JP2000504317A - 気泡懸濁物と超音波造影剤への応用 - Google Patents

気泡懸濁物と超音波造影剤への応用

Info

Publication number
JP2000504317A
JP2000504317A JP9525697A JP52569797A JP2000504317A JP 2000504317 A JP2000504317 A JP 2000504317A JP 9525697 A JP9525697 A JP 9525697A JP 52569797 A JP52569797 A JP 52569797A JP 2000504317 A JP2000504317 A JP 2000504317A
Authority
JP
Japan
Prior art keywords
water
fatty acid
porous matrix
mol
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9525697A
Other languages
English (en)
Japanese (ja)
Inventor
ベルグマン，マルティナ
ヘルドマン，ディーター
バイトシーズ，ヴェルナー
フリッツ，トーマス
サドマン，フィオレッタ
Original Assignee
シェリング アクチェンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シェリング アクチェンゲゼルシャフト filed Critical シェリング アクチェンゲゼルシャフト
Publication of JP2000504317A publication Critical patent/JP2000504317A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C08J9/147—Halogen containing compounds containing carbon and halogen atoms only
    • C08J9/148—Halogen containing compounds containing carbon and halogen atoms only perfluorinated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP9525697A 1996-01-18 1997-01-16 気泡懸濁物と超音波造影剤への応用 Pending JP2000504317A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19602930.9 1996-01-18
DE19602930A DE19602930A1 (de) 1996-01-18 1996-01-18 Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
PCT/EP1997/000208 WO1997026016A2 (fr) 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores

Publications (1)

Publication Number Publication Date
JP2000504317A true JP2000504317A (ja) 2000-04-11

Family

ID=7783852

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9525697A Pending JP2000504317A (ja) 1996-01-18 1997-01-16 気泡懸濁物と超音波造影剤への応用

Country Status (8)

Country Link
EP (1) EP0874644A2 (fr)
JP (1) JP2000504317A (fr)
AU (1) AU1592597A (fr)
CA (1) CA2243174A1 (fr)
DE (1) DE19602930A1 (fr)
NO (1) NO983332D0 (fr)
WO (1) WO1997026016A2 (fr)
ZA (1) ZA97414B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3178724B2 (ja) 1996-03-05 2001-06-25 エイカスフィアー・インコーポレーテッド 画像化剤として使用するためのミクロカプセル化フッ素化ガス
JP2009018284A (ja) * 2007-07-13 2009-01-29 Kao Corp 微細気泡前駆体の製造方法
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
JP2013231079A (ja) * 2005-11-28 2013-11-14 Verrow Pharmaceuticals Inc 腎毒性の低減に有用な組成物及びその使用方法
KR101927614B1 (ko) 2017-03-30 2018-12-10 숭실대학교산학협력단 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법
JP2019048779A (ja) * 2017-09-11 2019-03-28 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240226418A1 (en) * 2021-01-26 2024-07-11 Agitated Solutions Inc. Syringe-Based Microbubble Generator

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
DK0586524T3 (fr) * 1991-06-03 1997-05-20 Nycomed Imaging As
FI940027A7 (fi) * 1991-07-05 1994-01-04 Nycomed Imaging As Parannuksia itse varjoaineisiin tai parannuksia, jotka liittyvät niihi n
CA2112905A1 (fr) * 1991-07-05 1993-01-21 Michael R. Violante Particules poreuses ultra petites, non solidarisees, a bulles de gaz piegees
KR100191303B1 (ko) * 1991-09-17 1999-06-15 씨. 큐웨이 스티븐 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DK0711179T3 (da) * 1993-07-30 2005-02-14 Imcor Pharmaceutical Co Stabiliserede sammensætninger med mikrobobler til ultralyd
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
PT682530E (pt) * 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
GB9402867D0 (en) * 1994-02-15 1994-04-06 Nycomed Imaging As Improvements in or relating to contrast agents
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3178724B2 (ja) 1996-03-05 2001-06-25 エイカスフィアー・インコーポレーテッド 画像化剤として使用するためのミクロカプセル化フッ素化ガス
JP2013231079A (ja) * 2005-11-28 2013-11-14 Verrow Pharmaceuticals Inc 腎毒性の低減に有用な組成物及びその使用方法
JP2009018284A (ja) * 2007-07-13 2009-01-29 Kao Corp 微細気泡前駆体の製造方法
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
KR101927614B1 (ko) 2017-03-30 2018-12-10 숭실대학교산학협력단 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법
JP2019048779A (ja) * 2017-09-11 2019-03-28 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤
JP7211699B2 (ja) 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤

Also Published As

Publication number Publication date
EP0874644A2 (fr) 1998-11-04
WO1997026016A3 (fr) 1997-10-23
AU1592597A (en) 1997-08-11
ZA97414B (en) 1997-07-17
NO983332L (no) 1998-07-17
NO983332D0 (no) 1998-07-17
CA2243174A1 (fr) 1997-07-24
DE19602930A1 (de) 1997-07-24
WO1997026016A2 (fr) 1997-07-24

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