ITMI20020148A1 - Nuovi corticosteroidi - Google Patents

Nuovi corticosteroidi

Info

Publication number: ITMI20020148A1
Authority: IT; Italy
Prior art keywords: corticosteroids; new; new corticosteroids
Prior art date: 2002-01-29

Application number

IT2002MI000148A

Other languages

English (en)

Inventor

Ennio Ongini

Soldato Piero Del

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-29

Filing date

2002-01-29

Publication date

2003-07-29

2002-01-29 Application filed by Nicox Sa filed Critical Nicox Sa

2002-01-29 Priority to IT2002MI000148A priority Critical patent/ITMI20020148A1/it

2002-01-29 Publication of ITMI20020148A0 publication Critical patent/ITMI20020148A0/it

2003-01-16 Priority to PCT/EP2003/000394 priority patent/WO2003064443A2/en

2003-01-16 Priority to PL03370457A priority patent/PL370457A1/xx

2003-01-16 Priority to BR0307027-1A priority patent/BR0307027A/pt

2003-01-16 Priority to JP2003564063A priority patent/JP2005516070A/ja

2003-01-16 Priority to AU2003210161A priority patent/AU2003210161B2/en

2003-01-16 Priority to NZ534147A priority patent/NZ534147A/en

2003-01-16 Priority to CA002473249A priority patent/CA2473249A1/en

2003-01-16 Priority to US10/501,335 priority patent/US20060052594A1/en

2003-01-16 Priority to MXPA04007337A priority patent/MXPA04007337A/es

2003-01-16 Priority to EP03734674A priority patent/EP1470150A2/en

2003-07-29 Publication of ITMI20020148A1 publication Critical patent/ITMI20020148A1/it

2004-08-27 Priority to NO20043595A priority patent/NO327364B1/no

2008-12-15 Priority to AU2008258133A priority patent/AU2008258133A1/en

2009-05-12 Priority to US12/464,562 priority patent/US20090221543A1/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IT2002MI000148A 2002-01-29 2002-01-29 Nuovi corticosteroidi ITMI20020148A1 (it)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
IT2002MI000148A ITMI20020148A1 (it)	2002-01-29	2002-01-29	Nuovi corticosteroidi
EP03734674A EP1470150A2 (en)	2002-01-29	2003-01-16	Corticosteroids nitrate derivatives
NZ534147A NZ534147A (en)	2002-01-29	2003-01-16	New corticosteroids
US10/501,335 US20060052594A1 (en)	2002-01-29	2003-01-16	New corticosteroids
BR0307027-1A BR0307027A (pt)	2002-01-29	2003-01-16	Compostos derivados de nitróxi de compostos esteróides, uso dos compostos, e, formulações farmacêuticas
JP2003564063A JP2005516070A (ja)	2002-01-29	2003-01-16	新規なコルチコステロイド類
AU2003210161A AU2003210161B2 (en)	2002-01-29	2003-01-16	New corticosteroids
PCT/EP2003/000394 WO2003064443A2 (en)	2002-01-29	2003-01-16	New corticosteroids
CA002473249A CA2473249A1 (en)	2002-01-29	2003-01-16	New corticosteroids
PL03370457A PL370457A1 (en)	2002-01-29	2003-01-16	New corticosteroids
MXPA04007337A MXPA04007337A (es)	2002-01-29	2003-01-16	Corticosteroides novedosos.
NO20043595A NO327364B1 (no)	2002-01-29	2004-08-27	Nitrooksyderivater av steroidforbindelser, anvendelse derav, og farmasoytisk formulering omfattende slike
AU2008258133A AU2008258133A1 (en)	2002-01-29	2008-12-15	New corticosteroids
US12/464,562 US20090221543A1 (en)	2002-01-29	2009-05-12	New corticosteroids

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2002MI000148A ITMI20020148A1 (it)	2002-01-29	2002-01-29	Nuovi corticosteroidi

Publications (2)

Publication Number	Publication Date
ITMI20020148A0 ITMI20020148A0 (it)	2002-01-29
ITMI20020148A1 true ITMI20020148A1 (it)	2003-07-29

Family

ID=11449016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2002MI000148A ITMI20020148A1 (it)	2002-01-29	2002-01-29	Nuovi corticosteroidi

Country Status (12)

