JP2000504722A5 - - Google Patents

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Publication number: JP2000504722A5
Authority: JP; Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

JP1997529318A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000504722A (ja

Filing date

1996-08-21

Publication date

2004-09-16

1996-02-16 Priority claimed from PCT/US1996/002260 external-priority patent/WO1996025157A1/fr

1996-08-21 Application filed filed Critical

2000-04-18 Publication of JP2000504722A publication Critical patent/JP2000504722A/ja

2004-09-16 Publication of JP2000504722A5 publication Critical patent/JP2000504722A5/ja

Status Withdrawn legal-status Critical Current

Links

JP9529318A 1995-02-17 1996-08-21 Ｉｌ―８レセプターアンタゴニスト Withdrawn JP2000504722A (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US39026095A	1995-02-17	1995-02-17
WO96/02260		1996-02-16
PCT/US1996/002260 WO1996025157A1 (fr)	1995-02-17	1996-02-16	Antagonistes des recepteurs d'il-8
PCT/US1996/013632 WO1997029743A1 (fr)	1995-02-17	1996-08-21	Antagonistes de recepteurs de l'interleukine-8

Publications (2)

Publication Number	Publication Date
JP2000504722A JP2000504722A (ja)	2000-04-18
JP2000504722A5 true JP2000504722A5 (fr)	2004-09-16

Family

ID=23541762

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP8525199A Withdrawn JPH11503110A (ja)	1995-02-17	1996-02-16	Ｉｌ−８受容体拮抗剤
JP9529318A Withdrawn JP2000504722A (ja)	1995-02-17	1996-08-21	Ｉｌ―８レセプターアンタゴニスト

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP8525199A Withdrawn JPH11503110A (ja)	1995-02-17	1996-02-16	Ｉｌ−８受容体拮抗剤

Country Status (19)

