ITMI20032020A1 - Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici - Google Patents

Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici

Info

Publication number
ITMI20032020A1
ITMI20032020A1 IT002020A ITMI20032020A ITMI20032020A1 IT MI20032020 A1 ITMI20032020 A1 IT MI20032020A1 IT 002020 A IT002020 A IT 002020A IT MI20032020 A ITMI20032020 A IT MI20032020A IT MI20032020 A1 ITMI20032020 A1 IT MI20032020A1
Authority
IT
Italy
Prior art keywords
antifungal agents
cytocommas
azolic
metabolic
new
Prior art date
Application number
IT002020A
Other languages
English (en)
Inventor
Maria Lattanzio
Paolo Mascagni
Massimo Pinori
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to IT002020A priority Critical patent/ITMI20032020A1/it
Priority to EP04790506A priority patent/EP1673368B1/en
Priority to DK04790506.2T priority patent/DK1673368T3/da
Priority to PT04790506T priority patent/PT1673368E/pt
Priority to PL04790506T priority patent/PL1673368T3/pl
Priority to PCT/EP2004/011667 priority patent/WO2005040156A1/en
Priority to KR1020067007093A priority patent/KR101182740B1/ko
Priority to US10/576,194 priority patent/US7427620B2/en
Priority to AT04790506T priority patent/ATE463493T1/de
Priority to ES04790506T priority patent/ES2344703T3/es
Priority to BRPI0415319-7A priority patent/BRPI0415319A/pt
Priority to DE602004026457T priority patent/DE602004026457D1/de
Priority to SI200431440T priority patent/SI1673368T1/sl
Priority to CN2004800306079A priority patent/CN1867565B/zh
Priority to CA2542361A priority patent/CA2542361C/en
Priority to JP2006534715A priority patent/JP4744446B2/ja
Publication of ITMI20032020A1 publication Critical patent/ITMI20032020A1/it
Priority to CY20101100539T priority patent/CY1112166T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT002020A 2003-10-17 2003-10-17 Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici ITMI20032020A1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT002020A ITMI20032020A1 (it) 2003-10-17 2003-10-17 Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
US10/576,194 US7427620B2 (en) 2003-10-17 2004-10-14 Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes
BRPI0415319-7A BRPI0415319A (pt) 2003-10-17 2004-10-14 derivado de azol útil como agentes antifúngicos com reduzida interação com citocromos metabólicos
PT04790506T PT1673368E (pt) 2003-10-17 2004-10-14 Derivados de azole uteis como agentes antifungicos com interacão reduzida com citocromos metabëlicos
PL04790506T PL1673368T3 (pl) 2003-10-17 2004-10-14 Pochodna azolowa użyteczna jako środki grzybobójcze o mniejszym oddziaływaniu z cytochromami metabolicznymi
PCT/EP2004/011667 WO2005040156A1 (en) 2003-10-17 2004-10-14 Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes
KR1020067007093A KR101182740B1 (ko) 2003-10-17 2004-10-14 대사성 시토크롬과 감소된 상호작용을 하는 항진균제로서유용한 아졸 유도체
EP04790506A EP1673368B1 (en) 2003-10-17 2004-10-14 Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes
AT04790506T ATE463493T1 (de) 2003-10-17 2004-10-14 Als antipilzmittel geeignete azolderivate mit reduzierter wechselwirkung mit metabolischen zytochromen
ES04790506T ES2344703T3 (es) 2003-10-17 2004-10-14 Derivados de azol utiles como agentes antifungicos con interaccion reducida con citocromos metabolicos.
DK04790506.2T DK1673368T3 (da) 2003-10-17 2004-10-14 Azolderivat der er anvendelig som antifungale midler med reduceret interaktion moed metaboliske cytochromer
DE602004026457T DE602004026457D1 (de) 2003-10-17 2004-10-14 Als antipilzmittel geeignete azolderivate mit reduzierter wechselwirkung mit metabolischen zytochromen
SI200431440T SI1673368T1 (sl) 2003-10-17 2004-10-14 Derivat azola za uporabo kot sredstva proti glivicam z zmanjĺˇano interakcijo z metaboliäśnimi citokromi
CN2004800306079A CN1867565B (zh) 2003-10-17 2004-10-14 可用作抗真菌剂的、降低了与代谢细胞色素之间相互作用的吡咯衍生物
CA2542361A CA2542361C (en) 2003-10-17 2004-10-14 Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes
JP2006534715A JP4744446B2 (ja) 2003-10-17 2004-10-14 代謝シトクロムとの相互作用が低減された抗真菌剤として有用なアゾール誘導体
CY20101100539T CY1112166T1 (el) 2003-10-17 2010-06-11 Παραγωγο αζολιου χρησιμο ως αντιμυκητιακοι παραγοντες με μειωμενη αλληλεπιδραση με μεταβολικα κυτοχρωματα

