ITMI930141A1 - Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina - Google Patents

Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina

Info

Publication number
ITMI930141A1
ITMI930141A1 IT000141A ITMI930141A ITMI930141A1 IT MI930141 A1 ITMI930141 A1 IT MI930141A1 IT 000141 A IT000141 A IT 000141A IT MI930141 A ITMI930141 A IT MI930141A IT MI930141 A1 ITMI930141 A1 IT MI930141A1
Authority
IT
Italy
Prior art keywords
acid
cyclodextrine
constituted
high solubility
inclusion complexes
Prior art date
Application number
IT000141A
Other languages
English (en)
Inventor
Paolo Chiesi
Massimo Pasini
Josef Szejtli
Paolo Ventura
Maria Vikmon
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of ITMI930141A0 publication Critical patent/ITMI930141A0/it
Priority to ITMI930141A priority Critical patent/IT1263831B/it
Priority to NZ261115A priority patent/NZ261115A/en
Priority to HU9502251A priority patent/HU218796B/hu
Priority to PCT/EP1994/000205 priority patent/WO1994016733A1/en
Priority to JP6516681A priority patent/JPH08508711A/ja
Priority to DE69431747T priority patent/DE69431747D1/de
Priority to FI953590A priority patent/FI953590A7/fi
Priority to KR1019950702913A priority patent/KR960700074A/ko
Priority to CA002154874A priority patent/CA2154874A1/en
Priority to AU59710/94A priority patent/AU691115B2/en
Priority to BR9406779A priority patent/BR9406779A/pt
Priority to AT94905707T priority patent/ATE228013T1/de
Priority to US08/481,519 priority patent/US5855916A/en
Priority to CZ951943A priority patent/CZ284606B6/cs
Priority to EP94905707A priority patent/EP0681481B1/en
Priority to IL10846094A priority patent/IL108460A/en
Priority to ZA94572A priority patent/ZA94572B/xx
Publication of ITMI930141A1 publication Critical patent/ITMI930141A1/it
Priority to NO952981A priority patent/NO952981D0/no
Application granted granted Critical
Publication of IT1263831B publication Critical patent/IT1263831B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ITMI930141A 1993-01-29 1993-01-29 Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina IT1263831B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ITMI930141A IT1263831B (it) 1993-01-29 1993-01-29 Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina
CA002154874A CA2154874A1 (en) 1993-01-29 1994-01-26 Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin
BR9406779A BR9406779A (pt) 1993-01-29 1994-01-26 Complexos de inclusão de multicomponentes altamente solúveis contendo uma droga de tipo básico um ácido e uma ciclodextrina
PCT/EP1994/000205 WO1994016733A1 (en) 1993-01-29 1994-01-26 Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin
JP6516681A JPH08508711A (ja) 1993-01-29 1994-01-26 塩基型薬剤と酸とシクロデキストリンを含有する高可溶性多成分包接錯体
DE69431747T DE69431747D1 (de) 1993-01-29 1994-01-26 Hochlösliche multikomponenten-inklusionskomplexe, welche ein basisches arzneimittel, eine säure und ein zyklodextrin enthalten
FI953590A FI953590A7 (fi) 1993-01-29 1994-01-26 Erittäin liukoiset monta komponenttia sisältävät sulkeumakompleksit, j otka sisältävät emästyyppistä lääkeainetta, happoa sekä syklodekstriin iä
KR1019950702913A KR960700074A (ko) 1993-01-29 1994-01-26 고용해성다성분봉입체착화합물(Highy soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin)
NZ261115A NZ261115A (en) 1993-01-29 1994-01-26 Cyclodextrin complexes comprising basic drug and an acid
AU59710/94A AU691115B2 (en) 1993-01-29 1994-01-26 Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin
HU9502251A HU218796B (hu) 1993-01-29 1994-01-26 Többkomponensű, bázikus gyógyszerhatóanyagot, savat és ciklodextrint tartalmazó zárványkomplexek
AT94905707T ATE228013T1 (de) 1993-01-29 1994-01-26 Hochlösliche multikomponenten-inklusionskomplexe, welche ein basisches arzneimittel, eine säure und ein zyklodextrin enthalten
US08/481,519 US5855916A (en) 1993-01-29 1994-01-26 Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin
CZ951943A CZ284606B6 (cs) 1993-01-29 1994-01-26 Vícesložkové inklusní komplexy a způsob jejich výroby
EP94905707A EP0681481B1 (en) 1993-01-29 1994-01-26 Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin
IL10846094A IL108460A (en) 1993-01-29 1994-01-27 Highly soluble multicomponent inclusion complexes containing a base type drug an acid and a cyclodextrin
ZA94572A ZA94572B (en) 1993-01-29 1994-01-27 Highly soluble multicomponent inclusion complexes containing a base type drug an acid and a cyclodextrin
NO952981A NO952981D0 (no) 1993-01-29 1995-07-27 Höyopplöselige flerkomponent-innleiringskomplekser inneholdende et basisk medikament, en syre og et cyklodekstrin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI930141A IT1263831B (it) 1993-01-29 1993-01-29 Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina

