JO3023B1 - عملية لتحضير هاليدات n -الكيل نالتريكسون - Google Patents

عملية لتحضير هاليدات n -الكيل نالتريكسون

Info

Publication number
JO3023B1
JO3023B1 JOP/2007/0399A JOP20070399A JO3023B1 JO 3023 B1 JO3023 B1 JO 3023B1 JO P20070399 A JOP20070399 A JO P20070399A JO 3023 B1 JO3023 B1 JO 3023B1
Authority
JO
Jordan
Prior art keywords
carbonate
preparing
alkylnal
trexone
halides
Prior art date
Application number
JOP/2007/0399A
Other languages
English (en)
Inventor
Alain Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of JO3023B1 publication Critical patent/JO3023B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

يتعلق الاختراع الحالي بعملية جديدة لتحضير بروميد N-مثيل نالتريكسون، وتتضمن على الاقل على الخطوات المتكونة من: (i)تفاعل كبريتات مثيل N-مثيل نالتريكسون، في محلول مائي مع عامل قلوي مختار من المجموعة المتكونة من كربونات صوديوم، كربونات بوتاسيوم، كربونات كالسيوم، كربونات ماغنيسيوم، كربونات سزيوم، كربونات استرنتيوم ومخاليط منها، لأس هيدروجيني لوسط التفاعل المائي بين 7و 10، وبعد ذلك (ii) تفاعل الناتج الذي تم الحصول عليه بذلك مع حمض هيدروبروميك، والذي يضاف لاس هيدروجيني لوسط التفاعل المائي بين 0،5 و5، وذلك للحصول على بروميد N-مثيل نالتريكسون.
JOP/2007/0399A 2006-09-21 2007-09-20 عملية لتحضير هاليدات n -الكيل نالتريكسون JO3023B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
JO3023B1 true JO3023B1 (ar) 2016-09-05

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2007/0399A JO3023B1 (ar) 2006-09-21 2007-09-20 عملية لتحضير هاليدات n -الكيل نالتريكسون

Country Status (35)

Country Link
US (2) US7645880B2 (ar)
EP (1) EP2069362B1 (ar)
JP (1) JP5214615B2 (ar)
KR (1) KR101434693B1 (ar)
CN (2) CN101516892B (ar)
AR (1) AR062918A1 (ar)
AU (1) AU2007298855B2 (ar)
BR (1) BRPI0718440A2 (ar)
CA (1) CA2663509C (ar)
CL (1) CL2007002711A1 (ar)
CO (1) CO6170362A2 (ar)
CR (1) CR10660A (ar)
DO (1) DOP2011000307A (ar)
EA (1) EA015426B1 (ar)
ES (1) ES2531093T3 (ar)
FR (1) FR2906252B1 (ar)
GT (1) GT200900060A (ar)
HN (1) HN2009000503A (ar)
IL (1) IL197402A (ar)
JO (1) JO3023B1 (ar)
MA (1) MA30793B1 (ar)
ME (1) MEP10509A (ar)
MX (1) MX2009003084A (ar)
MY (1) MY148094A (ar)
NI (1) NI200900035A (ar)
NO (1) NO20091561L (ar)
NZ (1) NZ575417A (ar)
PE (1) PE20080867A1 (ar)
SV (1) SV2009003192A (ar)
TN (1) TN2009000080A1 (ar)
TW (1) TWI465451B (ar)
UA (1) UA96957C2 (ar)
UY (1) UY30599A1 (ar)
WO (1) WO2008034973A1 (ar)
ZA (1) ZA200901846B (ar)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010522756A (ja) 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) * 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CA2738246C (en) * 2008-09-30 2017-09-05 Mallinckrodt Inc. Processes for the alkylation of secondary amine groups of morphinan derivatives
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
EP2398806A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
SMT201700177T1 (it) * 2010-11-05 2017-05-08 H Lundbeck As Procedimento per la fabbricazione di naltrexone
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
AR090916A1 (es) 2012-05-03 2014-12-17 Lundbeck & Co As H Metodo para la fabricacion de naltrexona
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617B (zh) * 2020-07-10 2025-06-06 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
WO2022076470A1 (en) 2020-10-06 2022-04-14 Sorrento Therapeutics, Inc. Oral delayed burst formulation of low-dose naltrexone or naloxone used for|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
EP1562953B1 (en) * 2002-11-08 2009-09-30 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
HN2009000503A (es) 2011-03-02
CN101516892A (zh) 2009-08-26
MA30793B1 (fr) 2009-10-01
AR062918A1 (es) 2008-12-17
AU2007298855B2 (en) 2012-09-13
GT200900060A (es) 2011-01-04
AU2007298855A1 (en) 2008-03-27
JP2010504308A (ja) 2010-02-12
TN2009000080A1 (en) 2010-08-19
KR101434693B1 (ko) 2014-08-27
CR10660A (es) 2009-06-24
HK1135389A1 (en) 2010-06-04
KR20090057031A (ko) 2009-06-03
MY148094A (en) 2013-02-28
FR2906252A1 (fr) 2008-03-28
US8288547B2 (en) 2012-10-16
US7645880B2 (en) 2010-01-12
NO20091561L (no) 2009-06-16
EA015426B1 (ru) 2011-08-30
CA2663509A1 (fr) 2008-03-27
ES2531093T3 (es) 2015-03-10
ME00613B (me) 2011-12-20
US20100145051A1 (en) 2010-06-10
CO6170362A2 (es) 2010-06-18
TW200821314A (en) 2008-05-16
NZ575417A (en) 2011-09-30
CN102225939A (zh) 2011-10-26
MX2009003084A (es) 2009-04-02
WO2008034973A1 (fr) 2008-03-27
TWI465451B (zh) 2014-12-21
IL197402A0 (en) 2009-12-24
EP2069362B1 (fr) 2014-07-09
ZA200901846B (en) 2010-07-28
UA96957C2 (ru) 2011-12-26
SV2009003192A (es) 2009-10-27
EP2069362A1 (fr) 2009-06-17
IL197402A (en) 2012-12-31
FR2906252B1 (fr) 2008-11-28
EA200970307A1 (ru) 2009-12-30
DOP2011000307A (es) 2011-10-31
UY30599A1 (es) 2008-05-02
NI200900035A (es) 2010-01-26
CN101516892B (zh) 2012-06-20
BRPI0718440A2 (pt) 2013-11-19
MEP10509A (en) 2011-12-20
CA2663509C (fr) 2014-03-18
PE20080867A1 (es) 2008-08-22
US20080214817A1 (en) 2008-09-04
CL2007002711A1 (es) 2008-04-18
JP5214615B2 (ja) 2013-06-19

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