ES2531093T3 - Procedimiento de preparación de halogenuros de N-alquil-naltrexona - Google Patents

Procedimiento de preparación de halogenuros de N-alquil-naltrexona Download PDF

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Publication number
ES2531093T3
ES2531093T3 ES07848250T ES07848250T ES2531093T3 ES 2531093 T3 ES2531093 T3 ES 2531093T3 ES 07848250 T ES07848250 T ES 07848250T ES 07848250 T ES07848250 T ES 07848250T ES 2531093 T3 ES2531093 T3 ES 2531093T3
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Spain
Prior art keywords
naltrexone
halides
alkyl
preparation procedure
formula
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Active
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ES07848250T
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English (en)
Inventor
Alain Dlubala
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Sanofi SA
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Sanofi SA
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Publication date
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ion doble de N-metil-naltrexona, de la fórmula:**Fórmula** en forma de anhidro o de hidrato.
ES07848250T 2006-09-21 2007-09-19 Procedimiento de preparación de halogenuros de N-alquil-naltrexona Active ES2531093T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone
PCT/FR2007/001516 WO2008034973A1 (fr) 2006-09-21 2007-09-19 Procede de preparation d'halogenures de n-alkyl naltrexone

Publications (1)

Publication Number Publication Date
ES2531093T3 true ES2531093T3 (es) 2015-03-10

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07848250T Active ES2531093T3 (es) 2006-09-21 2007-09-19 Procedimiento de preparación de halogenuros de N-alquil-naltrexona

Country Status (35)

Country Link
US (2) US7645880B2 (es)
EP (1) EP2069362B1 (es)
JP (1) JP5214615B2 (es)
KR (1) KR101434693B1 (es)
CN (2) CN102225939A (es)
AR (1) AR062918A1 (es)
AU (1) AU2007298855B2 (es)
BR (1) BRPI0718440A2 (es)
CA (1) CA2663509C (es)
CL (1) CL2007002711A1 (es)
CO (1) CO6170362A2 (es)
CR (1) CR10660A (es)
DO (1) DOP2011000307A (es)
EA (1) EA015426B1 (es)
ES (1) ES2531093T3 (es)
FR (1) FR2906252B1 (es)
GT (1) GT200900060A (es)
HN (1) HN2009000503A (es)
IL (1) IL197402A (es)
JO (1) JO3023B1 (es)
MA (1) MA30793B1 (es)
ME (1) ME00613B (es)
MX (1) MX2009003084A (es)
MY (1) MY148094A (es)
NI (1) NI200900035A (es)
NO (1) NO20091561L (es)
NZ (1) NZ575417A (es)
PE (1) PE20080867A1 (es)
SV (1) SV2009003192A (es)
TN (1) TN2009000080A1 (es)
TW (1) TWI465451B (es)
UA (1) UA96957C2 (es)
UY (1) UY30599A1 (es)
WO (1) WO2008034973A1 (es)
ZA (1) ZA200901846B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
EP2344506B1 (en) * 2008-09-30 2016-02-10 Mallinckrodt LLC Processes for the alkylation of secondary amine groups of morphinan derivatives
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
CN102459275A (zh) 2009-04-24 2012-05-16 布鲁克大学 制备吗啡烷和吗啡酮化合物的方法
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
RS55777B1 (sr) 2010-11-05 2017-07-31 H Lundbeck As Postupak za proizvodnju naltreksona
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
US20140155608A1 (en) 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617B (zh) * 2020-07-10 2025-06-06 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
EP4225312A1 (en) 2020-10-06 2023-08-16 Scilex Holding Company Oral delayed burst formulation of low-dose naltrexone or naloxone used for treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
ES2332453T3 (es) * 2002-11-08 2010-02-05 Mallinckrodt Inc. Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano.
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
TWI465451B (zh) 2014-12-21
FR2906252B1 (fr) 2008-11-28
US20080214817A1 (en) 2008-09-04
AU2007298855B2 (en) 2012-09-13
MX2009003084A (es) 2009-04-02
CL2007002711A1 (es) 2008-04-18
WO2008034973A1 (fr) 2008-03-27
HN2009000503A (es) 2011-03-02
CA2663509A1 (fr) 2008-03-27
JP2010504308A (ja) 2010-02-12
JP5214615B2 (ja) 2013-06-19
CN101516892B (zh) 2012-06-20
CO6170362A2 (es) 2010-06-18
TW200821314A (en) 2008-05-16
NI200900035A (es) 2010-01-26
US7645880B2 (en) 2010-01-12
MA30793B1 (fr) 2009-10-01
US8288547B2 (en) 2012-10-16
CR10660A (es) 2009-06-24
MEP10509A (en) 2011-12-20
IL197402A0 (en) 2009-12-24
DOP2011000307A (es) 2011-10-31
CN102225939A (zh) 2011-10-26
CA2663509C (fr) 2014-03-18
BRPI0718440A2 (pt) 2013-11-19
EA200970307A1 (ru) 2009-12-30
MY148094A (en) 2013-02-28
UA96957C2 (ru) 2011-12-26
TN2009000080A1 (en) 2010-08-19
PE20080867A1 (es) 2008-08-22
EA015426B1 (ru) 2011-08-30
ZA200901846B (en) 2010-07-28
AR062918A1 (es) 2008-12-17
AU2007298855A1 (en) 2008-03-27
EP2069362A1 (fr) 2009-06-17
ME00613B (me) 2011-12-20
NO20091561L (no) 2009-06-16
CN101516892A (zh) 2009-08-26
GT200900060A (es) 2011-01-04
FR2906252A1 (fr) 2008-03-28
IL197402A (en) 2012-12-31
KR101434693B1 (ko) 2014-08-27
JO3023B1 (ar) 2016-09-05
EP2069362B1 (fr) 2014-07-09
KR20090057031A (ko) 2009-06-03
HK1135389A1 (en) 2010-06-04
SV2009003192A (es) 2009-10-27
US20100145051A1 (en) 2010-06-10
NZ575417A (en) 2011-09-30
UY30599A1 (es) 2008-05-02

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