Country	Link
US (2)	US5886044A (fr)
EP (2)	EP0809492A4 (fr)
JP (2)	JPH11503110A (fr)
KR (1)	KR19990082622A (fr)
CN (2)	CN1539816A (fr)
AU (1)	AU725456B2 (fr)
BG (1)	BG102690A (fr)
BR (1)	BR9612779A (fr)
CA (1)	CA2245927A1 (fr)
EA (1)	EA001436B1 (fr)
HU (1)	HUP0000467A3 (fr)
IL (1)	IL125717A0 (fr)
NO (1)	NO983737L (fr)
NZ (1)	NZ316710A (fr)
OA (1)	OA10840A (fr)
PL (1)	PL328562A1 (fr)
SK (1)	SK110198A3 (fr)
TR (1)	TR199801592T2 (fr)
WO (2)	WO1996025157A1 (fr)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11503110A (ja) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体拮抗剤
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EP0914319B1 (fr)	1996-05-20	2001-11-21	Teijin Limited	Derives de diamine cyclique de diarylaklyle utilises en tant qu'antagonistes des recepteurs de chimiokines
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EP0934066A4 (fr)	1996-08-06	2001-10-17	Smithkline Beecham Corp	Antagonistes du recepteur de l'interleukine-8 (il-8)
WO1998005317A1 (fr) *	1996-08-06	1998-02-12	Smithkline Beecham Corporation	Antagonistes du recepteur de l'il-8
EP0939634A4 (fr) *	1996-08-15	2001-02-21	Smithkline Beecham Corp	Antagonistes du recepteur il-8
AU3048797A (en) *	1996-10-22	1998-05-15	Chugai Seiyaku Kabushiki Kaisha	Sepsis remedy comprising anti-il-8 antibody as active ingredient
DE19651040C2 (de) *	1996-12-09	1999-01-28	Bayer Ag	Verfahren zur Herstellung von 2-Amino-5-alkyl-phenolen
CN1217660C (zh)	1997-01-23	2005-09-07	史密丝克莱恩比彻姆公司	Il－8受体拮抗剂
US6436927B1 (en)	1997-02-12	2002-08-20	Smithkline Beecham Corporation	IL-8 receptor antagonists
JP2001512445A (ja) *	1997-02-12	2001-08-21	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８レセプターアンタゴニスト
US6696475B2 (en)	1997-04-22	2004-02-24	Neurosearch A/S	Substituted phenyl derivatives, their preparation and use
US6344476B1 (en) *	1997-05-23	2002-02-05	Bayer Corporation	Inhibition of p38 kinase activity by aryl ureas
EP1014962A4 (fr) *	1997-06-26	2007-06-27	Lilly Co Eli	Agents antithrombotiques
JP2001512096A (ja) *	1997-07-29	2001-08-21	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８レセプターアンタゴニスト
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7329670B1 (en)	1997-12-22	2008-02-12	Bayer Pharmaceuticals Corporation	Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
AU2003204708B2 (en) *	1997-12-22	2006-05-25	Bayer Healthcare Llc	Inhibition of Raf Kinase using Substituted Heterocyclic Ureas
ATE291011T1 (de) *	1997-12-22	2005-04-15	Bayer Pharmaceuticals Corp	Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen
US7517880B2 (en)	1997-12-22	2009-04-14	Bayer Pharmaceuticals Corporation	Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
JP4437270B2 (ja) *	1997-12-22	2010-03-24	バイエルコーポレイション	置換複素環式尿素を用いたｒａｆキナーゼの阻害
US20080300281A1 (en) *	1997-12-22	2008-12-04	Jacques Dumas	Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
WO1999065310A1 (fr) *	1998-06-17	1999-12-23	Smithkline Beecham Corporation	Antagonistes des recepteurs d'il-8
EP1098884A4 (fr) *	1998-07-23	2003-01-22	Smithkline Beecham Corp	Antagonistes de recepteur d'il-8
WO2000012468A1 (fr) *	1998-08-28	2000-03-09	Smithkline Beecham Corporation	Synthese amelioree de 3-hydroxy-4-amino-benzonitrile
EP1514867A3 (fr) *	1998-10-22	2005-03-23	NeuroSearch A/S	Dérivés de phényle substitués, leur préparation et utilisation
US6201013B1 (en)	1998-12-09	2001-03-13	American Home Products Corporation	Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
US6197803B1 (en)	1998-12-09	2001-03-06	American Home Products Corporation	Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US6262090B1 (en)	1998-12-09	2001-07-17	American Home Products Corporation	Aminopyridine-containing thiourea inhibitors of herpes viruses
US6255349B1 (en)	1998-12-09	2001-07-03	American Home Products Corporation	Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
US6207715B1 (en)	1998-12-09	2001-03-27	American Home Products Corporation	Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
ATE267824T1 (de) *	1998-12-09	2004-06-15	Wyeth Corp	Alpha-methylbenzyl-enthaltende thioharnstoffe als inhibitoren von herpes-viren mit einer phenylenediamingruppe
US6166028A (en)	1998-12-09	2000-12-26	American Home Products Corporation	Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6335350B1 (en)	1998-12-09	2002-01-01	American Home Products Corporation	Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