Country	Link
US (2)	US20060052594A1 (it)
EP (1)	EP1470150A2 (it)
JP (1)	JP2005516070A (it)
AU (2)	AU2003210161B2 (it)
BR (1)	BR0307027A (it)
CA (1)	CA2473249A1 (it)
IT (1)	ITMI20020148A1 (it)
MX (1)	MXPA04007337A (it)
NO (1)	NO327364B1 (it)
NZ (1)	NZ534147A (it)
PL (1)	PL370457A1 (it)
WO (1)	WO2003064443A2 (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR047732A1 (es) *	2003-12-02	2006-02-15	Nicox Sa	Nitrooxiderivados de drogas antihipertensivas
CN101300265A (zh)	2005-09-02	2008-11-05	尼科克斯公司	糖皮质激素硝酰氧基衍生物
US8802726B2 (en)	2006-02-03	2014-08-12	Nicox S.A.	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US20100041633A1 (en)	2007-02-05	2010-02-18	Nicox S.A.	Nitric oxide releasing steroids
EP1964550A1 (en) *	2007-03-01	2008-09-03	NicOx S.A.	Glucocorticoid-nitrooxyderivative compositions
WO2009037584A2 (en) *	2007-08-10	2009-03-26	Topigen Pharmaceuticals Inc.	Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) *	2007-08-31	2009-04-02	Topigen Pharmaceuticals Inc.	No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
ES2324007A1 (es) *	2007-10-25	2009-07-28	Ferrer Internacional, S.A.	Una forma amorfa de un compuesto antiinflamatorio.
KR101919093B1 (ko) *	2008-05-23	2018-11-16	더 유니버시티 오브 브리티쉬 콜롬비아	리포좀 나노입자에 사용하기 위한 변형된 약물
CN101624414B (zh) *	2008-07-07	2013-02-13	天津金耀集团有限公司	一种抑制血管新生的硝酸酯药物
NZ590454A (en)	2008-07-31	2012-09-28	Nicox Sa	Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
CN102186873A (zh)	2008-08-05	2011-09-14	尼科克斯公司	用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
CN102040643B (zh) *	2009-10-16	2013-01-09	天津金耀集团有限公司	环索奈德硝酸酯衍生物
CN102302501B (zh) *	2010-06-07	2012-10-03	刘超	糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
KR20250114431A (ko)	2016-11-08	2025-07-29	리제너론 파마슈티칼스 인코포레이티드	스테로이드 및 이의 단백질-접합체
KR20200007905A (ko)	2017-05-18	2020-01-22	리제너론 파마슈티칼스 인코포레이티드	사이클로덱스트린 단백질 약물 접합체
IL313068A (en)	2017-11-07	2024-07-01	Regeneron Pharma	Hydrophilic linkers for antibody drug conjugates
IL275757B2 (en)	2018-01-08	2025-08-01	Regeneron Pharma	Steroids and antibody-conjugates thereof
CN108484714A (zh) *	2018-03-13	2018-09-04	岳阳环宇药业有限公司	地夫可特的制备工艺
MX2020011546A (es)	2018-05-09	2021-01-29	Regeneron Pharma	Anticuerpos anti-msr1 y metodos de uso de los mismos.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1037451B (de) *	1957-04-04	1958-08-28	Schering Ag	Verfahren zur Herstellung der Aminoacetate von gesaettigten und ungesaettigten 21-Hydroxypregnan-verbindungen bzw. deren wasserloeslichen Saeureadditionsprodukten
US3183252A (en) *	1963-09-05	1965-05-11	Syntex Corp	16-nitratoalkyl-pregnanes
US3494941A (en)	1967-12-04	1970-02-10	American Home Prod	Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (it)	1971-05-07	1973-12-28
CY1359A (en) *	1981-02-02	1987-08-07	Schering Corp	Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
GR1001529B (el) *	1990-09-07	1994-03-31	Elmuquimica Farm Sl	Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
US6248723B1 (en) *	1997-06-10	2001-06-19	National Jewish Medical And Research Center	Method for treatment of inflammatory disease
US6254853B1 (en) *	1998-05-08	2001-07-03	Vyrex Corporation	Water soluble pro-drugs of propofol
IT1311922B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1320176B1 (it) *	2000-12-22	2003-11-26	Nicox Sa	Dispersioni solide di principi attivi nitrati.
EP1336602A1 (en) *	2002-02-13	2003-08-20	Giovanni Scaramuzzino	Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases

