JO3308B1 - أشكال بلورية من 4-ميثيل-ان-[3-(4-ميثيل-اميدازول-1-واي ال)-5-ترفلوروميثيل-فينيل]-3-(4-بيريدين-3-واي ال-بيريميدين-2-يلامينو)-بنزاميد - Google Patents

أشكال بلورية من 4-ميثيل-ان-[3-(4-ميثيل-اميدازول-1-واي ال)-5-ترفلوروميثيل-فينيل]-3-(4-بيريدين-3-واي ال-بيريميدين-2-يلامينو)-بنزاميد

Info

Publication number
JO3308B1
JO3308B1 JOP/2016/0047A JOP20160047A JO3308B1 JO 3308 B1 JO3308 B1 JO 3308B1 JO P20160047 A JOP20160047 A JO P20160047A JO 3308 B1 JO3308 B1 JO 3308B1
Authority
JO
Jordan
Prior art keywords
methyl
ylamino
imidazol
pyrimidin
pyridin
Prior art date
Application number
JOP/2016/0047A
Other languages
English (en)
Inventor
Allen Sutton Paul
W Manley Paul
H Karpinski Piotr
Wu Raeann
Monnier Stephanie
Shieh Wen-Chung
Brozio Jorg
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37451227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3308(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3308B1 publication Critical patent/JO3308B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتم تحضير الأشكال البلورية من القاعدة الحرة 4- ميثيل-N-[3-(4- ميثيل- إيميدازول-1- يل)-5- ثالث فلوروميثيل فنيل]-3-(4- بيريدين-3- يل- بيريميدين-2- يل أمينو)- بنزاميد وأملاحها بواسطة عمليات مختلفة.
JOP/2016/0047A 2005-07-20 2016-03-17 أشكال بلورية من 4-ميثيل-ان-[3-(4-ميثيل-اميدازول-1-واي ال)-5-ترفلوروميثيل-فينيل]-3-(4-بيريدين-3-واي ال-بيريميدين-2-يلامينو)-بنزاميد JO3308B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70140505P 2005-07-20 2005-07-20
US71621405P 2005-09-12 2005-09-12

Publications (1)

Publication Number Publication Date
JO3308B1 true JO3308B1 (ar) 2018-09-16

Family

ID=37451227

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0047A JO3308B1 (ar) 2005-07-20 2016-03-17 أشكال بلورية من 4-ميثيل-ان-[3-(4-ميثيل-اميدازول-1-واي ال)-5-ترفلوروميثيل-فينيل]-3-(4-بيريدين-3-واي ال-بيريميدين-2-يلامينو)-بنزاميد

Country Status (42)

Country Link
US (4) US8343984B2 (ar)
EP (5) EP2543665A3 (ar)
JP (3) JP5289948B2 (ar)
KR (3) KR20130077915A (ar)
CN (2) CN103804356A (ar)
AR (1) AR054846A1 (ar)
AU (3) AU2006276204A1 (ar)
BR (1) BRPI0613615B1 (ar)
CA (1) CA2614334C (ar)
CR (1) CR9657A (ar)
CU (1) CU23916B1 (ar)
CY (2) CY1113076T1 (ar)
DK (2) DK2284167T4 (ar)
EA (2) EA013464B1 (ar)
EC (1) ECSP088119A (ar)
ES (3) ES2386974T3 (ar)
GE (1) GEP20115302B (ar)
GT (1) GT200600315A (ar)
HN (1) HN2008000311A (ar)
HR (2) HRP20120573T1 (ar)
HU (1) HUE031791T2 (ar)
IL (2) IL188189A0 (ar)
JO (1) JO3308B1 (ar)
LT (1) LT2284167T (ar)
MA (1) MA29626B1 (ar)
MX (1) MX2008000899A (ar)
MY (1) MY148554A (ar)
NI (1) NI200800017A (ar)
NO (1) NO341930B1 (ar)
NZ (1) NZ564409A (ar)
PE (1) PE20070214A1 (ar)
PH (1) PH12013501590A1 (ar)
PL (2) PL1912973T3 (ar)
PT (2) PT1912973E (ar)
RS (1) RS55929B2 (ar)
SG (1) SG163620A1 (ar)
SI (2) SI2284167T2 (ar)
SM (1) SMP200800011B (ar)
TN (1) TNSN08029A1 (ar)
TW (1) TWI406661B (ar)
UA (1) UA94234C2 (ar)
WO (1) WO2007015870A2 (ar)

