JO3392B1 - مركبات عطرية حلقية غير متجانسة كمركبات مضادة للالتهاب - Google Patents

مركبات عطرية حلقية غير متجانسة كمركبات مضادة للالتهاب

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Publication number
JO3392B1
JO3392B1 JOP/2015/0032A JOP20150032A JO3392B1 JO 3392 B1 JO3392 B1 JO 3392B1 JO P20150032 A JOP20150032 A JO P20150032A JO 3392 B1 JO3392 B1 JO 3392B1
Authority
JO
Jordan
Prior art keywords
compounds
aromatic heterocyclic
antiinflammatory
heterocyclic compounds
medicament
Prior art date
Application number
JOP/2015/0032A
Other languages
English (en)
Inventor
Alexander Fraser FORDYCE -Euan
Thomas Onions -Stuart
D Venable -Jennifer
Ian Longshaw Alistair
KING-UNDERWOOD -John
Original Assignee
Respivert Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Respivert Ltd filed Critical Respivert Ltd
Application granted granted Critical
Publication of JO3392B1 publication Critical patent/JO3392B1/ar

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    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بتوفير مركب من الصيغة (<span dir="LTR">I</span>) كما هو محدد في الوصف والذي هو عبارة عن مثبط كيناز <span dir="LTR">p38 MAP</span> للاستخدام كدواء لعلاج الأمراض الالتهابية من بين أمراض أخرى.
JOP/2015/0032A 2014-02-14 2015-02-15 مركبات عطرية حلقية غير متجانسة كمركبات مضادة للالتهاب JO3392B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461940282P 2014-02-14 2014-02-14
US201461941064P 2014-02-18 2014-02-18

Publications (1)

Publication Number Publication Date
JO3392B1 true JO3392B1 (ar) 2019-10-20

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JOP/2015/0032A JO3392B1 (ar) 2014-02-14 2015-02-15 مركبات عطرية حلقية غير متجانسة كمركبات مضادة للالتهاب

Country Status (20)

Country Link
US (8) US9447076B2 (ar)
EP (4) EP3357919B1 (ar)
JP (4) JP6586098B2 (ar)
KR (1) KR102413704B1 (ar)
CN (4) CN113264921B (ar)
AU (3) AU2015216957B2 (ar)
BR (1) BR112016015838B1 (ar)
CA (1) CA2938924C (ar)
DK (2) DK3105222T3 (ar)
EA (1) EA034927B1 (ar)
ES (2) ES2677595T3 (ar)
JO (1) JO3392B1 (ar)
MX (2) MX371353B (ar)
PL (2) PL3105222T3 (ar)
PT (2) PT3357919T (ar)
SG (1) SG11201607058PA (ar)
TR (1) TR201809072T4 (ar)
TW (2) TWI664967B (ar)
UY (1) UY35998A (ar)
WO (2) WO2015121660A1 (ar)

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NZ601085A (en) 2010-02-01 2015-04-24 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
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CN103917536B (zh) * 2011-10-03 2016-07-06 瑞斯比维特有限公司 1-吡唑基-3-(4-((2-(苯氨基)嘧啶-4-基)氧基)萘-1-基)脲用作p38 MAP激酶抑制剂
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
EP2890701B1 (en) 2012-08-29 2017-03-29 Respivert Limited Kinase inhibitors
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US20150225373A1 (en) 2012-08-29 2015-08-13 Respivert Limited Kinase inhibitors
WO2014076484A1 (en) 2012-11-16 2014-05-22 Respivert Limited Kinase inhibitors
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KR102283876B1 (ko) 2013-04-02 2021-07-29 옥슬러 액퀴지션즈 리미티드 키나제 저해제로서 유용한 우레아 유도체
US9771353B2 (en) 2013-04-02 2017-09-26 Topivert Pharma Limited Kinase inhibitors based upon N-alkyl pyrazoles
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
EP3083604A1 (en) 2013-12-20 2016-10-26 Respivert Limited Urea derivatives useful as kinase inhibitors
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