ATE444954T1 - Verfahren zur herstellung von s)-(+)-10,11- dihydro-10-hydroxy-5h-dibenzäb,füazepin-5- carboxamid - Google Patents
Verfahren zur herstellung von s)-(+)-10,11- dihydro-10-hydroxy-5h-dibenzäb,füazepin-5- carboxamidInfo
- Publication number
- ATE444954T1 ATE444954T1 AT05819292T AT05819292T ATE444954T1 AT E444954 T1 ATE444954 T1 AT E444954T1 AT 05819292 T AT05819292 T AT 05819292T AT 05819292 T AT05819292 T AT 05819292T AT E444954 T1 ATE444954 T1 AT E444954T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydro
- hydroxy
- fuazepine
- dibenzäb
- carboxamide
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QQSMCHOABQHASF-HNNXBMFYSA-N (5s)-5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carbonitrile Chemical compound O[C@H]1CC2=CC=CC=C2N(C#N)C2=CC=CC=C12 QQSMCHOABQHASF-HNNXBMFYSA-N 0.000 abstract 1
- ARWDKBAZURSFOU-HNNXBMFYSA-N 2-[(5S)-5-hydroxy-5,6-dihydrobenzo[b][1]benzazepin-11-yl]acetamide Chemical compound O[C@H]1CC2=C(N(C3=C1C=CC=C3)CC(=O)N)C=CC=C2 ARWDKBAZURSFOU-HNNXBMFYSA-N 0.000 abstract 1
- QQSMCHOABQHASF-UHFFFAOYSA-N 5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carbonitrile Chemical compound OC1CC2=CC=CC=C2N(C#N)C2=CC=CC=C12 QQSMCHOABQHASF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 abstract 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/30—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002291A ITMI20042291A1 (it) | 2004-11-26 | 2004-11-26 | Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide |
| PCT/EP2005/012205 WO2006056339A1 (en) | 2004-11-26 | 2005-11-15 | A process for the preparation of (s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenz (b,f) azepine-5-carboxyamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444954T1 true ATE444954T1 (de) | 2009-10-15 |
Family
ID=36084359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05819292T ATE444954T1 (de) | 2004-11-26 | 2005-11-15 | Verfahren zur herstellung von s)-(+)-10,11- dihydro-10-hydroxy-5h-dibenzäb,füazepin-5- carboxamid |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7858780B2 (de) |
| EP (1) | EP1833798B1 (de) |
| AT (1) | ATE444954T1 (de) |
| CA (1) | CA2589147C (de) |
| CY (1) | CY1110526T1 (de) |
| DE (1) | DE602005017073D1 (de) |
| ES (1) | ES2331320T3 (de) |
| IT (1) | ITMI20042291A1 (de) |
| PT (1) | PT1833798E (de) |
| WO (1) | WO2006056339A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011045648A2 (en) * | 2009-10-12 | 2011-04-21 | Matrix Laboratories Limited | Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof |
| WO2012120356A2 (en) | 2011-03-08 | 2012-09-13 | Jubilant Life Sciences Limited | Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof |
| WO2012156987A2 (en) * | 2011-05-19 | 2012-11-22 | Glenmark Generics Limited | A novel process for the preparation of eslicarbazepine |
| IN2015DN02296A (de) | 2012-09-26 | 2015-08-21 | Ranbaxy Lab Ltd | |
| EP3064490A1 (de) | 2015-03-06 | 2016-09-07 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Verbessertes verfahren zur herstellung von eslicarbazepin und eslicarbazepinacetat |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1317854B1 (it) * | 2000-02-25 | 2003-07-15 | Farchemia Srl | 5-ciano-10-idrossi-10,11-diidro-5h-dibenz(b,f)azepina e procedimentiper la sua preparazione e per la sua conversione in |
| GB0112812D0 (en) | 2001-05-25 | 2001-07-18 | Portela & Ca Sa | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
-
2004
- 2004-11-26 IT IT002291A patent/ITMI20042291A1/it unknown
-
2005
- 2005-11-15 ES ES05819292T patent/ES2331320T3/es not_active Expired - Lifetime
- 2005-11-15 PT PT05819292T patent/PT1833798E/pt unknown
- 2005-11-15 WO PCT/EP2005/012205 patent/WO2006056339A1/en not_active Ceased
- 2005-11-15 EP EP05819292A patent/EP1833798B1/de not_active Expired - Lifetime
- 2005-11-15 US US11/791,582 patent/US7858780B2/en not_active Expired - Fee Related
- 2005-11-15 CA CA2589147A patent/CA2589147C/en not_active Expired - Fee Related
- 2005-11-15 AT AT05819292T patent/ATE444954T1/de not_active IP Right Cessation
- 2005-11-15 DE DE602005017073T patent/DE602005017073D1/de not_active Expired - Fee Related
-
2009
- 2009-10-30 CY CY20091101130T patent/CY1110526T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1110526T1 (el) | 2015-04-29 |
| ES2331320T3 (es) | 2009-12-29 |
| PT1833798E (pt) | 2009-10-28 |
| DE602005017073D1 (de) | 2009-11-19 |
| EP1833798B1 (de) | 2009-10-07 |
| WO2006056339A1 (en) | 2006-06-01 |
| EP1833798A1 (de) | 2007-09-19 |
| CA2589147A1 (en) | 2006-06-01 |
| CA2589147C (en) | 2013-11-05 |
| ITMI20042291A1 (it) | 2005-02-26 |
| US7858780B2 (en) | 2010-12-28 |
| US20090105472A1 (en) | 2009-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |