JOP20200020A1 - ميوتينات إنترليوكين-21 وطرق العلاج - Google Patents

ميوتينات إنترليوكين-21 وطرق العلاج

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Publication number
JOP20200020A1
JOP20200020A1 JOP/2020/0020A JOP20200020A JOP20200020A1 JO P20200020 A1 JOP20200020 A1 JO P20200020A1 JO P20200020 A JOP20200020 A JO P20200020A JO P20200020 A1 JOP20200020 A1 JO P20200020A1
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JO
Jordan
Prior art keywords
methods
muteins
interleukin
treatment
treating
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JOP/2020/0020A
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English (en)
Inventor
Ian Foltz
Neeraj Jagdish Agrawal
Gunasekaran Kannan
Daren Bates
Marissa Mock
Khaled M K Z Ali
Zhulun Wang
Shunseke Takenaka
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Amgen Inc
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Publication of JOP20200020A1 publication Critical patent/JOP20200020A1/ar
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Publication of JOP20200020B1 publication Critical patent/JOP20200020B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biochemistry (AREA)
  • Biophysics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يوفر الاختراع الحالي ميوتينات IL-21 وبروتينات دمج تشتمل على ذلك للاستخدام في طرق لعلاج مرض. يتم توفير المترافقات، الأحماض النووية، النواقل، الخلايا العائلة، التركيبات الصيدلية والأطقم ذات الصلة هنا أيضًا. يتم توفير طرق عمل ميوتينات IL-21 وبروتينات الدمج التي تشتمل على ذلك، بالإضافة إلى طرق علاج خاضع للعلاج بحاجة لذلك، من خلال الكشف الحالي. يتم كذلك توفير بروتينات تربط مولد ضد PD-1.
JOP/2020/0020A 2017-08-03 2018-08-03 ميوتينات إنترليوكين-21 وطرق العلاج JOP20200020B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762540692P 2017-08-03 2017-08-03
US201862616733P 2018-01-12 2018-01-12
PCT/US2018/045105 WO2019028316A1 (en) 2017-08-03 2018-08-03 INTERLEUKIN-21 MUTÉINS AND METHODS OF TREATMENT

Publications (2)

Publication Number Publication Date
JOP20200020A1 true JOP20200020A1 (ar) 2020-02-02
JOP20200020B1 JOP20200020B1 (ar) 2023-09-17

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ID=63350603

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JOP/2020/0020A JOP20200020B1 (ar) 2017-08-03 2018-08-03 ميوتينات إنترليوكين-21 وطرق العلاج
JOJO/P/2022/0225A JOP20220225B1 (ar) 2017-08-03 2022-09-19 ميوتينات إنترليوكين-21 وطرق العلاج

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Country Status (38)

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US (2) US11541103B2 (ar)
EP (2) EP3661954B1 (ar)
JP (2) JP7079171B2 (ar)
KR (2) KR102414120B1 (ar)
CN (2) CN118126157A (ar)
AU (2) AU2018311079B2 (ar)
BR (2) BR122021015266B1 (ar)
CA (1) CA3071376A1 (ar)
CL (3) CL2020000252A1 (ar)
CO (1) CO2020001113A2 (ar)
CR (1) CR20200099A (ar)
CY (1) CY1125429T1 (ar)
DK (1) DK3661954T3 (ar)
ES (2) ES2975221T3 (ar)
HR (1) HRP20220404T1 (ar)
HU (1) HUE058233T2 (ar)
IL (2) IL272137B2 (ar)
JO (2) JOP20200020B1 (ar)
LT (1) LT3661954T (ar)
MA (1) MA56289B1 (ar)
MX (2) MX2020001328A (ar)
MY (1) MY195974A (ar)
NZ (2) NZ761008A (ar)
PE (2) PE20250757A1 (ar)
PH (1) PH12020500231A1 (ar)
PL (1) PL3661954T3 (ar)
PT (1) PT3661954T (ar)
RS (1) RS63101B1 (ar)
SA (2) SA522432917B1 (ar)
SG (1) SG11202000821SA (ar)
SI (1) SI3661954T1 (ar)
SM (1) SMT202200162T1 (ar)
TN (1) TN2020000015A1 (ar)
TW (3) TWI844073B (ar)
UA (1) UA130113C2 (ar)
UY (2) UY37829A (ar)
WO (1) WO2019028316A1 (ar)
ZA (2) ZA202001251B (ar)

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JP7079171B2 (ja) 2022-06-01
MA56289B1 (fr) 2022-04-29
CN111164100A (zh) 2020-05-15
US20190046611A1 (en) 2019-02-14
PL3661954T3 (pl) 2022-05-16
HRP20220404T1 (hr) 2022-05-27
MA56289A (fr) 2020-06-10
AU2022228122A1 (en) 2022-09-29
EP4029877B1 (en) 2024-01-17
PE20250757A1 (es) 2025-03-13
PH12020500231A1 (en) 2021-01-11
TW202342501A (zh) 2023-11-01
CL2022000300A1 (es) 2022-09-23
JOP20220225B1 (ar) 2025-10-01
DK3661954T3 (da) 2022-04-19

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