EP1137632B1 (fr) *	1998-12-09	2004-07-28	Wyeth	Thio-urees inhibitrices des virus de l'herpes
US20080269265A1 (en) *	1998-12-22	2008-10-30	Scott Miller	Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US7351834B1 (en)	1999-01-13	2008-04-01	Bayer Pharmaceuticals Corporation	ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en)	1999-01-13	2012-02-28	Bayer Healthcare Llc	ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2298311B1 (fr) *	1999-01-13	2012-05-09	Bayer HealthCare LLC	Urées de diphényle à substitution omega-carboxyaryle en tant qu'inhibiteurs de la p38 kinase
EP1140840B1 (fr) *	1999-01-13	2006-03-22	Bayer Pharmaceuticals Corp.	Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
US7928239B2 (en)	1999-01-13	2011-04-19	Bayer Healthcare Llc	Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
UA73492C2 (en)	1999-01-19	2005-08-15		Aromatic heterocyclic compounds as antiinflammatory agents
MXPA01008440A (es)	1999-02-22	2002-04-24	Boehringer Ingelheim Pharma	Derivados heterociclicos policiclos como agentes anti-inflamatorios..
TR200102817T2 (tr)	1999-03-12	2002-05-21	Boehringer Ingelheim Pharmaceuticals, Inc.	Antiinflamatuar ajanlar olarak faydalı bileşikler
WO2000055152A1 (fr) *	1999-03-12	2000-09-21	Boehringer Ingelheim Pharmaceuticals, Inc.	Composes aromatiques heterocycliques utilises en tant qu'agents anti-inflammatoires
EP1163212B1 (fr) *	1999-03-17	2005-08-31	AstraZeneca AB	Derives amides
CO5170528A1 (es) *	1999-05-28	2002-06-27	Smithkline Beecham Corp	Antagonistas de los receptores de la il-8 nistas del recpetor de la il-8
CO5190710A1 (es) *	1999-06-15	2002-08-29	Smithkline Beecham Corp	Antagonistas de un receptor de il-8 un receptor de il-8
CO5200760A1 (es) *	1999-06-16	2002-09-27	Smithkline Beecham Corp	Antagonistas del receptor de la il-8 ceptor il-8
KR20020029419A (ko) *	1999-07-07	2002-04-18	다비드 에 질레스	퀴나졸린 유도체
CA2374737C (fr)	1999-07-09	2008-02-12	Boehringer Ingelheim Pharmaceuticals, Inc.	Nouveau procede de synthese de composes d'uree a substitution heteroaryle
EP1199306B1 (fr)	1999-07-26	2005-12-07	Banyu Pharmaceutical Co., Ltd.	Derives de biaryluree
CO5271663A1 (es) *	1999-11-09	2003-04-30	Smithkline Beecham Corp	Antagonistas del receptor il-8
ES2292488T3 (es)	1999-11-16	2008-03-16	Boehringer Ingelheim Pharmaceuticals Inc.	Derivados de la urea, como agentes antiinflamatorios.
US6525046B1 (en)	2000-01-18	2003-02-25	Boehringer Ingelheim Pharmaceuticals, Inc.	Aromatic heterocyclic compounds as antiinflammatory agents
US6608052B2 (en)	2000-02-16	2003-08-19	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as anti-inflammatory agents
EP1274413A4 (fr) *	2000-03-01	2005-08-10	Smithkline Beecham Corp	Antagonistes du recepteur il-8
EP1261329A4 (fr) *	2000-03-10	2005-08-17	Smithkline Beecham Corp	Antagonistes du recepteur de il-8
AR030273A1 (es) *	2000-03-10	2003-08-20	Smithkline Beecham Corp	Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina
EP1274415A4 (fr) *	2000-03-14	2005-09-07	Smithkline Beecham Corp	Antagonistes du recepteur de il-8
CO5280089A1 (es) *	2000-03-16	2003-05-30	Smithkline Beecham Corp	Antagonistas del receptor il-8
UY26627A1 (es) *	2000-03-24	2001-09-28	Smithkline Beecham Corp	Antagonistas de receptores de il-8
CN1423635A (zh) *	2000-04-14	2003-06-11	吴羽化学工业株式会社	含氮化合物以及使用该化合物的抗病毒药
WO2001092202A1 (fr) *	2000-05-30	2001-12-06	Smithkline Beecham Corporation	Antagonistes du recepteur de l'il-8
AU2001273497A1 (en) *	2000-07-18	2002-01-30	Smithkline Beecham Corporation	Use of IL-8 receptor antagonists in the treatment of virus infections
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WO2002070467A1 (fr)	2001-02-26	2002-09-12	4Sc Ag	Derives de diphenyluree, de diamide d'acide diphenyloxalique et de diamide d'acide diphenylsulfurique et leur utilisation comme medicaments
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DK1379508T3 (da)	2001-02-28	2011-01-03	Univ Temple	N-(aryl)-2arylethensulfonamider og terapeutiske anvendelser deraf
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EP2305255B1 (fr) *	2001-12-03	2012-08-22	Bayer HealthCare LLC	Composes de type uree aryle combines a d'autres agents cytostatiques ou cytotoxiques et servant a traiter des cancers humains