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002020A ITMI20032020A1 (it) 2003-10-17 2003-10-17 Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici

Publications (1)

Publication Number Publication Date
ITMI20032020A1 true ITMI20032020A1 (it) 2005-04-18

Family

ID=34509451

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002020A ITMI20032020A1 (it) 2003-10-17 2003-10-17 Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici

Country Status (17)

Country Link
US (1) US7427620B2 (it)
EP (1) EP1673368B1 (it)
JP (1) JP4744446B2 (it)
KR (1) KR101182740B1 (it)
CN (1) CN1867565B (it)
AT (1) ATE463493T1 (it)
BR (1) BRPI0415319A (it)
CA (1) CA2542361C (it)
CY (1) CY1112166T1 (it)
DE (1) DE602004026457D1 (it)
DK (1) DK1673368T3 (it)
ES (1) ES2344703T3 (it)
IT (1) ITMI20032020A1 (it)
PL (1) PL1673368T3 (it)
PT (1) PT1673368E (it)
SI (1) SI1673368T1 (it)
WO (1) WO2005040156A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10738324B2 (en) 2010-09-30 2020-08-11 Kagoshima University Growth-regulated viral vector containing the aurora kinase promoter

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0237693A1 (fr) 1986-03-21 1987-09-23 Ambrogio Catracchia Gicleur pour le nettoyage des dents et des appareils dentaires
DE3609596A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
US4788190A (en) * 1986-12-24 1988-11-29 Schering Corporation 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
ZA9410142B (en) 1993-12-21 1996-05-02 Schering Corp Tetrahydrofuran antifungals
JP2000514057A (ja) * 1996-06-28 2000-10-24 シェーリング コーポレイション 増強されたバイオアベイラビリティを有する抗真菌剤の固溶体
HU227744B1 (en) 1997-02-11 2012-02-28 Janssen Pharmaceutica Nv Amino acid ester containing azole antifungals, process for their preparation, pharmaceuticals containing the same and intermediates
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
FR2807434B1 (fr) * 2000-04-05 2002-10-18 Hoechst Marion Roussel Inc Nouveaux derives de la 1,2,3,4-tetrahydroisoquinoleine, leur procede de preparation et leur application comme fongicides

Also Published As

Publication number Publication date
CN1867565A (zh) 2006-11-22
DK1673368T3 (da) 2010-06-07
KR20060130554A (ko) 2006-12-19
EP1673368B1 (en) 2010-04-07
US7427620B2 (en) 2008-09-23
PL1673368T3 (pl) 2010-09-30
EP1673368A1 (en) 2006-06-28
ES2344703T3 (es) 2010-09-03
PT1673368E (pt) 2010-07-09
WO2005040156A8 (en) 2005-06-23
CA2542361C (en) 2012-04-24
JP2007533638A (ja) 2007-11-22
BRPI0415319A (pt) 2006-12-05
CY1112166T1 (el) 2015-12-09
SI1673368T1 (sl) 2010-08-31
JP4744446B2 (ja) 2011-08-10
CN1867565B (zh) 2011-06-22
ATE463493T1 (de) 2010-04-15
KR101182740B1 (ko) 2012-09-13
WO2005040156A1 (en) 2005-05-06
CA2542361A1 (en) 2005-05-06
US20070129376A1 (en) 2007-06-07
DE602004026457D1 (de) 2010-05-20

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