Publications (3)

Publication Number Publication Date
ITMI930141A0 ITMI930141A0 (it) 1993-01-29
ITMI930141A1 true ITMI930141A1 (it) 1994-07-30
IT1263831B IT1263831B (it) 1996-09-04

Family

ID=11364792

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI930141A IT1263831B (it) 1993-01-29 1993-01-29 Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina

Country Status (18)

Country Link
US (1) US5855916A (it)
EP (1) EP0681481B1 (it)
JP (1) JPH08508711A (it)
KR (1) KR960700074A (it)
AT (1) ATE228013T1 (it)
AU (1) AU691115B2 (it)
BR (1) BR9406779A (it)
CA (1) CA2154874A1 (it)
CZ (1) CZ284606B6 (it)
DE (1) DE69431747D1 (it)
FI (1) FI953590A7 (it)
HU (1) HU218796B (it)
IL (1) IL108460A (it)
IT (1) IT1263831B (it)
NO (1) NO952981D0 (it)
NZ (1) NZ261115A (it)
WO (1) WO1994016733A1 (it)
ZA (1) ZA94572B (it)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
AUPM456894A0 (en) * 1994-03-18 1994-04-14 Glyzinc Pharmaceuticals Limited Treatment for gastric disorders
IT1269578B (it) * 1994-04-22 1997-04-08 Chiesi Farma Spa Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo acido, una ciclodestrina e una base.
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
US6255502B1 (en) * 1996-07-11 2001-07-03 Farmarc Nederland B.V. Pharmaceutical composition containing acid addition salt of basic drug
GB9711643D0 (en) * 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
EP0893121B1 (en) * 1997-06-27 2002-03-13 Akzo Nobel N.V. Oral liquid medicine solution
US6077871A (en) * 1997-11-26 2000-06-20 Pfizer Inc. Droloxifene pharmaceutical compositions
DK172860B1 (da) * 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman
JP2000080123A (ja) * 1998-09-03 2000-03-21 Toagosei Co Ltd シアノアクリレート用硬化促進剤
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
FI982733L (fi) 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
FI109332B (fi) 1998-12-17 2002-07-15 Orion Yhtymae Oyj Toremifeenin liukoisia koostumuksia
US6740639B1 (en) * 2000-03-29 2004-05-25 Council Of Scientific & Industrial Research Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment
GB0015239D0 (en) * 2000-06-21 2000-08-16 Biochemie Gmbh Organic compounds
US6663897B2 (en) 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
JP2003063965A (ja) * 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
AU2002365077A1 (en) * 2001-09-19 2003-06-30 Massachusetts Institute Of Technology Methods and products related to non-viral transfection
WO2004000284A1 (en) 2002-06-21 2003-12-31 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2477923C (en) 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
EP1511490A4 (en) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
CA2495864C (en) * 2002-08-20 2011-09-27 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US20050085446A1 (en) * 2003-04-14 2005-04-21 Babu M.K. M. Fluoroquinolone formulations and methods of making and using the same
US7157446B2 (en) * 2003-05-02 2007-01-02 Bristol Myers Squibb Company Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol
CN1515260B (zh) * 2003-06-26 2010-05-05 沈阳药科大学 含hpcd的桂利嗪粉针剂和其固体制剂及其制备方法
ATE555133T1 (de) 2003-11-13 2012-05-15 Hanmi Holdings Co Ltd Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
EP1570862A1 (en) * 2004-02-25 2005-09-07 JPM - The Jordanian Pharmaceutical Manufacturing Co. Ltd. Highly soluble binary cyclodextrin inclusion complexes
WO2005092884A1 (en) * 2004-02-26 2005-10-06 Transform Pharmaceuticals, Inc. Novel crystalline forms of conazoles and methods of making and using the same
US9492446B2 (en) * 2004-06-24 2016-11-15 Ctc Bio, Inc. Manufacturing method of solid dispersion containing itraconazole
WO2006052922A2 (en) * 2004-11-08 2006-05-18 Eastman Chemical Company Pharmaceutical formulations of cyclodextrins and selective estrogen receptor modulator compounds
US20060105045A1 (en) * 2004-11-08 2006-05-18 Buchanan Charles M Cyclodextrin solubilizers for liquid and semi-solid formulations
DE102005041860A1 (de) * 2005-09-02 2007-03-08 Schering Ag Nanopartikulärer Einschluss- und Ladungskomplex für pharmazeutische Formulierungen
US20070082870A1 (en) * 2005-10-11 2007-04-12 Buchanan Charles M Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
CN101990542A (zh) * 2008-02-08 2011-03-23 德克萨斯大学董事会 环巴胺酒石酸盐及其用途
CN101314045B (zh) * 2008-05-09 2013-01-23 沈阳药科大学 桂利嗪的磺丁基醚-β-环糊精包合物及其制剂和制备方法
CN102119023B (zh) 2008-07-03 2014-04-09 弗吉尼亚大学专利基金会 阿帕地松单位剂量
US9492417B2 (en) 2008-08-21 2016-11-15 The Johns Hopkins University Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
CA2763365C (en) 2009-05-29 2016-09-13 Cydex Pharmaceuticals, Inc. Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
JP5803150B2 (ja) * 2011-03-02 2015-11-04 三菱瓦斯化学株式会社 ピロロキノリンキノンーシクロデキストリン包接体
US9657059B2 (en) 2013-09-09 2017-05-23 Canimguide Therapeutics Ab Immune system modulators
WO2015108933A1 (en) * 2014-01-14 2015-07-23 The Johns Hopkins University Cyclodextrin compositions encapsulating a selective atp inhibitor and uses thereof
WO2016072985A1 (en) 2014-11-05 2016-05-12 Halliburton Energy Services, Inc. Delayed acid breaker systems for filtercakes
CA2978617A1 (en) 2015-03-06 2016-09-15 Canimguide Therapeutics Ab Immune system modulators and compositions
CN106539752B (zh) * 2015-09-18 2019-10-29 成都康弘药业集团股份有限公司 一种含有阿立哌唑的口服溶液及其制备方法
WO2017079563A1 (en) 2015-11-06 2017-05-11 The Johns Hopkins University Methods of treating liver fibrosis by administering 3-bromopyruvate
US20230233572A1 (en) 2020-06-11 2023-07-27 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent
KR102356618B1 (ko) * 2021-11-17 2022-02-08 명지대학교 산학협력단 신규 포접복합체 및 이의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182217B (en) * 1980-10-17 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing inclusive complexes of cyclodextrines and strong inorganic oxyacids
JPS60185772A (ja) * 1984-03-05 1985-09-21 Mitsui Pharmaceut Inc 安定なカルモフ−ル−β−シクロデキストリンの包接化合物
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
JP2571199B2 (ja) * 1987-11-25 1997-01-16 塩水港精糖株式会社 溶解性の高いサイクロデキストリンの製造方法
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids