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WO2003068229A1 (fr)	2002-02-11	2003-08-21	Bayer Pharmaceuticals Corporation	N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase
ATE529406T1 (de)	2002-02-11	2011-11-15	Bayer Healthcare Llc	Aryl-harnstoffe als kinase inhibitoren
DK1478358T3 (da)	2002-02-11	2013-10-07	Bayer Healthcare Llc	Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
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EP1480973B1 (fr)	2002-02-25	2008-02-13	Boehringer Ingelheim Pharmaceuticals Inc.	Composes de cycloalkyle uree benzofusionnes a disubstitution en position 1,4 utiles dans le traitement de maladies mediees par la cytokine
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WO2004089296A2 (fr) *	2003-04-03	2004-10-21	The Regents Of The University Of California	Inhibiteurs ameliores pour hydrolase epoxyde soluble
EP1636585B2 (fr)	2003-05-20	2012-06-13	Bayer HealthCare LLC	Diaryl-urees presentant une activite d'inhibition des kinases
NZ544331A (en)	2003-07-22	2010-03-26	Arena Pharm Inc	Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
PL1663978T3 (pl)	2003-07-23	2008-04-30	Bayer Healthcare Llc	Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
CN1845726A (zh)	2003-09-04	2006-10-11	波塞东医药公司	用于治疗心脏心律失常的erg通道开放剂
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KR101149124B1 (ko) *	2004-03-10	2012-05-25	가부시끼가이샤 구레하	아민계 염기성 화합물과 그의 용도
EP1765311A4 (fr)	2004-03-16	2009-04-29	Univ California	Reduction de la nephropathie au moyen d'inhibiteurs d'hydrolase d'epoxyde soluble et d'epoxyeicosanoides
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AU2005273612B2 (en)	2004-08-12	2010-10-14	Pfizer Inc.	Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
EP1634573A1 (fr) *	2004-08-16	2006-03-15	The Procter and Gamble Company	Composés 2-(Amino ou amino substitué)-5-6-substituée de phenol, compositions les contenant et leur utilisation
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WO2006043950A1 (fr) *	2004-10-20	2006-04-27	Smithkline Beecham Corporation	Antagonistes du récepteur il-8
WO2006045119A2 (fr) *	2004-10-20	2006-04-27	The Regents Of The University Of California	Inhibiteurs ameliores de l'epoxyde hydrolase soluble
EP1809619A1 (fr)	2004-10-21	2007-07-25	Transtech Pharma, Inc.	Composes bissulfonamide utilises en tant qu'agonistes du galr1, compositions, et procedes d'utilisation associes
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WO2006060762A2 (fr) *	2004-12-03	2006-06-08	Arena Pharmaceuticals, Inc.	Derives de pyrazole en tant que modulateurs du recepteur de serotinine 5-ht2a utiles dans le traitement de troubles associes a ce recepteur
CA2594563A1 (fr) *	2005-01-19	2006-07-27	Arena Pharmaceuticals, Inc.	Derives de diaryl-uree et d'arylheteroaryl-uree utilises comme modulateurs du recepteur de la serotonine 5-ht2a et utiles pour la prevention ou le traitement de la leucoencephalopathie multifocale progressive
MX2007008434A (es)	2005-01-19	2007-07-25	Squibb Bristol Myers Co	Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos.
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WO2007002634A1 (fr)	2005-06-27	2007-01-04	Bristol-Myers Squibb Company	Antagonistes carbocycliques et heherocycliques du recepteur p2y1, utiles pour traiter des etats pathologiques thrombotiques
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1998
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1999
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JP2000500033A5 (fr)	2004-09-09
JP2000500228A5 (fr)	2004-09-09
JP2000500445A5 (fr)	2004-10-14
JPH11514289A5 (fr)	2004-10-14
JP2000500327A5 (fr)	2005-10-06
JPH11510779A5 (fr)	2004-08-26
JP2000500155A5 (fr)	2004-10-21
JP2000500406A5 (fr)	2004-10-14
JPH11507746A5 (fr)	2004-07-29
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JP2000500322A5 (fr)	2004-09-30
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JP2000500342A5 (fr)	2004-10-21
JP2000500112A5 (fr)	2004-10-14
JPH11507655A5 (fr)	2004-07-29
JP2000500166A5 (fr)	2004-09-24
JP2000500051A5 (fr)	2004-10-14
JP2000500397A5 (fr)	2004-10-21
JP2000500407A5 (fr)	2004-10-21
JP2000500019A5 (fr)	2004-11-04
JP2000500125A5 (fr)	2004-10-21
JP2000500044A5 (fr)	2006-01-05
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JP2000500257A5 (fr)	2004-08-12