JOP20160154B1 - أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها - Google Patents

أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها

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Publication number
JOP20160154B1
JOP20160154B1 JOP/2016/0154A JOP20160154A JOP20160154B1 JO P20160154 B1 JOP20160154 B1 JO P20160154B1 JO P20160154 A JOP20160154 A JO P20160154A JO P20160154 B1 JOP20160154 B1 JO P20160154B1
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psma
antibodies
bind
antigen
binding molecules
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JOP/2016/0154A
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English (en)
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R Kirshner Jessica
Crawford Alison
Thurston Gavin
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Regeneron Pharma
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

يتعلق الاختراع الحالي بأجسام مضادة ترتبط بمولد ضد غشائي خاص بالبروستاتا (PSMA)، وأجسام مضادة ثنائية النوعية ترتبط بـ PSMA وCD3، وطرق لاستخدامها. وفقاً لتجسيدات معينة، تربط الأجسام المضادة الخاصة بالاختراع PSMA بشري بألفة عالية وتربط CD3 لإحداث تكاثر الخلية التائية. ويتضمن الاختراع أجساماً مضادة ترتبط بـ PSMA و CD3 وتحدث قتل لخلايا الورم المعبرة عن PSMA تتوسطه الخلية التائية. ووفقاً لتجسيدات معينة، يوفر الاختراع الحالي جزيئات رابطة لمولد ضد ثنائية النوعية تشتمل على نطاق أول رابط لمولد الضد يرتبط تحديداً بـ CD3 بشري، وجزيء ثان رابط لمولد الضد يرتبط تحديداً بـ PSMA بشري. وفي تجسيدات معينة، تكون الجزيئات الرابطة لمولد الضد ثنائية النوعية الخاصة بالاختراع الحالي قادرة على تثبيط نمو أورام البروستاتا المعبرة عن PSMA. وتعد الأجسام المضادة والجزيئات الرابطة لمولد الضد ثنائية النوعية الخاصة بالاختراع مفيدة في علاج أمراض واضطرابات حيث تكون زيادة الاستجابة المناعية المتحكم فيها أو المستحثة المستهدفة أمراً مرغوباً فيه و/أو مفيد من الناحية العلاجية. على سبيل المثال، يتم استخدام الأجسام المضادة الخاصة بالاختراع في علاج مختلف أنواع السرطان.
JOP/2016/0154A 2015-07-31 2016-07-25 أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها JOP20160154B1 (ar)

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US201562199823P 2015-07-31 2015-07-31
US201562222590P 2015-09-23 2015-09-23
US201662351823P 2016-06-17 2016-06-17

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