285A IT 8520872 A0 IT8520872 A0 IT 8520872A0
Authority
IT
Italy
Prior art keywords
mercaptocylcarbonil
mercaptocicloalkylcarbonil
dipeptides
antihypertensive
suitability
Prior art date
Application number
IT8520872A
Other languages
English (en)
Other versions
IT1183677B (it
Inventor
Harold N Weller Iii
Eric M Gordon
Norma G Delaney
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8520872A0 publication Critical patent/IT8520872A0/it
Application granted granted Critical
Publication of IT1183677B publication Critical patent/IT1183677B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT20872/85A 1984-05-25 1985-05-24 Mercaptociloalchilcarbonil e mercaptoarilcarbonil dipeptidi ad attivita' antioertensiva e relative composizioni IT1183677B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/614,090 US4560506A (en) 1984-05-25 1984-05-25 Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides

Publications (2)

Publication Number Publication Date
IT8520872A0 true IT8520872A0 (it) 1985-05-24
IT1183677B IT1183677B (it) 1987-10-22

Family

ID=24459829

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20872/85A IT1183677B (it) 1984-05-25 1985-05-24 Mercaptociloalchilcarbonil e mercaptoarilcarbonil dipeptidi ad attivita' antioertensiva e relative composizioni

Country Status (7)

Country Link
US (1) US4560506A (it)
JP (1) JPH0762029B2 (it)
CA (1) CA1269496C (it)
DE (1) DE3518817A1 (it)
FR (1) FR2564845B1 (it)
GB (1) GB2159160B (it)
IT (1) IT1183677B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
EP0358660B1 (en) * 1987-03-17 1994-05-25 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US4849525A (en) * 1987-09-21 1989-07-18 E. R. Squibb & Sons, Inc. Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides
US5117335A (en) * 1989-12-28 1992-05-26 Koito Manufacturing Co., Ltd. Headlight for vehicle
ATE183645T1 (de) * 1993-10-13 1999-09-15 Karla Lehmann Verwendung von lithiumverbindungen in kombination mit ace-hemmern und/oder angiotensin ii-rezeptor- antagonisten zur behandlung von erhöhtem blutdruck
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7022677B1 (en) * 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
WO2003014062A1 (en) * 2001-08-03 2003-02-20 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents
DK1966130T3 (da) 2005-12-23 2014-02-10 Zealand Pharma As Modificerede lysin-mimetiske forbindelser
WO2008079266A2 (en) 2006-12-21 2008-07-03 Wyeth Synthesis of pyrrolidine compounds
JP6989864B2 (ja) 2017-05-05 2022-02-03 ジーランド ファーマ，アー／エス ギャップ結合細胞間コミュニケーションモジュレータ及び糖尿病性眼疾患の治療のためのそれらの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4440941A (en) * 1980-12-22 1984-04-03 Usv Pharmaceutical Corporation Aroyl-aminoacids, amides and esters thereof
IT1195287B (it) * 1981-11-05 1988-10-12 Ausonia Farma Srl Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
DE3518817A1 (de) 1985-11-28
US4560506A (en) 1985-12-24
GB2159160B (en) 1987-10-28
JPH0762029B2 (ja) 1995-07-05
IT1183677B (it) 1987-10-22
FR2564845A1 (fr) 1985-11-29
CA1269496A (en) 1990-05-22
FR2564845B1 (fr) 1990-04-27
JPS617295A (ja) 1986-01-13
GB2159160A (en) 1985-11-27
GB8513178D0 (en) 1985-06-26
CA1269496C (en) 1990-05-22

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940526