JP2000505306A - ２つまたはそれ以上の相互作用性（ポリ）ペプチドをコードする核酸配列の新規同定方法 - Google Patents

２つまたはそれ以上の相互作用性（ポリ）ペプチドをコードする核酸配列の新規同定方法

Info

Publication number
JP2000505306A
JP2000505306A JP9530595A JP53059597A JP2000505306A JP 2000505306 A JP2000505306 A JP 2000505306A JP 9530595 A JP9530595 A JP 9530595A JP 53059597 A JP53059597 A JP 53059597A JP 2000505306 A JP2000505306 A JP 2000505306A
Authority
JP
Japan
Prior art keywords
poly
nucleic acid
peptide
vector
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9530595A
Other languages
English (en)
Japanese (ja)
Inventor
イラグ，ヴィック
ゲ，リミン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphosys GmbH
Original Assignee
Morphosys GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys GmbH filed Critical Morphosys GmbH
Publication of JP2000505306A publication Critical patent/JP2000505306A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP9530595A 1996-02-26 1997-02-26 ２つまたはそれ以上の相互作用性（ポリ）ペプチドをコードする核酸配列の新規同定方法 Pending JP2000505306A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96102852 1996-02-26
EP96102852.9 1996-02-26
PCT/EP1997/000931 WO1997032017A1 (fr) 1996-02-26 1997-02-26 Nouvelle methode pour l'identification de sequences d'acides nucleiques codant pour deux (poly)peptides interactifs, ou plus

Publications (1)

Publication Number Publication Date
JP2000505306A true JP2000505306A (ja) 2000-05-09

Family

ID=8222506

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9530595A Pending JP2000505306A (ja) 1996-02-26 1997-02-26 ２つまたはそれ以上の相互作用性（ポリ）ペプチドをコードする核酸配列の新規同定方法

Country Status (3)

Country Link
EP (1) EP0883686A1 (fr)
JP (1) JP2000505306A (fr)
WO (1) WO1997032017A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007501007A (ja) * 2003-08-06 2007-01-25 リナ ネッツヴェルク エルエヌアー−テクノローギエン ゲゼルシャフト ミット ベグレンツター ハフトゥング 無細胞タンパク質生合成用溶解物の産生法

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WO1997021728A1 (fr) 1995-12-12 1997-06-19 Karolinska Innovations Ab PEPTIDE FIXANT LA SEQUENCE KLVFF DE L'AMYLOIDE $g(b)
WO1999006587A2 (fr) * 1997-08-01 1999-02-11 Morphosys Ag Nouvelle methode et nouveau phage d'identification d'une sequence d'acide nucleique
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
ATE282717T1 (de) * 1998-04-30 2004-12-15 Max Planck Gesellschaft Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank
US7060670B1 (en) 1999-05-05 2006-06-13 Neurochem (International) Limited Stereoselective antifibrillogenic peptides and peptidomimetics thereof
AU1979301A (en) * 1999-12-09 2002-02-13 Select Therapeutics Inc. Methods for detecting compound interactions using phage display
AU3040101A (en) * 2000-02-03 2001-08-14 Domantis Limited Combinatorial protein domains
EP1283878B1 (fr) 2000-05-22 2005-07-27 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Piege a interaction base sur des recepteurs
AU2001277614A1 (en) * 2000-08-07 2002-02-18 Domantis Limited Novel proteins
US6830885B1 (en) 2000-08-18 2004-12-14 Phenogene Therapeutiques Inc. Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
WO2003004643A2 (fr) 2001-07-03 2003-01-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Piege a interaction proteine-proteine de mammifere inverse
US7175983B2 (en) * 2001-11-02 2007-02-13 Abmaxis, Inc. Adapter-directed display systems
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
DE10256669B4 (de) 2002-12-04 2006-03-09 Universitätsklinikum Charité an der Humboldt-Universität zu Berlin Technologietransferstelle Gemisch mindestens zweier Fusionsproteine sowie ihre Herstellung und Verwendung
TWI306458B (en) 2003-05-30 2009-02-21 Elan Pharma Int Ltd Humanized antibodies that recognize beta amyloid peptide
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
EP1838348B1 (fr) 2004-12-15 2013-06-26 Janssen Alzheimer Immunotherapy Anticorps du peptide beta-amyloide humanises utilises dans l'amelioration de la cognition
US7625560B2 (en) 2004-12-15 2009-12-01 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
DK2182983T3 (da) 2007-07-27 2014-07-14 Janssen Alzheimer Immunotherap Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US8637435B2 (en) 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
GB201103453D0 (en) 2011-03-01 2011-04-13 Vib Vzw Kinase substrate sensor
CA2866097C (fr) 2012-03-06 2021-02-02 Vib Vzw Proteine de fusion transmembranaire-kinase et les utilisations de celle-ci
CA2874268C (fr) 2012-05-24 2022-06-07 Universiteit Gent Particule de type viral sur la base d'une interaction proteine-proteine
GB201504859D0 (en) 2015-03-23 2015-05-06 Vib Vzw Viral particle based small molecule-protein interaction trap
JP2023507172A (ja) 2019-12-17 2023-02-21 オリオニス バイオサイエンシズ，インコーポレイテッド タンパク質分解の調節

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4122598C1 (fr) * 1991-07-08 1992-07-30 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg, De
CA2131151A1 (fr) * 1992-03-24 1994-09-30 Kevin S. Johnson Methodes de production d'elements formant des paires specifiques de liaison
EP0614989A1 (fr) * 1993-02-17 1994-09-14 MorphoSys AG Procédé de sélection in vivo des protéines attachées des ligands
SE9503151D0 (sv) * 1995-09-13 1995-09-13 Bioinvent Internatioal Ab Combined ligand and receptor display

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007501007A (ja) * 2003-08-06 2007-01-25 リナ ネッツヴェルク エルエヌアー−テクノローギエン ゲゼルシャフト ミット ベグレンツター ハフトゥング 無細胞タンパク質生合成用溶解物の産生法
JP4850064B2 (ja) * 2003-08-06 2012-01-11 キアゲン ゲーエムベーハー 無細胞タンパク質生合成用溶解物の産生法

Also Published As

Publication number Publication date
WO1997032017A1 (fr) 1997-09-04
EP0883686A1 (fr) 1998-12-16

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