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AU2006276204A1 (en) 2007-02-08
TNSN08029A1 (en) 2009-07-14
CA2614334A1 (en) 2007-02-08
MY148554A (en) 2013-04-30
UA94234C2 (uk) 2011-04-26
NO20080820L (no) 2008-04-15
US20080269269A1 (en) 2008-10-30
EP2284167A3 (en) 2011-03-02
EA016856B1 (ru) 2012-08-30
WO2007015870A2 (en) 2007-02-08
IL214659A0 (en) 2011-09-27
PT2284167T (pt) 2017-05-15
EP2284168A2 (en) 2011-02-16
SG163620A1 (en) 2010-08-30
AU2011202047A1 (en) 2011-05-26
HRP20120573T1 (hr) 2012-08-31
EP2284168A3 (en) 2011-04-13
GEP20115302B (en) 2011-10-10
SI1912973T1 (sl) 2012-08-31
PL2284167T5 (pl) 2020-07-27
ES2623608T5 (es) 2020-06-18
EP2284167B1 (en) 2017-02-01
SMAP200800011A (it) 2008-02-27
TW200740793A (en) 2007-11-01
EP2543665A3 (en) 2013-05-29
ES2386974T3 (es) 2012-09-10
SI2284167T1 (sl) 2017-05-31
US20130165465A1 (en) 2013-06-27
NZ564409A (en) 2011-07-29
HRP20170634T4 (hr) 2020-02-07
TWI406661B (zh) 2013-09-01
EP1912973A2 (en) 2008-04-23
AU2012201453A1 (en) 2012-04-05
PE20070214A1 (es) 2007-04-02
HUE031791T2 (en) 2017-08-28
JP2013018789A (ja) 2013-01-31
HRP20170634T1 (hr) 2017-06-30
CY1119624T1 (el) 2018-04-04
MX2008000899A (es) 2008-03-18
AR054846A1 (es) 2007-07-18
US20140343087A1 (en) 2014-11-20
KR20130085444A (ko) 2013-07-29
CU20080006A7 (es) 2011-02-24
PL1912973T3 (pl) 2012-09-28
DK2284167T3 (en) 2017-05-01
GT200600315A (es) 2007-03-19
PH12013501590A1 (en) 2015-09-21
KR101651288B1 (ko) 2016-08-25
BRPI0613615B1 (pt) 2022-02-08
KR20130077915A (ko) 2013-07-09
CN102358736A (zh) 2012-02-22
WO2007015870A3 (en) 2007-06-07
EA013464B1 (ru) 2010-04-30
RS55929B2 (sr) 2020-12-31
DK2284167T4 (da) 2020-03-02
EP2284167B2 (en) 2019-11-27
HK1116783A1 (en) 2009-01-02
EA201000145A1 (ru) 2010-06-30
ES2648288T3 (es) 2017-12-29
EP2535337B1 (en) 2017-08-23
DK1912973T3 (da) 2012-07-23
IL188189A0 (en) 2008-03-20
EP2543665A2 (en) 2013-01-09
SMP200800011B (it) 2008-02-27
US8415363B2 (en) 2013-04-09
AU2012201453C1 (en) 2024-05-23
CN103804356A (zh) 2014-05-21
JP5289948B2 (ja) 2013-09-11
BRPI0613615A2 (pt) 2011-01-18
CA2614334C (en) 2015-04-21
ECSP088119A (es) 2008-02-20
KR20080027853A (ko) 2008-03-28
SI2284167T2 (sl) 2020-03-31
US8343984B2 (en) 2013-01-01
RS55929B1 (sr) 2017-09-29
AU2012201453B2 (en) 2013-09-05
EP1912973B1 (en) 2012-06-13
JP2009502795A (ja) 2009-01-29
US20130023548A1 (en) 2013-01-24
NI200800017A (es) 2009-03-03
US8829015B2 (en) 2014-09-09
JP5798101B2 (ja) 2015-10-21
HN2008000311A (es) 2011-01-24
PT1912973E (pt) 2012-09-03
EP2535337A1 (en) 2012-12-19
JP2014221831A (ja) 2014-11-27
MA29626B1 (fr) 2008-07-01
EA200800201A1 (ru) 2008-06-30
NO341930B1 (no) 2018-02-19
CY1113076T1 (el) 2016-04-13
LT2284167T (lt) 2017-04-25
CR9657A (es) 2008-04-16
ES2623608T3 (es) 2017-07-11
PL2284167T3 (pl) 2017-07-31
EP2284167A2 (en) 2011-02-16
CU23916B1 (es) 2013-07-31

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