JO3503B1 - مشتقات فينيل تريازول مستبدلة مع هيدروكسي ألكيل واستخداماتها - Google Patents

مشتقات فينيل تريازول مستبدلة مع هيدروكسي ألكيل واستخداماتها

Info

Publication number
JO3503B1
JO3503B1 JOP/2015/0271A JOP20150271A JO3503B1 JO 3503 B1 JO3503 B1 JO 3503B1 JO P20150271 A JOP20150271 A JO P20150271A JO 3503 B1 JO3503 B1 JO 3503B1
Authority
JO
Jordan
Prior art keywords
hydroxyalkyl
phenyltriazole derivatives
substituted
compounds
treatment
Prior art date
Application number
JOP/2015/0271A
Other languages
English (en)
Inventor
Mondritzki Thomas
Sonja Vollmer Dr
Peter Kolkhof Dr
Florian K?Lling Dr
Dieter Lang Dr
Su?Meier Frank
Carsten Schmeck Dr
Klemens Lustig Dr
Nils Griebenow Dr
Pierre Wasnaire Dr
Michael Gerisch Dr
Elisabeth Pook Dr
Axel Kretschmer Dr
Hartmut Beck Dr
Anna Engelen Dr
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of JO3503B1 publication Critical patent/JO3503B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بمشتقات 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole جديدة، بعمليات لتحضير هذه المركبات، بتركيبات دوائية تحتوي على هذه المركبات، وباستخدام هذه المركبات أو التركيبات لمعالجة و/أو منع أمراض، تحديداً لمعالجة و/أو منع أمراض قلبية وعائية وكلوية.
JOP/2015/0271A 2014-11-03 2015-11-02 مشتقات فينيل تريازول مستبدلة مع هيدروكسي ألكيل واستخداماتها JO3503B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14191491 2014-11-03

Publications (1)

Publication Number Publication Date
JO3503B1 true JO3503B1 (ar) 2020-07-05

Family

ID=51897095

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2015/0271A JO3503B1 (ar) 2014-11-03 2015-11-02 مشتقات فينيل تريازول مستبدلة مع هيدروكسي ألكيل واستخداماتها

Country Status (41)

Country Link
US (2) US20170313665A1 (ar)
EP (1) EP3215498B1 (ar)
JP (1) JP6623220B2 (ar)
KR (1) KR20170081178A (ar)
CN (1) CN107074783B (ar)
AR (1) AR102487A1 (ar)
AU (1) AU2015342017B2 (ar)
BR (1) BR112017009204A2 (ar)
CA (1) CA2966256A1 (ar)
CL (1) CL2017001087A1 (ar)
CO (1) CO2017004471A2 (ar)
CU (1) CU24462B1 (ar)
CY (1) CY1120941T1 (ar)
DK (1) DK3215498T3 (ar)
DO (1) DOP2017000109A (ar)
EA (1) EA032137B1 (ar)
EC (1) ECSP17026733A (ar)
ES (1) ES2697902T3 (ar)
GT (1) GT201700094A (ar)
HR (1) HRP20181742T1 (ar)
HU (1) HUE040696T2 (ar)
IL (1) IL251354B (ar)
JO (1) JO3503B1 (ar)
LT (1) LT3215498T (ar)
MA (1) MA40893B1 (ar)
MX (1) MX375779B (ar)
MY (1) MY186908A (ar)
PE (1) PE20170945A1 (ar)
PH (1) PH12017500802B1 (ar)
PL (1) PL3215498T3 (ar)
PT (1) PT3215498T (ar)
RS (1) RS58049B1 (ar)
SA (1) SA517381429B1 (ar)
SG (1) SG11201703199UA (ar)
SI (1) SI3215498T1 (ar)
SV (1) SV2017005426A (ar)
TW (1) TWI694072B (ar)
UA (1) UA121558C2 (ar)
UY (1) UY36383A (ar)
WO (1) WO2016071212A1 (ar)
ZA (1) ZA201703802B (ar)

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