Also Published As

Publication number Publication date
BR9406779A (pt) 1996-02-06
NZ261115A (en) 1996-11-26
FI953590A0 (fi) 1995-07-27
AU5971094A (en) 1994-08-15
WO1994016733A1 (en) 1994-08-04
HU218796B (hu) 2000-12-28
DE69431747D1 (de) 2003-01-02
IL108460A (en) 1999-01-26
EP0681481B1 (en) 2002-11-20
CZ194395A3 (en) 1996-01-17
KR960700074A (ko) 1996-01-19
JPH08508711A (ja) 1996-09-17
CA2154874A1 (en) 1994-08-04
EP0681481A1 (en) 1995-11-15
NO952981L (no) 1995-07-27
NO952981D0 (no) 1995-07-27
HUT72500A (en) 1996-05-28
ATE228013T1 (de) 2002-12-15
US5855916A (en) 1999-01-05
ITMI930141A0 (it) 1993-01-29
AU691115B2 (en) 1998-05-07
FI953590L (fi) 1995-09-14
IL108460A0 (en) 1994-04-12
IT1263831B (it) 1996-09-04
FI953590A7 (fi) 1995-09-14
HU9502251D0 (en) 1995-09-28
CZ284606B6 (cs) 1999-01-13
ZA94572B (en) 1994-09-13

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960130