2002
- 2002-01-29 IT IT2002MI000148A patent/ITMI20020148A1/it unknown
2003
- 2003-01-16 BR BR0307027-1A patent/BR0307027A/pt not_active IP Right Cessation
- 2003-01-16 PL PL03370457A patent/PL370457A1/xx unknown
- 2003-01-16 EP EP03734674A patent/EP1470150A2/en not_active Ceased
- 2003-01-16 CA CA002473249A patent/CA2473249A1/en not_active Abandoned
- 2003-01-16 MX MXPA04007337A patent/MXPA04007337A/es unknown
- 2003-01-16 AU AU2003210161A patent/AU2003210161B2/en not_active Ceased
- 2003-01-16 WO PCT/EP2003/000394 patent/WO2003064443A2/en not_active Ceased
- 2003-01-16 JP JP2003564063A patent/JP2005516070A/ja active Pending
- 2003-01-16 NZ NZ534147A patent/NZ534147A/en not_active IP Right Cessation
- 2003-01-16 US US10/501,335 patent/US20060052594A1/en not_active Abandoned
2004
- 2004-08-27 NO NO20043595A patent/NO327364B1/no not_active IP Right Cessation
2008
- 2008-12-15 AU AU2008258133A patent/AU2008258133A1/en not_active Abandoned
2009
- 2009-05-12 US US12/464,562 patent/US20090221543A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2005516070A (ja)	2005-06-02
EP1470150A2 (en)	2004-10-27
CA2473249A1 (en)	2003-08-07
NO20043595L (no)	2004-10-20
PL370457A1 (en)	2005-05-30
WO2003064443A3 (en)	2004-02-26
US20090221543A1 (en)	2009-09-03
MXPA04007337A (es)	2004-11-26
AU2003210161B2 (en)	2008-12-04
NO327364B1 (no)	2009-06-15
ITMI20020148A0 (it)	2002-01-29
US20060052594A1 (en)	2006-03-09
BR0307027A (pt)	2004-11-03
WO2003064443A2 (en)	2003-08-07
AU2008258133A1 (en)	2009-01-08
NZ534147A (en)	2006-09-29

Publication	Publication Date	Title
DE60323499D1 (de)	2008-10-23	Tastverhältnisschätzer
DE60328364D1 (de)	2009-08-27	Abdominalretraktor
DE50313647D1 (de)	2011-06-01	Knochenfixationseinrichtumg
DE60321537D1 (de)	2008-07-24	Schtrockner
ATE318817T1 (de)	2006-03-15	Aza-arylpiperazine
DE60320334D1 (de)	2008-05-29	Klebwalzereiniger
DE60231753D1 (de)	2009-05-07	Betonsteintexturiermaschine
DE50301200D1 (de)	2005-10-20	Wischblatt
DE50311715D1 (de)	2009-08-27	Weltzeituhr
DE60328304D1 (de)	2009-08-20	-zusammensetzungen
ITMI20020148A0 (it)	2002-01-29	Nuovi corticosteroidi
DE60330661D1 (de)	2010-02-04	Einführdichtungsanordnung
DE60226008D1 (de)	2008-05-21	Sicherheitsgurtpresentiereinrichtung
DE50309536D1 (de)	2008-05-15	Fadenabsaugvorrichtung
DE60228135D1 (de)	2008-09-18	Eifen
DE60318029D1 (de)	2008-01-24	Zünder
DE60302827D1 (de)	2006-01-26	Hochgeschwindigheitfräsmaschine
FI20021957A0 (fi)	2002-11-01	Lipeäruisku
FI5303U1 (fi)	2002-03-22	Ammesovitelma
ATA19152002A (de)	2004-11-15	Hubkupplung
DE60304326D1 (de)	2006-05-18	Wärmeniet
DE60205924T2 (de)	2006-06-14	Mikrogreifer
ITMI20021327A1 (it)	2003-12-15	Nuove ossialchilpiperazine
ITMI20021329A1 (it)	2003-12-15	Nuove ossialchilammine sostituite
DE60320010D1 (de)	2008-05-08	Endgeraetevorrichtung